LOCUS       NM_133308               3178 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor NMDA type subunit
            3B (Grin3b), mRNA.
ACCESSION   NM_133308
VERSION     NM_133308.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3178)
  AUTHORS   Berg,L.K., Larsson,M., Morland,C. and Gundersen,V.
  TITLE     Pre- and postsynaptic localization of NMDA receptor subunits at
            hippocampal mossy fibre synapses
  JOURNAL   Neuroscience 230, 139-150 (2013)
   PUBMED   23159309
REFERENCE   2  (bases 1 to 3178)
  AUTHORS   Liu,Q. and Wong-Riley,M.T.
  TITLE     Postnatal development of N-methyl-D-aspartate receptor subunits 2A,
            2B, 2C, 2D, and 3B immunoreactivity in brain stem respiratory
            nuclei of the rat
  JOURNAL   Neuroscience 171 (3), 637-654 (2010)
   PUBMED   20887777
  REMARK    GeneRIF: In contrast to NR2D, NR3B expression rises gradually from
            postnatal day P2 to P21.
REFERENCE   3  (bases 1 to 3178)
  AUTHORS   Fukumori,R., Takarada,T., Nakamichi,N., Kambe,Y., Kawagoe,H.,
            Nakazato,R. and Yoneda,Y.
  TITLE     Requirement of both NR3A and NR3B subunits for dominant negative
            properties on Ca2+ mobilization mediated by acquired
            N-methyl-D-aspartate receptor channels into mitochondria
  JOURNAL   Neurochem Int 57 (7), 730-737 (2010)
   PUBMED   20813147
  REMARK    GeneRIF: NMDA receptor subunit NR3B is essential for the dominant
            negative properties of calcium moblization into mitochondria.
REFERENCE   4  (bases 1 to 3178)
  AUTHORS   Bendova,Z., Sumova,A. and Mikkelsen,J.D.
  TITLE     Circadian and developmental regulation of
            N-methyl-d-aspartate-receptor 1 mRNA splice variants and
            N-methyl-d-aspartate-receptor 3 subunit expression within the rat
            suprachiasmatic nucleus
  JOURNAL   Neuroscience 159 (2), 599-609 (2009)
   PUBMED   19361480
  REMARK    GeneRIF: The NMDAR3b subunits exhibit developmental loss around the
            time of eye opening in rat suprachiasmatic nucleus.
REFERENCE   5  (bases 1 to 3178)
  AUTHORS   Wee,K.S., Zhang,Y., Khanna,S. and Low,C.M.
  TITLE     Immunolocalization of NMDA receptor subunit NR3B in selected
            structures in the rat forebrain, cerebellum, and lumbar spinal cord
  JOURNAL   J Comp Neurol 509 (1), 118-135 (2008)
   PUBMED   18425811
  REMARK    GeneRIF: NR3B is widely expressed in the structures examined in the
            rat forebrain (hippocampus, cerebral cortex, caudoputamen, and
            nucleus accumbens), cerebellum, and lumbar sections of the spinal
            cord.
REFERENCE   6  (bases 1 to 3178)
  AUTHORS   Matsuda,K., Fletcher,M., Kamiya,Y. and Yuzaki,M.
  TITLE     Specific assembly with the NMDA receptor 3B subunit controls
            surface expression and calcium permeability of NMDA receptors
  JOURNAL   J Neurosci 23 (31), 10064-10073 (2003)
   PUBMED   14602821
REFERENCE   7  (bases 1 to 3178)
  AUTHORS   Chatterton,J.E., Awobuluyi,M., Premkumar,L.S., Takahashi,H.,
            Talantova,M., Shin,Y., Cui,J., Tu,S., Sevarino,K.A., Nakanishi,N.,
            Tong,G., Lipton,S.A. and Zhang,D.
  TITLE     Excitatory glycine receptors containing the NR3 family of NMDA
            receptor subunits
  JOURNAL   Nature 415 (6873), 793-798 (2002)
   PUBMED   11823786
  REMARK    GeneRIF: Excitatory glycine receptors containing the NR3 family of
            NMDA receptor subunits
REFERENCE   8  (bases 1 to 3178)
  AUTHORS   Nishi,M., Hinds,H., Lu,H.P., Kawata,M. and Hayashi,Y.
  TITLE     Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate
            receptor subunit that works in a dominant-negative manner
  JOURNAL   J Neurosci 21 (23), RC185 (2001)
   PUBMED   11717388
REFERENCE   9  (bases 1 to 3178)
  AUTHORS   Andersson,O., Stenqvist,A., Attersand,A. and von Euler,G.
  TITLE     Nucleotide sequence, genomic organization, and chromosomal
            localization of genes encoding the human NMDA receptor subunits
            NR3A and NR3B
  JOURNAL   Genomics 78 (3), 178-184 (2001)
   PUBMED   11735224
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF440691.2.
            
            On May 1, 2002 this sequence version replaced NM_133308.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF440691.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132276,
                                           SAMD00132277 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3178
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3178
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /note="glutamate ionotropic receptor NMDA type subunit 3B"
                     /db_xref="GeneID:170796"
                     /db_xref="RGD:621705"
     exon            1..501
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..3084
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /note="glutamate [NMDA] receptor subunit 3B;
                     N-methyl-D-aspartate receptor subtype 3B; glutamate
                     receptor, ionotropic, N-methyl-D-aspartate 3B; glutamate
                     receptor, ionotropic, NMDA3B; glutamate receptor
                     ionotropic, NMDA 3B"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 3B
                     precursor"
                     /protein_id="NP_579842.2"
                     /db_xref="GeneID:170796"
                     /db_xref="RGD:621705"
                     /translation="MESVRTLWLSVALALAVGSRVVRGHPQPCRVPTRAGASVRLAAL
                     LPRAPAARARVLAALATPAPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVA
                     SIAFPEARPELRLLQFLAAATETPVVSVLRREVRTALGAPTPFHLQLDWASPLETILD
                     VLVSLVRAHAWEDIALVLCRVRDPGSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAG
                     LALLGALEGGGTPVPAAVLLGCSTARAHEVLEAAPPGPQWLLGTPLPAEALPTTGLPP
                     GVLALGETEQHSLEAVVHDMVELVAQALSSMALVHPERALLPAVVNCDDLKTGGSEAT
                     GRTLARFLGNTSFQGRTGAVWVTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDG
                     QLDFQPGAAALRVPSPSGTQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGT
                     NDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGAL
                     RDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPI
                     GAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCY
                     AILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHD
                     PKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLN
                     AFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSG
                     FIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVFY
                     RLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAEQERSGPKDELPATDGAGR
                     WRRVRRAVERERRVRFLLEPGEAGGDRPWLCSNGPGLQAELRELELRIEAARERLRSA
                     LLRRGELRALLGDGTRLRPLRLLHAAPAES"
     exon            502..1094
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..2127
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2273
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2389
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2541
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2706
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2774
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..3171
                     /gene="Grin3b"
                     /gene_synonym="GluN3B; NMDAR3B; NR3B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacgagggg acaagagcgg gtctggctgg ggtgtctcct tcccttcgca cagcacagtg
       61 gtaacttctt tcgggatgga gagtgtgcgg acgctgtggc tcagcgtggc cctggcgctg
      121 gcggtggggt cccgagtggt gcgcggtcac cctcagccct gccgggttcc cacgcgcgct
      181 ggggcctccg tgcgcctggc ggcgctcctg ccccgggcgc ccgccgcccg cgcccgcgtc
      241 ctagctgccc tggccacccc tgcgccgcgg ctgccgcaca acctgagtct ggaactggtg
      301 gccgtcgcgt ccccgacccg ggaccccgcg tcgctagctc gaggtctgtg ccaggttctg
      361 gcaccgcctg gcgtggtggc ctctatagcc tttcccgagg cgcggcccga gctgcggcta
      421 ctgcagttcc tggcagccgc cacagagacc ccagtggtga gcgtcctgcg gagggaggtg
      481 cgcacggccc tcggagcccc gactccgttc catctgcagc tggactgggc tagtcccctg
      541 gagaccatac tggatgtgct ggtgtccctg gtacgggcac atgcctggga ggacattgct
      601 ctagtactct gccgtgtccg ggaccctggc agcctggtga cactctggac taaccatgct
      661 agccaggctc caaagtttgt gctggacctg agccggctgg acagcaggaa tgacagcctt
      721 cgggctggac tggccctgtt gggggcgctg gaaggagggg gaaccccagt gcctgcagca
      781 gtcctcctag gctgcagcac tgcccgtgca catgaggtcc tagaggctgc accaccgggt
      841 ccccagtggt tgctgggcac accattgccc gctgaggcac tgcccacgac tggtctgcca
      901 cctggcgtgc tggcgctggg ggaaaccgaa caacactctc tggaagctgt cgtccacgac
      961 atggtggagc ttgtggctca ggcactcagt agcatggccc ttgtacaccc agagcgggca
     1021 ctgcttccag ctgtggtgaa ctgtgatgac ctgaaaacag gcggatctga ggcaacaggg
     1081 cgcaccttgg ctcggtttct cggcaacacc tcatttcagg gccgaacagg ggccgtgtgg
     1141 gtgacaggct cctctcaggt gcatgtgtct cggcatttca aggtatggag cctgcgccgg
     1201 gatccgctgg gtgccccagc ctgggcaacc gtgggcagct ggcaggatgg acagctggac
     1261 ttccagccag gggcagccgc tctccgagtc ccatctccgt ctggcaccca ggcccgacca
     1321 aagctgcgtg tggtaaccct ggtggaacac ccgtttgtgt tcaccaggga atctgatgaa
     1381 gacggacagt gcccagctgg gcagctgtgt ctggacccag gcaccaatga ctcagccagg
     1441 ctggatgccc tctttgctgc actggtgaat ggctcagtac ctcgaacgct gagaagatgc
     1501 tgctatggct actgcatcga cctgctggag cggctggccg aggacctggc ctttgacttt
     1561 gagctctata ttgtggggga tggcaagtac ggggccctgc gtgatgggcg ctggacgggc
     1621 ctggtgggtg acctgctggc tggccgggca cacatggctg tgaccagctt cagcatcaac
     1681 tcagctcgct ctcaggtggt ggatttcacc agccctttct tctccaccag cctggggatt
     1741 atggtgcgca cgagagacac ggcctcgccc atcggggctt tcatgtggcc cctgcactgg
     1801 tccatgtggg tgggcgtgtt tgctgctctg cacctcacag cgctctttct caccctgtac
     1861 gaatggcgaa gtccctacgg gctcacgccg cgcggccgca accgtggcac tgtcttctct
     1921 tactcctccg cgctcaacct gtgctatgcc attctctttg gacgcactgt ctccagtaag
     1981 acgcccaagt gccctactgg acgcttcctc atgaacctct gggcaatctt ctgcctgctg
     2041 gtgctttcca gttacacggc caacctggct gctgtcatgg ttggggacaa aacctttgag
     2101 gagctgtctg gaatccatga tcccaagctg caccaccctt cccaaggctt tcgctttggc
     2161 accgtatggg agagcagcgc ggaggcctac atcaaggcaa gcttccctga gatgcacgca
     2221 cacatgcgtc ggcacagcgc acccaccact ccacatgggg tggccatgct cacgagcgac
     2281 ccgcccaagc tcaacgcctt catcatggat aaatcactac tggactatga ggtgtccata
     2341 gatgcggact gcaagctgct caccgttggc aaaccctttg ctatcgaggg ctacggcata
     2401 gggctacccc aaaactcgcc gctcacctcc aacctgtcgg agttcatcag taggtacaag
     2461 tcttcaggct tcattgatct gctccatgac aagtggtaca agatggtgcc ttgcgggaag
     2521 cgggtgttcg ccgtgacgga gacgctgcag atgggggtct accacttctc aggattgttt
     2581 gtcctgctgt gcctcgggct gggcagcgcg cttctcacct ctctgggtga gcatgtcttc
     2641 taccgcctgg tgctgccgcg catccgcagg ggtaataagc tgcagtattg gcttcacacg
     2701 agccagaaga tccaccgagc cctcaataca ggaccacccg aggggcaaca ggagagggca
     2761 gagcaggagc gcagcggccc caaggacgag ctgcctgcca ccgatggtgc agggcgctgg
     2821 aggcgggtgc gccgggctgt ggaacgggag cgacgcgtgc gtttcctgct ggaacctggg
     2881 gaggctggcg gagaccgccc gtggctctgc tccaacgggc ccgggctgca agcggagctg
     2941 cgggagctgg agctgcgcat tgaggctgca cgggagcggc tgcgcagtgc gctgttgcgg
     3001 cgcggggagc tgcgggccct gcttggggat ggcacccggc tcaggccact gcgcctgttg
     3061 catgcggcgc ctgctgagag ctgaggaacc acaaggccgc actgtccacg acagtttatt
     3121 ctatatacaa acacgactct gtacactgca attaaatagc gtggaacgtg aaaaaaaa
//
