LOCUS       NM_001198583            4326 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor NMDA type subunit
            3A (Grin3a), transcript variant 2, mRNA.
ACCESSION   NM_001198583
VERSION     NM_001198583.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4326)
  AUTHORS   Beesley,S., Sullenberger,T., Lee,C. and Kumar,S.S.
  TITLE     GluN3 subunit expression correlates with increased vulnerability of
            hippocampus and entorhinal cortex to neurodegeneration in a model
            of temporal lobe epilepsy
  JOURNAL   J Neurophysiol 127 (6), 1496-1510 (2022)
   PUBMED   35475675
  REMARK    GeneRIF: GluN3 subunit expression correlates with increased
            vulnerability of hippocampus and entorhinal cortex to
            neurodegeneration in a model of temporal lobe epilepsy.
REFERENCE   2  (bases 1 to 4326)
  AUTHORS   Chen,L.F., Lyons,M.R., Liu,F., Green,M.V., Hedrick,N.G.,
            Williams,A.B., Narayanan,A., Yasuda,R. and West,A.E.
  TITLE     The NMDA receptor subunit GluN3A regulates synaptic
            activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent
            transcription
  JOURNAL   J Biol Chem 295 (25), 8613-8627 (2020)
   PUBMED   32393578
  REMARK    GeneRIF: The NMDA receptor subunit GluN3A regulates synaptic
            activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent
            transcription.
REFERENCE   3  (bases 1 to 4326)
  AUTHORS   Skrenkova,K., Hemelikova,K., Kolcheva,M., Kortus,S., Kaniakova,M.,
            Krausova,B. and Horak,M.
  TITLE     Structural features in the glycine-binding sites of the GluN1 and
            GluN3A subunits regulate the surface delivery of NMDA receptors
  JOURNAL   Sci Rep 9 (1), 12303 (2019)
   PUBMED   31444392
  REMARK    GeneRIF: Structural features in the glycine-binding sites of the
            GluN1 and GluN3A subunits regulate the surface delivery of NMDA
            receptors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4326)
  AUTHORS   Zhang,X.Y., Ji,F., Wang,N., Chen,L.L., Tian,T. and Lu,W.
  TITLE     Glycine induces bidirectional modifications in N-methyl-D-aspartate
            receptor-mediated synaptic responses in hippocampal CA1 neurons
  JOURNAL   J Biol Chem 289 (45), 31200-31211 (2014)
   PUBMED   25231980
  REMARK    GeneRIF: N-methyl-D-aspartate receptor-mediated synaptic responses
            are induced by glycine in hippocampal CA1 neurons
REFERENCE   5  (bases 1 to 4326)
  AUTHORS   Larsen,R.S., Smith,I.T., Miriyala,J., Han,J.E., Corlew,R.J.,
            Smith,S.L. and Philpot,B.D.
  TITLE     Synapse-specific control of experience-dependent plasticity by
            presynaptic NMDA receptors
  JOURNAL   Neuron 83 (4), 879-893 (2014)
   PUBMED   25144876
  REMARK    Erratum:[Neuron. 2014 Sep 17;83(6);1481]
REFERENCE   6  (bases 1 to 4326)
  AUTHORS   Perez-Otano,I., Schulteis,C.T., Contractor,A., Lipton,S.A.,
            Trimmer,J.S., Sucher,N.J. and Heinemann,S.F.
  TITLE     Assembly with the NR1 subunit is required for surface expression of
            NR3A-containing NMDA receptors
  JOURNAL   J Neurosci 21 (4), 1228-1237 (2001)
   PUBMED   11160393
REFERENCE   7  (bases 1 to 4326)
  AUTHORS   Sun,L., Margolis,F.L., Shipley,M.T. and Lidow,M.S.
  TITLE     Identification of a long variant of mRNA encoding the NR3 subunit
            of the NMDA receptor: its regional distribution and developmental
            expression in the rat brain
  JOURNAL   FEBS Lett 441 (3), 392-396 (1998)
   PUBMED   9891978
REFERENCE   8  (bases 1 to 4326)
  AUTHORS   Das,S., Sasaki,Y.F., Rothe,T., Premkumar,L.S., Takasu,M.,
            Crandall,J.E., Dikkes,P., Conner,D.A., Rayudu,P.V., Cheung,W.,
            Chen,H.S., Lipton,S.A. and Nakanishi,N.
  TITLE     Increased NMDA current and spine density in mice lacking the NMDA
            receptor subunit NR3A
  JOURNAL   Nature 393 (6683), 377-381 (1998)
   PUBMED   9620802
REFERENCE   9  (bases 1 to 4326)
  AUTHORS   Sucher,N.J., Akbarian,S., Chi,C.L., Leclerc,C.L., Awobuluyi,M.,
            Deitcher,D.L., Wu,M.K., Yuan,J.P., Jones,E.G. and Lipton,S.A.
  TITLE     Developmental and regional expression pattern of a novel NMDA
            receptor-like subunit (NMDAR-L) in the rodent brain
  JOURNAL   J Neurosci 15 (10), 6509-6520 (1995)
   PUBMED   7472413
REFERENCE   10 (bases 1 to 4326)
  AUTHORS   Ciabarra,A.M., Sullivan,J.M., Gahn,L.G., Pecht,G., Heinemann,S. and
            Sevarino,K.A.
  TITLE     Cloning and characterization of chi-1: a developmentally regulated
            member of a novel class of the ionotropic glutamate receptor family
  JOURNAL   J Neurosci 15 (10), 6498-6508 (1995)
   PUBMED   7472412
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U29873.1 and BI294379.1.
            
            On Oct 9, 2014 this sequence version replaced NM_001198583.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            resulting isoform (2) lacks an internal segment, compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U29873.1, L34938.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4176              U29873.1           1-4176
            4177-4185           BI294379.1         18-26               c
            4186-4326           U29873.1           4186-4326
FEATURES             Location/Qualifiers
     source          1..4326
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..4326
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /note="glutamate ionotropic receptor NMDA type subunit 3A"
                     /db_xref="GeneID:191573"
                     /db_xref="RGD:621704"
     exon            1..1172
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             474..3821
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; glutamate [NMDA] receptor subunit 3A; NR3A;
                     NMDAR-L; NMDAR-L1; N-methyl-D-aspartate receptor subtype
                     3A; NMDAR3A; glutamate receptor chi-1; glutamate receptor
                     ionotropic, NMDA 3A; NR3 chi-1; glutamate receptor,
                     ionotropic, N-methyl-D-aspartate 3A"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 3A isoform 2
                     precursor"
                     /protein_id="NP_001185512.1"
                     /db_xref="GeneID:191573"
                     /db_xref="RGD:621704"
                     /translation="MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRI
                     GHAVRVGAVHLQPWTTAPRAASRAQEGGRAGAQRDDPESGTWRPPAPSQGARWLGSAL
                     HGRGPPGSRKLGEGAGAETLWPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAGLGD
                     LPLMPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELDLVSSVLHI
                     PVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNI
                     TDFLLLTENNSKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDS
                     IRQIFEMSTQFGLSPPELHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDA
                     MELVARAVATATMIQPELALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIK
                     VKGSTIISSENNFFIWNLQHDPMGKPMWTRLGSWQGGRIVMDSGIWPEQAQRHKTHFQ
                     HPNKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSND
                     TVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGT
                     ANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIF
                     VALHITAIFLTLYEWKSPFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAAIKPPKCW
                     TGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVR
                     ESSAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEVSID
                     ADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKWYKVVPCG
                     KRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKLQYW
                     LHTSQRFHRALNTSFVEEKQPRSKTKRVEKRSNLGPQQLMVWNTSNLSHDNQRKYIFN
                     DEEGQNQLGTQAHQDIPLPQRRRELPASLTTNGKADSLNVTRSSVIQELSELEKQIQV
                     IRQELQLAVSRKTELEEYQKTNRTCES"
     exon            1173..1777
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2825
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..2971
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3087
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3088..3239
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..3404
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3405..3481
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..4326
                     /gene="Grin3a"
                     /gene_synonym="chi-1; GluN3A; NR3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctctgcca cctcagtaaa taagtgggtg tcgcctgaac tgaacagcaa gagaaaagaa
       61 gccagccaag tgagagcaca gctcctctgt cactgccgcc cccttgcaag tctggcggct
      121 tctcgcgggg ccagacgctg cgccccaggc gccctgcaga tggggtggac agggacccgg
      181 agctcaagcc accggtgacc cgcgcgtggc tggccgaccg gccttccccg cttgcagagg
      241 atgttaagca gaggagccct ggaaccgcat ccgacactgg ccgacgttcg ctaggctgca
      301 acttggaatg cccagggagc ggtcgggctc ctaagaccgc gtcgccgcgt ctagggaagc
      361 tgcgctccgg atttggaggc ggagacctca ggcggcggag acctccggcg gcggctgcag
      421 agggacgagc cgggcgcagg agggggcgcg ctttctccca gcgggtctca gtaatgagga
      481 gactgagttt gtggtggctg ctgagcaggg tctgtctgct gctgccgccg ccctgcgcac
      541 tggtgctggc cggggtgccc agctcctcct cgcacccgca accctgccag atcctcaagc
      601 gcatcggaca cgcggtgagg gtgggcgcgg tgcacttgca accctggacc acggccccac
      661 gcgcagccag tcgcgctcag gaaggcggca gggcgggtgc ccagagggat gatccagagt
      721 ccgggacgtg gcggccaccg gcgccctcgc aaggcgcacg ctggttgggg agcgccctgc
      781 atggccgggg tccacccggc tcccgaaagc tcggggaggg cgcgggggcc gagaccctgt
      841 ggccgcggga tgccctactg ttcgctgtgg aaaacttgaa ccgtgtggaa gggctcctac
      901 cctacaacct gtctttggaa gtagtgatgg ccattgaggc gggcctgggc gatctgccgc
      961 ttatgccctt ctcttcccca agctcaccgt ggagcagtga ccctttctcc tttctgcaga
     1021 gcgtgtgcca caccgtagtg gtacaagggg tgtcggcgct gctggccttc ccccagagcc
     1081 agggcgaaat gatggagctg gacttggtca gctctgtcct gcacatccca gtgctcagca
     1141 tagtgcgcca cgagtttccg cgggagagtc agaatcccct gcacctacag ctgagtttag
     1201 aaaactcact aagttctgat gctgatgtca ctgtctcaat cctgaccatg aacaactggt
     1261 acaattttag cttgttgctc tgccaggaag actggaatat cacggacttc ctcctcctta
     1321 cggagaataa ctccaagttc cacctcgagt ctgttatcaa catcactgct aatctgtcct
     1381 ccacaaagga ccttctaagt ttcctgcagg tccagatgga caacattagg aacagcacac
     1441 ccacaatggt gatgtttggc tgtgacatgg acagtatccg gcagatattt gaaatgtcca
     1501 cacagtttgg gctatcacct cctgaacttc actgggtttt aggagactcc cagaatgtgg
     1561 aggaactgag gacagaaggc ctgcccttag ggctcattgc tcatggaaaa accacacaat
     1621 ctgtctttga gtactacgtt caggatgcca tggagttggt tgcaagagct gtagccacag
     1681 ccaccatgat ccagccagag cttgctctcc ttcccagcac aatgaactgc atggatgtga
     1741 aaaccacaaa tctcacttct ggacagtatt tatcaaggtt tttagccaac accactttca
     1801 gaggtctcag tggttccatc aaagtaaagg gctccaccat catcagctca gagaacaact
     1861 ttttcatctg gaacttgcag cacgacccta tgggaaagcc aatgtggact cgcctgggca
     1921 gctggcaagg aggaaggata gtcatggact ctggaatatg gccagagcag gcccagaggc
     1981 acaaaaccca cttccagcac ccaaacaagt tacacttgag agtggtgaca ttgattgaac
     2041 acccatttgt tttcacgaga gaagtagacg atgaaggctt atgccctgct ggacagctct
     2101 gtctagaccc tatgactaac gactcttcca tgctggatcg tctgtttagc agcctgcata
     2161 gcagtaatga cacagtgcca atcaagttca agaagtgctg ttatgggtac tgcatcgatc
     2221 tcctggagca gctagcagaa gacatgaact ttgactttga cctctacatt gtaggggatg
     2281 gaaagtacgg agcttggaaa aatggtcact ggactgggct ggttggtgat ctcctgagtg
     2341 ggacagccaa catggcggtc acttctttca gcatcaatac cgcacgaagc caggtgatag
     2401 atttcaccag ccctttcttc tcaaccagtt tggggatctt agtgaggact cgagacacag
     2461 cagctccaat tggagccttc atgtggccac tccactggac catgtggctg ggaattttcg
     2521 tggctctcca tatcactgcc atttttctca ctctgtatga atggaagagc ccctttggta
     2581 tgacccctaa ggggaggaac agaaacaaag tcttctcctt ctcctcagct ttgaatgtct
     2641 gctatgccct tctgtttggc agaacagcag ccatcaaacc cccaaaatgc tggactggaa
     2701 ggtttctgat gaatctttgg gccattttct gtatgttttg cctttctaca tacacagcga
     2761 acttggctgc tgtcatggta ggtgagaaga tctatgaaga gctttctgga attcatgacc
     2821 ctaagcttca tcatccttct caaggcttcc gctttggaac tgtccgggaa agcagtgctg
     2881 aagactatgt gcgccagagc ttcccagaga tgcatgagta catgagaagg tacaacgtgc
     2941 cagccacccc tgatggagtg cagtatctga agaatgatcc agagaaacta gacgccttca
     3001 tcatggacaa agcccttctg gattatgaag tgtcaataga tgctgactgc aagcttctga
     3061 ccgtaggaaa gccatttgcc atcgaaggat atggcattgg tctccctcca aactctccat
     3121 tgacctctaa tatatctgag ctcatcagtc agtacaagtc tcacgggttt atggatgtgc
     3181 tccatgacaa gtggtacaag gtggttccct gcggaaagag aagctttgcc gtcactgaga
     3241 ctttgcaaat gggcatcaag cacttctctg gactcttcgt gctgttgtgc ataggatttg
     3301 gtctctccat cctgaccacc attggtgaac acatagtgca cagactgctg ttaccacgca
     3361 tcaaaaacaa atccaagctg cagtactggc tgcacacgag tcagaggttt cacagagcat
     3421 taaacacgtc attcgtagaa gaaaagcagc cacgttccaa gacaaaacgt gtggagaaga
     3481 ggtccaacct gggaccccag cagctcatgg tatggaatac ttccaatctg agtcatgaca
     3541 accaacgaaa atacatcttt aatgacgagg aaggacaaaa ccagctgggt acccaggccc
     3601 accaggacat ccctctccct cagaggagaa gagagctccc tgcctcactg accaccaatg
     3661 ggaaagcaga ctccctcaat gtaactcgga gctccgtgat tcaggaactc tctgagttgg
     3721 agaagcagat ccaagtgatc cgccaggagc tgcagttggc tgtaagcagg aagacagagc
     3781 tggaggagta tcaaaagaca aatcggactt gtgaatccta ggctgtgtct ccccccactt
     3841 tctcagcccc tggtactctg aagcccttga gacactttgt aaagcccttt tatattcctt
     3901 gacaaaggtg tggggtctgg caatgaagtg tgctgttctc tgcctaaggt gcagcagcag
     3961 cagcagcagc agttcttccc acaaaggccc ccaggtcttc agggtagtaa tcgttccgat
     4021 agtaggaagc tagggttagt cgggagtaaa gtctgtctga ggggatcggc gagctgccag
     4081 acaactctgg ctcctctcaa ccttttcacc tggtgccaca aaaaaaattc tggtttttag
     4141 ccctttctct gcacctcaac aagagataaa aagccgtcgc tcatacctgt gtcttactgg
     4201 gttggttttt aatattacta caaaacaaaa ttatccaatg ttgcagattt gatacaactc
     4261 cccaatctag atctgatcta acattctgaa tgagcagggt aggagccagg aaaacgggac
     4321 agaaca
//
