LOCUS       NM_022797               5254 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor NMDA type subunit
            2D (Grin2d), mRNA.
ACCESSION   NM_022797
VERSION     NM_022797.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5254)
  AUTHORS   Zhang,J.B., Wang,F., Tang,Y.T., Pang,M.Z., Li,D. and Liu,C.F.
  TITLE     Inhibition of GluN2D-Containing NMDA Receptors Protects
            Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via
            Activating ERK/NRF2/HO-1 Signaling
  JOURNAL   ACS Chem Neurosci 15 (3), 572-581 (2024)
   PUBMED   38277219
  REMARK    GeneRIF: Inhibition of GluN2D-Containing NMDA Receptors Protects
            Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via
            Activating ERK/NRF2/HO-1 Signaling.
REFERENCE   2  (bases 1 to 5254)
  AUTHORS   Wang,J.X., Irvine,M.W., Burnell,E.S., Sapkota,K., Thatcher,R.J.,
            Li,M., Simorowski,N., Volianskis,A., Collingridge,G.L.,
            Monaghan,D.T., Jane,D.E. and Furukawa,H.
  TITLE     Structural basis of subtype-selective competitive antagonism for
            GluN2C/2D-containing NMDA receptors
  JOURNAL   Nat Commun 11 (1), 423 (2020)
   PUBMED   31969570
  REMARK    GeneRIF: UBP791
            ((2S*,
            3R*)-1-(7-(2-carboxyethyl)phenanthrene-2-carbonyl)piperazine-2,
            3-dicarboxylic acid) inhibits GluN2C/2D with 40-fold selectivity
            over GluN2A-containing receptors, and that a methionine and a
            lysine residue in the ligand binding pocket are the critical
            molecular elements for the subtype-specific binding.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5254)
  AUTHORS   Mellone,M., Zianni,E., Stanic,J., Campanelli,F., Marino,G.,
            Ghiglieri,V., Longhi,A., Thiolat,M.L., Li,Q., Calabresi,P.,
            Bezard,E., Picconi,B., Di Luca,M. and Gardoni,F.
  TITLE     NMDA receptor GluN2D subunit participates to levodopa-induced
            dyskinesia pathophysiology
  JOURNAL   Neurobiol Dis 121, 338-349 (2019)
   PUBMED   30261285
  REMARK    GeneRIF: Study supports a role for GluN2D-NMDARs in L-DOPA-induced
            dyskinesia (LID), and they confirm that cell-type and subunit
            specific modifications of NMDARs underlie the pathophysiology of
            LID.
REFERENCE   4  (bases 1 to 5254)
  AUTHORS   Li,D., Yuan,H., Ortiz-Gonzalez,X.R., Marsh,E.D., Tian,L.,
            McCormick,E.M., Kosobucki,G.J., Chen,W., Schulien,A.J.,
            Chiavacci,R., Tankovic,A., Naase,C., Brueckner,F., von
            Stulpnagel-Steinbeis,C., Hu,C., Kusumoto,H., Hedrich,U.B.,
            Elsen,G., Hortnagel,K., Aizenman,E., Lemke,J.R., Hakonarson,H.,
            Traynelis,S.F. and Falk,M.J.
  TITLE     GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe
            Epileptic Encephalopathy Treatable with NMDA Receptor Channel
            Blockers
  JOURNAL   Am J Hum Genet 99 (4), 802-816 (2016)
   PUBMED   27616483
REFERENCE   5  (bases 1 to 5254)
  AUTHORS   Volgraf,M., Sellers,B.D., Jiang,Y., Wu,G., Ly,C.Q., Villemure,E.,
            Pastor,R.M., Yuen,P.W., Lu,A., Luo,X., Liu,M., Zhang,S., Sun,L.,
            Fu,Y., Lupardus,P.J., Wallweber,H.J., Liederer,B.M., Deshmukh,G.,
            Plise,E., Tay,S., Reynen,P., Herrington,J., Gustafson,A., Liu,Y.,
            Dirksen,A., Dietz,M.G., Liu,Y., Wang,T.M., Hanson,J.E., Hackos,D.,
            Scearce-Levie,K. and Schwarz,J.B.
  TITLE     Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric
            Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based
            Design
  JOURNAL   J Med Chem 59 (6), 2760-2779 (2016)
   PUBMED   26919761
REFERENCE   6  (bases 1 to 5254)
  AUTHORS   Ikeda,K., Araki,K., Takayama,C., Inoue,Y., Yagi,T., Aizawa,S. and
            Mishina,M.
  TITLE     Reduced spontaneous activity of mice defective in the epsilon 4
            subunit of the NMDA receptor channel
  JOURNAL   Brain Res Mol Brain Res 33 (1), 61-71 (1995)
   PUBMED   8774946
REFERENCE   7  (bases 1 to 5254)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
REFERENCE   8  (bases 1 to 5254)
  AUTHORS   Monyer,H., Burnashev,N., Laurie,D.J., Sakmann,B. and Seeburg,P.H.
  TITLE     Developmental and regional expression in the rat brain and
            functional properties of four NMDA receptors
  JOURNAL   Neuron 12 (3), 529-540 (1994)
   PUBMED   7512349
REFERENCE   9  (bases 1 to 5254)
  AUTHORS   Ishii,T., Moriyoshi,K., Sugihara,H., Sakurada,K., Kadotani,H.,
            Yokoi,M., Akazawa,C., Shigemoto,R., Mizuno,N., Masu,M. et al.
  TITLE     Molecular characterization of the family of the
            N-methyl-D-aspartate receptor subunits
  JOURNAL   J Biol Chem 268 (4), 2836-2843 (1993)
   PUBMED   8428958
REFERENCE   10 (bases 1 to 5254)
  AUTHORS   Ikeda,K., Nagasawa,M., Mori,H., Araki,K., Sakimura,K., Watanabe,M.,
            Inoue,Y. and Mishina,M.
  TITLE     Cloning and expression of the epsilon 4 subunit of the NMDA
            receptor channel
  JOURNAL   FEBS Lett 313 (1), 34-38 (1992)
   PUBMED   1385220
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000033.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022797.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L31612.1, U08260.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-718               JACYVU010000033.1  20221030-20221747   c
            719-1200            JACYVU010000033.1  20217434-20217915   c
            1201-1820           JACYVU010000033.1  20213295-20213914   c
            1821-1935           JACYVU010000033.1  20209744-20209858   c
            1936-2147           JACYVU010000033.1  20209221-20209432   c
            2148-2316           JACYVU010000033.1  20208812-20208980   c
            2317-2470           JACYVU010000033.1  20208092-20208245   c
            2471-2596           JACYVU010000033.1  20205950-20206075   c
            2597-2826           JACYVU010000033.1  20205629-20205858   c
            2827-2987           JACYVU010000033.1  20204601-20204761   c
            2988-3175           JACYVU010000033.1  20187705-20187892   c
            3176-3408           JACYVU010000033.1  20187319-20187551   c
            3409-5254           JACYVU010000033.1  20185319-20187164   c
FEATURES             Location/Qualifiers
     source          1..5254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5254
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /note="glutamate ionotropic receptor NMDA type subunit 2D"
                     /db_xref="GeneID:24412"
                     /db_xref="RGD:2740"
     exon            1..718
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1200
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     CDS             745..4716
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /note="glutamate [NMDA] receptor subunit epsilon-4; NR2D;
                     NMDAR2D; N-methyl D-aspartate receptor subtype 2D;
                     glutamate receptor, ionotropic, NMDA2D; glutamate receptor
                     ionotropic, NMDA 2D; glutamate receptor, ionotropic,
                     N-methyl D-aspartate 2D"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 2D
                     precursor"
                     /protein_id="NP_073634.2"
                     /db_xref="GeneID:24412"
                     /db_xref="RGD:2740"
                     /translation="MRGAGGPRGPRGPAKMLLLLALACASPFPEEVPGPGAVGGGTGG
                     ARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCD
                     LLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQ
                     LGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGAL
                     TLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQL
                     AGGGGSGVPGEPLLLPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRD
                     YGFLPELGHDCRTQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRD
                     RTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISG
                     TCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNG
                     KHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN
                     GTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTF
                     TIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEE
                     YVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEE
                     ALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKR
                     PIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLS
                     LLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPS
                     PAYPAARPPPGPAPFVPRERAAADRWRRAKGTGPPGGAAIADGFHRYYGPIEPQGLGL
                     GEARAAPRGAAGRPLSPPTTQPPQKPPPSYFAIVREQEPTEPPAGAFPGFPSPPAPPA
                     AAAAAVGPPLCRLAFEDESPPAPSRWPRSDPESQPLLGGGAGGPSAGAPTAPPPRRAA
                     PPPCAYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDK
                     LGGWRAGSWDYLPPRGGPAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAA
                     GPPPRRRARCGCPRPHPHRPRASHRAPAAAPHHHRHRRAAGGWDFPPPAPTSRSLEDL
                     SSCPRAAPTRRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLE
                     SEV"
     exon            1201..1820
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1935
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2147
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2316
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2470
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2596
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2826
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2827..2987
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3175
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..3408
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..5254
                     /gene="Grin2d"
                     /gene_synonym="GluN2D"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcatcaa gctccggggg tgttgagggg gaatcccggg gaagtgagat tgtatgtgtg
       61 agcatctgca tgtgtgtttc tgcctgtgct tgagagtggg ggaactaacg gggggggggg
      121 ggtctggagg tggccaagca aggaatggac aagcagttcc cctgacaggc agcctcacac
      181 tccttataaa acatacacac gagccattgg cttcagaggt gacccagaca gacagacaga
      241 gacaagggag ggggtgctgt gagcacaaag ggggtgccaa taagctaggg agaagtaatg
      301 ggacatgcca gccaggggag gagcccagac tgaagccggc agaggggggc accccaggtg
      361 ggtggagggg gatccccatg gggtcaggcc gcaagaggac accccgacag cctccgcaat
      421 gtccggggcc caacttccag cgcaacatgt gtagcctcat ccttgcctag tctggtggcc
      481 gcaaccttgg gggacagggc agggcaggat caagaagagg agggacagag ccgggacagg
      541 caaaaggtcc ccgccactgc tgcctgcact gctgctgctg ctgctgctgc ctccgctgcc
      601 gccctgggcc tggcccccaa ccagctcccc aacactctac ggaatctttg ggtctctgga
      661 cgctggttcc ggtcctggcc ccccagcaat ttcctccaaa gaacagggtc atgaaaagag
      721 gccgcccggc ggggcccgca ggcgatgcgc ggcgccggtg gcccccgcgg ccctcggggc
      781 cccgctaaga tgctgctgct gctggcgctg gcgtgcgcca gcccgttccc ggaggaggtg
      841 ccggggccgg gcgcggtcgg cgggggcacg ggcggggcgc ggccactcaa cgtggcgctt
      901 gtcttctccg gcccggcata tgcggcagag gcggcgcgct tgggcccggc cgtggcagcg
      961 gcagtgcgca gccccggcct ggacgtacgg cccgtggcgc tggtgctcaa cggctccgac
     1021 cctcgcagcc ttgtgctgca gctctgcgac ctgctgtcgg ggctgcgcgt gcacggcgtg
     1081 gtgttcgagg acgactcgcg cgcgcccgcc gtcgcgccca ttctcgactt cctgtccgcg
     1141 cagacctcgc tgcccatcgt agccgtgcac ggcggcgccg cgctcgtgct cacacccaag
     1201 gagaagggct ccaccttcct gcagcttggc tcctccacag agcaacagtt gcaggtcatt
     1261 tttgaggtgc tggaggagta cgactggaca tcctttgtgg cagtgaccac gcgtgcccca
     1321 ggccatcggg ccttcttgtc atacatcgag gtgctgactg atggcagcct ggtgggctgg
     1381 gagcatcgag gagcgctgac actggacccc ggggcgggtg aggctgtact gggcgcacag
     1441 ctccgtagtg tcagtgcgca gatccgcctg ctcttctgcg cccgcgagga ggcagagcct
     1501 gttttccggg cagcggaaga ggccggcctc actgggcctg gctacgtctg gttcatggtg
     1561 ggaccccagc tggctggagg cgggggctcc ggggtccctg gggagcccct tcttctgcca
     1621 ggaggttccc cactgcctgc cgggctgttt gcagtgcgct ctgctggctg gcgtgacgac
     1681 ttggcacgtc gagtggctgc tggtgtggcg gtggtggcca gaggtgccca ggccctgctg
     1741 cgagactatg gcttcctgcc tgagctgggt catgactgcc gcacccagaa tcgcacccac
     1801 cgcggggaga gtctgcacag gtacttcatg aacatcacct gggataaccg agactactcc
     1861 ttcaatgagg atggctttct ggtgaaccct tcactggtgg tcatctccct caccagagac
     1921 aggacatggg aagtggtggg cagctgggaa cagcagaccc tccgcctcaa gtaccctcta
     1981 tggtcccgct atggccgctt cctgcagcca gtggatgaca cacagcacct cactgtggcc
     2041 acgctggagg agagaccctt tgtcattgta gagcctgcag accccatcag cggcacttgc
     2101 atcagagact cggtcccctg ccggagccag ctcaaccgta cccacagccc tccgcctgac
     2161 gctccccgcc cggagaagag atgctgcaag ggtttctgca ttgatattct gaagaggctg
     2221 gcgcacacca tcggtttcag ctatgacctc tacctggtta ccaacggcaa gcatggcaag
     2281 aagatcgatg gcgtctggaa tggcatgatt ggtgaggtgt tctatcagcg tgcggacatg
     2341 gccatcggct ctctcaccat caatgaggag cggtcagaga tcgtggactt ctccgtcccc
     2401 tttgtagaga caggcatcag cgtcatggtg gcacgcagca atggcactgt gtccccctct
     2461 gccttcctcg agccctacag ccctgctgtc tgggtgatga tgttcgtcat gtgcctcacc
     2521 gtggtcgccg tcacagtttt catctttgag tacctcagtc ctgtgggcta taaccgaagc
     2581 ctggccacgg gcaaacgccc tggtggctct accttcacca ttgggaaatc catctggctg
     2641 ctgtgggccc tggtcttcaa caactccgtg ccagtggaga atcctcgggg caccaccagc
     2701 aagatcatgg tgctggtgtg ggccttcttc gcggtcatct ttcttgccag ctacacagcc
     2761 aatctggccg ccttcatgat ccaggaggag tacgtggaca ccgtgtctgg gctcagcgac
     2821 cggaagttcc agcgacccca ggagcaatac ccacctctga agtttggcac ggtgcccaat
     2881 gggtccacgg aaaagaacat ccggagcaac taccctgaca tgcacagcta catggtgcga
     2941 tacaaccagc cgagagtgga ggaggcactc acacagctca aggcagggaa actggacgcc
     3001 ttcatctatg acgcagcagt gctcaactac atggcccgca aggatgaggg ctgcaagctg
     3061 gtcaccatcg gctccggcaa ggtcttcgcc accactggtt atggcatcgc cctacacaag
     3121 ggctcccgct ggaagaggcc catcgacctg gcgctgctgc agttcctggg ggacgatgag
     3181 attgagatgc tggagcggct gtggctttca gggatctgcc acaatgacaa aatcgaagtg
     3241 atgagtagca agctggatat cgacaacatg gcaggtgtct tctacatgct ccttgtggcc
     3301 atgggcctct ccttgctggt cttcgcctgg gaacatctgg tgtactggcg cctgcggcat
     3361 tgcctgggtc ccacccaccg catggatttc ctactggcct tctccagggg tatgtacagc
     3421 tgctgcagcg ccgaggctgc tccaccgccg gccaagcctc cgccaccgcc tcagccgctg
     3481 cccagtcccg catatcccgc cgctcgcccg ccccctggcc ccgcaccctt cgtgccccga
     3541 gagcgcgcag ctgccgaccg ctggcgccga gccaagggca cagggccccc ggggggcgca
     3601 gcgatagccg acggcttcca ccgatactac ggccccatcg agccacaggg gctgggcctc
     3661 ggcgaggcac gcgcggcacc gagaggcgca gccggacgcc cactgtcccc acccaccaca
     3721 cagcccccgc agaagccacc accttcctac ttcgccatcg tgcgcgagca ggagccgacc
     3781 gagcccccgg ccggcgcctt ccccggcttc ccatctccgc ctgcgccgcc cgctgcggct
     3841 gccgctgccg tcgggccgcc actgtgtcgc ctggctttcg aggacgaaag cccgcccgca
     3901 ccctcgcgct ggccgcgttc agatcccgag agccagcctc tgttgggtgg gggcgcgggc
     3961 ggcccgagcg cgggggcccc aaccgcacca ccgccgcgcc gtgccgcgcc accaccgtgc
     4021 gcctacctgg acctcgagcc ttcgccttcg gactccgagg actcggagag cctgggcgga
     4081 gcatcgctcg gtggcctgga gccctggtgg ttcgccgact tcccctaccc gtatgccgag
     4141 cgcctcgggc cgccgcccgg ccgctactgg tcggtcgaca agctcggggg ctggcgcgct
     4201 ggtagctggg actacctgcc cccgcgcgga ggccccgcgt ggcactgccg ccactgcgcc
     4261 agcctggagc tgctaccgcc accgcgccac ctcagctgct cgcacgacgg cttagacggc
     4321 ggctggtggg cgcctccgcc tccaccctgg gccgcggggc cacctccccg gcgccgggcg
     4381 cgctgtggtt gtccgcgacc tcacccacac cgcccccggg cctcgcaccg tgcgcccgcc
     4441 gccgcgccgc accaccaccg acacaggcgc gcggccggtg gctgggactt cccgccgccc
     4501 gcgcccacct cgcgttcgct ggaggacctg agctcctgcc cgcgggcggc ccccacgcgc
     4561 aggctcaccg ggccatcccg ccacgcgcgc cgctgcccgc acgctgcgca ctgggggccg
     4621 cccctgccca ccgcatcgca ccggagacac cggggcgggg acctgggcac acgcaggggc
     4681 tctgcgcatt tctccagcct ggagtccgag gtatgacgcg gctccggccc ccacccccac
     4741 ccccgccgcc ccctcggtca gcgcaggcca cggcccgagg gggcgcgcta agtggacagg
     4801 accctcatgg gttgggaagg acagaaacgg acctggccgg accccgcctg gagcagcgtc
     4861 ctgcgccccc acccccttcg ccttggggga actatgagcc agaggggact tggtcgccca
     4921 aatctcaccc atcctgagag caagggggcg gggttcttgg agcccaccga ctcttttttt
     4981 tttaaacccg aaaagggctt tttaacgtca cctgattggc gggaggtgtg ggggagtcac
     5041 gccgcgcccc acccctacgc tccgggccat ggccctcaca tcactgtgca gctccctagc
     5101 cccagacaca cctctcgggg agcctgtttt taacctttca ttcatcagga ctcaaaactg
     5161 tgagacgcgt atgccaaact gtgactccag accttggccc cgccacacag aaacccctga
     5221 ccccagactg tgacttccaa cacctaaaat gatc
//
