LOCUS       NM_012575               4388 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor NMDA type subunit
            2C (Grin2c), mRNA.
ACCESSION   NM_012575 XM_212682
VERSION     NM_012575.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4388)
  AUTHORS   Zhang,J., Zhang,M., Wang,Q., Wen,H., Liu,Z., Wang,F., Wang,Y.,
            Yao,F., Song,N., Kou,Z., Li,Y., Guo,F. and Zhu,S.
  TITLE     Distinct structure and gating mechanism in diverse NMDA receptors
            with GluN2C and GluN2D subunits
  JOURNAL   Nat Struct Mol Biol 30 (5), 629-639 (2023)
   PUBMED   36959261
REFERENCE   2  (bases 1 to 4388)
  AUTHORS   Wang,J.X., Irvine,M.W., Burnell,E.S., Sapkota,K., Thatcher,R.J.,
            Li,M., Simorowski,N., Volianskis,A., Collingridge,G.L.,
            Monaghan,D.T., Jane,D.E. and Furukawa,H.
  TITLE     Structural basis of subtype-selective competitive antagonism for
            GluN2C/2D-containing NMDA receptors
  JOURNAL   Nat Commun 11 (1), 423 (2020)
   PUBMED   31969570
  REMARK    GeneRIF: UBP791
            ((2S*,
            3R*)-1-(7-(2-carboxyethyl)phenanthrene-2-carbonyl)piperazine-2,
            3-dicarboxylic acid) inhibits GluN2C/2D with 40-fold selectivity
            over GluN2A-containing receptors, and that a methionine and a
            lysine residue in the ligand binding pocket are the critical
            molecular elements for the subtype-specific binding.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4388)
  AUTHORS   Chung,C., Marson,J.D., Zhang,Q.G., Kim,J., Wu,W.H., Brann,D.W. and
            Chen,B.S.
  TITLE     Neuroprotection Mediated through GluN2C-Containing
            N-methyl-D-aspartate (NMDA) Receptors Following Ischemia
  JOURNAL   Sci Rep 6, 37033 (2016)
   PUBMED   27845401
  REMARK    GeneRIF: a neuroprotective role of GluN2C, suggesting a mechanism
            by which GluN2C is upregulated to promote neuronal survival
            following ischemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4388)
  AUTHORS   Volgraf,M., Sellers,B.D., Jiang,Y., Wu,G., Ly,C.Q., Villemure,E.,
            Pastor,R.M., Yuen,P.W., Lu,A., Luo,X., Liu,M., Zhang,S., Sun,L.,
            Fu,Y., Lupardus,P.J., Wallweber,H.J., Liederer,B.M., Deshmukh,G.,
            Plise,E., Tay,S., Reynen,P., Herrington,J., Gustafson,A., Liu,Y.,
            Dirksen,A., Dietz,M.G., Liu,Y., Wang,T.M., Hanson,J.E., Hackos,D.,
            Scearce-Levie,K. and Schwarz,J.B.
  TITLE     Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric
            Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based
            Design
  JOURNAL   J Med Chem 59 (6), 2760-2779 (2016)
   PUBMED   26919761
REFERENCE   5  (bases 1 to 4388)
  AUTHORS   Hackos,D.H., Lupardus,P.J., Grand,T., Chen,Y., Wang,T.M.,
            Reynen,P., Gustafson,A., Wallweber,H.J., Volgraf,M., Sellers,B.D.,
            Schwarz,J.B., Paoletti,P., Sheng,M., Zhou,Q. and Hanson,J.E.
  TITLE     Positive Allosteric Modulators of GluN2A-Containing NMDARs with
            Distinct Modes of Action and Impacts on Circuit Function
  JOURNAL   Neuron 89 (5), 983-999 (2016)
   PUBMED   26875626
REFERENCE   6  (bases 1 to 4388)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
REFERENCE   7  (bases 1 to 4388)
  AUTHORS   Chazot,P.L., Coleman,S.K., Cik,M. and Stephenson,F.A.
  TITLE     Molecular characterization of N-methyl-D-aspartate receptors
            expressed in mammalian cells yields evidence for the coexistence of
            three subunit types within a discrete receptor molecule
  JOURNAL   J Biol Chem 269 (39), 24403-24409 (1994)
   PUBMED   7929101
REFERENCE   8  (bases 1 to 4388)
  AUTHORS   Ishii,T., Moriyoshi,K., Sugihara,H., Sakurada,K., Kadotani,H.,
            Yokoi,M., Akazawa,C., Shigemoto,R., Mizuno,N., Masu,M. et al.
  TITLE     Molecular characterization of the family of the
            N-methyl-D-aspartate receptor subunits
  JOURNAL   J Biol Chem 268 (4), 2836-2843 (1993)
   PUBMED   8428958
REFERENCE   9  (bases 1 to 4388)
  AUTHORS   Kutsuwada,T., Kashiwabuchi,N., Mori,H., Sakimura,K., Kushiya,E.,
            Araki,K., Meguro,H., Masaki,H., Kumanishi,T., Arakawa,M. et al.
  TITLE     Molecular diversity of the NMDA receptor channel
  JOURNAL   Nature 358 (6381), 36-41 (1992)
   PUBMED   1377365
REFERENCE   10 (bases 1 to 4388)
  AUTHORS   Monyer,H., Sprengel,R., Schoepfer,R., Herb,A., Higuchi,M.,
            Lomeli,H., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Heteromeric NMDA receptors: molecular and functional distinction of
            subtypes
  JOURNAL   Science 256 (5060), 1217-1221 (1992)
   PUBMED   1350383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D13212.1.
            
            On Jun 10, 2007 this sequence version replaced NM_012575.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13212.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132264,
                                           SAMD00132266 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..4388
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /note="glutamate ionotropic receptor NMDA type subunit 2C"
                     /db_xref="GeneID:24411"
                     /db_xref="RGD:2739"
     exon            1..226
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            227..283
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            284..800
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1399
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1514
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1726
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1892
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2046
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2172
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2402
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2563
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2751
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2984
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..4388
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatttcccc agacgctgcc cccaacgtct tggttcccct cagctctgcg tgctccaaaa
       61 gaagggtggt aggaaaaggc cacgggagag cctgcgctcc ggtgccctgg gccctggaag
      121 caccggttgg cagctgtggt ctcttggggc ttcaaccagg acccccgacg gctgagagga
      181 gaagcccaag cctttggctg cggaaggctt tttgtgcttg gcctaggaag aacgggcagg
      241 aacaaaggca cgataaggac agcttaccat tcgaatagca gggggaggtt ctctcttctc
      301 tgtcctctgg ctgtgtggtc tctggccctt cccttcttct gtttgtccat ctacctctct
      361 ctatgcctgc tctggtttct ctgcaggacc ctccagtgga catgggtggg gccctagggc
      421 ccgccctgct gctcacttca ctccttggtg cttgggcaag gctgggcgca gggcagggag
      481 aacaggccgt gactgtggcg gtggtgtttg gcagctctgg gccactgcag acccaggccc
      541 ggactcgtct tacctcccag aacttcctgg acctgcctct ggagatccag ccactcaccg
      601 taggggtcaa caataccaat cccagcagca tcctcaccca aatctgcggg cttctgggtg
      661 ccgcccgtgt ccacggcatc gtctttgagg acaacgtgga caccgaggcc gtggcccagc
      721 tactggactt cgtctcctcc cagacccacg tgcccatcct cagcatcagc ggaggctctg
      781 ctgtggtcct cacccccaag gagccaggct ccgccttcct acagctgggc gtgtccctgg
      841 agcagcagct gcaggtgctg ttcaaggtgc tggaggaata cgactggagc gcgttcgcgg
      901 tcatcaccag cctgcatccg ggccacgcgc tcttcctcga aggcgtgcgc gccgtcgcgg
      961 acgccagcta cctgagctgg cggctgctgg acgtgctcac gctggagcta ggtccgggtg
     1021 ggccgcgagc gcgcactcag cgcctgctac gccaggtcga cgcgccggtg ctggtggctt
     1081 actgctcccg tgaagaggcc gaggtgctct tcgctgaggc tgcacaggct ggcctggtgg
     1141 gacccgggca cgtgtggttg gtacctaacc tggcgctggg aagcaccgac gcaccccctg
     1201 cagctttccc ggtgggcctc atcagtgtgg tcaccgagag ttggcgcctt agtctacgcc
     1261 agaaggttcg cgacggagtg gccattctgg ccctcggtgc ccacagctac cgacgccagt
     1321 acggtaccct gccagccccg gctggggact gccgaagcca cccgggaccc gtcagccctg
     1381 ctagggaggc cttctacagg catctgctga atgtcacctg ggagggccga gacttctctt
     1441 tcagccctgg tgggtacctg gttcggccca ccatggttgt gatcgccctc aaccggcacc
     1501 gcctctggga gatggtggga cggtgggacc atggagtcct gtacatgaag tatccagtat
     1561 ggcctcgcta cagcacttct ctgcagcctg tggtggacag ccggcacctg acagtggcca
     1621 cactggaaga aaggcccttt gtcattgtgg agagccctga ccctggcaca ggtggctgtg
     1681 ttcccaacac cgtgccctgc cgcagacaga gcaaccacac cttcagcagc ggggatctaa
     1741 ccccctacac caagctctgt tgtaagggct tctgcatcga catcctcaaa aagctggcca
     1801 aggtggtcaa gttctcctac gacttgtacc tggtgaccaa cggcaaacac ggcaagaggg
     1861 ttcgtggtgt gtggaacggc atgatcgggg aggtatacta caagcgggca gacatggcca
     1921 tcggctccct caccatcaat gaggagcgct ctgagattat agatttctct gtgccttttg
     1981 tggagaccgg catcagtgtt atggtatcaa ggagcaacgg caccgtctcc ccctcagctt
     2041 ttctggaacc ctacagccct gccgtgtggg tgatgatgtt cgtgatgtgt ctcacggtgg
     2101 ttgccatcac tgtcttcatg ttcgagtact tcagccctgt cagctacaac cagaacctca
     2161 ccaagggcaa gaaacctggt ggaccatctt tcaccattgg caagtccgtg tggttgctgt
     2221 gggcactggt cttcaacaac tctgttccca tcgagaaccc ccggggtacc accagcaaga
     2281 tcatggtcct ggtgtgggcc ttcttcgctg tcatcttcct cgctagctat acggccaatc
     2341 tggcggcctt catgatccag gagcaataca tcgacactgt gtcgggcctt agtgacaaga
     2401 agtttcagcg gcctcaagac caatacccac ccttccgttt tggcacggta cctaacggca
     2461 gcacagagag gaacatccgt agcaactacc gtgacatgca cacccacatg gtcaagttca
     2521 accagcgctc ggtggaggac gctctcacaa gcctgaagat ggggaagctg gacgccttca
     2581 tctatgatgc tgctgtgctc aactacatgg cgggcaagga cgaaggctgc aagctggtca
     2641 ccattgggtc tggcaaagtc tttgccacca ctggctatgg cattgccatg cagaaagact
     2701 cccactggaa gcgggccata gacctggcac tcctgcaact tctgggggat ggagagacgc
     2761 agaagctgga gacagtgtgg ctctcaggga tctgccagaa cgagaagaat gaggtgatga
     2821 gcagcaagct ggacattgac aacatggcgg gggtcttcta catgctgttg gtggccatgg
     2881 gactggccct tctggtcttt gcctgggagc acctggtcta ctggaaactt cgacactcgg
     2941 tgcccaactc atcccagctg gacttcctgc tggctttcag caggggcatc tacagctgct
     3001 tcaacggggt acagagcctt ccgagtcccg cacggccgcc cagcccggat ctcaccgcag
     3061 actcagccca ggccaatgtg ctgaagatgc tgcaggcggc ccgagacatg gtgaacaccg
     3121 cggacgtgag cagctctttg gaccgcgcca ctcgcaccat cgagaactgg ggcaacaacc
     3181 gccgcgtgcc tgctcccacc gcctctggcc cgcggtcctc caccccgggt cctccgggac
     3241 aaccgagccc cagcggctgg gggcctcctg gtgggggccg caccccgcta gcgcgcaggg
     3301 ccccgcagcc tccggctcgc cccgcgacgt gcgggccacc tttgcccgat gtgtcccgac
     3361 catcctgcag gcacgcttcg gacgcgcggt ggccggtgcg agttgggcat cagggaccgc
     3421 acgtctcggc ttccgagcgg cgcgcgctcc cggagcgctc tctgttgccc gcgcactgcc
     3481 actacagttc cttccctcga gcggagagat ccgggcgccc ctacctcccg ttattcccgg
     3541 agcccccgga gcccgacgac ctgcctctgc tcgggccgga acagctggct cggcgggaag
     3601 caatgctgcg cgcggcctgg gcccggggcc cgcgccctcg ccacgcttcc ttgcccagct
     3661 cggtggcaga agctttcact cgatccaacc ctctgcctgc caggtgtacc ggtcacgcct
     3721 gtgcctgccc gtgcccccaa agccggccat cctgcaggca cttggctcag gcacagtcgc
     3781 tgaggctgcc gtcctacccg gaggcctgtg tggagggcgt accagcaggg gtggccacct
     3841 ggcagcccag acagcacgtc tgcctgcacg cccatacccg cctgccgttc tgttggggaa
     3901 ctgtctgccg tcaccctcca ccctgtacca gccacagccc ctggctcatt ggaacctggg
     3961 agcctccagc acacagagtc aggaccctgg ggctaggcac aggctacagg gacagtgggg
     4021 tgctggaaga ggtcagcagg gaagcctgtg ggacacaagg ttttccaagg tcctgcacct
     4081 ggaggcgggt ctccagcctg gaatcagaag tgtgaggtta ctggcagctt tggttcctgc
     4141 tggactggct tctgtggccg gccttggcca ggtttggggg acaggccagc ttgggctcct
     4201 ctggcttcta ttttgaaatc ctggccatgg gaccccagtg aaaaggatat cttccaggcc
     4261 cagcttttga ccttagtgtg ggctgggatc ttgttcatca catgacctct tgcggtggtc
     4321 acagggagta aaaatgtgtc cctgtcctgt tgtcagctag ttcctagttg tggttgctgt
     4381 ggccttgg
//
