LOCUS       NP_036707               1250 aa            linear   ROD 06-NOV-2024
DEFINITION  glutamate receptor ionotropic, NMDA 2C [Rattus norvegicus].
ACCESSION   NP_036707 XP_212682
VERSION     NP_036707.3
DBSOURCE    REFSEQ: accession NM_012575.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1250)
  AUTHORS   Zhang,J., Zhang,M., Wang,Q., Wen,H., Liu,Z., Wang,F., Wang,Y.,
            Yao,F., Song,N., Kou,Z., Li,Y., Guo,F. and Zhu,S.
  TITLE     Distinct structure and gating mechanism in diverse NMDA receptors
            with GluN2C and GluN2D subunits
  JOURNAL   Nat Struct Mol Biol 30 (5), 629-639 (2023)
   PUBMED   36959261
REFERENCE   2  (residues 1 to 1250)
  AUTHORS   Wang,J.X., Irvine,M.W., Burnell,E.S., Sapkota,K., Thatcher,R.J.,
            Li,M., Simorowski,N., Volianskis,A., Collingridge,G.L.,
            Monaghan,D.T., Jane,D.E. and Furukawa,H.
  TITLE     Structural basis of subtype-selective competitive antagonism for
            GluN2C/2D-containing NMDA receptors
  JOURNAL   Nat Commun 11 (1), 423 (2020)
   PUBMED   31969570
  REMARK    GeneRIF: UBP791
            ((2S*,
            3R*)-1-(7-(2-carboxyethyl)phenanthrene-2-carbonyl)piperazine-2,
            3-dicarboxylic acid) inhibits GluN2C/2D with 40-fold selectivity
            over GluN2A-containing receptors, and that a methionine and a
            lysine residue in the ligand binding pocket are the critical
            molecular elements for the subtype-specific binding.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1250)
  AUTHORS   Chung,C., Marson,J.D., Zhang,Q.G., Kim,J., Wu,W.H., Brann,D.W. and
            Chen,B.S.
  TITLE     Neuroprotection Mediated through GluN2C-Containing
            N-methyl-D-aspartate (NMDA) Receptors Following Ischemia
  JOURNAL   Sci Rep 6, 37033 (2016)
   PUBMED   27845401
  REMARK    GeneRIF: a neuroprotective role of GluN2C, suggesting a mechanism
            by which GluN2C is upregulated to promote neuronal survival
            following ischemia.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1250)
  AUTHORS   Volgraf,M., Sellers,B.D., Jiang,Y., Wu,G., Ly,C.Q., Villemure,E.,
            Pastor,R.M., Yuen,P.W., Lu,A., Luo,X., Liu,M., Zhang,S., Sun,L.,
            Fu,Y., Lupardus,P.J., Wallweber,H.J., Liederer,B.M., Deshmukh,G.,
            Plise,E., Tay,S., Reynen,P., Herrington,J., Gustafson,A., Liu,Y.,
            Dirksen,A., Dietz,M.G., Liu,Y., Wang,T.M., Hanson,J.E., Hackos,D.,
            Scearce-Levie,K. and Schwarz,J.B.
  TITLE     Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric
            Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based
            Design
  JOURNAL   J Med Chem 59 (6), 2760-2779 (2016)
   PUBMED   26919761
REFERENCE   5  (residues 1 to 1250)
  AUTHORS   Hackos,D.H., Lupardus,P.J., Grand,T., Chen,Y., Wang,T.M.,
            Reynen,P., Gustafson,A., Wallweber,H.J., Volgraf,M., Sellers,B.D.,
            Schwarz,J.B., Paoletti,P., Sheng,M., Zhou,Q. and Hanson,J.E.
  TITLE     Positive Allosteric Modulators of GluN2A-Containing NMDARs with
            Distinct Modes of Action and Impacts on Circuit Function
  JOURNAL   Neuron 89 (5), 983-999 (2016)
   PUBMED   26875626
REFERENCE   6  (residues 1 to 1250)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
REFERENCE   7  (residues 1 to 1250)
  AUTHORS   Chazot,P.L., Coleman,S.K., Cik,M. and Stephenson,F.A.
  TITLE     Molecular characterization of N-methyl-D-aspartate receptors
            expressed in mammalian cells yields evidence for the coexistence of
            three subunit types within a discrete receptor molecule
  JOURNAL   J Biol Chem 269 (39), 24403-24409 (1994)
   PUBMED   7929101
REFERENCE   8  (residues 1 to 1250)
  AUTHORS   Ishii,T., Moriyoshi,K., Sugihara,H., Sakurada,K., Kadotani,H.,
            Yokoi,M., Akazawa,C., Shigemoto,R., Mizuno,N., Masu,M. et al.
  TITLE     Molecular characterization of the family of the
            N-methyl-D-aspartate receptor subunits
  JOURNAL   J Biol Chem 268 (4), 2836-2843 (1993)
   PUBMED   8428958
REFERENCE   9  (residues 1 to 1250)
  AUTHORS   Kutsuwada,T., Kashiwabuchi,N., Mori,H., Sakimura,K., Kushiya,E.,
            Araki,K., Meguro,H., Masaki,H., Kumanishi,T., Arakawa,M. et al.
  TITLE     Molecular diversity of the NMDA receptor channel
  JOURNAL   Nature 358 (6381), 36-41 (1992)
   PUBMED   1377365
REFERENCE   10 (residues 1 to 1250)
  AUTHORS   Monyer,H., Sprengel,R., Schoepfer,R., Herb,A., Higuchi,M.,
            Lomeli,H., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Heteromeric NMDA receptors: molecular and functional distinction of
            subtypes
  JOURNAL   Science 256 (5060), 1217-1221 (1992)
   PUBMED   1350383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D13212.1.
            
            On Jun 10, 2007 this sequence version replaced NP_036707.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D13212.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132264,
                                           SAMD00132266 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1250
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     Protein         1..1250
                     /product="glutamate receptor ionotropic, NMDA 2C"
                     /note="glutamate [NMDA] receptor subunit epsilon-3; NMDA
                     glutamate receptor; NMDAR2C; N-methyl D-aspartate receptor
                     subtype 2C; glutamate receptor, ionotropic, NMDA2C;
                     glutamate receptor, ionotropic, N-methyl D-aspartate 2C"
                     /calculated_mol_wt=136504
     Region          41..397
                     /region_name="PBP1_iGluR_NMDA_NR2"
                     /note="N-terminal leucine-isoleucine-valine-binding
                     protein (LIVBP)-like domain of the NR2 subunit of NMDA
                     receptor family; cd06378"
                     /db_xref="CDD:380601"
     Site            order(41,86..88,123,144,184,186,201,216..217,320..321)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:380601"
     Site            order(84..89,91..92,127..128,184,188,215,217,320..326,
                     330..332,343)
                     /site_type="other"
                     /note="heterodimer interface [polypeptide binding]"
                     /db_xref="CDD:380601"
     Region          413..813
                     /region_name="PBP2_iGluR_NMDA_Nr2"
                     /note="The ligand-binding domain of the NR2 subunit of
                     ionotropic NMDA (N-methyl-D-aspartate) glutamate
                     receptors, a member of the type 2 periplasmic binding fold
                     protein superfamily; cd13718"
                     /db_xref="CDD:270436"
     Site            order(522..525,527,529..531,677,699..700,704,742,767..769,
                     772,778,794..797,800)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:270436"
     Site            order(522..524,529,699..701,741..742)
                     /site_type="other"
                     /note="peptide binding site [polypeptide binding]"
                     /db_xref="CDD:270436"
     Region          850..>925
                     /region_name="NMDAR2_C"
                     /note="N-methyl D-aspartate receptor 2B3 C-terminus;
                     pfam10565"
                     /db_xref="CDD:463148"
     CDS             1..1250
                     /gene="Grin2c"
                     /gene_synonym="GluN2C; NR2C"
                     /coded_by="NM_012575.3:363..4115"
                     /db_xref="GeneID:24411"
                     /db_xref="RGD:2739"
ORIGIN      
        1 mpalvslqdp pvdmggalgp allltsllga warlgagqge qavtvavvfg ssgplqtqar
       61 trltsqnfld lpleiqpltv gvnntnpssi ltqicgllga arvhgivfed nvdteavaql
      121 ldfvssqthv pilsisggsa vvltpkepgs aflqlgvsle qqlqvlfkvl eeydwsafav
      181 itslhpghal flegvravad asylswrlld vltlelgpgg prartqrllr qvdapvlvay
      241 csreeaevlf aeaaqaglvg pghvwlvpnl algstdappa afpvglisvv teswrlslrq
      301 kvrdgvaila lgahsyrrqy gtlpapagdc rshpgpvspa reafyrhlln vtwegrdfsf
      361 spggylvrpt mvvialnrhr lwemvgrwdh gvlymkypvw prystslqpv vdsrhltvat
      421 leerpfvive spdpgtggcv pntvpcrrqs nhtfssgdlt pytklcckgf cidilkklak
      481 vvkfsydlyl vtngkhgkrv rgvwngmige vyykradmai gsltineers eiidfsvpfv
      541 etgisvmvsr sngtvspsaf lepyspavwv mmfvmcltvv aitvfmfeyf spvsynqnlt
      601 kgkkpggpsf tigksvwllw alvfnnsvpi enprgttski mvlvwaffav iflasytanl
      661 aafmiqeqyi dtvsglsdkk fqrpqdqypp frfgtvpngs ternirsnyr dmhthmvkfn
      721 qrsvedalts lkmgkldafi ydaavlnyma gkdegcklvt igsgkvfatt gygiamqkds
      781 hwkraidlal lqllgdgetq kletvwlsgi cqneknevms skldidnmag vfymllvamg
      841 lallvfaweh lvywklrhsv pnssqldfll afsrgiyscf ngvqslpspa rppspdltad
      901 saqanvlkml qaardmvnta dvsssldrat rtienwgnnr rvpaptasgp rsstpgppgq
      961 pspsgwgppg ggrtplarra pqpparpatc gpplpdvsrp scrhasdarw pvrvghqgph
     1021 vsaserralp ersllpahch yssfpraers grpylplfpe ppepddlpll gpeqlarrea
     1081 mlraawargp rprhaslpss vaeaftrsnp lparctghac acpcpqsrps crhlaqaqsl
     1141 rlpsypeacv egvpagvatw qprqhvclha htrlpfcwgt vcrhpppcts hspwligtwe
     1201 ppahrvrtlg lgtgyrdsgv leevsreacg tqgfprsctw rrvsslesev
//
