LOCUS       NM_012574               5259 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus glutamate ionotropic receptor NMDA type subunit
            2B (Grin2b), mRNA.
ACCESSION   NM_012574
VERSION     NM_012574.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5259)
  AUTHORS   Song,K., Cao,Q., Yang,Y., Zuo,Y. and Wu,X.
  TITLE     ALKBH5 modulates bone cancer pain in a rat model by suppressing
            NR2B expression
  JOURNAL   Biotechnol Appl Biochem 71 (5), 1105-1115 (2024)
   PUBMED   38764325
  REMARK    GeneRIF: ALKBH5 modulates bone cancer pain in a rat model by
            suppressing NR2B expression.
REFERENCE   2  (bases 1 to 5259)
  AUTHORS   Chou,T.H., Epstein,M., Fritzemeier,R.G., Akins,N.S., Paladugu,S.,
            Ullman,E.Z., Liotta,D.C., Traynelis,S.F. and Furukawa,H.
  TITLE     Molecular mechanism of ligand gating and opening of NMDA receptor
  JOURNAL   Nature 632 (8023), 209-217 (2024)
   PUBMED   39085540
  REMARK    GeneRIF: Molecular mechanism of ligand gating and opening of NMDA
            receptor.
REFERENCE   3  (bases 1 to 5259)
  AUTHORS   Schmidt,C.C., Tong,R. and Emptage,N.J.
  TITLE     GluN2A- and GluN2B-containing pre-synaptic N-methyl-d-aspartate
            receptors differentially regulate action potential-evoked Ca2+
            influx via modulation of SK channels
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 379 (1906), 20230222 (2024)
   PUBMED   38853550
  REMARK    GeneRIF: GluN2A- and GluN2B-containing pre-synaptic
            N-methyl-d-aspartate receptors differentially regulate action
            potential-evoked Ca[2+] influx via modulation of SK channels.
REFERENCE   4  (bases 1 to 5259)
  AUTHORS   Kim,K., Nan,G., Bak,H., Kim,H.Y., Kim,J., Cha,M. and Lee,B.H.
  TITLE     Insular cortex stimulation alleviates neuropathic pain through
            changes in the expression of collapsin response mediator protein 2
            involved in synaptic plasticity
  JOURNAL   Neurobiol Dis 194, 106466 (2024)
   PUBMED   38471625
  REMARK    GeneRIF: Insular cortex stimulation alleviates neuropathic pain
            through changes in the expression of collapsin response mediator
            protein 2 involved in synaptic plasticity.
REFERENCE   5  (bases 1 to 5259)
  AUTHORS   Lv,D., Xiao,B., Liu,H., Wang,L., Li,Y., Zhang,Y.H. and Jin,Q.
  TITLE     Enhanced NMDA receptor pathway and glutamate transmission in the
            hippocampal dentate gyrus mediate the spatial learning and memory
            impairment of obese rats
  JOURNAL   Pflugers Arch 476 (5), 821-831 (2024)
   PUBMED   38416255
  REMARK    GeneRIF: Enhanced NMDA receptor pathway and glutamate transmission
            in the hippocampal dentate gyrus mediate the spatial learning and
            memory impairment of obese rats.
REFERENCE   6  (bases 1 to 5259)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
REFERENCE   7  (bases 1 to 5259)
  AUTHORS   Tsuzuki,K., Mochizuki,S., Iino,M., Mori,H., Mishina,M. and Ozawa,S.
  TITLE     Ion permeation properties of the cloned mouse epsilon 2/zeta 1 NMDA
            receptor channel
  JOURNAL   Brain Res Mol Brain Res 26 (1-2), 37-46 (1994)
   PUBMED   7531804
REFERENCE   8  (bases 1 to 5259)
  AUTHORS   Sullivan,J.M., Traynelis,S.F., Chen,H.S., Escobar,W.,
            Heinemann,S.F. and Lipton,S.A.
  TITLE     Identification of two cysteine residues that are required for redox
            modulation of the NMDA subtype of glutamate receptor
  JOURNAL   Neuron 13 (4), 929-936 (1994)
   PUBMED   7524561
REFERENCE   9  (bases 1 to 5259)
  AUTHORS   Kutsuwada,T., Kashiwabuchi,N., Mori,H., Sakimura,K., Kushiya,E.,
            Araki,K., Meguro,H., Masaki,H., Kumanishi,T., Arakawa,M. et al.
  TITLE     Molecular diversity of the NMDA receptor channel
  JOURNAL   Nature 358 (6381), 36-41 (1992)
   PUBMED   1377365
REFERENCE   10 (bases 1 to 5259)
  AUTHORS   Monyer,H., Sprengel,R., Schoepfer,R., Herb,A., Higuchi,M.,
            Lomeli,H., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Heteromeric NMDA receptors: molecular and functional distinction of
            subtypes
  JOURNAL   Science 256 (5060), 1217-1221 (1992)
   PUBMED   1350383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U11419.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U11419.1, M91562.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760384 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5259
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q43"
     gene            1..5259
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /note="glutamate ionotropic receptor NMDA type subunit 2B"
                     /db_xref="GeneID:24410"
                     /db_xref="RGD:2738"
     exon            1..332
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            333..761
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..4799
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /note="glutamate [NMDA] receptor subunit epsilon-2; NR2B;
                     NMDAR2B; N-methyl D-aspartate receptor subtype 2B;
                     glutamate receptor, ionotropic, NMDA2B; glutamate receptor
                     ionotropic, NMDA 2B; glutamate receptor, ionotropic,
                     N-methyl D-aspartate 2B"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 2B
                     precursor"
                     /protein_id="NP_036706.1"
                     /db_xref="GeneID:24410"
                     /db_xref="RGD:2738"
                     /translation="MKPSAECCSPKFWLVLAVLAVSGSKARSQKSPPSIGIAVILVGT
                     SDEVAIKDAHEKDDFHHLSVVPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADD
                     TDQEAIAQILDFISAQTLTPILGIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNI
                     MEEYDWYIFSIVTTYFPGYQDFVNKIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQN
                     QLKKLQSPIILLYCTKEEATYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPSEFPTG
                     LISVSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNM
                     LNRYLINVTFEGRNLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYYVWP
                     RMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSGTCMRNTVPCQKRIISENKTDEEP
                     GYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYM
                     AVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVML
                     LIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIWLLWGLVFNNSVPVQNPK
                     GTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQVSGLSDKKFQRPNDFSPPFR
                     FGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAFIYDAAVLNYMA
                     GRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLT
                     GICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFYWQFRHCFMGVCSG
                     KPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGV
                     NGSPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGN
                     LQLKDSNVYQDHYHHHHRPHSIGSTSSIDGLYDCDNPPFTTQPRSISKKPLDIGLPSS
                     KHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHTVTYGNIEGNAAKRRKQQYKDS
                     LKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKEGLRDFYLDQFRTKENSPHW
                     EHVDLTDIYKERSDDFKRDSVSGGGPCTNRSHLKHGTGEKHGVVGGVPAPWEKNLTNV
                     DWEDRSGGNFCRSCPSKLHNYSSTVAGQNSGRQACIRCEACKKAGNLYDISKDNSLQE
                     LDQPAAPVAVTSNASSTKYPQSPTNSKAQKKNRNKLRRQHSYDTFVDLQKEEAALAPR
                     SVSLKDKGRFMDGSPYAHMFEMPAGESSFANKSSVPTAGHHHNNPGSGYMLSKSLYPD
                     RVTQNPFIPTFGDDQCLLHGSKSYFFRQPTVAGASKTRPDFRALVTNKPVVSALHGAV
                     PGRFQKDICIGNQSNPCVPNNKNPRAFNGSSNGHVYEKLSSIESDV"
     exon            762..1360
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1475
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1678
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1850
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..2004
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2130
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2360
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2521
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2709
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2948
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..5259
                     /gene="Grin2b"
                     /gene_synonym="GluN2B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgaagact ccttaaatat atatatatat atatatattc gggctactaa cctcacatgc
       61 acatgggata atgactctgg attctgcatt gtgagctgct ctccacaccc tgagatcccc
      121 tcttacatta cattttttcc tttgaatttg catctcgtca agacacaaga ttaaaaccaa
      181 atttacacta cactggattt taaattttct tccgttcctt tatcctccgt ctttcttatg
      241 tggatatgca agcgagaaga ggaccctgga tattcccaac atgctctctc ccttaatctg
      301 tccgcctaga ggtttggcgt ctacaaacca agagagccga ctagctgaag atgaagccca
      361 gcgcagagtg ctgttccccc aagttctggt tggtgttggc cgtcttggcc gtatcaggca
      421 gcaaagctcg ttcccaaaag agccccccca gcatcggcat cgctgtcatc ctcgtgggca
      481 cttcagacga agtggccata aaagacgccc acgagaaaga tgacttccat catctctcag
      541 tagttccccg ggtggagctg gtagccatga acgaaactga cccaaagagc atcatcaccc
      601 gtatctgcga tcttatgtct gaccggaaga tccagggggt ggtgttcgcg gatgacaccg
      661 accaagaagc catcgctcag atcctcgact tcatttctgc tcagactctc acccccatcc
      721 tgggcatcca tgggggctca tctatgataa tggcggataa ggatgagtcc tccatgttct
      781 tccagtttgg cccgtctatc gaacagcaag cttccgtcat gctcaacatc atggaagaat
      841 atgactggta catcttttcc atcgtcacca cctacttccc tggctaccag gactttgtga
      901 acaagatccg cagtaccatc gagaacagct tcgtgggctg ggagctcgag gaagtcctcc
      961 tgctagacat gtctctggac gatggcgact ctaagattca gaatcagctg aagaagctcc
     1021 aaagccccat cattctcctt tattgcacga aggaggaagc cacctacatt tttgaagtag
     1081 ctaactcagt tgggctgact ggctacggct acacgtggat tgtgccgagt ctggtggccg
     1141 gggatacgga cacggtgcct tcagagttcc ccacggggct tatctctgtg tcttatgatg
     1201 aatgggacta tggccttcct gccagagtga gagatggaat tgccatcatc accactgctg
     1261 cctcggacat gctgtccgaa cacagtttca tccctgagcc caagagcagt tgctacaaca
     1321 cccacgagaa gaggatctac cagtctaaca tgttgaatag gtatctgatc aatgtcactt
     1381 ttgaagggag aaacctgtcc ttcagcgaag atggctacca gatgcatccg aagctggtga
     1441 taatccttct gaacaaggag aggaagtggg agagggtggg gaaatggaag gacaagtccc
     1501 tgcagatgaa gtattatgtg tggcctcgga tgtgtcctga gactgaggag caagaggatg
     1561 accatctgag cattgtcacc ttggaggagg cgccatttgt cattgtggaa agcgtggacc
     1621 ctctcagtgg aacctgcatg aggaatacag tcccgtgcca gaagcgcatc atctctgaga
     1681 ataaaacaga tgaggaacca ggctacatca aaaaatgctg caaggggttc tgtattgaca
     1741 tccttaagaa aatttctaag tctgtgaagt tcacctatga cctttacctg gtgaccaatg
     1801 gcaagcacgg gaagaagatt aatgggacct ggaatggcat gatcggtgag gtggtcatga
     1861 agagggccta catggcagtg ggatcactaa ctatcaatga agaacggtca gaggtggttg
     1921 acttctctgt acccttcata gaaactggca tcagtgtcat ggtatctcgc agcaatggga
     1981 ctgtgtcacc ttctgccttc ttagagccat tcagcgctga cgtgtgggtg atgatgtttg
     2041 tgatgctgct cattgtttct gcggtggctg tctttgtctt tgaatacttc agccctgtgg
     2101 gttacaacag gtgcctagcc gatggcagag agccaggagg cccatctttc accatcggca
     2161 aagcaatttg gttactctgg ggtctggtgt ttaacaactc cgtacctgtg cagaacccaa
     2221 aggggaccac ctccaagatc atggtgtcag tgtgggcctt ctttgctgtc attttcctgg
     2281 ccagctacac tgccaactta gcagccttca tgatccaaga ggagtatgtg gaccaggttt
     2341 ctggcctgag tgacaagaag ttccagagac ctaatgactt ctcaccccct ttccgctttg
     2401 ggactgtgcc caatggcagc acagagagga atatccgtaa taactatgca gaaatgcatg
     2461 cctacatggg aaagttcaac caaaggggtg tagatgatgc attgctctcc ctgaaaacag
     2521 ggaagcttga tgcattcatc tatgatgcag ctgtgctcaa ctacatggct ggaagggacg
     2581 aaggctgcaa actggtgacc attggcagtg gcaaggtctt tgcttctacc ggctatggca
     2641 ttgctatcca aaaggactcc gggtggaagc gccaggtgga cctggctatc ctgcagctgt
     2701 ttggagatgg ggagatggaa gaactggaag ctctctggct cactggcatt tgccacaatg
     2761 agaagaatga ggtgatgagc agccagctgg acatcgacaa tatggcaggt gtcttctata
     2821 tgttgggggc agccatggcc ctcagcctca tcaccttcat ctgtgagcat ctgttctatt
     2881 ggcagttccg gcattgcttc atgggtgtct gttctggcaa gcctggcatg gtcttctcca
     2941 tcagcagagg tatctacagc tgtatccatg gggtagccat agaggagcgc caatccgtga
     3001 tgaactcccc cactgccacc atgaacaaca cccactccaa catcctacgc ttgctccgca
     3061 cggccaagaa catggccaac ctgtctggag taaacggctc ccctcagagt gccctggact
     3121 tcatccgccg agagtcctcc gtctacgaca tctctgagca tcgtcgcagc ttcacgcatt
     3181 cagactgcaa gtcttacaat aacccaccct gtgaggaaaa cctgttcagt gactacatta
     3241 gcgaggtaga gagaacattt ggtaacctgc agctgaagga cagcaatgtg taccaagacc
     3301 actatcacca tcaccaccgg ccacacagca tcggcagcac cagctccatt gatgggctct
     3361 atgactgtga caacccaccc ttcaccaccc agcccaggtc aatcagcaag aaacccctgg
     3421 acatcggcct gccctcctcc aaacatagcc agctcagcga cctgtatggc aagttctctt
     3481 tcaagagtga ccgctacagt ggccacgacg acttgattcg atcggatgtc tccgacatct
     3541 ccacgcacac tgtcacctat gggaacatcg agggcaacgc agccaagagg aggaaacagc
     3601 agtataagga cagtctaaag aagcggccag cctcggccaa atcgaggagg gagtttgatg
     3661 aaatcgagct ggcctaccgt cgccgaccac cccgctcccc ggaccacaag cgctacttca
     3721 gggacaaaga agggctccga gacttctacc tggaccagtt ccgaacaaag gagaactcgc
     3781 ctcactggga gcacgtggac ttgactgaca tttacaaaga acgcagtgac gacttcaagc
     3841 gagattcggt cagtggaggt gggccctgta ccaacaggtc tcacctcaaa cacggaacgg
     3901 gcgagaagca cggagtggta ggcggggtgc ctgctccttg ggagaagaac ctgaccaatg
     3961 tggattggga ggaccggtct gggggcaact tctgccgcag ctgtccttcc aagctgcaca
     4021 attactcctc gacggtggca gggcagaact cgggccggca ggcctgcatc agatgtgagg
     4081 cctgtaagaa ggctggtaac ctgtacgaca tcagcaagga caactccctg caggaactgg
     4141 accagccggc tgcccccgtg gctgtgacat ccaacgcctc cagcaccaag taccctcaaa
     4201 gcccgactaa ttccaaggct cagaagaaga atcggaacaa actgcgccgg cagcattcct
     4261 acgacacctt cgtggacctg cagaaggagg aggccgcctt ggccccacgc agcgtgagcc
     4321 tgaaagacaa gggccgattc atggatggga gcccctacgc ccatatgttt gagatgccag
     4381 ctggtgagag ctcctttgcc aacaagtcct cagtgcccac tgccggacac caccacaaca
     4441 accccggcag cggctacatg ctcagcaagt cgctctaccc tgaccgggtc acgcaaaacc
     4501 ctttcatccc cacttttggg gatgaccagt gcttgcttca cggcagcaaa tcctacttct
     4561 tcaggcagcc cacggtggca ggggcgtcaa aaacaaggcc ggacttccgg gcccttgtca
     4621 ccaataagcc agtggtgtca gcccttcatg gggctgtgcc aggtcgtttc cagaaggaca
     4681 tttgtatagg gaaccagtcc aacccctgtg tgcctaacaa caaaaacccc agggctttca
     4741 atggctccag caatggacat gtttatgaga aactttctag tattgagtct gatgtctgag
     4801 tgagggaaga gagagaggtt aaggtgggta cgggagggat agggctgtgg gccgcgtggt
     4861 gcgcatgtca tggaaagagt cgggggtgaa cttggctccc attcgctttt tcttcttctt
     4921 ttaatttctc tatgggatcc tggagttctg gttccttact gaaggcaacc ctcgtggcca
     4981 gcaccatttc tcctccctcg cgcagttctc tccttcccgc atctgtccac cattcctgtt
     5041 tccatgagag aatagaacgg ggcctcagtg tgggaggatg gagaggagac caaagcgctg
     5101 cctgtgtgct tctttctagc gcagaagggc tcttagcagt tcactttgag cgaggctttc
     5161 ctgatgctgc tctctttgtt caggtgagga agcgaaggtg ttctgaggaa ggccattgaa
     5221 cctcctgttc ataagagaga agaggctttc actgaattc
//
