LOCUS       NM_017010               4280 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Rattus norvegicus glutamate ionotropic receptor NMDA type subunit 1
            (Grin1), transcript variant 2, mRNA.
ACCESSION   NM_017010
VERSION     NM_017010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4280)
  AUTHORS   Chou,T.H., Epstein,M., Fritzemeier,R.G., Akins,N.S., Paladugu,S.,
            Ullman,E.Z., Liotta,D.C., Traynelis,S.F. and Furukawa,H.
  TITLE     Molecular mechanism of ligand gating and opening of NMDA receptor
  JOURNAL   Nature 632 (8023), 209-217 (2024)
   PUBMED   39085540
  REMARK    GeneRIF: Molecular mechanism of ligand gating and opening of NMDA
            receptor.
REFERENCE   2  (bases 1 to 4280)
  AUTHORS   Prados-Pardo,A., Martin-Gonzalez,E., Mora,S., Martin,C.,
            Olmedo-Cordoba,M., Perez-Fernandez,C., Sanchez-Santed,F. and
            Moreno-Montoya,M.
  TITLE     Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and
            Cognitive Inflexibility in a Model of High Compulsive Rats
  JOURNAL   Mol Neurobiol 60 (12), 6975-6991 (2023)
   PUBMED   37523044
  REMARK    GeneRIF: Reduced Expression of the Htr2a, Grin1, and Bdnf Genes and
            Cognitive Inflexibility in a Model of High Compulsive Rats.
REFERENCE   3  (bases 1 to 4280)
  AUTHORS   Zhang,J., Zhang,M., Wang,Q., Wen,H., Liu,Z., Wang,F., Wang,Y.,
            Yao,F., Song,N., Kou,Z., Li,Y., Guo,F. and Zhu,S.
  TITLE     Distinct structure and gating mechanism in diverse NMDA receptors
            with GluN2C and GluN2D subunits
  JOURNAL   Nat Struct Mol Biol 30 (5), 629-639 (2023)
   PUBMED   36959261
REFERENCE   4  (bases 1 to 4280)
  AUTHORS   Jyothi,A.K., Thotakura,B., Priyadarshini,S.C., Patil,S.,
            Poojari,M.S. and Subramanian,M.
  TITLE     Paternal stress alters synaptic density and expression of GAP-43,
            GRIN1, M1 and SYP genes in the hippocampus and cortex of offspring
            of stress-induced male rats
  JOURNAL   Morphologie 107 (356), 67-79 (2023)
   PUBMED   35715368
  REMARK    GeneRIF: Paternal stress alters synaptic density and expression of
            GAP-43, GRIN1, M1 and SYP genes in the hippocampus and cortex of
            offspring of stress-induced male rats.
REFERENCE   5  (bases 1 to 4280)
  AUTHORS   Kolcheva,M., Ladislav,M., Netolicky,J., Kortus,S., Rehakova,K.,
            Krausova,B.H., Hemelikova,K., Misiachna,A., Kadkova,A., Klima,M.,
            Chalupska,D. and Horak,M.
  TITLE     The pathogenic N650K variant in the GluN1 subunit regulates the
            trafficking, conductance, and pharmacological properties of NMDA
            receptors
  JOURNAL   Neuropharmacology 222, 109297 (2023)
   PUBMED   36341805
  REMARK    GeneRIF: The pathogenic N650K variant in the GluN1 subunit
            regulates the trafficking, conductance, and pharmacological
            properties of NMDA receptors.
REFERENCE   6  (bases 1 to 4280)
  AUTHORS   Ikeda,K., Nagasawa,M., Mori,H., Araki,K., Sakimura,K., Watanabe,M.,
            Inoue,Y. and Mishina,M.
  TITLE     Cloning and expression of the epsilon 4 subunit of the NMDA
            receptor channel
  JOURNAL   FEBS Lett 313 (1), 34-38 (1992)
   PUBMED   1385220
REFERENCE   7  (bases 1 to 4280)
  AUTHORS   Kutsuwada,T., Kashiwabuchi,N., Mori,H., Sakimura,K., Kushiya,E.,
            Araki,K., Meguro,H., Masaki,H., Kumanishi,T., Arakawa,M. et al.
  TITLE     Molecular diversity of the NMDA receptor channel
  JOURNAL   Nature 358 (6381), 36-41 (1992)
   PUBMED   1377365
REFERENCE   8  (bases 1 to 4280)
  AUTHORS   Sugihara,H., Moriyoshi,K., Ishii,T., Masu,M. and Nakanishi,S.
  TITLE     Structures and properties of seven isoforms of the NMDA receptor
            generated by alternative splicing
  JOURNAL   Biochem Biophys Res Commun 185 (3), 826-832 (1992)
   PUBMED   1352681
REFERENCE   9  (bases 1 to 4280)
  AUTHORS   Monyer,H., Sprengel,R., Schoepfer,R., Herb,A., Higuchi,M.,
            Lomeli,H., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Heteromeric NMDA receptors: molecular and functional distinction of
            subtypes
  JOURNAL   Science 256 (5060), 1217-1221 (1992)
   PUBMED   1350383
REFERENCE   10 (bases 1 to 4280)
  AUTHORS   Meguro,H., Mori,H., Araki,K., Kushiya,E., Kutsuwada,T.,
            Yamazaki,M., Kumanishi,T., Arakawa,M., Sakimura,K. and Mishina,M.
  TITLE     Functional characterization of a heteromeric NMDA receptor channel
            expressed from cloned cDNAs
  JOURNAL   Nature 357 (6373), 70-74 (1992)
   PUBMED   1374164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM039130.1, U08261.1 and JAXUCZ010000003.1.
            
            On Jul 20, 2012 this sequence version replaced NM_017010.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (1a) has the same
            N- and C-termini but is shorter compared to isoform 1b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U08261.1, X63255.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                FM039130.1         1-92
            93-4272             U08261.1           4-4183
            4273-4280           JAXUCZ010000003.1  28501836-28501843   c
FEATURES             Location/Qualifiers
     source          1..4280
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..4280
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /note="glutamate ionotropic receptor NMDA type subunit 1"
                     /db_xref="GeneID:24408"
                     /db_xref="RGD:2736"
     exon            1..582
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..3141
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /note="isoform 1a precursor is encoded by transcript
                     variant 2; glutamate [NMDA] receptor subunit zeta-1;
                     neurotransmitter receptor; NMDA R1 receptor C1 cassette;
                     N-methyl-D-aspartate glutamate receptor; NMD-R1;
                     N-methyl-D-aspartate receptor subunit NR1; glutamate
                     receptor ionotropic, NMDA 1; glutamate receptor,
                     ionotropic, N-methyl D-aspartate 1"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 1 isoform 1a
                     precursor"
                     /protein_id="NP_058706.1"
                     /db_xref="GeneID:24408"
                     /db_xref="RGD:2736"
                     /translation="MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFRE
                     AVNQANKRHGSWKIQLNATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHF
                     TPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNW
                     NHIILLVSDDHEGRAAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEARELEARV
                     IILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKN
                     ESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGV
                     TGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGY
                     QMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHT
                     VPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSG
                     QADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLV
                     GLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAP
                     RSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYA
                     TVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA
                     SQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC
                     DSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVN
                     VWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGALQNQKD
                     TVLPRRAIEREEGQLQLCSRHRES"
     exon            583..717
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..894
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..995
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1117
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1292
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1437
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1521
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1663
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1791
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1956
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2075
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2188
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2337
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..2495
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2657
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2767
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2913
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3024
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..4280
                     /gene="Grin1"
                     /gene_synonym="GluN1; NMDAR1; NR1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcactcg actcagcgtc aggaagcggg ggcggtggga ggggtagaac gcgtaggtcc
       61 cgctcatgac tccgcagctg ctgcagtcgc cgcagcatcg ggaccagtcg cgcagtccgc
      121 gctgctgtcc tttccgcctt ttccgcgcgg gtgttcgagc agcgccaaac acgcttcagc
      181 acctcggaca gcatccgccg cgctcgcccg gggctcctag agaacccggg ggcgcttgac
      241 cgcgcgcggg cggcccgcgg gtcgtacatc gcgaggtcgt cgcactcgcg caacccagag
      301 ccaggcccgc tgtgcccgga gctcatgagc accatgcacc tgctgacatt cgccctgctt
      361 ttttcctgct ccttcgcccg cgccgcctgc gaccccaaga tcgtcaacat cggcgcggtg
      421 ctgagcacgc gcaagcatga acagatgttc cgcgaggcag taaaccaggc caataagcga
      481 cacggctctt ggaagataca gctcaacgcc acttctgtca cccacaagcc caacgccata
      541 cagatggccc tgtcagtgtg tgaggacctc atctctagcc aggtctacgc tatcctagtt
      601 agccacccgc ctactcccaa cgaccacttc actcccaccc ctgtctccta cacagctggc
      661 ttctacagaa tccctgtcct gggactgact acccgaatgt ccatctactc tgacaagagt
      721 atccacctga gtttccttcg cacggtgccg ccctactccc accagtccag cgtctggttt
      781 gagatgatgc gagtctacaa ctggaaccac atcatcctgc tggtcagcga cgaccacgag
      841 ggacgggcag cgcagaagcg cttggagacg ttgctggagg aacgggagtc caaggcagag
      901 aaggtgctgc agtttgaccc aggaaccaag aatgtgacgg ctctgctgat ggaggcccgg
      961 gaactggagg cccgggtcat catcctttct gcaagcgagg acgacgctgc cacagtgtac
     1021 cgcgcagccg caatgctgaa catgacgggc tctgggtacg tgtggctggt cggggaacgc
     1081 gagatctctg ggaacgccct gcgctacgct cctgatggca tcatcggact tcagctcatc
     1141 aatggcaaga atgagtcagc ccacatcagt gacgccgtgg gcgtggtggc acaggcagtt
     1201 cacgaactcc tagagaagga gaatatcact gacccaccgc ggggttgcgt gggcaacacc
     1261 aacatctgga agacaggacc attgttcaag agggtgctga tgtcttctaa gtatgcggac
     1321 ggagtgactg gccgtgtgga attcaatgag gatggggacc ggaagtttgc caactatagt
     1381 atcatgaacc tgcagaaccg caagctggtg caagtgggca tctacaatgg tacccatgtc
     1441 atcccaaatg acaggaagat catctggcca ggaggagaga cagagaaacc tcgaggatac
     1501 cagatgtcca ccagactaaa gatagtgaca atccaccaag agcccttcgt gtacgtcaag
     1561 cccacaatga gtgatgggac atgcaaagag gagttcacag tcaatggtga cccagtgaag
     1621 aaggtgatct gtacggggcc taatgacacg tccccaggca gcccacgcca cacagtgccc
     1681 cagtgctgct atggcttctg catagacctg ctcatcaagc tggcgcggac catgaatttt
     1741 acctatgagg tgcacctggt ggcagatggc aagtttggca cacaggagcg ggtaaacaac
     1801 agcaacaaaa aggagtggaa cggaatgatg ggcgagctac tcagtggcca agcggacatg
     1861 attgtggcac cactgaccat caacaatgag cgtgcgcagt acatagagtt ctccaagccc
     1921 ttcaagtacc agggcctgac cattttggtc aagaaggaga ttcccaggag cacactggac
     1981 tcatttatgc agccttttca gagcacactg tggttgctag taggactgtc agttcatgtg
     2041 gtggctgtga tgctgtacct gctggaccgc ttcagtccct ttggccgatt caaggtgaac
     2101 agtgaggagg aggaggaaga tgcactgacc ctgtcctctg ccatgtggtt ttcctggggc
     2161 gtcctgctca actccggcat tggggaaggt gccccccgga gtttctctgc acgtatccta
     2221 ggcatggtgt gggctggttt cgccatgatc atagtggctt cctacactgc caacttggca
     2281 gctttcctgg tgctggatcg gcctgaggag cgcatcacgg gcatcaatga ccccaggctc
     2341 agaaacccct cagacaagtt catctacgca actgtaaagc agagctccgt ggacatctac
     2401 ttccggaggc aggtggagtt gagtaccatg taccggcaca tggaaaaaca caattacgag
     2461 agcgcagctg aggccatcca ggctgtgcgg gacaacaagc tgcacgcctt tatctgggac
     2521 tcggccgtgc tggagtttga ggcttcacag aagtgcgatc tggtgaccac gggtgagctg
     2581 ttcttccgct caggctttgg catcggcatg cgcaaggaca gcccctggaa gcagaacgtt
     2641 tccctgtcca tactcaagtc ccatgagaat ggcttcatgg aagatctgga taagacatgg
     2701 gttcggtatc aggaatgcga ctcccgcagc aatgctcctg caaccctcac ttttgagaac
     2761 atggcagggg tcttcatgct ggtggctgga ggcatcgtag ctgggatttt cctcattttc
     2821 attgagatcg cctacaagcg acacaaggat gcccgtagga agcagatgca gctggctttt
     2881 gcagccgtga acgtgtggag gaagaacctg caggatagaa agagtggtag agcagagccc
     2941 gaccctaaaa agaaagccac atttagggct atcacctcca ccctggcctc cagcttcaag
     3001 agacgtaggt cctccaaaga cacgagcacc gggggtggac gcggcgcttt gcaaaaccaa
     3061 aaagacacag tgctgccgcg acgcgctatt gagagggagg agggccagct gcagctgtgt
     3121 tcccgtcata gggagagctg agacgccccg cccgccctcc tctgcccctc ccccgcagac
     3181 agacgcacgg gacagcggcc tggcccacgc agagccccgg agcacgacgg ggtcggggga
     3241 ggagcactcc cagcctcccc caggccgtgc ccgcctgccc accggtcggc cggctggccg
     3301 gtccaccctg tcccggcccc gcgcgtgccc ccgacgtcgg agctaacggg ccgccttgtc
     3361 tgtgtatttc tattttacag cagtaccatc ccactgatat cacgggcccg ctcaacctct
     3421 cagatccctc ggtcagcacc gtggtgtgag gccccccgga ggcgcccacc tgcccagtta
     3481 gcccggccaa ggacactgat gagtcctgct gctcgggaag gcctgaggga agcccacccg
     3541 ccccagagac tgcccaccct gggcctcccg tccgcctgct ctgctgcctg gcgggcagcc
     3601 cctgcaggac caaggtgcgg accagagcgg ctgaggatgg gccagagctg agccggctgg
     3661 gcagggccac agggcgctcc ggcagaggca gggccctgag gtctctgagc agtggggtga
     3721 ggggcctaag tggccccggt cggaggagtc tggagcagaa atggcagccc catccttcct
     3781 ccagccacta ccccaagcta cagtgggggc ctatggcccc agcttgctag gtcacccccg
     3841 acccttcctc cagcgcctgc tctctgcaac ttgatttcca cctctctcct gctgcaccac
     3901 cctcccacga catttcccca ccccattcac tgggttgtct ctgacctttc ccagggctag
     3961 ccttcactgc cctagtggca gtgcttcagg ggtgctttct ggctcccaga catctagggc
     4021 tccagactcc aagagggctg agccttctct tctgtccgca gccacaatag gcttcctcag
     4081 acgctggctc gtgatgagtc ccgcaccttg ggcaccaggg agcgccatct gcctcccagt
     4141 ccggtgtcac tcaccccact accttgtaca tgaccagctc tcccagtgtc ccagtgtctg
     4201 ccccagggac accgggcgcg cacagccacc cctaatcccg gtattcagtg gtgatgccta
     4261 aaggaatgtc agaaaatttc
//
