LOCUS       NM_031508               3776 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor kainate type
            subunit 5 (Grik5), mRNA.
ACCESSION   NM_031508 NM_017262
VERSION     NM_031508.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3776)
  AUTHORS   Korytina,G.F., Akhmadishina,L.Z., Kochetova,O.V., Aznabaeva,Y.G.,
            Zagidullin,S.Z. and Victorova,T.V.
  TITLE     [Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and
            Serotonin Receptor (HTR2A) Genes Are Associated with Chronic
            Obstructive Pulmonary Disease]
  JOURNAL   Mol Biol (Mosk) 51 (4), 603-614 (2017)
   PUBMED   28900078
REFERENCE   2  (bases 1 to 3776)
  AUTHORS   Fisher,M.T. and Fisher,J.L.
  TITLE     Contributions of different kainate receptor subunits to the
            properties of recombinant homomeric and heteromeric receptors
  JOURNAL   Neuroscience 278, 70-80 (2014)
   PUBMED   25139762
REFERENCE   3  (bases 1 to 3776)
  AUTHORS   Fisher,J.L. and Housley,P.R.
  TITLE     Agonist binding to the GluK5 subunit is sufficient for functional
            surface expression of heteromeric GluK2/GluK5 kainate receptors
  JOURNAL   Cell Mol Neurobiol 33 (8), 1099-1108 (2013)
   PUBMED   23975096
  REMARK    GeneRIF: These findings indicate that ligand binding to only the
            GluK5 subunit is both necessary and sufficient to allow trafficking
            of recombinant GluK2/K5 heteromers to the cell membrane, but that
            occupancy of the GluK2 site alone is not.
REFERENCE   4  (bases 1 to 3776)
  AUTHORS   Carta,M., Opazo,P., Veran,J., Athane,A., Choquet,D., Coussen,F. and
            Mulle,C.
  TITLE     CaMKII-dependent phosphorylation of GluK5 mediates plasticity of
            kainate receptors
  JOURNAL   EMBO J 32 (4), 496-510 (2013)
   PUBMED   23288040
  REMARK    GeneRIF: CaMKII-dependent phosphorylation of GluK5 is responsible
            for synaptic depression by untrapping of KARs from the PSD and
            increased diffusion away from synaptic sites.
REFERENCE   5  (bases 1 to 3776)
  AUTHORS   Reiner,A., Arant,R.J. and Isacoff,E.Y.
  TITLE     Assembly stoichiometry of the GluK2/GluK5 kainate receptor complex
  JOURNAL   Cell Rep 1 (3), 234-240 (2012)
   PUBMED   22509486
  REMARK    GeneRIF: GluK2 and GluK5 assemble with 2:2 stoichiometry.
REFERENCE   6  (bases 1 to 3776)
  AUTHORS   Lomeli,H., Wisden,W., Kohler,M., Keinanen,K., Sommer,B. and
            Seeburg,P.H.
  TITLE     High-affinity kainate and domoate receptors in rat brain
  JOURNAL   FEBS Lett 307 (2), 139-143 (1992)
   PUBMED   1322826
REFERENCE   7  (bases 1 to 3776)
  AUTHORS   Kamboj,R.K., Schoepp,D.D., Nutt,S., Shekter,L., Korczak,B.,
            True,R.A., Zimmerman,D.M. and Wosnick,M.A.
  TITLE     Molecular structure and pharmacological characterization of
            humEAA2, a novel human kainate receptor subunit
  JOURNAL   Mol Pharmacol 42 (1), 10-15 (1992)
   PUBMED   1321949
REFERENCE   8  (bases 1 to 3776)
  AUTHORS   Bettler,B., Egebjerg,J., Sharma,G., Pecht,G., Hermans-Borgmeyer,I.,
            Moll,C., Stevens,C.F. and Heinemann,S.
  TITLE     Cloning of a putative glutamate receptor: a low affinity
            kainate-binding subunit
  JOURNAL   Neuron 8 (2), 257-265 (1992)
   PUBMED   1371217
REFERENCE   9  (bases 1 to 3776)
  AUTHORS   Sakimura,K., Morita,T., Kushiya,E. and Mishina,M.
  TITLE     Primary structure and expression of the gamma 2 subunit of the
            glutamate receptor channel selective for kainate
  JOURNAL   Neuron 8 (2), 267-274 (1992)
   PUBMED   1310861
REFERENCE   10 (bases 1 to 3776)
  AUTHORS   Sussman,H.M., MacNeilage,P.F. and Lumbley,J.L.
  TITLE     Pursuit auditory tracking of dichotically presented tonal
            amplitudes
  JOURNAL   J Speech Hear Res 18 (1), 74-81 (1975)
   PUBMED   1127911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC101853.1 and Z11581.1.
            
            On or before Mar 28, 2009 this sequence version replaced
            NM_017262.1, NM_031508.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z11581.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-991               BC101853.1         54-1044
            992-3776            Z11581.1           890-3674
FEATURES             Location/Qualifiers
     source          1..3776
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3776
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /note="glutamate ionotropic receptor kainate type subunit
                     5"
                     /db_xref="GeneID:24407"
                     /db_xref="RGD:2735"
     exon            1..254
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            255..383
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..3244
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /note="glutamate receptor KA2; glutamate receptor KA-2;
                     glutamate receptor, ionotropic, kainate 5"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 5
                     precursor"
                     /protein_id="NP_113696.1"
                     /db_xref="GeneID:24407"
                     /db_xref="RGD:2735"
                     /translation="MPAELLLLLIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLAL
                     ALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPAS
                     ASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPS
                     ASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDA
                     NASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPF
                     YPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLAC
                     TSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWY
                     SNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDM
                     LRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREK
                     VIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAAR
                     LSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVW
                     WAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSR
                     YQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIG
                     GLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKG
                     LGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCR
                     KTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQRLLDDPGP
                     PGGPRPQAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGTPAEATSPPRPRPGPTGP
                     RELTEHE"
     exon            384..548
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            549..646
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            647..812
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            813..991
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1045
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1207
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1360
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1465
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1573
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1777
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1891
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2001
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2175
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2341
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2567
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2696
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2818
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..3762
                     /gene="Grik5"
                     /gene_synonym="GluK5; iGlu5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctctcctcc attttctcct ttccccttcc tcccctcctg gcccgccctt tgcttttcca
       61 cctgtccttc ctccccgctg ctggggagac accgttttgg attagttggg ggccaccgcc
      121 ggcggcgggg gagggggccc agtggactgc cctctccccc ggccccagcc tcaccagcac
      181 ccagcgtcgg agcacctcct ggttgtcgtt cctcgggcct cgagggagcc cagccctccg
      241 tcccaccagg atccgtggcg agtgggggcc gcggcagctg cgtccccatg aggaggggag
      301 gaagatgccg gctgagctgc tgctgctgct gatagtcgcc ttcgccaacc ccagctgcca
      361 ggtgctgtca tcactgcgca tggctgcaat cctggacgac cagaccgtgt gtggccgtgg
      421 tgagcgtctg gccctggccc tggcccgaga gcagatcaat gggatcatcg aggtcccagc
      481 caaggcccga gtggaagtag acatctttga gctgcaacgg gacagccagt acgagactac
      541 ggacaccatg tgtcagatcc tgcccaaggg ggttgtgtct gtcttgggac cctcctccag
      601 cccagcttct gcctccaccg tgagccatat ctgtggggag aaggagattc cccacatcaa
      661 ggtaggccct gaggagacac cccgccttca gtacctccgc tttgcatctg tcagcctgta
      721 tcccagtaat gaagatgtca gcctggcagt ctcccggatc ctcaagtcct ttaactaccc
      781 ctccgctagc ctcatctgcg ccaaagctga gtgcctgctg cggttagaag aactggtgcg
      841 aggcttcctc atctccaagg agacactgtc cgtgaggatg cttgatgaca gccgggaccc
      901 cacgccgcta ctcaaggaga tccgagatga caaagtgtcc accatcatca tcgatgccaa
      961 cgcgtccatc tcccaccttg tcctccgtaa ggcttcggag ctgggaatga cctcagcgtt
     1021 ttacaagtac atcctcacca ccatggactt ccccatcctg catctggacg gtatcgtaga
     1081 ggactcctcc aacatcttgg gcttttccat gttcaacacc tcccatccct tctacccgga
     1141 gtttgtgcgc agcctcaaca tgtcctggag ggagaactgc gaagccagca cctaccctgg
     1201 ccctgcgctg tcggcagccc tgatgtttga tgccgtgcat gtggtggtaa gcgctgtccg
     1261 agagctgaac cggagccagg agattggtgt caagccactg gcttgcactt cggccaacat
     1321 ctggccccat gggaccagcc tcatgaacta cctgcgcatg gtagagtatg acgggctgac
     1381 tgggcgggtt gagttcaaca gcaaagggca gaggaccaac tacacactgc gcatcctgga
     1441 gaagtcccgc cagggccacc gtgagatagg ggtgtggtac tctaaccgga ccctggccat
     1501 gaatgctacc accctggaca tcaacctgtc acagactcta gccaacaaga ctctggtggt
     1561 cacaacaatc ctggagaacc cgtatgtcat gcgccggccc aacttccagg ccctgtcagg
     1621 gaacgagcgc tttgagggct tctgcgtgga catgcttcgg gagctggccg agctgctgcg
     1681 cttccggtat cgcctgcggt tggtggagga cggactgtac ggggcacctg agcccaatgg
     1741 ttcctggaca ggaatggttg gcgagctcat caaccggaag gcagacctgg ctgtggcagc
     1801 cttcaccatc accgcggaga gagagaaggt catcgacttc tccaagccat tcatgaccct
     1861 ggggatcagc atcctctaca gggtgcacat gggccgcaag cctggctact tctccttcct
     1921 ggaccctttc tcccctgccg tgtggctctt catgcttctt gcctacctgg ctgtcagctg
     1981 tgtcttgttt ctggctgcca ggctgagccc ttatgagtgg tataaccctc acccgtgtct
     2041 tcgggcgcgt ccccatatcc tggagaacca gtacacgctg ggtaacagcc tttggttccc
     2101 tgtgggtggc ttcatgcagc agggctcgga gatcatgccc cgggcgctgt ccacacgctg
     2161 tgtcagcgga gtctggtggg ccttcacctt gatcatcatc tcctcctaca cggccaacct
     2221 ggctgccttc ctcacggtgc agcgcatgga ggtgccggtg gagtctgcag acgacttggc
     2281 ggatcagacc aacattgagt acggcactat ccacgctggc tccaccatga ccttctttca
     2341 gaactcacgg taccagacgt accagcggat gtggaattac atgcagtcga agcagcccag
     2401 cgtgttcgtc aagagcacag aggaggggat cgcccgtgtc ctcaactcac gttacgcctt
     2461 cctgctggag tccaccatga acgagtacca caggcgcctc aattgcaacc tcacccagat
     2521 cgggggcctc ctcgacacca agggctacgg catcggcatg ccgctgggct ccccattccg
     2581 ggatgagatc acgctggcca tcctgcagct ccaggagaac aacaggctgg agatcctgaa
     2641 gcgcaagtgg tgggagggcg gccggtgccc caaggaggag gaccacaggg ccaaaggttt
     2701 gggcatggag aacattggcg gtatttttgt cgtgctgatc tgtggcctca tcattgctgt
     2761 cttcgtggcg gtcatggaat tcatctggtc cacgcggagg tcagcggagt ctgaggaggt
     2821 gtcggtgtgc caggagatgc tgcaggagct gcgccacgcc gtgtcttgcc gcaagacctc
     2881 gcgttcccgc cggcgccggc gccctggcgg cccgagccgg gccctgctgt cgctgcgcgc
     2941 ggtccgcgag atgcgactca gcaacggcaa gctctactcg gccggcgcgg gcggggacgc
     3001 gggcgcgcac gggggtccgc agcgcctcct ggacgacccc gggcctcctg ggggaccccg
     3061 gccccaggct cccacgccct gcacgcacgt gcgcgtctgc caggagtgca ggcgcatcca
     3121 ggcgctgcga gcttcagggg ccggggcgcc cccgcgtggc ctgggcactc cggccgaagc
     3181 caccagcccg cctcggccgc ggcctggacc cactggaccc cgcgagctga ctgagcatga
     3241 atgaccgtgg acggggccgg gcgtgcgccc cgactgactg cagggacgcg atgcgcccca
     3301 ggcggacagg acgccgcgat tttgccttca gtttctggtg aagtccaagc ccggctccgg
     3361 agcaggcctg cgcctcctag tggactccag cgagggtgtc gcggacgccc gcattccatc
     3421 ccgcgccgcg ggcgggagga gcgcagagac cgaggactct taagggccgt ggactgtgag
     3481 ggccgctcct ggcgttggaa agcggtccgc ggggaggacc ccaacctggg actgcccaga
     3541 tgtcccaaga cttgacacgg ctctccacac ttctggaggt cgagagggcc tctggacatg
     3601 tgggtgtccc ctggtgcccc tctcttcttt ctctcttttt tggggggaga aacctcagaa
     3661 tttctatgag acgcccccag gagagggtct cttgggcccc tatatctccc cctgccacat
     3721 ctcagaccct gttggaataa aaaaagaaca aaaccccaaa aaaaaaaaaa aaaaaa
//
