LOCUS       NM_012572               3320 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor kainate type
            subunit 4 (Grik4), mRNA.
ACCESSION   NM_012572
VERSION     NM_012572.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3320)
  AUTHORS   Kristensen,O., Kristensen,L.B., Mollerud,S., Frydenvang,K.,
            Pickering,D.S. and Kastrup,J.S.
  TITLE     The Structure of a High-Affinity Kainate Receptor: GluK4
            Ligand-Binding Domain Crystallized with Kainate
  JOURNAL   Structure 24 (9), 1582-1589 (2016)
   PUBMED   27524200
  REMARK    GeneRIF: The structure of a high-affinity kainate receptor gluk4
            ligand-binding domain crystallized with kainite has been presented.
REFERENCE   2  (bases 1 to 3320)
  AUTHORS   Fisher,M.T. and Fisher,J.L.
  TITLE     Contributions of different kainate receptor subunits to the
            properties of recombinant homomeric and heteromeric receptors
  JOURNAL   Neuroscience 278, 70-80 (2014)
   PUBMED   25139762
REFERENCE   3  (bases 1 to 3320)
  AUTHORS   Tang,M., Pelkey,K.A., Ng,D., Ivakine,E., McBain,C.J., Salter,M.W.
            and McInnes,R.R.
  TITLE     Neto1 is an auxiliary subunit of native synaptic kainate receptors
  JOURNAL   J Neurosci 31 (27), 10009-10018 (2011)
   PUBMED   21734292
REFERENCE   4  (bases 1 to 3320)
  AUTHORS   Nakamura,M., Choi,K.H., Choi,S.K., Do,C.S., Jun,J.H., Kwon,H.K.,
            Lee,S.M., Moon,R.J., Yi,K.J. and Jang,I.S.
  TITLE     Presynaptic kainate receptors increase GABAergic neurotransmission
            in rat periaqueductal gray neurons
  JOURNAL   Eur J Pharmacol 635 (1-3), 72-78 (2010)
   PUBMED   20303934
  REMARK    GeneRIF: Presynaptic kainate receptors on GABAergic nerve terminals
            appear to modulate GABAergic transmission, and in doing so may play
            an important role in the regulation of PAG neuron excitability.
REFERENCE   5  (bases 1 to 3320)
  AUTHORS   Hunter,R.G., Bellani,R., Bloss,E., Costa,A., McCarthy,K. and
            McEwen,B.S.
  TITLE     Regulation of kainate receptor subunit mRNA by stress and
            corticosteroids in the rat hippocampus
  JOURNAL   PLoS One 4 (1), e4328 (2009)
   PUBMED   19180187
  REMARK    GeneRIF: adrenalectomy results in increased expression of
            hippocampal KA1 mRNA, an effect which is reversed by treatment with
            corticosterone...
REFERENCE   6  (bases 1 to 3320)
  AUTHORS   Lu,C.R., Willcockson,H.H., Phend,K.D., Lucifora,S., Darstein,M.,
            Valtschanoff,J.G. and Rustioni,A.
  TITLE     Ionotropic glutamate receptors are expressed in GABAergic terminals
            in the rat superficial dorsal horn
  JOURNAL   J Comp Neurol 486 (2), 169-178 (2005)
   PUBMED   15844209
REFERENCE   7  (bases 1 to 3320)
  AUTHORS   Darstein,M., Petralia,R.S., Swanson,G.T., Wenthold,R.J. and
            Heinemann,S.F.
  TITLE     Distribution of kainate receptor subunits at hippocampal mossy
            fiber synapses
  JOURNAL   J Neurosci 23 (22), 8013-8019 (2003)
   PUBMED   12954862
REFERENCE   8  (bases 1 to 3320)
  AUTHORS   Schiffer,H.H., Swanson,G.T. and Heinemann,S.F.
  TITLE     Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are
            functional kainate receptor subunits with a low sensitivity to
            glutamate
  JOURNAL   Neuron 19 (5), 1141-1146 (1997)
   PUBMED   9390526
REFERENCE   9  (bases 1 to 3320)
  AUTHORS   Szpirer,C., Molne,M., Antonacci,R., Jenkins,N.A., Finelli,P.,
            Szpirer,J., Riviere,M., Rocchi,M., Gilbert,D.J., Copeland,N.G. et
            al.
  TITLE     The genes encoding the glutamate receptor subunits KA1 and KA2
            (GRIK4 and GRIK5) are located on separate chromosomes in human,
            mouse, and rat
  JOURNAL   Proc Natl Acad Sci U S A 91 (25), 11849-11853 (1994)
   PUBMED   7527545
REFERENCE   10 (bases 1 to 3320)
  AUTHORS   Werner,P., Voigt,M., Keinanen,K., Wisden,W. and Seeburg,P.H.
  TITLE     Cloning of a putative high-affinity kainate receptor expressed
            predominantly in hippocampal CA3 cells
  JOURNAL   Nature 351 (6329), 742-744 (1991)
   PUBMED   1648176
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            [WARNING] On Jul 16, 2024 this sequence was replaced by
            NM_012572.3.
            
            On Nov 26, 2020 this sequence version replaced NM_012572.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U08257.1, SRR26643298.43707.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                JAXUCZ010000008.1  52102038-52102063   c
            27-158              JAXUCZ010000008.1  52090589-52090720   c
            159-323             JAXUCZ010000008.1  51972460-51972624   c
            324-421             JAXUCZ010000008.1  51959264-51959361   c
            422-587             JAXUCZ010000008.1  51955077-51955242   c
            588-766             JAXUCZ010000008.1  51943898-51944076   c
            767-820             JAXUCZ010000008.1  51939320-51939373   c
            821-982             JAXUCZ010000008.1  51912516-51912677   c
            983-1135            JAXUCZ010000008.1  51903658-51903810   c
            1136-1240           JAXUCZ010000008.1  51902763-51902867   c
            1241-1348           JAXUCZ010000008.1  51879086-51879193   c
            1349-1552           JAXUCZ010000008.1  51873748-51873951   c
            1553-1666           JAXUCZ010000008.1  51847609-51847722   c
            1667-1776           JAXUCZ010000008.1  51831935-51832044   c
            1777-1950           JAXUCZ010000008.1  51828974-51829147   c
            1951-2116           JAXUCZ010000008.1  51825001-51825166   c
            2117-2342           JAXUCZ010000008.1  51823081-51823306   c
            2343-2471           JAXUCZ010000008.1  51818723-51818851   c
            2472-2590           JAXUCZ010000008.1  51805977-51806095   c
            2591-3320           JAXUCZ010000008.1  51802058-51802787   c
FEATURES             Location/Qualifiers
     source          1..3320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3320
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /note="glutamate ionotropic receptor kainate type subunit
                     4"
                     /db_xref="GeneID:24406"
                     /db_xref="RGD:2734"
     exon            1..26
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            27..158
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2947
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /note="kainate receceptor; glutamate receptor KA-1;
                     glutamate receptor ionotropic, kainate 4"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 4
                     precursor"
                     /protein_id="NP_036704.1"
                     /db_xref="GeneID:24406"
                     /db_xref="RGD:2734"
                     /translation="MPRVSAPLVLLPAWLLMVACSPHSLRIAAILDDPMECSRGERLS
                     ITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPA
                     SSSIISNICGEKEVPHFKVAPEEFVRFQLQRFTTLNLHPSNTDISVAVAGILNFFNCT
                     TACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIH
                     ANASMSHTILLKAAELGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHA
                     FFQEFSQSLNQSWQENCDHVPFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLS
                     CGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQW
                     HVAEGLSMDSRLYASNISDSLFNTTLVVTTILENPYLMLKGNHQDMEGNDRYEGFCVD
                     MLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTITAERE
                     KVIDFSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVA
                     RLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGV
                     WWAFTLIIISSYTANLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNS
                     RYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQI
                     GGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWEGGKCPKEEDHRAK
                     GLGMENIGGIFVVLICGLIVAIFMAMLEFLWTLRHSEASEVSVCQEMMTELRSIILCQ
                     DNIHPRRRRSGGLPPQPPVLEERRPRGTATLSNGKLCGAGEPDQLAQRLAQEAALVAR
                     GCTHIRVCPECRRFQGLRARPSPARSEESLEWDKTTNSSEPE"
     exon            159..323
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..421
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..587
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..766
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..820
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..982
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1135
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1240
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1348
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1552
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1666
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1776
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1950
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2116
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2342
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2471
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2472..2590
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..3320
                     /gene="Grik4"
                     /gene_synonym="GluK4; KA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttttctggt tcttgttgtc ccggagcgtt atgtcatgcc cagaccagca gagggctcca
       61 tgaggagtta tagaagatgc cccgtgtctc tgctcctctg gtgctgcttc ctgcttggct
      121 cttgatggtg gcctgtagcc cacactccct gaggatcgct gctatcttgg atgaccccat
      181 ggagtgcagc agaggggaac ggctctccat caccctggcc aagaaccgca tcaaccgcgc
      241 accagagagg ctgggcaagg ccaaagtcga agtggacatc tttgagcttc tcagagacag
      301 cgagtacgaa actgcagaaa ccatgtgtca gatcctcccc aagggagtgg tcgctgtcct
      361 gggaccgtcg tccagcccag cctccagctc catcatcagc aacatctgtg gagagaagga
      421 ggtccctcat ttcaaagtgg ccccagagga gtttgtcagg ttccaactcc agagattcac
      481 caccctgaac cttcacccca gcaacaccga catcagcgtg gctgtggctg ggatcctgaa
      541 cttcttcaac tgcaccaccg cctgcctcat ctgtgccaaa gcagaatgcc ttttaaacct
      601 ggagaagctg ctccggcaat tccttatctc caaggacaca ctgtcggtcc ggatgctgga
      661 tgacacacgg gaccccactc cgctcctcaa ggagatccgg gatgacaaga cagctactat
      721 catcatccat gccaacgcct ccatgtcgca caccatcctc ctgaaggcag ctgaactggg
      781 gatggtgtca gcctattaca cctacatctt caccaatctg gagttctccc tccagagaat
      841 ggacagcctt gtggatgata gagtcaacat cttaggattt tccattttca accaatccca
      901 tgctttcttc caagagttct cccagagcct caaccaatcc tggcaggaga actgtgacca
      961 cgtgcccttc accggccctg cgttgtcctc agccctactg tttgacgctg tctacgctgt
     1021 ggtgacagcg gtacaggaac tgaaccggag ccaggaaatt ggcgtgaagc ccctgtcctg
     1081 tggctcggcc cagatctggc agcatggcac cagcctcatg aactacctgc gcatggtaga
     1141 attggaaggt cttaccggcc acattgaatt caacagcaaa ggccagaggt ccaactatgc
     1201 cttgaaaatc ttacagttca ccaggaatgg gtttcggcag attggccagt ggcatgtggc
     1261 agagggcctc agcatggaca gccgcctcta cgcctccaac atctctgaca gtctcttcaa
     1321 caccaccctg gtcgtcacca ccatcctgga aaacccatac ctaatgctga aggggaacca
     1381 ccaggacatg gaaggcaatg accggtacga gggattctgc gtggacatgc tcaaggagtt
     1441 ggctgagatc ctacggttca actacaagat ccgcctcgtt ggggatggtg tttacggcgt
     1501 acctgaggcc aacggcacct ggacgggcat ggttggggag ctgatcgctc ggaaagcaga
     1561 tctggctgtg gcgggcctca ccatcacagc tgaacgtgag aaagtgattg atttctccaa
     1621 gccgttcatg acgctgggaa ttagtattct ttacagagtt catatgggac gcagaccggg
     1681 ctatttctcc tttctggacc ccttttctcc aggagtctgg ctcttcatgc ttctagctta
     1741 tctggctgtc agctgtgtcc tcttcctggt ggctcggtta actccttatg agtggtacag
     1801 tccacatcct tgtgcacagg gccggtgtaa tctcctggtc aaccagtact ctctgggcaa
     1861 cagcctctgg tttccagtgg gaggcttcat gcagcaaggc tccaccatcg ccccgcgggc
     1921 tttgtccaca cgctgcgtca gtggtgtctg gtgggccttc acgttgatca tcatctcatc
     1981 gtacacagcc aacctggcag ccttcctgac ggtgcagcgc atggaagtgc ccatcgagtc
     2041 tgtggatgac ctggctgacc agaccgccat tgagtatggc acgattcacg gaggctccag
     2101 catgaccttc ttccaaaatt cccgctacca gacctaccag cgcatgtgga attacatgta
     2161 ctccaagcag cccagtgtgt ttgtgaagag cacagaggag ggaattgcca gggtgttgaa
     2221 ttccaactac gccttcctgc tggagtccac catgaacgag tactaccggc agaggaactg
     2281 caacctcact cagattgggg gcctgctgga caccaagggc tatgggattg gcatgccagt
     2341 cggctcagtg ttccgggatg agttcgacct ggccattctc cagctgcagg agaacaaccg
     2401 cctggagatt ctgaagcgga agtggtggga agggggaaaa tgtcccaagg aggaggacca
     2461 cagagccaaa ggcctgggaa tggagaatat tggtggaatc tttgtggttc ttatttgtgg
     2521 cttaatagtg gccattttta tggctatgct ggagttttta tggactctca gacactcaga
     2581 agcatcagag gtgtctgtgt gtcaggagat gatgactgag ctgcgcagca tcatcctgtg
     2641 ccaggacaat atccatcccc ggaggcggcg ctctggaggc ctgccacccc agcccccggt
     2701 cctggaggag cgccggccca ggggtacagc gacgctcagc aatggcaagc tatgtggcgc
     2761 cggggagccg gaccaactgg cgcagagact ggctcaggag gccgccctgg tggcccgagg
     2821 ctgcacgcac atccgcgtgt gcccggagtg ccggcgcttc cagggcctgc gggctcgacc
     2881 gtcgccagcg cgcagcgagg agagcctgga gtgggacaag accaccaaca gcagcgagcc
     2941 tgagtagtgg cggcgaagga ccgtggagcc aggcggggag gcgggagggc taatgttaca
     3001 acctccttct ctccggattg aagattcagt gactttacaa agcgacgaga gcctgatgcc
     3061 ccagcagggg gcggatcccg ccctatctga gacttgcaaa cacgtggcag agacattgtc
     3121 cctcttgggc acaaggaccc atctcctccc agagggtctt tccctcacat tcaaaaacat
     3181 ggattctggg tagtggggcc ctgctgagag agcagtccaa gaaattgatg gtgtcatcag
     3241 ttggattacc ccctaggaag gggccattgt accctgggtc tagttcttac aggaaaaaaa
     3301 aattaaactc aacagggaag
//
