LOCUS       NM_001112716            3594 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor kainate type
            subunit 3 (Grik3), transcript variant 1, mRNA.
ACCESSION   NM_001112716
VERSION     NM_001112716.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3594)
  AUTHORS   Selvakumar,P., Lee,J., Khanra,N., He,C., Munguba,H., Kiese,L.,
            Broichhagen,J., Reiner,A., Levitz,J. and Meyerson,J.R.
  TITLE     Structural and compositional diversity in the kainate receptor
            family
  JOURNAL   Cell Rep 37 (4), 109891 (2021)
   PUBMED   34706237
REFERENCE   2  (bases 1 to 3594)
  AUTHORS   Kumari,J., Vinnakota,R. and Kumar,J.
  TITLE     Structural and Functional Insights into GluK3-kainate Receptor
            Desensitization and Recovery
  JOURNAL   Sci Rep 9 (1), 10254 (2019)
   PUBMED   31311973
  REMARK    GeneRIF: Structural and Functional Insights into GluK3-kainate
            Receptor Desensitization and Recovery.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3594)
  AUTHORS   Fujikawa,T., Petralia,R.S., Fitzgerald,T.S., Wang,Y.X., Millis,B.,
            Morgado-Diaz,J.A., Kitamura,K. and Kachar,B.
  TITLE     Localization of kainate receptors in inner and outer hair cell
            synapses
  JOURNAL   Hear Res 314, 20-32 (2014)
   PUBMED   24858010
REFERENCE   4  (bases 1 to 3594)
  AUTHORS   Zhou,W., Zhou,L.Q., Zhang,S.L., Liu,B., Leng,Y.M., Zhou,R.H. and
            Kong,W.J.
  TITLE     The changes in mGluR2 and mGluR7 expression in rat medial
            vestibular nucleus and flocculus following unilateral
            labyrinthectomy
  JOURNAL   Int J Mol Sci 14 (11), 22857-22875 (2013)
   PUBMED   24264036
  REMARK    GeneRIF: Our results suggest that mGluR2 and mGluR7 may contribute
            to the early rebalancing of spontaneous resting activity in the MVN
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3594)
  AUTHORS   Veran,J., Kumar,J., Pinheiro,P.S., Athane,A., Mayer,M.L.,
            Perrais,D. and Mulle,C.
  TITLE     Zinc potentiates GluK3 glutamate receptor function by stabilizing
            the ligand binding domain dimer interface
  JOURNAL   Neuron 76 (3), 565-578 (2012)
   PUBMED   23141068
  REMARK    GeneRIF: Zinc binding stabilizes the labile GluK3 dimer interface,
            slows desensitization and potentiates currents.
REFERENCE   6  (bases 1 to 3594)
  AUTHORS   Schiffer,H.H., Swanson,G.T. and Heinemann,S.F.
  TITLE     Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are
            functional kainate receptor subunits with a low sensitivity to
            glutamate
  JOURNAL   Neuron 19 (5), 1141-1146 (1997)
   PUBMED   9390526
REFERENCE   7  (bases 1 to 3594)
  AUTHORS   Flor,P.J., Van Der Putten,H., Ruegg,D., Lukic,S., Leonhardt,T.,
            Bence,M., Sansig,G., Knopfel,T. and Kuhn,R.
  TITLE     A novel splice variant of a metabotropic glutamate receptor, human
            mGluR7b
  JOURNAL   Neuropharmacology 36 (2), 153-159 (1997)
   PUBMED   9144652
REFERENCE   8  (bases 1 to 3594)
  AUTHORS   Nutt,S.L., Hoo,K.H., Rampersad,V., Deverill,R.M., Elliott,C.E.,
            Fletcher,E.J., Adams,S.L., Korczak,B., Foldes,R.L. and Kamboj,R.K.
  TITLE     Molecular characterization of the human EAA5 (GluR7) receptor: a
            high-affinity kainate receptor with novel potential RNA editing
            sites
  JOURNAL   Recept Channels 2 (4), 315-326 (1994)
   PUBMED   7719709
REFERENCE   9  (bases 1 to 3594)
  AUTHORS   Lomeli,H., Wisden,W., Kohler,M., Keinanen,K., Sommer,B. and
            Seeburg,P.H.
  TITLE     High-affinity kainate and domoate receptors in rat brain
  JOURNAL   FEBS Lett 307 (2), 139-143 (1992)
   PUBMED   1322826
REFERENCE   10 (bases 1 to 3594)
  AUTHORS   Bettler,B., Egebjerg,J., Sharma,G., Pecht,G., Hermans-Borgmeyer,I.,
            Moll,C., Stevens,C.F. and Heinemann,S.
  TITLE     Cloning of a putative glutamate receptor: a low affinity
            kainate-binding subunit
  JOURNAL   Neuron 8 (2), 257-265 (1992)
   PUBMED   1371217
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z11716.1, JAXUCZ010000005.1 and
            M83552.1.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. This gene
            product belongs to the kainate family of glutamate receptors, which
            are composed of four subunits and function as ligand-activated ion
            channels. Compared to other kainate or AMPA receptors, this subunit
            exhibits a lower sensitivity to glutamate, and thus may play a
            unique role in neurotransmission in the brain. Alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1, also known as GluR7a) encodes
            the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z11716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                Z11716.1           1-62
            63-370              Z11716.1           66-373
            371-372             JAXUCZ010000005.1  143184826-143184827
            373-998             Z11716.1           376-1001
            999-1279            M83552.1           775-1055
            1280-1281           JAXUCZ010000005.1  143219728-143219729
            1282-2907           Z11716.1           1285-2910
            2908-3418           M83552.1           2684-3194
            3419-3496           Z11716.1           3418-3495
            3497-3498           JAXUCZ010000005.1  143268776-143268777
            3499-3594           Z11716.1           3498-3593
FEATURES             Location/Qualifiers
     source          1..3594
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3594
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /note="glutamate ionotropic receptor kainate type subunit
                     3"
                     /db_xref="GeneID:298521"
                     /db_xref="RGD:71027"
     exon            1..246
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..2891
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glutamate receptor subunit kainate subtype;
                     glutamate receptor 7; glutamate receptor, ionotropic,
                     kainate 3"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 3 isoform
                     1 precursor"
                     /protein_id="NP_001106187.1"
                     /db_xref="GeneID:298521"
                     /db_xref="RGD:71027"
                     /translation="MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEY
                     ADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQL
                     ALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLS
                     HAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLL
                     KEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSG
                     VNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVS
                     VCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDL
                     DIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFR
                     KSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELI
                     DHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIW
                     MYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQ
                     GSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKI
                     EYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMES
                     TTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK
                     WWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQR
                     SFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSL
                     APVFP"
     exon            247..423
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            424..681
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            682..863
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            864..917
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1091
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1235
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1343
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1457
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1661
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1885
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2004
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2222
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2445
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2696
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..3594
                     /gene="Grik3"
                     /gene_synonym="GluK3; gluR-7; GluR7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcgc tcgggagccg ggcggctggg ccaggcggcg cctcgggggc tgctgcgcgc
       61 ccgcgcctag agctgccgcc ccagggagcc cgccacggcc gcgccccggg cacgctcggt
      121 ggcgcccaac gatgaccgct ccctggcggc gcctccggag tctggtttgg gaatactggg
      181 ccgggttcct cgtgtgcgcc ttctggatcc cagactcgcg cgggatgccc cacgtcatcc
      241 ggatcggcgg aatctttgag tacgcggacg gccccaacgc ccaggtcatg aacgctgagg
      301 agcacgcctt tcggttttct gccaatatca tcaacaggaa cagaactctg ctgcccaaca
      361 cgaccctgac ttacgacatt cagaggattc acttccatga cagttttgag gccaccaaga
      421 aggcctgtga ccagttggcg ctcggtgtgg tagccatctt tgggccatcc cagggctcct
      481 gcaccaatgc cgtccagtcc atctgcaatg ccttggaggt tcctcacatc caactgcgct
      541 ggaagcacca ccccctggac aacaaggaca ccttctacgt gaacctctac cccgactacg
      601 cctctctcag ccacgccatc ctcgacttgg tccagtccct caagtggcgg tcagccaccg
      661 tagtctatga tgacagtaca ggtctcatcc ggctgcagga gctcatcatg gctccatcta
      721 ggtacaacat ccgcctgaag attcgccagc tccccatcga ctccgatgac tcacgcccct
      781 tgctcaaaga gatgaagcgg ggccgggagt tccgtatcat ctttgactgc agtcacacca
      841 tggcagccca gatcctcaag caggccatgg ccatgggcat gatgacggaa tactaccact
      901 tcatcttcac cactctggat ctctatgcgc tagacctgga accctaccgc tactcgggag
      961 tgaacctgac tgggttccgc atactcaacg tggacaaccc ccatgtctca gccattgtgg
     1021 agaagtggtc catggagcgg ctacaggcag ctccccgggc agagtcaggc ctgctggatg
     1081 gagtgatgat gaccgatgca gccctgctct acgatgcggt ccacattgtg tctgtgtgct
     1141 accagcgagc gccgcagatg actgtgaact ccctacagtg ccatcggcac aaggcctggc
     1201 gcttcggtgg ccgcttcatg aacttcatca aggaggctca atgggaagga ttaactggac
     1261 ggattgtttt caacaaaact agtggcttgc ggactgattt tgatctggac atcatcagcc
     1321 tcaaggaaga tggcctcgag aaggtcgggg tgtggagtcc agctgacggt ctcaatatca
     1381 ctgaggttgc caaaggccga ggtcctaatg tcaccgactc tctgaccaac aggtcactca
     1441 tcgtcaccac tctgctggag gagccttttg tcatgttccg caagtctgat aggacccttt
     1501 acggcaatga ccggttcgag ggctactgca tcgacttgct caaggagctg gcgcacatcc
     1561 tgggcttctc ctacgagatc cggctggtgg aagacggcaa gtacggggca caggacgaca
     1621 agggccagtg gaacggcatg gtcaaggaac tcattgacca caaagcagat ctggctgtgg
     1681 ctcccctgac catcacccat gtccgagaga aggccattga cttctctaag ccttttatga
     1741 ccctcggagt gagcatctta tatcgaaaac ccaatggcac caaccccagt gtcttctcct
     1801 tcctcaaccc cctgtcccca gacatctgga tgtacgtgct actcgcctac ctgggtgtca
     1861 gctgtgtcct cttcgtcatt gccagattca gcccttatga atggtatgat gcccacccct
     1921 gcaaccccgg ctctgaggtg gtggagaata acttcacgct gctcaacagc ttctggtttg
     1981 gaatgggctc cctgatgcaa caaggatctg aactgatgcc caaagctctg tctacccgca
     2041 tcattggcgg catctggtgg ttcttcaccc ttattatcat ctcctcctac acggccaacc
     2101 tggctgcctt cctgaccgtg gagcgcatgg agtcacccat cgactctgcc gatgacctgg
     2161 ccaagcagac caaaatagag tacggtgctg tcaaggatgg ggccaccatg accttcttca
     2221 agaaatccaa gatctccacc tttgagaaga tgtgggcctt catgagcagc aagccctcgg
     2281 ctctggtgaa gaacaatgag gagggcatcc agcggacact cacagctgac tacgctctgc
     2341 tcatggagtc cacgaccata gagtacatca cacaaaggaa ctgcaatctc acccagatcg
     2401 gcggcctcat cgattccaag ggctacggca tcggcacgcc catgggctcc ccctacaggg
     2461 acaaaatcac catcgccatt ctgcagctgc aggaggagga caagctgcac atcatgaagg
     2521 agaagtggtg gcgaggcagc gggtgccccg aggaggagaa caaggaggcc agcgcactgg
     2581 gcatccagaa gattggcggc atcttcatcg tcctggctgc cggcttagtc ctgtccgtgt
     2641 tggtggcagt gggcgagttt atatacaaac tccgcaagac agcggaacgg gagcagcgct
     2701 ctttctgcag cacagtggcc gacgagatcc gcttctccct cacctgccag cggcgtctca
     2761 agcacaagcc acagcctcct atgatggtca agacagatgc ggttatcaac atgcacacct
     2821 ttaatgaccg aaggcttcca ggcaaggaca gcatgagctg cagcacctcg ctagcccctg
     2881 tcttccctta gacttgggtc cagcggggac ttcaggcccg gtccacgcag aggaaggcaa
     2941 aggagacccg aaaggacatc ctcatctcat gctggccttg gggatggagc tgctgcccgc
     3001 atccggctgt gaaccatcag ctcttaccta ccggggaaac ccatgggccc tcagcagctg
     3061 cttgggcttc atctcctctt gtcttttttg tggctttctg aagctgtgaa ggccagcgga
     3121 agcacacgcc tctcaggctg cactcaccga ccatctccat agccagctac ttcggccagg
     3181 gctctgcaga ggcctcggaa caccagagat agctcttaca cctccctccc tcccctcaag
     3241 tccaggcctt ctagcacgca cccatgagag cagagactcc agctcagaac gccttgaggg
     3301 tgttctgagg aggccaccag tgggagcccc aaggcagcca tccatacctg gacagaagca
     3361 aagcttcagc ccttaagggc tattcacctg ggtctgccct ccccaacgtg gcttcgccga
     3421 cagcagcccc tcggcaacac gaaaagaggt gtgggaagga ggggggttgg catgggagaa
     3481 ggggacactc ggacggagac tgccgtctca gatgcttcgg gtcagtgtcc ctgagccacg
     3541 agcgtttaga gagtccccag gaatgcgaac gaaagtcgta gtcacagcga attc
//
