LOCUS       NM_019309               3058 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor kainate type
            subunit 2 (Grik2), mRNA.
ACCESSION   NM_019309 XM_346606
VERSION     NM_019309.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3058)
  AUTHORS   Guo,R., Xue,J., Shao,P., Cai,C. and Wang,Y.
  TITLE     NETO2-GluK2 interaction contributes to postoperative pain
            hypersensitivity through inducing PKCgamma activation and synaptic
            incorporation of AMPA receptor GluR1 subunits in rat dorsal horn
  JOURNAL   Neurosci Lett 813, 137430 (2023)
   PUBMED   37544581
  REMARK    GeneRIF: NETO2-GluK2 interaction contributes to postoperative pain
            hypersensitivity through inducing PKCgamma activation and synaptic
            incorporation of AMPA receptor GluR1 subunits in rat dorsal horn.
REFERENCE   2  (bases 1 to 3058)
  AUTHORS   Selvakumar,P., Lee,J., Khanra,N., He,C., Munguba,H., Kiese,L.,
            Broichhagen,J., Reiner,A., Levitz,J. and Meyerson,J.R.
  TITLE     Structural and compositional diversity in the kainate receptor
            family
  JOURNAL   Cell Rep 37 (4), 109891 (2021)
   PUBMED   34706237
REFERENCE   3  (bases 1 to 3058)
  AUTHORS   Zhang,W., Wang,F., Zhang,L., Sun,T. and Fu,Z.
  TITLE     Intrathecal injection of ozone alleviates CCI-induced neuropathic
            pain via the GluR6-NF-kappaB/p65 signalling pathway in rats
  JOURNAL   Mol Med Rep 23 (4) (2021)
   PUBMED   33537798
  REMARK    GeneRIF: Intrathecal injection of ozone alleviates CCIinduced
            neuropathic pain via the GluR6NFkappaB/p65 signalling pathway in
            rats.
REFERENCE   4  (bases 1 to 3058)
  AUTHORS   Li,Y.J., Duan,G.F., Sun,J.H., Wu,D., Ye,C., Zang,Y.Y., Chen,G.Q.,
            Shi,Y.Y., Wang,J., Zhang,W. and Shi,Y.S.
  TITLE     Neto proteins regulate gating of the kainate-type glutamate
            receptor GluK2 through two binding sites
  JOURNAL   J Biol Chem 294 (47), 17889-17902 (2019)
   PUBMED   31628192
  REMARK    GeneRIF: Neto1 and Neto2 differentially regulate GluK2 fast gating
            kinetics
REFERENCE   5  (bases 1 to 3058)
  AUTHORS   Gurung,S., Evans,A.J., Wilkinson,K.A. and Henley,J.M.
  TITLE     ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor
            upscaling in response to suppression of synaptic activity
  JOURNAL   J Cell Sci 131 (24) (2018)
   PUBMED   30559217
  REMARK    GeneRIF: that activity-dependent regulation of ADAR2 proteostasis
            and GluK2 Q/R editing are key determinants of kainate receptors
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3058)
  AUTHORS   Kohler,M., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Determinants of Ca2+ permeability in both TM1 and TM2 of high
            affinity kainate receptor channels: diversity by RNA editing
  JOURNAL   Neuron 10 (3), 491-500 (1993)
   PUBMED   7681676
REFERENCE   7  (bases 1 to 3058)
  AUTHORS   Lomeli,H., Wisden,W., Kohler,M., Keinanen,K., Sommer,B. and
            Seeburg,P.H.
  TITLE     High-affinity kainate and domoate receptors in rat brain
  JOURNAL   FEBS Lett 307 (2), 139-143 (1992)
   PUBMED   1322826
REFERENCE   8  (bases 1 to 3058)
  AUTHORS   Sakimura,K., Morita,T., Kushiya,E. and Mishina,M.
  TITLE     Primary structure and expression of the gamma 2 subunit of the
            glutamate receptor channel selective for kainate
  JOURNAL   Neuron 8 (2), 267-274 (1992)
   PUBMED   1310861
REFERENCE   9  (bases 1 to 3058)
  AUTHORS   Egebjerg,J., Bettler,B., Hermans-Borgmeyer,I. and Heinemann,S.
  TITLE     Cloning of a cDNA for a glutamate receptor subunit activated by
            kainate but not AMPA
  JOURNAL   Nature 351 (6329), 745-748 (1991)
   PUBMED   1648177
REFERENCE   10 (bases 1 to 3058)
  AUTHORS   Sussman,H.M., MacNeilage,P.F. and Lumbley,J.L.
  TITLE     Pursuit auditory tracking of dichotically presented tonal
            amplitudes
  JOURNAL   J Speech Hear Res 18 (1), 74-81 (1975)
   PUBMED   1127911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z11548.1.
            
            On Dec 20, 2007 this sequence version replaced NM_019309.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z11548.1, Z11715.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            undergoes RNA editing  :: PMID: 7681676
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3058              Z11548.1           21-3078
FEATURES             Location/Qualifiers
     source          1..3058
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q13"
     gene            1..3058
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /note="glutamate ionotropic receptor kainate type subunit
                     2"
                     /db_xref="GeneID:54257"
                     /db_xref="RGD:2733"
     exon            1..395
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..3007
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /note="glutamate receptor 6; gluR-6; glutamate receptor,
                     ionotropic, kainate 2"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 2
                     precursor"
                     /protein_id="NP_062182.1"
                     /db_xref="GeneID:54257"
                     /db_xref="RGD:2733"
                     /translation="MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEY
                     VESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLG
                     VAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAI
                     LDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM
                     KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNM
                     TGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAV
                     QQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVI
                     SLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSD
                     KPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDH
                     KADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMY
                     VLLACLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMRQGS
                     ELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY
                     GAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMEST
                     TIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKW
                     WRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRS
                     FCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA"
     exon            396..563
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            564..821
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1003
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1057
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1231
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1375
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1483
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1597
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1804
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..2028
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2147
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2365
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2591
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2842
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..3058
                     /gene="Grik2"
                     /gene_synonym="GluK2; GluR6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctggacat tgtgcttgct ggatttttcc cggatgctcc cggactaaca tggatgtccc
       61 accatccctt gcagtggaag cttgctcctt ggcgcagtga gagtgaagaa catgcagcga
      121 ctgctaatgg gtttgggaag cggagactcc ttcctctttc tgtgaccatg ccgtgattgt
      181 gtctgcggcc actactccac gcatcttcct tctcgtccaa gcccggagcc taacgctaga
      241 tcggggaagt gggtgccgcg cgcgcaggca cggaaacatc atgaagatta tttccccagt
      301 tttaagtaat ctagtcttca gtcgctccat taaagtcctg ctctgcttat tgtggatcgg
      361 atattcgcaa ggaaccacac atgtgttaag attcggtggt atatttgaat atgtggaatc
      421 tggccccatg ggagcagaag aacttgcatt cagatttgct gtgaatacca tcaacagaaa
      481 caggactttg ctgcccaaca ccactttaac ttatgatact cagaagatca atctctatga
      541 cagttttgaa gcatctaaga aagcttgtga tcagctgtct cttggggtgg ctgctatctt
      601 cggtccttca cacagttcat cagccaatgc tgtgcagtcc atctgcaatg ctctgggggt
      661 tccccacata cagacccgct ggaagcacca ggtgtcagac aacaaggatt ccttctacgt
      721 cagtctctac ccagacttct cttccctgag ccgcgccatc ttggatttgg tgcagttttt
      781 taagtggaaa actgtcacag ttgtgtatga cgacagcact ggtctcattc gcttgcaaga
      841 gctcatcaaa gctccatcga ggtacaatct tcgacttaaa attcgtcagc tgccagctga
      901 taccaaagat gcaaaacctt tgctgaagga gatgaaaaga ggcaaggagt tccacgtgat
      961 cttcgactgc agccatgaga tggcagcagg cattttaaaa caggcattag ctatgggaat
     1021 gatgacagaa tactatcact atatatttac aactctggac ctctttgctc ttgacgtgga
     1081 gccctacaga tacagtggcg taaatatgac agggttcagg atactaaata cagagaatac
     1141 ccaagtctcc tccatcatcg aaaagtggtc tatggaacgg ttacaggcgc ctccaaaacc
     1201 tgactcaggt ttgctggatg gatttatgac gactgatgct gctctgatgt atgatgcagt
     1261 gcacgttgtg tctgtggctg tccaacagtt tccccagatg acagtcagct ccttgcaatg
     1321 caatcgacac aaaccctggc gctttgggac ccgcttcatg agtctaatta aagaggctca
     1381 ctgggaaggt ctcacaggca gaataacatt taacaaaacc aatggattac ggacagattt
     1441 tgatttggat gtgatcagtc tcaaggaaga aggtctggag aagattggaa cttgggatcc
     1501 agccagtggc ctgaatatga cagaaagtca gaaaggaaag ccagcaaata tcacagactc
     1561 attgtctaat cgttctttga ttgttaccac cattttggaa gaaccgtatg ttctgtttaa
     1621 gaagtctgac aaaccactct atgggaatga tcgatttgaa ggctactgta ttgatctcct
     1681 acgagagtta tctacaatcc ttggctttac atatgagatt aggcttgtgg aggatgggaa
     1741 atatggagcc caggatgatg tgaacggaca atggaatgga atggttcgtg aactaatcga
     1801 tcataaagct gaccttgcag ttgctccact ggctataacc tatgttcgtg agaaggtcat
     1861 cgacttttca aagccgttta tgacacttgg aataagtatt ttgtaccgca agcccaatgg
     1921 tacaaaccca ggcgtcttct ccttcctgaa tcctctctcc cctgatatct ggatgtatgt
     1981 tctgctggct tgcttgggtg tcagttgtgt gctctttgtc atagccaggt ttagtcccta
     2041 tgagtggtat aacccacacc cttgcaaccc tgactcagac gtggtggaaa acaattttac
     2101 cttgctaaat agtttctggt ttggagttgg agctctcatg cggcaaggtt ctgagctcat
     2161 gcccaaagca ctctccacca ggatagtggg aggcatttgg tggtttttca cacttatcat
     2221 catttcttcg tataccgcta acctagccgc ctttctgact gtggaacgca tggagtcgcc
     2281 cattgactct gctgacgatt tagctaagca aaccaagata gagtatggag cagtggagga
     2341 cggcgcaacc atgacgtttt ttaagaaatc aaaaatttca acgtatgata aaatgtgggc
     2401 gtttatgagc agcaggagac agtctgtgct tgtcaaaagc aatgaggaag ggatccaacg
     2461 agtcctcacc tcggattatg ctttcttaat ggagtcaaca accatcgagt ttgttacaca
     2521 gcggaactgt aacctcacgc agattggcgg ccttatagac tccaaaggct atggcgttgg
     2581 cactcctatg ggctctccat atcgagacaa aatcaccata gcaattcttc agctgcagga
     2641 ggaaggcaag ctgcacatga tgaaggagaa atggtggcgg ggcaatggct gcccagagga
     2701 ggagagcaaa gaggccagtg ctctgggggt gcagaatatt ggtggtatct tcattgtcct
     2761 ggcagccggc ttggtgctct cagtttttgt ggcagtggga gagtttttat acaaatccaa
     2821 aaaaaacgct caattggaaa agaggtcctt ctgtagcgct atggtggaag agctgagaat
     2881 gtccctgaag tgccagcgtc ggctcaaaca taagccacag gccccagtta ttgtgaaaac
     2941 agaagaagtt atcaacatgc acacatttaa cgacagaagg ttgccaggta aagaaaccat
     3001 ggcatgaagc tgggaggcca atcacccaag cacaaactgt cgtctttttt tttttttt
//
