LOCUS       NM_001111114            3199 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor kainate type
            subunit 1 (Grik1), transcript variant 3, mRNA.
ACCESSION   NM_001111114
VERSION     NM_001111114.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3199)
  AUTHORS   Selvakumar,P., Lee,J., Khanra,N., He,C., Munguba,H., Kiese,L.,
            Broichhagen,J., Reiner,A., Levitz,J. and Meyerson,J.R.
  TITLE     Structural and compositional diversity in the kainate receptor
            family
  JOURNAL   Cell Rep 37 (4), 109891 (2021)
   PUBMED   34706237
REFERENCE   2  (bases 1 to 3199)
  AUTHORS   Jack,A., Hamad,M.I.K., Gonda,S., Gralla,S., Pahl,S., Hollmann,M.
            and Wahle,P.
  TITLE     Development of Cortical Pyramidal Cell and Interneuronal Dendrites:
            a Role for Kainate Receptor Subunits and NETO1
  JOURNAL   Mol Neurobiol 56 (7), 4960-4979 (2019)
   PUBMED   30421168
  REMARK    GeneRIF: Gluk1 and NETO1 specifically promote dendrite growth of
            interneurons in the visual cortex.
REFERENCE   3  (bases 1 to 3199)
  AUTHORS   Duan,G.F., Ye,Y., Xu,S., Tao,W., Zhao,S., Jin,T., Nicoll,R.A.,
            Shi,Y.S. and Sheng,N.
  TITLE     Signal peptide represses GluK1 surface and synaptic trafficking
            through binding to amino-terminal domain
  JOURNAL   Nat Commun 9 (1), 4879 (2018)
   PUBMED   30451858
  REMARK    GeneRIF: Signal peptide represses GluK1 surface and synaptic
            trafficking through binding to amino-terminal domain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3199)
  AUTHORS   Sheng,N., Shi,Y.S. and Nicoll,R.A.
  TITLE     Amino-terminal domains of kainate receptors determine the
            differential dependence on Neto auxiliary subunits for trafficking
  JOURNAL   Proc Natl Acad Sci U S A 114 (5), 1159-1164 (2017)
   PUBMED   28100490
  REMARK    GeneRIF: In the CA1 hippocampal pyramidal cell, GluK1 had no effect
            on synaptic transmission. GluK1 which requires the auxiliary
            subunits Neto1 and Neto2 for surface and synaptic trafficking. It
            is the amino-terminal domains of GluK1 and GluK2 that control their
            strikingly different trafficking properties.
REFERENCE   5  (bases 1 to 3199)
  AUTHORS   Fisher,M.T. and Fisher,J.L.
  TITLE     Contributions of different kainate receptor subunits to the
            properties of recombinant homomeric and heteromeric receptors
  JOURNAL   Neuroscience 278, 70-80 (2014)
   PUBMED   25139762
REFERENCE   6  (bases 1 to 3199)
  AUTHORS   Sailer,A., Swanson,G.T., Perez-Otano,I., O'Leary,L., Malkmus,S.A.,
            Dyck,R.H., Dickinson-Anson,H., Schiffer,H.H., Maron,C., Yaksh,T.L.,
            Gage,F.H., O'Gorman,S. and Heinemann,S.F.
  TITLE     Generation and analysis of GluR5(Q636R) kainate receptor mutant
            mice
  JOURNAL   J Neurosci 19 (20), 8757-8764 (1999)
   PUBMED   10516295
REFERENCE   7  (bases 1 to 3199)
  AUTHORS   Brakeman,P.R., Lanahan,A.A., O'Brien,R., Roche,K., Barnes,C.A.,
            Huganir,R.L. and Worley,P.F.
  TITLE     Homer: a protein that selectively binds metabotropic glutamate
            receptors
  JOURNAL   Nature 386 (6622), 284-288 (1997)
   PUBMED   9069287
REFERENCE   8  (bases 1 to 3199)
  AUTHORS   Lomeli,H., Wisden,W., Kohler,M., Keinanen,K., Sommer,B. and
            Seeburg,P.H.
  TITLE     High-affinity kainate and domoate receptors in rat brain
  JOURNAL   FEBS Lett 307 (2), 139-143 (1992)
   PUBMED   1322826
REFERENCE   9  (bases 1 to 3199)
  AUTHORS   Sommer,B., Burnashev,N., Verdoorn,T.A., Keinanen,K., Sakmann,B. and
            Seeburg,P.H.
  TITLE     A glutamate receptor channel with high affinity for domoate and
            kainate
  JOURNAL   EMBO J 11 (4), 1651-1656 (1992)
   PUBMED   1373382
REFERENCE   10 (bases 1 to 3199)
  AUTHORS   Bettler,B., Boulter,J., Hermans-Borgmeyer,I., O'Shea-Greenfield,A.,
            Deneris,E.S., Moll,C., Borgmeyer,U., Hollmann,M. and Heinemann,S.
  TITLE     Cloning of a novel glutamate receptor subunit, GluR5: expression in
            the nervous system during development
  JOURNAL   Neuron 5 (5), 583-595 (1990)
   PUBMED   1977421
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M83561.1, JAXUCZ010000011.1 and
            AI145540.1.
            
            Summary: Glutamate receptors are the predominant excitatory
            neurotransmitter receptors in the mammalian brain and are activated
            in a variety of normal neurophysiologic processes. This gene
            product belongs to the kainate family of glutamate receptors, which
            are composed of four subunits and function as ligand-activated ion
            channels. The subunit encoded by this gene is subject to RNA
            editing (CAG->CGG; Q->R) within the second transmembrane domain,
            which is thought to alter the properties of ion flow. Alternative
            splicing, resulting in transcript variants encoding different
            isoforms, has been noted for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (3) is missing two in-frame coding
            exons compared to transcript variant 1, resulting in a shorter
            isoform (3) lacking two protein segments of 15 aa and 29 aa,
            compared to isoform 1. RNA editing (CAG->CGG) changes Gln621Arg.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M83561.1, SRR26643298.66033.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            undergoes RNA editing  :: PMID: 10516295
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-721               M83561.1           3-723
            722-723             JAXUCZ010000011.1  40810447-40810448   c
            724-3183            M83561.1           726-3185
            3184-3199           AI145540.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..3199
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..3199
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /note="glutamate ionotropic receptor kainate type subunit
                     1"
                     /db_xref="GeneID:29559"
                     /db_xref="RGD:2732"
     exon            1..303
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2903
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /note="isoform 3 is encoded by transcript variant 3;
                     glutamate receptor 5; glutamate receptor ionotropic,
                     kainate 1"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, kainate 1 isoform
                     3"
                     /protein_id="NP_001104584.1"
                     /db_xref="GeneID:29559"
                     /db_xref="RGD:2732"
                     /translation="MERSTVLIQPGLWTRDTSWTLLYFLCYILPQTSPQVLRIGGIFE
                     TVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLAL
                     GVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDSRDLFYINLYPDYAAISRA
                     VLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPPANKDAKPLLKE
                     MKKSKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVN
                     MTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIA
                     SHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDI
                     ISLKEEGTEKIGIWNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEPYVMYRKS
                     DKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDH
                     RADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMY
                     VLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGS
                     ELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY
                     GAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMEST
                     SIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKW
                     WRGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFLYKSRKNNDVEQCL
                     SFNAIMEELGISLKNQKKLKKKSRTKGKSSFTSILTCHQRRTQRKETVA"
     exon            304..471
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            472..729
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            730..911
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            912..965
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1139
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1283
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1391
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1505
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1709
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1933
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2052
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2270
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2496
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2747
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..3184
                     /gene="Grik1"
                     /gene_synonym="GluK1; GluR5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctaggaagcc cgcttcacgt ccccacgctt gttccctcca cctcgctctc ctgagagcag
       61 agagcgcgcg gtgtgcagac tcggagcatt ccgggaggat gaggcgggga cccagcccaa
      121 gttgggtgca tcttgcgggc gtgaggccac aactgggttt cggcatgaat taagaagctt
      181 gaaagatgga gcgcagcaca gtccttatcc aacccgggct ctggaccagg gacaccagct
      241 ggacactcct ctatttcctg tgctacatcc tccctcagac ctcccctcaa gtgctcagga
      301 tcggagggat ttttgaaact gtggaaaatg aacctgttaa tgttgaagaa ttagctttca
      361 agtttgcagt caccagtatt aaccgaaacc gaaccttgat gcccaatacc acattaacct
      421 atgacatcca gagaattaat ctttttgata gttttgaagc ctcccgaaga gcatgcgacc
      481 agctggctct cggggtggcc gcactcttcg gcccttccca cagctcctcc gtcagtgctg
      541 tacagtctat ttgcaatgct ctggaagttc cacacattca gactcgctgg aaacaccctt
      601 ccgtggacag cagagaccta ttttatatca acctctaccc ggactatgcg gctatcagca
      661 gggcggtcct ggatttggtc ctctattaca actggaaaac agtgacggtg gtgtatgaag
      721 acagcacagg tctaattcgt ctgcaagagc tcatcaaagc tccctccaga tacaacatta
      781 aaatcaaaat ccgccagctt ccccctgcga ataaagacgc caaacctctg ctcaaggaga
      841 tgaagaaaag caaagagttc tatgtgatat ttgattgttc gcacgaaaca gctgcggaaa
      901 ttcttaagca gattttgttc atgggcatga tgactgaata ttatcactac ttcttcacaa
      961 ccctggactt gtttgcttta gatctggaac tctataggta cagcggtgta aatatgactg
     1021 gatttcggtt gctgaatatt gacaaccctc acgtgtcatc catcattgag aagtggtcca
     1081 tggagaggtt gcaggccccg cccagacccg agactggtct tctggatggc atgatgacaa
     1141 ctgaagcagc gctgatgtac gatgctgtgt acatggtagc cattgcgtcc caccgtgcct
     1201 ctcagctgac cgtcagctcc ctgcagtgcc atcgacataa gccatggcgc cttggaccca
     1261 gatttatgaa cctcatcaaa gaggctcggt gggacggctt gactgggcgg atcaccttca
     1321 ataagaccga tggcttgaga aaggattttg acctggacat tatcagtctc aaagaggaag
     1381 gaactgaaaa gattgggatt tggaactcca acagtgggct gaacatgacg gatggcaaca
     1441 gagacaggtc caacaatatc acggactcgc tggctaaccg cacactcatt gtcaccacta
     1501 ttctggaaga gccctacgtg atgtacagga aatccgataa gcccttgtat ggaaacgaca
     1561 ggtttgaagg atattgcctg gatctgctga aagaactgtc caatatcctg ggttttcttt
     1621 acgatgttaa actggttcct gatggcaaat atggagcaca gaatgacaaa ggggaatgga
     1681 atgggatggt aaaagaactc atcgaccaca gagctgacct ggcagtggcc cctctcacca
     1741 tcacatacgt acgggagaaa gtcattgact tctccaagcc cttcatgacc ctgggcatta
     1801 gcatccttta ccggaagccc aatggaacca acccgggtgt cttctccttc ctcaaccccc
     1861 tatctccgga catttggatg tacgtgctgc tcgcctgcct aggagtcagt tgtgtactgt
     1921 ttgtgattgc gaggttcaca ccctacgagt ggtataaccc ccacccatgc aaccccgact
     1981 cagacgtggt ggaaaacaat ttcactttgc taaatagttt ctggtttgga gttggagctc
     2041 tcatgcagca aggatcagag ctgatgccca aggctctatc gaccagaata gttggaggaa
     2101 tatggtggtt tttcacccta atcatcattt catcctacac ggccaacctg gctgccttct
     2161 tgacggtaga aagaatggaa tcccccatcg attccgcaga cgatctggcc aaacaaacca
     2221 agatagaata tggggcagtc agagatggct cgacgatgac cttcttcaag aaatcaaaga
     2281 tctccaccta tgagaaaatg tgggctttca tgagcagtag acagcagagc gcactggtta
     2341 aaaacagtga cgaggggatc caaagggtgc tcaccaccga ctacgcactg ctgatggagt
     2401 ccaccagcat tgagtatgtg acgcagagga actgcaacct cactcagatc gggggcctca
     2461 tagactccaa aggctatgga gtggggacgc ctatcggctc cccttaccgg gataaaatta
     2521 cgattgccat tcttcaactg caagaagaag ggaagcttca tatgatgaaa gagaagtggt
     2581 ggagggggaa tggctgccct gaagaagaca gtaaggaagc cagtgctctg ggagtggaaa
     2641 atatcggcgg catcttcatt gttctggctg caggactcgt gctttctgtg tttgtagcca
     2701 ttggagaatt tttatacaaa tcacggaaga acaatgacgt tgagcagtgt ctctctttca
     2761 atgccatcat ggaagagctg ggaatatccc tcaagaatca gaaaaaatta aagaaaaagt
     2821 caagaactaa gggcaaatct tctttcacaa gtatccttac ttgtcaccag agacgaactc
     2881 agagaaaaga gacagtggcg tgatcaaaga acacacctgt aagaagaaaa agcccacacg
     2941 tccgctgcac atatttggag gacagatttc agaggactat gtctttatcc ataaccccag
     3001 tcgtggacag agggggaaga aatgcacaat ttttaaagct cacatagata ttacttgaga
     3061 agtgaaactg attcttttca gatgaatttg tatgcacact tattttgaat ttttccattt
     3121 cctccgataa attgctatgt gtgctttcta aataataata aacaagcgga ctttgttttt
     3181 cataaaaaaa aaaaaaaaa
//
