LOCUS       NM_024379               4618 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor delta type subunit
            2 (Grid2), mRNA.
ACCESSION   NM_024379 XM_346701
VERSION     NM_024379.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4618)
  AUTHORS   Burada,A.P., Vinnakota,R. and Kumar,J.
  TITLE     The architecture of GluD2 ionotropic delta glutamate receptor
            elucidated by cryo-EM
  JOURNAL   J Struct Biol 211 (2), 107546 (2020)
   PUBMED   32512155
  REMARK    GeneRIF: The architecture of GluD2 ionotropic delta glutamate
            receptor elucidated by cryo-EM.
REFERENCE   2  (bases 1 to 4618)
  AUTHORS   Tapken,D., Steffensen,T.B., Leth,R., Kristensen,L.B., Gerbola,A.,
            Gajhede,M., Jorgensen,F.S., Olsen,L. and Kastrup,J.S.
  TITLE     The low binding affinity of D-serine at the ionotropic glutamate
            receptor GluD2 can be attributed to the hinge region
  JOURNAL   Sci Rep 7, 46145 (2017)
   PUBMED   28387240
  REMARK    GeneRIF: the hinge region connecting the two subdomains of the
            GluD2 ligand-binding domain is responsible for the low affinity of
            D-serine.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4618)
  AUTHORS   Cheng,S., Seven,A.B., Wang,J., Skiniotis,G. and Ozkan,E.
  TITLE     Conformational Plasticity in the Transsynaptic
            Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex
  JOURNAL   Structure 24 (12), 2163-2173 (2016)
   PUBMED   27926833
  REMARK    GeneRIF: Results determined the crystal structures of the trimeric
            C1q-like domain of cerebellin-1, and the first complete ectodomain
            of GluD2. Cerebellin binds to the LNS6 domain of alpha- and
            beta-neurexin-1 through a high-affinity interaction that involves
            its highly flexible N-terminal domain.
REFERENCE   4  (bases 1 to 4618)
  AUTHORS   Wang,Y., Dong,J., Wang,Y., Wei,W., Song,B., Shan,Z., Teng,W. and
            Chen,J.
  TITLE     Developmental Hypothyroxinemia and Hypothyroidism Reduce Parallel
            Fiber-Purkinje Cell Synapses in Rat Offspring by Downregulation of
            Neurexin1/Cbln1/GluD2 Tripartite Complex
  JOURNAL   Biol Trace Elem Res 173 (2), 465-474 (2016)
   PUBMED   27033232
  REMARK    GeneRIF: study supports the hypothesis that developmental
            hypothyroxinemia and hypothyroidism reduce PF-PC synapses, which
            may be attributed to the downregulation of Neurexin1/Cbln1/GluD2
            tripartite complex.
REFERENCE   5  (bases 1 to 4618)
  AUTHORS   Elegheert,J., Kakegawa,W., Clay,J.E., Shanks,N.F., Behiels,E.,
            Matsuda,K., Kohda,K., Miura,E., Rossmann,M., Mitakidis,N.,
            Motohashi,J., Chang,V.T., Siebold,C., Greger,I.H., Nakagawa,T.,
            Yuzaki,M. and Aricescu,A.R.
  TITLE     Structural basis for integration of GluD receptors within synaptic
            organizer complexes
  JOURNAL   Science 353 (6296), 295-299 (2016)
   PUBMED   27418511
REFERENCE   6  (bases 1 to 4618)
  AUTHORS   Roche,K.W., Ly,C.D., Petralia,R.S., Wang,Y.X., McGee,A.W.,
            Bredt,D.S. and Wenthold,R.J.
  TITLE     Postsynaptic density-93 interacts with the delta2 glutamate
            receptor subunit at parallel fiber synapses
  JOURNAL   J Neurosci 19 (10), 3926-3934 (1999)
   PUBMED   10234023
REFERENCE   7  (bases 1 to 4618)
  AUTHORS   Landsend,A.S., Amiry-Moghaddam,M., Matsubara,A., Bergersen,L.,
            Usami,S., Wenthold,R.J. and Ottersen,O.P.
  TITLE     Differential localization of delta glutamate receptors in the rat
            cerebellum: coexpression with AMPA receptors in parallel
            fiber-spine synapses and absence from climbing fiber-spine synapses
  JOURNAL   J Neurosci 17 (2), 834-842 (1997)
   PUBMED   8987804
REFERENCE   8  (bases 1 to 4618)
  AUTHORS   Rossi,F., Jankovski,A. and Sotelo,C.
  TITLE     Target neuron controls the integrity of afferent axon phenotype: a
            study on the Purkinje cell-climbing fiber system in cerebellar
            mutant mice
  JOURNAL   J Neurosci 15 (3 Pt 1), 2040-2056 (1995)
   PUBMED   7891151
REFERENCE   9  (bases 1 to 4618)
  AUTHORS   Hirano,T., Kasono,K., Araki,K. and Mishina,M.
  TITLE     Suppression of LTD in cultured Purkinje cells deficient in the
            glutamate receptor delta 2 subunit
  JOURNAL   Neuroreport 6 (3), 524-526 (1995)
   PUBMED   7766857
REFERENCE   10 (bases 1 to 4618)
  AUTHORS   Lomeli,H., Sprengel,R., Laurie,D.J., Kohr,G., Herb,A., Seeburg,P.H.
            and Wisden,W.
  TITLE     The rat delta-1 and delta-2 subunits extend the excitatory amino
            acid receptor family
  JOURNAL   FEBS Lett 315 (3), 318-322 (1993)
   PUBMED   8422924
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 26, 2020 this sequence version replaced NM_024379.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U08256.1, Z17239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-399               JAXUCZ010000004.1  93745165-93745563
            400-555             JAXUCZ010000004.1  94032935-94033090
            556-840             JAXUCZ010000004.1  94441871-94442155
            841-1046            JAXUCZ010000004.1  94460365-94460570
            1047-1100           JAXUCZ010000004.1  94575570-94575623
            1101-1274           JAXUCZ010000004.1  94583189-94583362
            1275-1436           JAXUCZ010000004.1  94591465-94591626
            1437-1556           JAXUCZ010000004.1  94611773-94611892
            1557-1658           JAXUCZ010000004.1  94794873-94794974
            1659-1856           JAXUCZ010000004.1  94861620-94861817
            1857-2169           JAXUCZ010000004.1  94880177-94880489
            2170-2308           JAXUCZ010000004.1  94931196-94931334
            2309-2504           JAXUCZ010000004.1  94970245-94970440
            2505-2671           JAXUCZ010000004.1  95072069-95072235
            2672-2912           JAXUCZ010000004.1  95182682-95182922
            2913-4618           JAXUCZ010000004.1  95185335-95187040
FEATURES             Location/Qualifiers
     source          1..4618
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q31"
     gene            1..4618
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /note="glutamate ionotropic receptor delta type subunit 2"
                     /db_xref="GeneID:79220"
                     /db_xref="RGD:68368"
     exon            1..399
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..3335
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /note="gluR delta-2 subunit; glutamate receptor delta-2
                     subunit; glutamate receptor ionotropic, delta-2"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, delta-2
                     precursor"
                     /protein_id="NP_077355.2"
                     /db_xref="GeneID:79220"
                     /db_xref="RGD:68368"
                     /translation="MEVFPLLFFLSFWWSRTWDLATSDSIIHIGAIFDESAKKDDEVF
                     RTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSA
                     GSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRPPVYLNEVILRVV
                     TEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIE
                     ELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDVDVQELVRR
                     SIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLL
                     ANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVNGLTGDLEFGENGG
                     NPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTVLE
                     EPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGL
                     VGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFD
                     LSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVP
                     YTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTV
                     LDSAVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFV
                     WDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMD
                     ILKHKWWPKNGQCDLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWS
                     RRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQ
                     ALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGSVPEHRTGPFRHRAPNG
                     GFFRSPIKTMSSIPYQPTPTLGLNLGNDPDRGTSI"
     exon            400..555
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..840
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1046
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1100
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1274
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1436
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1556
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1658
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1856
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2169
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2308
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2504
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2671
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2912
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..4618
                     /gene="Grid2"
                     /gene_synonym="GluD2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccccgtcc gagagcagcc aaggctgccg gatacatttt ttaaaaagcc caactgcaaa
       61 caactctggc aatgccaaaa ttcccctccg agtgacaggg cttgggagga ggctgcctct
      121 ggctgtgcta gctctcgggt cgcctgtgcc tcctcggcaa ccaggaaagg ttgtgttctg
      181 tcaagaggga tttggaaatt agggggaaag ctgcactcaa ctctattgtg acctcaaact
      241 ctgtggaccg cttaagagaa tatctacata ttggaagcaa agtcgtggtc aaggaggatc
      301 ggcatcggag gatggaagtt ttccccttgc tcttctttct atccttctgg tggtctcgaa
      361 cctgggacct ggcgacctcc gattccatca tccacatcgg agcaattttt gatgaatctg
      421 ctaaaaaaga tgatgaagta ttccgcacag cagttggtga cctcaaccag aatgaggaaa
      481 tcttacagac tgagaaaatc acgttttcag tgacatttgt ggatggcaac aacccttttc
      541 aagctgttca agaagcatgt gaacttatga accagggcat cttggccttg gtcagctcca
      601 ttggttgcac atctgctggg tccctccagt ctttggcaga cgccatgcat atccctcacc
      661 tcttcattca gcgttcaaca gctgggaccc caagaagtgg ctgcggcctc accaggagca
      721 acagaaacga tgactatacc ctttcagttc gtccacctgt ctacttgaat gaagtcatcc
      781 taagagtagt cacagagtat gcatggcaga aatttattat cttctatgat agtgaatatg
      841 atatccgtgg catacaggaa tttttggaca aagtttccca gcagggaatg gatgttgccc
      901 ttcaaaaggt ggaaaacaac atcaataaaa tgatcaccac gctctttgac accatgagga
      961 tagaggagtt gaatcgctat cgagacactc tcagaagagc catccttgtt atgaaccccg
     1021 ccacagccaa atccttcata agtgaggtgg tggagactaa tctggttgct tttgactgtc
     1081 actggatcat catcaatgag gaaataaatg atgtggatgt tcaggaactt gtcagaaggt
     1141 ccattggaag gttaacaatt attcggcaga catttccagt cccccagaat ataagtcagc
     1201 gctgtttccg tggcaaccat cgaatttctt caacactgtg tgatcccaag gatcccttcg
     1261 cacagaatat ggagatttct aacctttaca tctatgacac ggtgcttctg cttgcaaacg
     1321 ccttccataa gaagctggag gaccggaagt ggcacagcat ggcgagcttg tcctgtatca
     1381 ggaaaaactc caagccctgg cagggagggc ggtccatgct ggagaccatc aagaagggtg
     1441 gagttaatgg attgactgga gatctagaat ttggagaaaa tggaggtaac cccaatgtcc
     1501 acttcgaaat ccttggaacc aactatggag aagaacttgg caggggtgtc cgtaaacttg
     1561 ggtgctggaa tcctgtcaca ggtctgaatg gatcactgac agacaagaaa ctggagaata
     1621 acatgcgagg tgtggttcta cgcgtggtga ctgtattgga ggagcctttt gtaatggtct
     1681 ctgaaaatgt cttgggaaaa ccgaagaaat accagggctt ctccattgat gttttagatg
     1741 ccctatctaa ctatctgggt tttaactatg aaatttatgt tgcaccggac cacaaatatg
     1801 gaagcccaca agaagatggg acatggaatg gactagtagg agaacttgtt tttaagagag
     1861 ctgacatcgg gatttcagct ttaaccatca ctccagaccg ggagaatgtt gtggatttta
     1921 caacacgcta catggactac tcagtagggg tcctactgcg aagggcagaa aaaacagtgg
     1981 atatgtttgc ctgccttgca ccatttgatc tatctctgtg ggcctgcatt gccggcacag
     2041 tccttcttgt gggactcctg gtctacctct tgaactggct taatccccca cggttgcaaa
     2101 tgggatcaat gacatctact acactctata actccatgtg gtttgtgtac gggtcctttg
     2161 tacagcaagg tggggaagta ccatacacaa ctttggcaac ccgaatgatg atgggggctt
     2221 ggtggttatt tgctctgatt gtcatctcat cttatacagc aaatcttgcc gctttcctca
     2281 ctatcacccg cattgagagc tccatccagt ctcttcagga tctgtccaag caaacggata
     2341 tcccttatgg cacagtcttg gattccgcag tatatcagca tgttcgcatg aaggggctga
     2401 atccttttga gagggacagc atgtattccc agatgtggag gatgatcaac cgaagcaatg
     2461 gctcagaaaa caatgttctg gagtcccaag caggcattca aaaggtaaaa tatggaaact
     2521 atgcttttgt atgggatgca gctgtgttgg aatatgtggc catcaatgac cccgactgtt
     2581 ccttctacac tgttggaaat actgttgctg accgggggta tggcatcgca ctgcagcatg
     2641 gcagtcccta ccgtgatgtc ttttcacaaa ggatcctgga gctgcagcag agtggcgaca
     2701 tggacatcct caagcacaaa tggtggccta agaatggcca gtgtgacctg tactcctcag
     2761 tagatgcaaa gcagaaggga ggagccctgg acatcaagag tctggcaggc gtgttctgca
     2821 tcctggccgc ggggattgta ctctcctgcc tcatagccgt cctcgagaca tggtggagtc
     2881 ggcggaaggg ctcccgagtc ccatcgaaag aggatgacaa ggaaattgac ctggagcacc
     2941 tccatagacg tgtaaatagc ttgtgcacag atgacgacag cccccataaa cagttttcca
     3001 cctcgtcaat tgacttgacc cctctggaca ttgacacttt gccaacacga caagccctgg
     3061 agcagatcag tgatttcaga aacactcaca tcaccaccac caccttcatc ccagagcaga
     3121 tccagactct tagccgcaca ctctcagcaa aagctgcctc tggcttcact ttcggcagtg
     3181 tgcccgagca ccgaactggc ccttttaggc acagggcccc taatgggggc tttttcagga
     3241 gtcctatcaa aacaatgtca tctattcctt atcagcctac tcccactctg gggctcaatc
     3301 tgggcaatga ccccgaccga ggcacgtcca tatgagcagc agacagctcg gcctatatcc
     3361 taggactgcc ccaaaggagc aactgtaatg tgggactaac atggatgtga tgttttattt
     3421 aaaagaaatc aggataatta gtaacaattc tagttctttc tctcccctgc tctacttttt
     3481 ttcctctttc tccctctctc tgtctatcac cctccatttt ttttccatta ctcaacttat
     3541 tccccaagaa tatagtattc taggatccaa gtagtctgct tttcatatac tgtacttcaa
     3601 gtatagggaa tgggcactga gactgagaac acttgcaggg ttgactttgc atacagggct
     3661 cccatgcacc caccgtccct ctgtttcgaa actctaactg caataacctc ggtctttctc
     3721 catcttcagc cacatccata aaaccctcca ctgctgtcga gtgtccttta actgtggacc
     3781 aaaggcaacc cctgcagtgt ggatgacatg attttgaaga ccgttcaggc cacacaatat
     3841 gagatcacgg tttcgtagga ttacaaaaca aaacaaaaca aaacaaaaaa aagccattaa
     3901 tctgccagtc aagactacag ttaaaacccc ctttgcactg cagcagtgcc cacccccttc
     3961 gtgcgattgt acagtattca aaccttttct tatgtacagt aaactttacc atatggcaaa
     4021 ggcctttatt gtgttaaata acttagtatc tcatatatac atatatatgc acctatataa
     4081 tgtgtatata tatagaaatg cagccattgc tattgcaatt catttaataa agctttagtt
     4141 taaaaaccaa gcattgtgta caggagctgt ggcagcgcag gaggccttgt caggtggaga
     4201 ggcaggttgc tttaatgtca ctctgacctg cgttgtttgc caagagactt ttttataatt
     4261 ttgttattaa aacatccagg gtgatttcat ctttgttcct agatgtactc atttgaatag
     4321 gttttgcatt cattattcag cagtgtataa agctaacctc gataatttta ccttctgtta
     4381 attatctaaa cgggaaatgc catgagccga accccacaca cagcacagag agcagagttt
     4441 aaccgtagat catggtaggt tcaacgtcct cttccaaagc tgcaagcgaa tcactgtaac
     4501 tgaagctggg gaggagggga aaccccttcg aagtgtcgat gtggccttat atgtgtcata
     4561 catcacccta cagcagacac gtgacaacca tactgggctc tcatctgaac ccctcttc
//
