LOCUS       NM_031608               2980 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus glutamate ionotropic receptor AMPA type subunit 1
            (Gria1), mRNA.
ACCESSION   NM_031608
VERSION     NM_031608.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2980)
  AUTHORS   Li,H.L., Guo,R.J., Ai,Z.R., Han,S., Guan,Y., Li,J.F. and Wang,Y.
  TITLE     Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters
            Interactions Between Neuroligin-2 and Postsynaptic Scaffolding
            Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal
            Cord Dorsal Horn
  JOURNAL   Neurochem Res 49 (2), 507-518 (2024)
   PUBMED   37955815
  REMARK    GeneRIF: Upregulation of Spinal MDGA1 in Rats After Nerve Injury
            Alters Interactions Between Neuroligin-2 and Postsynaptic
            Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery
            in the Spinal Cord Dorsal Horn.
REFERENCE   2  (bases 1 to 2980)
  AUTHORS   Yang,J., Ma,R.N., Dong,J.M., Hu,S.Q., Liu,Y. and Yan,J.Z.
  TITLE     Phosphorylation of 4.1N by CaMKII Regulates the Trafficking of
            GluA1-containing AMPA Receptors During Long-term Potentiation in
            Acute Rat Hippocampal Brain Slices
  JOURNAL   Neuroscience 536, 131-142 (2024)
   PUBMED   37993087
  REMARK    GeneRIF: Phosphorylation of 4.1N by CaMKII Regulates the
            Trafficking of GluA1-containing AMPA Receptors During Long-term
            Potentiation in Acute Rat Hippocampal Brain Slices.
REFERENCE   3  (bases 1 to 2980)
  AUTHORS   Peng,Y., Wang,Y., Liu,L., Yang,G., Zhang,D., Hong,S. and Li,L.
  TITLE     The effects of ketamine and methamphetamine on neurotransmitters,
            glutamate receptors, and conditioned place preference in rat
  JOURNAL   Leg Med (Tokyo) 65, 102328 (2023)
   PUBMED   37778205
REFERENCE   4  (bases 1 to 2980)
  AUTHORS   Guo,R., Xue,J., Shao,P., Cai,C. and Wang,Y.
  TITLE     NETO2-GluK2 interaction contributes to postoperative pain
            hypersensitivity through inducing PKCgamma activation and synaptic
            incorporation of AMPA receptor GluR1 subunits in rat dorsal horn
  JOURNAL   Neurosci Lett 813, 137430 (2023)
   PUBMED   37544581
  REMARK    GeneRIF: NETO2-GluK2 interaction contributes to postoperative pain
            hypersensitivity through inducing PKCgamma activation and synaptic
            incorporation of AMPA receptor GluR1 subunits in rat dorsal horn.
REFERENCE   5  (bases 1 to 2980)
  AUTHORS   Kang,Y., Xue,J., Zheng,J., Liang,J., Cai,C. and Wang,Y.
  TITLE     Upregulation of Hevin contributes to postoperative pain
            hypersensitivity by inducing neurexin1beta/neuroligin1-mediated
            synaptic targeting of GluA1-containing AMPA receptors in rat dorsal
            horn
  JOURNAL   Brain Res 1792, 148004 (2022)
   PUBMED   35820448
  REMARK    GeneRIF: Upregulation of Hevin contributes to postoperative pain
            hypersensitivity by inducing neurexin1beta/neuroligin1-mediated
            synaptic targeting of GluA1-containing AMPA receptors in rat dorsal
            horn.
REFERENCE   6  (bases 1 to 2980)
  AUTHORS   Wenthold,R.J., Yokotani,N., Doi,K. and Wada,K.
  TITLE     Immunochemical characterization of the non-NMDA glutamate receptor
            using subunit-specific antibodies. Evidence for a hetero-oligomeric
            structure in rat brain
  JOURNAL   J Biol Chem 267 (1), 501-507 (1992)
   PUBMED   1309749
REFERENCE   7  (bases 1 to 2980)
  AUTHORS   Hollmann,M., Hartley,M. and Heinemann,S.
  TITLE     Ca2+ permeability of KA-AMPA--gated glutamate receptor channels
            depends on subunit composition
  JOURNAL   Science 252 (5007), 851-853 (1991)
   PUBMED   1709304
REFERENCE   8  (bases 1 to 2980)
  AUTHORS   Sommer,B., Keinanen,K., Verdoorn,T.A., Wisden,W., Burnashev,N.,
            Herb,A., Kohler,M., Takagi,T., Sakmann,B. and Seeburg,P.H.
  TITLE     Flip and flop: a cell-specific functional switch in
            glutamate-operated channels of the CNS
  JOURNAL   Science 249 (4976), 1580-1585 (1990)
   PUBMED   1699275
REFERENCE   9  (bases 1 to 2980)
  AUTHORS   Keinanen,K., Wisden,W., Sommer,B., Werner,P., Herb,A.,
            Verdoorn,T.A., Sakmann,B. and Seeburg,P.H.
  TITLE     A family of AMPA-selective glutamate receptors
  JOURNAL   Science 249 (4968), 556-560 (1990)
   PUBMED   2166337
REFERENCE   10 (bases 1 to 2980)
  AUTHORS   Hollmann,M., Rogers,S.W., O'Shea-Greenfield,A., Deneris,E.S.,
            Hughes,T.E., Gasic,G.P. and Heinemann,S.
  TITLE     Glutamate receptor GluR-K1: structure, function, and expression in
            the brain
  JOURNAL   Cold Spring Harb Symp Quant Biol 55, 41-55 (1990)
   PUBMED   1966768
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 3, 2021 this sequence version replaced NM_031608.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X17184.1, M36418.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               JAXUCZ010000010.1  41711235-41711501
            268-405             JAXUCZ010000010.1  41714349-41714486
            406-645             JAXUCZ010000010.1  41880721-41880960
            646-830             JAXUCZ010000010.1  41885069-41885253
            831-884             JAXUCZ010000010.1  41895991-41896044
            885-1046            JAXUCZ010000010.1  41913968-41914129
            1047-1214           JAXUCZ010000010.1  41917100-41917267
            1215-1319           JAXUCZ010000010.1  41924975-41925079
            1320-1430           JAXUCZ010000010.1  41934027-41934137
            1431-1637           JAXUCZ010000010.1  41935039-41935245
            1638-2008           JAXUCZ010000010.1  41939573-41939943
            2009-2207           JAXUCZ010000010.1  41983100-41983298
            2208-2455           JAXUCZ010000010.1  41989698-41989945
            2456-2570           JAXUCZ010000010.1  42009747-42009861
            2571-2705           JAXUCZ010000010.1  42017486-42017620
            2706-2980           JAXUCZ010000010.1  42027504-42027778
FEATURES             Location/Qualifiers
     source          1..2980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2980
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /note="glutamate ionotropic receptor AMPA type subunit 1"
                     /db_xref="GeneID:50592"
                     /db_xref="RGD:621531"
     exon            1..267
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..2909
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /note="glutamate receptor 1; glutamate receptor A;
                     glutamate receptor subunit GluR1; gluR-1; gluR-K1;
                     AMPA-selective glutamate receptor 1; glutamate receptor,
                     ionotropic, AMPA1 (alpha 1); glutamate receptor,
                     ionotropic, AMPA 1"
                     /codon_start=1
                     /product="glutamate receptor 1 precursor"
                     /protein_id="NP_113796.1"
                     /db_xref="GeneID:50592"
                     /db_xref="RGD:621531"
                     /translation="MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRF
                     ALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCG
                     ALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQR
                     VLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVK
                     LEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSR
                     DHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQG
                     IDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAA
                     TDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHV
                     GYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKP
                     FMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWH
                     SEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTL
                     IIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFE
                     KMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGN
                     LDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKT
                     SALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRT
                     STLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGATGL"
     exon            268..405
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            406..645
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            646..830
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            831..884
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1046
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1214
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1319
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1430
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1637
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..2008
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2207
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2455
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2570
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2705
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2980
                     /gene="Gria1"
                     /gene_synonym="GluA1; gluR-A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcggctcc ccttccaaga gaaacaagag aaacctcacg gaaggaaggg aggaaggaaa
       61 gaagcaagca aggaactgca ggaagaaaag agccggcaga gcatcaagaa gaatcgaagg
      121 gaggggaggg aagaccaaat ctatggttgg accagggctt ctttttcgcc aatgtaaaaa
      181 ggaatatgcc gtacatcttt gcctttttct gcaccggttt tctaggtgcg gttgtgggtg
      241 ccaatttccc caacaatatc cagatagggg ggttatttcc aaaccaacaa tcacaggaac
      301 atgcggcttt taggtttgct ttgtcacaac tcacggagcc ccccaagttg cttccccaga
      361 tcgatattgt gaacatcagc gacagctttg agatgactta ccgtttctgt tcccagttct
      421 ccaaaggagt ctatgccatc tttggatttt atgaacgaag gactgtcaac atgctgacct
      481 ccttctgtgg ggccctccat gtgtgcttca ttactccaag ttttcctgtt gacacatcca
      541 atcaatttgt ccttcagcta cgcccggaac tacaggaagc tctcattagc attatcgacc
      601 attacaagtg gcaaaccttt gtctacattt atgatgctga ccggggcctg tcagtcctgc
      661 agagagtctt ggatacagcc gcagagaaga actggcaggt aacggctgtc aacattctga
      721 caaccaccga ggaaggatac cggatgctct ttcaggacct ggagaagaaa aaggagaggc
      781 tggtggtggt tgactgtgaa tcagaacgcc tcaacgccat cctgggccag atcgtgaagc
      841 tagaaaagaa tggcatcggg taccactaca tcctcgccaa tctgggcttc atggacattg
      901 acttaaataa gttcaaggag agcggagcca atgtgacagg tttccagctg gtgaactaca
      961 cagacacgat cccagccaga atcatgcagc aatggaggac aagtgactcc cgagaccata
     1021 ccagggtgga ctggaagagg ccaaagtaca cttctgctct cacctatgat ggtgtcaagg
     1081 tgatggctga ggccttccag agcctgcgga ggcagaggat tgacatatcc cgccggggga
     1141 atgctgggga ctgtctggct aacccagctg tgccctgggg tcaagggatc gacatccaga
     1201 gagccctgca gcaggtgcgc ttcgaaggtt tgacaggaaa tgtgcagttc aacgagaaag
     1261 ggcgccggac caattacacc ctccacgtga tcgaaatgaa acatgatgga atccgaaaga
     1321 ttggttactg gaatgaagat gataaatttg tccccgcagc caccgacgct caggctggag
     1381 gggacaactc aagcgtccag aataggacct acatcgtcac tactatcctc gaagatcctt
     1441 acgtgatgct taaaaagaat gccaaccagt ttgagggcaa tgaccgctat gagggctact
     1501 gtgtggagct ggctgcagag atcgccaagc acgtgggcta ctcctaccga cttgagattg
     1561 tcagcgacgg caaatatgga gcccgggatc ccgacacaaa ggcttggaat ggcatggtgg
     1621 gagaactggt ctatggaaga gcagacgtgg ctgtggctcc cttgaccata accttggtcc
     1681 gggaggaagt catcgacttc tccaagccat tcatgagttt gggaatctcc attatgatta
     1741 agaagccaca gaagtccaag ccaggtgtct tctcctttct tgaccctttg gcctatgaga
     1801 tctggatgtg tatagtgttt gcctacattg gagtgagcgt cgtcctcttc ctggtcagcc
     1861 gtttcagccc ctacgaatgg cacagcgaag agtttgaaga gggacgagac cagacaacca
     1921 gtgaccagtc aaatgagttt ggcatattca acagcctgtg gttctccctg ggggccttca
     1981 tgcagcaagg atgtgacatt tcccccaggt ccctgtccgg acgcatcgtc ggcggcgtct
     2041 ggtggttctt cactttgatc atcatctcct cgtacacagc caacctggct gccttcctga
     2101 ctgtggagag gatggtgtct cccattgaga gtgcagagga cctggcaaag cagacggaaa
     2161 ttgcttatgg gacattggaa gcaggctcca ctaaggagtt cttcaggaga tctaaaatcg
     2221 ctgtgtttga gaaaatgtgg acatacatga agtctgcaga accatccgtg tttgttcgga
     2281 ccacagagga aggcatgatc agagtgagaa aatctaaagg caaatacgcc tacctcctgg
     2341 agtccaccat gaatgagtat atcgagcaac gaaagccctg tgacaccatg aaagtgggag
     2401 gtaacttgga ttccaaaggc tatggcattg cgacacccaa ggggtccgcc ctgagaaatc
     2461 cagtaaacct ggcagtgtta aaactgaacg agcaggggct tttggacaaa ttgaaaaaca
     2521 aatggtggta cgacaagggc gagtgcggca gcgggggagg tgactccaag gacaagacca
     2581 gcgctttgag cctcagcaat gtggcaggcg tgttctacat cctgattgga gggctgggac
     2641 tggccatgct ggttgcctta atcgagttct gctacaaatc ccgtagcgag tcgaagcgga
     2701 tgaagggttt ctgtttgatc ccacagcaat ccatcaatga agccatacgg acatcgaccc
     2761 tcccccggaa cagtggggca ggagccagcg gaggaggcgg cagtggagag aatggccggg
     2821 tggtcagcca ggacttcccc aagtccatgc aatccattcc ctgcatgagt cacagttcag
     2881 ggatgccctt gggagccaca ggattgtaac tggagcagac aggaaaccct tggggagcag
     2941 gctcaggctt ccacagcccc atcccaagcc cttcagtgcc
//
