LOCUS       NM_001113754            1267 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus glyoxylate and hydroxypyruvate reductase (Grhpr),
            mRNA.
ACCESSION   NM_001113754 XM_001055358 XM_001065009
VERSION     NM_001113754.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1267)
  AUTHORS   Takayama,T., Nagata,M., Ozono,S., Nonomura,K. and Cramer,S.D.
  TITLE     A novel mutation in the GRHPR gene in a Japanese patient with
            primary hyperoxaluria type 2
  JOURNAL   Nephrol Dial Transplant 22 (8), 2371-2374 (2007)
   PUBMED   17510093
REFERENCE   5  (bases 1 to 1267)
  AUTHORS   Booth,M.P., Conners,R., Rumsby,G. and Brady,R.L.
  TITLE     Structural basis of substrate specificity in human glyoxylate
            reductase/hydroxypyruvate reductase
  JOURNAL   J Mol Biol 360 (1), 178-189 (2006)
   PUBMED   16756993
REFERENCE   6  (bases 1 to 1267)
  AUTHORS   Cramer,S.D., Ferree,P.M., Lin,K., Milliner,D.S. and Holmes,R.P.
  TITLE     The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in
            patients with primary hyperoxaluria type II
  JOURNAL   Hum Mol Genet 8 (11), 2063-2069 (1999)
   PUBMED   10484776
  REMARK    Erratum:[Hum Mol Genet 1999 Dec;8(13):2574]
REFERENCE   7  (bases 1 to 1267)
  AUTHORS   Rumsby,G. and Cregeen,D.P.
  TITLE     Identification and expression of a cDNA for human
            hydroxypyruvate/glyoxylate reductase
  JOURNAL   Biochim Biophys Acta 1446 (3), 383-388 (1999)
   PUBMED   10524214
REFERENCE   8  (bases 1 to 1267)
  AUTHORS   Van Schaftingen,E., Draye,J.P. and Van Hoof,F.
  TITLE     Coenzyme specificity of mammalian liver D-glycerate dehydrogenase
  JOURNAL   Eur J Biochem 186 (1-2), 355-359 (1989)
   PUBMED   2689175
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Jan 26, 2008 this sequence version replaced
            XM_001055358.1, XM_001065009.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ218443.1, BC158680.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1267
                     /gene="Grhpr"
                     /note="glyoxylate and hydroxypyruvate reductase"
                     /db_xref="GeneID:680021"
                     /db_xref="RGD:1308851"
     exon            1..141
                     /gene="Grhpr"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1045
                     /gene="Grhpr"
                     /EC_number="1.1.1.79"
                     /codon_start=1
                     /product="glyoxylate reductase/hydroxypyruvate reductase"
                     /protein_id="NP_001107226.1"
                     /db_xref="GeneID:680021"
                     /db_xref="RGD:1308851"
                     /translation="MFAAAGLVKPARLMKVFVTGPLPAQGRAALAQATDCEVEQWNSD
                     DPIPSKDLEQGVAGAYGLLCRLSDRVDKKLLDAAGANLRVISTLSVGVDHLALDEIKK
                     RGIRVGYTPGVLTDATAELAVSLLLTTCRRLPEAIEEVKNGGWSSWSPLWMCGYGLSE
                     STVGIVGLGRIGQAIARRLKPFGVQRFLYTGRQPRPQEAAEFQAEFVPIAQLAAESDF
                     IVVSCSLTPATRGLCNKDFFQKMKNTAVFINISRGDVVNQEDLYQALASGQIAAAGLD
                     VTTPEPLPPSHPLLTLKNCVILPHIGSATYKTRNTMSLLAANNLLAGLRGEPMPSELK
                     L"
     exon            142..272
                     /gene="Grhpr"
                     /inference="alignment:Splign:2.1.0"
     exon            273..345
                     /gene="Grhpr"
                     /inference="alignment:Splign:2.1.0"
     exon            346..462
                     /gene="Grhpr"
                     /inference="alignment:Splign:2.1.0"
     exon            463..551
                     /gene="Grhpr"
                     /inference="alignment:Splign:2.1.0"
     exon            552..656
                     /gene="Grhpr"
                     /inference="alignment:Splign:2.1.0"
     exon            657..792
                     /gene="Grhpr"
                     /inference="alignment:Splign:2.1.0"
     exon            793..923
                     /gene="Grhpr"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1267
                     /gene="Grhpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacttccg tcgccttttg ctaggctagg ttggttaatg tttgcagctg cgggtcttgt
       61 gaaacccgcg cgactcatga aggtgttcgt cactggccct ttgccggccc agggcagggc
      121 tgcgctcgcc caggccacag actgtgaggt agagcagtgg aattcggatg atcccatccc
      181 cagcaaggat ctggagcaag gcgtggcggg ggcctatggc ttgctctgcc gcctcagtga
      241 ccgcgtggac aagaaacttc tggatgctgc gggagccaac ctcagagtca tcagcaccct
      301 gtctgtgggg gttgaccact tggctttaga tgagatcaag aaacgcggga tccgggtggg
      361 ctacacgcca ggtgtcctga cagacgccac ggcagaactt gctgtctccc tcctgctcac
      421 cacctgccgc cggttgccgg aagccataga ggaagtaaag aacggtggct ggagctcctg
      481 gagccccttg tggatgtgcg gttatggact ctccgagagc actgttggca ttgtggggct
      541 ggggcgcata ggtcaggcca ttgctcgacg actgaaacca tttggtgtcc agagatttct
      601 ctacacgggg cgccagccca ggcctcagga agcagcagag tttcaggcag agtttgtgcc
      661 tattgctcag ctggctgccg agtcagactt cattgtagtg tcctgctcct taacaccggc
      721 taccaggggg ctctgcaaca aggacttctt ccagaagatg aagaacactg ctgtcttcat
      781 caacatcagc agaggagatg tggtaaacca ggaagacctg taccaggcat tagccagtgg
      841 tcagattgca gcagcaggac tggatgtgac caccccagaa ccactgcctc caagccaccc
      901 cctgctgacc ctcaagaact gcgtgatcct gccccacatc ggcagtgcca cctacaaaac
      961 tcgcaacacc atgtccttgc tggcggctaa caacttgctg gctggcctaa gaggggagcc
     1021 aatgcccagt gaactcaagc tgtagccaga tgggctttca tggactggag acatctcgct
     1081 ggacaaaccc aagctgaagt ctggactgag gccagagctt ggggcatgcc ccctctgctg
     1141 tgttctcagt ggacatggga acggacagat gggcttgcca tatacttgcc aaaagcctgt
     1201 aattctaaca ttaaacagtt tctgacacgg tgtctaggtc tatgacttgg ggcactaaca
     1261 aaaagag
//
