LOCUS       NM_001415833            2772 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus grainyhead-like transcription factor 3 (Grhl3),
            transcript variant 1, mRNA.
ACCESSION   NM_001415833 XM_008764216
VERSION     NM_001415833.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2772)
  AUTHORS   Gordon,W.M., Zeller,M.D., Klein,R.H., Swindell,W.R., Ho,H.,
            Espetia,F., Gudjonsson,J.E., Baldi,P.F. and Andersen,B.
  TITLE     A GRHL3-regulated repair pathway suppresses immune-mediated
            epidermal hyperplasia
  JOURNAL   J Clin Invest 124 (12), 5205-5218 (2014)
   PUBMED   25347468
REFERENCE   2  (bases 1 to 2772)
  AUTHORS   Haendeler,J., Mlynek,A., Buchner,N., Lukosz,M., Graf,M.,
            Guettler,C., Jakob,S., Farrokh,S., Kunze,K., Goy,C.,
            Guardiola-Serrano,F., Schaal,H., Cortese-Krott,M., Deenen,R.,
            Kohrer,K., Winkler,C. and Altschmied,J.
  TITLE     Two isoforms of Sister-Of-Mammalian Grainyhead have opposing
            functions in endothelial cells and in vivo
  JOURNAL   Arterioscler Thromb Vasc Biol 33 (7), 1639-1646 (2013)
   PUBMED   23685552
REFERENCE   3  (bases 1 to 2772)
  AUTHORS   Brouns,M.R., De Castro,S.C., Terwindt-Rouwenhorst,E.A., Massa,V.,
            Hekking,J.W., Hirst,C.S., Savery,D., Munts,C., Partridge,D.,
            Lamers,W., Kohler,E., van Straaten,H.W., Copp,A.J. and Greene,N.D.
  TITLE     Over-expression of Grhl2 causes spina bifida in the Axial defects
            mutant mouse
  JOURNAL   Hum Mol Genet 20 (8), 1536-1546 (2011)
   PUBMED   21262862
REFERENCE   4  (bases 1 to 2772)
  AUTHORS   Boglev,Y., Wilanowski,T., Caddy,J., Parekh,V., Auden,A., Darido,C.,
            Hislop,N.R., Cangkrama,M., Ting,S.B. and Jane,S.M.
  TITLE     The unique and cooperative roles of the Grainy head-like
            transcription factors in epidermal development reflect unexpected
            target gene specificity
  JOURNAL   Dev Biol 349 (2), 512-522 (2011)
   PUBMED   21081122
REFERENCE   5  (bases 1 to 2772)
  AUTHORS   Rifat,Y., Parekh,V., Wilanowski,T., Hislop,N.R., Auden,A.,
            Ting,S.B., Cunningham,J.M. and Jane,S.M.
  TITLE     Regional neural tube closure defined by the Grainy head-like
            transcription factors
  JOURNAL   Dev Biol 345 (2), 237-245 (2010)
   PUBMED   20654612
REFERENCE   6  (bases 1 to 2772)
  AUTHORS   Yu,Z., Lin,K.K., Bhandari,A., Spencer,J.A., Xu,X., Wang,N., Lu,Z.,
            Gill,G.N., Roop,D.R., Wertz,P. and Andersen,B.
  TITLE     The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates
            epidermal terminal differentiation and interacts functionally with
            LMO4
  JOURNAL   Dev Biol 299 (1), 122-136 (2006)
   PUBMED   16949565
REFERENCE   7  (bases 1 to 2772)
  AUTHORS   Ting,S.B., Caddy,J., Hislop,N., Wilanowski,T., Auden,A., Zhao,L.L.,
            Ellis,S., Kaur,P., Uchida,Y., Holleran,W.M., Elias,P.M.,
            Cunningham,J.M. and Jane,S.M.
  TITLE     A homolog of Drosophila grainy head is essential for epidermal
            integrity in mice
  JOURNAL   Science 308 (5720), 411-413 (2005)
   PUBMED   15831758
REFERENCE   8  (bases 1 to 2772)
  AUTHORS   Ting,S.B., Wilanowski,T., Auden,A., Hall,M., Voss,A.K., Thomas,T.,
            Parekh,V., Cunningham,J.M. and Jane,S.M.
  TITLE     Inositol- and folate-resistant neural tube defects in mice lacking
            the epithelial-specific factor Grhl-3
  JOURNAL   Nat Med 9 (12), 1513-1519 (2003)
   PUBMED   14608380
REFERENCE   9  (bases 1 to 2772)
  AUTHORS   Kudryavtseva,E.I., Sugihara,T.M., Wang,N., Lasso,R.J.,
            Gudnason,J.F., Lipkin,S.M. and Andersen,B.
  TITLE     Identification and characterization of Grainyhead-like epithelial
            transactivator (GET-1), a novel mammalian Grainyhead-like factor
  JOURNAL   Dev Dyn 226 (4), 604-617 (2003)
   PUBMED   12666198
REFERENCE   10 (bases 1 to 2772)
  AUTHORS   Hall,M., Gofflot,F., Iseki,S. and Morriss-Kay,G.M.
  TITLE     Effects of the curly tail genotype on neuroepithelial integrity and
            cell proliferation during late stages of primary neurulation
  JOURNAL   J Anat 199 (Pt 6), 645-655 (2001)
   PUBMED   11787818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 3, 2023 this sequence version replaced XM_008764216.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.14625.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16418971 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               JAXUCZ010000005.1  153089667-153089890 c
            225-411             JAXUCZ010000005.1  153077275-153077461 c
            412-473             JAXUCZ010000005.1  153075277-153075338 c
            474-819             JAXUCZ010000005.1  153073274-153073619 c
            820-893             JAXUCZ010000005.1  153072941-153073014 c
            894-1047            JAXUCZ010000005.1  153072070-153072223 c
            1048-1159           JAXUCZ010000005.1  153071789-153071900 c
            1160-1254           JAXUCZ010000005.1  153070630-153070724 c
            1255-1413           JAXUCZ010000005.1  153068665-153068823 c
            1414-1492           JAXUCZ010000005.1  153068106-153068184 c
            1493-1629           JAXUCZ010000005.1  153067855-153067991 c
            1630-1664           JAXUCZ010000005.1  153066228-153066262 c
            1665-1753           JAXUCZ010000005.1  153065176-153065264 c
            1754-1839           JAXUCZ010000005.1  153064336-153064421 c
            1840-1904           JAXUCZ010000005.1  153062185-153062249 c
            1905-2772           JAXUCZ010000005.1  153057760-153058627 c
FEATURES             Location/Qualifiers
     source          1..2772
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2772
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /note="grainyhead-like transcription factor 3"
                     /db_xref="GeneID:298555"
                     /db_xref="RGD:1308320"
     exon            1..224
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..2019
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor CP2-like 4; grainyhead-like protein 3
                     homolog; grainyhead-like 3"
                     /codon_start=1
                     /product="grainyhead-like protein 3 homolog isoform 1"
                     /protein_id="NP_001402762.1"
                     /db_xref="GeneID:298555"
                     /db_xref="RGD:1308320"
                     /translation="MSNELDFRSVRLLKNDPVSFQKFPYNNEDEAWKTYLENPLTAAT
                     KAIMRVNGDDESVAALSFLYDYYMGPKEKRILSSSTGGRNDQGKKYYHSMDYEPDLAP
                     LESPTHLMKFLTENVSGSPDYTDQLKKNNLLGLEGALPTPGKTSTLPPGPSKLEAGSM
                     DSYLLPTSDMYDNSSLNSLFESIHGVPPTQRWQPDSTFKDDPQESLLFPDILKTSPEA
                     PCPEDYPSLKSDFEYTLGSPKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLSLSS
                     SKVKSVVMIVFDNDKVPVEQLRFWRHWHSRQPTAKQRVIDVADCKENFNTVQHIEEVA
                     YNALSFVWNVNEEAKVFIGVNCLSTDFSSQKGVKGVPLNLQIDTYDCGAGTERLVHRA
                     VCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNNAGIKGCLLSGFRGNETTYLRPE
                     ADLETQPVLFIPNLHFSSLQRPGGVVPSAGHSSSDRLPLKRTCSPFAEEFEPLPSKQA
                     KEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGFPEENICKVYKKCKRG
                     ILVNMDNNIIQHYSNHVAFLLDMGELDGKIQIILKEL"
     exon            225..411
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            412..473
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            474..819
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            820..893
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1047
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1159
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1254
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1413
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1492
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1629
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1664
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1753
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1839
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1904
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2772
                     /gene="Grhl3"
                     /gene_synonym="Tfcp2l4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtcggca cctgtgcttc cagccaatca gcgccaccgc cgcaggggac cgctgtcagc
       61 aaaatctcaa catccagagc gcaccgtcga gcaaacgctt ccccgggcag ggagggaatg
      121 tctgtgtcac aggagaatta gagacaagcg atcagcagcg cctgcgagcc aacaggagcc
      181 ggatcgccgg aacctcggag aaggaagatg tcgaatgaac ttgatttcag gtctgtgcgg
      241 ctgctgaaaa atgaccccgt gagcttccag aagtttccct acaataatga ggatgaggcc
      301 tggaagacat acctggagaa ccctttgaca gccgccacca aggccataat gagagtcaat
      361 ggggacgatg agagtgtcgc tgctctgagc tttctctatg actactatat gggtcccaag
      421 gagaagcgga tactgtcctc cagcactggt ggccggaatg accaaggaaa gaagtactac
      481 cacagcatgg actatgagcc ggatcttgcc ccgcttgaga gccccacgca cctcatgaaa
      541 tttctgacag agaacgtgtc tggaagccca gactacacag accagctcaa gaagaacaac
      601 ctgctaggct tggagggggc tctacccacc cccggcaaga ccagtaccct gcccccaggt
      661 ccaagtaagc tggaagccgg ctccatggac agctacctct tgcccaccag tgacatgtat
      721 gacaacagct ccctcaactc actatttgag agcattcatg gcgttccacc cacacagcgc
      781 tggcagccag acagcacctt caaagacgac ccacaggagt cgctgctctt ccctgatatc
      841 ctgaagacat ccccggaagc cccatgtcca gaggattatc caagcctcaa gagcgacttt
      901 gagtacaccc tgggctcccc caaagccatt cacatcaaag cgggggagtc acccatggcc
      961 tacctcaaca agggtcagtt ctacccggtc accctacgca ccccagcggg aggaaaaggc
     1021 ctctctctgt cctccagcaa agtcaagagc gtggtgatga ttgtgttcga taatgacaag
     1081 gttccagtgg agcagctgcg cttctggagg cactggcatt cccggcagcc taccgccaag
     1141 cagcgtgtca tcgacgtagc cgactgtaag gaaaacttca acacagtcca gcacatcgag
     1201 gaggtggcct ataacgcact gtcctttgtg tggaatgtta acgaggaggc taaggtgttc
     1261 atcggtgtca actgtctgag cacagacttc tcctcgcaga agggggtgaa gggtgtcccc
     1321 ctcaacttgc aaattgacac ttatgactgt ggagcaggca ctgagcgcct ggtgcaccgt
     1381 gctgtctgcc aaatcaagat cttctgtgac aagggtgccg agaggaagat gcgcgatgat
     1441 gaacggaagc agtttcgaag gaaggtcaag tgcccagact ccagtaacaa tgcaggcatc
     1501 aagggctgcc tgctgtccgg cttcaggggc aatgagacca catacttgcg gccagaagcg
     1561 gacctggaga cccagcctgt gttgttcatc cccaacctgc atttctccag cctacaacgc
     1621 ccaggagggg ttgtcccctc agcaggacac agcagctctg acaggttgcc tctgaagcga
     1681 acctgctcgc cctttgctga ggagtttgag cctctcccct ccaaacaggc caaggaagat
     1741 gaccttcaga gagttctgct gtatgtgagg agggagacag aggaggtgtt tgacgcactc
     1801 atgttgaaga ccccggactt gaaggggctg aggaatgcga tctctgagaa gtatggcttc
     1861 cctgaggaga atatctgcaa agtctacaag aaatgcaagc gaggaatcct ggtcaacatg
     1921 gacaacaaca tcatccagca ttacagcaac cacgtggcct tcctgctgga catgggtgag
     1981 ctggatggca agattcagat tatcctgaag gagctatgag ggcccagcct caagcacccc
     2041 acactcaggg cccagctcga gcctcggctt tcaacctctt ctgtgtgtca gctgttactt
     2101 gaaatgcctc tctcaggggg aagcgctctc gtaagcaaca aactcagtga cgtccgaacc
     2161 agggagagac caagaaggtt ccaggatcta aatgccctac ccagacttga actcacttca
     2221 gagagcttcc tgcaaatacc caaaccccca ccccccagag acaggggctc tgatcagcac
     2281 agactgcctg ctttctcttc taagtctcac cgcagaggcc ctcacagggg acggtggtca
     2341 caccgccctc tctgcagggc tatatcagtt gtctcgactg gttctgaccc tcactctgca
     2401 tcctcccgcc aacttcagac caaagagttc tcgcaattaa ctcgaaaatg cctttatgag
     2461 gtcattggag aggaaacttt cttagtggct tccttgtaca agatgtaagt cgccgtcgtt
     2521 gagcagaaag gaaccaacac ccttgccatc tactgttgta cacatttctt atttacagtt
     2581 ttcatcatgt gatatatata tatataagta tatattgtgt atatatatgc aacattttgt
     2641 atgttcgtgt tacattttta tcatttcaaa aatatgtatt tcatattcgc tgaactattt
     2701 ttttagctgt tattcgagta tgcattttgt atatcatagg gtttagtaat aaaagcctac
     2761 ctgtgcacac tt
//
