LOCUS       NM_001134527            4871 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus grainyhead-like transcription factor 2 (Grhl2),
            mRNA.
ACCESSION   NM_001134527 XM_001060905 XM_238505
VERSION     NM_001134527.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4871)
  AUTHORS   Ming Q, Roske Y, Schuetz A, Walentin K, Ibraimi I, Schmidt-Ott KM
            and Heinemann U.
  TITLE     Structural basis of gene regulation by the Grainyhead/CP2
            transcription factor family
  JOURNAL   Nucleic Acids Res 46 (4), 2082-2095 (2018)
   PUBMED   29309642
REFERENCE   2  (bases 1 to 4871)
  AUTHORS   Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A,
            Potschke E, Warburton D, Qiu A, Barasch J, Purfurst B, Dieterich C,
            Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E and
            Schmidt-Ott KM.
  TITLE     A Grhl2-dependent gene network controls trophoblast branching
            morphogenesis
  JOURNAL   Development 142 (6), 1125-1136 (2015)
   PUBMED   25758223
REFERENCE   3  (bases 1 to 4871)
  AUTHORS   Petrof G, Nanda A, Howden J, Takeichi T, McMillan JR, Aristodemou
            S, Ozoemena L, Liu L, South AP, Pourreyron C, Dafou D, Proudfoot
            LE, Al-Ajmi H, Akiyama M, McLean WH, Simpson MA, Parsons M and
            McGrath JA.
  TITLE     Mutations in GRHL2 result in an autosomal-recessive ectodermal
            Dysplasia syndrome
  JOURNAL   Am J Hum Genet 95 (3), 308-314 (2014)
   PUBMED   25152456
REFERENCE   4  (bases 1 to 4871)
  AUTHORS   Werner S, Frey S, Riethdorf S, Schulze C, Alawi M, Kling L,
            Vafaizadeh V, Sauter G, Terracciano L, Schumacher U, Pantel K and
            Assmann V.
  TITLE     Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in
            breast cancer
  JOURNAL   J Biol Chem 288 (32), 22993-23008 (2013)
   PUBMED   23814079
REFERENCE   5  (bases 1 to 4871)
  AUTHORS   Chen W, Xiao Liu Z, Oh JE, Shin KH, Kim RH, Jiang M, Park NH and
            Kang MK.
  TITLE     Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation
            through epigenetic mechanism
  JOURNAL   Cell Death Dis 3 (12), e450 (2012)
   PUBMED   23254293
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4871)
  AUTHORS   Chen W, Dong Q, Shin KH, Kim RH, Oh JE, Park NH and Kang MK.
  TITLE     Grainyhead-like 2 enhances the human telomerase reverse
            transcriptase gene expression by inhibiting DNA methylation at the
            5'-CpG island in normal human keratinocytes
  JOURNAL   J Biol Chem 285 (52), 40852-40863 (2010)
   PUBMED   20938050
REFERENCE   7  (bases 1 to 4871)
  AUTHORS   Werth M, Walentin K, Aue A, Schonheit J, Wuebken A, Pode-Shakked N,
            Vilianovitch L, Erdmann B, Dekel B, Bader M, Barasch J, Rosenbauer
            F, Luft FC and Schmidt-Ott KM.
  TITLE     The transcription factor grainyhead-like 2 regulates the molecular
            composition of the epithelial apical junctional complex
  JOURNAL   Development 137 (22), 3835-3845 (2010)
   PUBMED   20978075
REFERENCE   8  (bases 1 to 4871)
  AUTHORS   Rifat Y, Parekh V, Wilanowski T, Hislop NR, Auden A, Ting SB,
            Cunningham JM and Jane SM.
  TITLE     Regional neural tube closure defined by the Grainy head-like
            transcription factors
  JOURNAL   Dev Biol 345 (2), 237-245 (2010)
   PUBMED   20654612
REFERENCE   9  (bases 1 to 4871)
  AUTHORS   Kang X, Chen W, Kim RH, Kang MK and Park NH.
  TITLE     Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and
            D, and GRHL2 in human oral squamous cell carcinoma cells
  JOURNAL   Oncogene 28 (4), 565-574 (2009)
   PUBMED   19015635
REFERENCE   10 (bases 1 to 4871)
  AUTHORS   Peters LM, Anderson DW, Griffith AJ, Grundfast KM, San Agustin TB,
            Madeo AC, Friedman TB and Morell RJ.
  TITLE     Mutation of a transcription factor, TFCP2L3, causes progressive
            autosomal dominant hearing loss, DFNA28
  JOURNAL   Hum Mol Genet 11 (23), 2877-2885 (2002)
   PUBMED   12393799
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC168688.1.
            
            On or before Sep 4, 2008 this sequence version replaced
            XM_238505.4, XM_001060905.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN16676784
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..4871
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /note="grainyhead-like transcription factor 2"
                     /db_xref="GeneID:299979"
                     /db_xref="RGD:1561191"
     exon            1..153
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2014
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /note="grainyhead-like 2"
                     /codon_start=1
                     /product="grainyhead-like protein 2 homolog"
                     /protein_id="NP_001127999.1"
                     /db_xref="GeneID:299979"
                     /db_xref="RGD:1561191"
                     /translation="MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPL
                     TAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDEEKRNCLGTSE
                     AQINLSGGENRVQVLKTVPVNLCLSQDHMENSKREQYSVSITESPAVIPVSGITVVKA
                     EDFTPVFMAPPVHYPRADGGEEQRVVIFEQTQYDLPSIASHSSYLKDDQRSTPDSTYS
                     ESFKDGAPEKFRSTSVGADEYTYDQTGSGTFQYTLEATKSLRQKQGEGPMTYLNKGQF
                     YAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLD
                     IADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMI
                     QIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCSNS
                     SDGKMAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGS
                     SVLVKRMFRPMEEEFGPTPSKQIKEENVKRVLLYVRKENDDVFDALMLKSPTVKGLME
                     ALSEKYGLPVEKITKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKITLM
                     EI"
     exon            154..349
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            350..417
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            418..814
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            815..870
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1027
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1139
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1234
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1393
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1481
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1621
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1653
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1748
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1834
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1899
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..4794
                     /gene="Grhl2"
                     /gene_synonym="RGD1561191"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagaatta cctgtagctc ttgttctgcc atctcgggcg ctctcacaca ccttcacctg
       61 cacagacttg aaagtccagt ttcaccagag gctgaggctc caggaaaagg ggagcgagtt
      121 cattggatca aacatgtcac aagagtcgga caataataaa agactagtgg ccttggtgcc
      181 catgcccagt gaccctccct tcaacacccg aagagcctac acaagtgagg atgaggcctg
      241 gaagtcgtat ctggagaacc ccctgacggc agccaccaag gcaatgatga gcatcaatgg
      301 ggatgaggac agtgctgctg ccctgggcct tctctatgac tactacaagg ttcctcgaga
      361 caagagactt ctgtctgtga gcaaagcaag cgacagccaa gaagacgagg aaaaaagaaa
      421 ctgtcttggc accagcgaag cccagatcaa cttgagcgga ggcgagaacc gagtgcaggt
      481 tctgaagacc gtccctgtga acctctgcct gagtcaagac cacatggaga attcgaagcg
      541 tgagcagtac agcgtgtcca tcactgagag ccccgccgtc atccccgtgt cgggcatcac
      601 ggtggtgaaa gctgaggatt tcacgcccgt gttcatggcg cccccggtgc actatccccg
      661 cgcggacggt ggcgaggagc agcgcgtggt tatctttgaa cagactcagt atgacctgcc
      721 ctccatagcc agccacagct cctatctaaa ggacgaccag cgcagcacgc ccgacagcac
      781 ctacagcgag agcttcaagg acggcgcccc ggagaaattt cggagtactt ctgttggtgc
      841 tgatgagtat acatatgacc agacggggag tggtacattt cagtacaccc tggaagccac
      901 caaatctctc cggcagaagc agggggaggg ccccatgacc tacctcaaca aaggacaatt
      961 ctatgccata acactcagtg agactggaga caacaaatgc ttccgacacc ccatcagcaa
     1021 agtcaggagt gtagtgatgg tggtctttag tgaagacaaa aaccgagacg aacagctgaa
     1081 gtactggaag tactggcact cccggcagca cactgctaag cagagggtcc ttgacattgc
     1141 tgattacaag gaaagcttca acaccatcgg gaacattgaa gagatcgcat acaatgccgt
     1201 ttccttcacc tgggatgtga atgaggaggc gaagatcttc atcaccgtga actgcttgag
     1261 tacagatttc tcctcccaga agggtgtgaa aggacttcct ctgatgattc agatcgacac
     1321 gtacagctat aacaaccgca gcaataaacc catccacaga gcgtactgcc agatcaaggt
     1381 cttctgcgac aagggagcag aaagaaaaat ccgggatgaa gagaggaagc agaacaggaa
     1441 gaaagggaag ggccaggcct cccaaaccca gtgcagcaat tcctctgatg ggaagatggc
     1501 cgccataccg ttacagaaga agagtgacat cacgtacttc aaaaccatgc ccgacctgca
     1561 ctcacagcct gtgctcttca taccagatgt tcactttgcc aacctgcaga ggactggaca
     1621 ggtctattac aacaccgatg atgagcgaga aggcagcagt gtcctcgtta aacggatgtt
     1681 caggcccatg gaagaggaat ttggtccaac accgtctaag cagattaaag aagaaaacgt
     1741 aaagcgagtg cttttatacg tgaggaagga gaacgatgac gtgttcgatg ctctgatgct
     1801 gaaatcgccc acagtgaagg gcctgatgga agcgctgtct gagaagtacg ggctgccggt
     1861 ggagaagatc acaaagcttt ataagaagag caaaaaggga atcctggtca acatggacga
     1921 caacatcatt gagcactatt caaatgagga caccttcatt ctcaacatgg agagcatggt
     1981 ggaaggcttc aagatcacat tgatggagat ctgaaccctg atggagtccc tgacaggagc
     2041 ttttggtgca ctccttcctg ggagagatgt gatctctgcc gccccagaac ctggagaccc
     2101 atctcaccct cctcacaaga ctgttacaag actgctggga aggggacggg gcccaaggcc
     2161 cagtaacaga cttccttcca ctcttccaag ctccctctgg agctgaagcc tgagcccctc
     2221 agcagattct ttgagcctgg taggccctta tttattgccc attctttccc caagagccct
     2281 ccaggactct gcaagttact gagagctcca tgggagacct ccagagtttc cccttcaagg
     2341 gcagcagcag cagcagcagc agcaagtcca ctgatctcga gcctggggag ctggtgtgtc
     2401 cttttcttac ctctcctcat ttcttgagtg gatggaccag atgagctgct tcttggtgca
     2461 gtcttcatgg atggagtaag aaggacccca aacctcagat tgctctgagg aaggtcattt
     2521 tgctaaatac ctccagggga ctctcagcaa atagccactg accgcgttcg ggaagactgc
     2581 actaccatgt cagcttattg aacacgagaa agagtgtgcc tgacgaccat gtacataatc
     2641 tgtacataac attgcagtaa tatatttacc tgtggtttgt gggcatgttt actgccattg
     2701 gcctggagga gacacactgg agattcagag cgttctgctc tacccaaggg gaggttagag
     2761 aagtggcctc tgggatgtca tgtgatggtg gtgaacacct ggatggactc tccaccgggc
     2821 catgcctgag gacttgtttc cccagagccc tctctcctca aacatgactc tccctcgagg
     2881 ctatggcgtt ttatctcatg gtgatatgtt gcctaagctc gtcctttgag ctgtctggga
     2941 aaggacataa ctgtcagtgc cttctctagc tttggtatgg ggcatctctt gagccttgcg
     3001 caaaatctat gcagagattt tcgctggggc cctgtcactg ggacctgctg cagaactgct
     3061 tggccgacac gggaatcctg gacacggtag caccccgcag tttacaagca tgtccttcat
     3121 ctcaagtggc ccctttaaaa gtccaactgc agcgttgtga atcgagccag cagctctgct
     3181 gggctgtgaa cagcagacag tgctttgcct tgcttctgac aggaagaagt gaggctatcc
     3241 accctggctg tgggaagctt gggagccctt gcacttctga aaccaactct gggaggcact
     3301 ggagagctaa ggctgtttca tcctctcctc acccttggaa ggtccagaga aaatggctta
     3361 cccaaacagt catgaaagcg tgccccatcg tgagcctctg ttctctttga gagaacaggt
     3421 cagtagttct gttagggtta aggactggta tgtgcccctg gggctgagca ctattagttt
     3481 ggagagccag acacatccca tcccaaggcc tagataatga aacagctttt atggaaaggt
     3541 ctaaatttgt ctgtgaagca ctttgatgtc ttacctggag gctctgctct ccagcccctt
     3601 gctctacctg cccccgaggc ccagagcagc tgaggctgac tccagcccag ctactgctct
     3661 tccaagctgc agagaaattg aatgggatgg ggagtaggtg ccgtaaccaa gaggatccca
     3721 aagggtagca gggggcacct ttctgagagc ccactgggct ccttatcctt cttcctgttg
     3781 ccaaaggttt gcatccaggg ctctgctcta ttccagctct gcactccaaa tgccagtcct
     3841 tgaaactagc agcctaggga ccctccaggg tactagtgga tctctgatct aagacggaca
     3901 aactccgtgt tggaaatata cgctctgtgc gcttcctgtg ctgtagcact tgggcttagc
     3961 tgcaaacgtg accttaggga tgggctcagg gttccagagc agggagacag atctgtagca
     4021 acccgacagg cgaccagctc ttctctctgg tctgtctgga aaattactgg tcccactggg
     4081 tccggagaca aaccagagcc ggctctccct ttgtcctgag tccctactct atgaggtagc
     4141 cattgccaga agaggggata ggaaggcacg aggagcagtg gagcgtcagg tccaggagtg
     4201 tctgctggtg gatctccatt cagctcgtcg ctcactgcgt ccgctgagct ttgctgagca
     4261 tcacctcctg aacaaaaaca ctcaaagaaa agtttgcctt gtcctgaact aatctcaccc
     4321 aaacaaggaa cttttttatt ttttattttt tggtaatcca taaaagaggg ggacacatgg
     4381 agcaggtatt tatttccttc tatgtctcca cattgttgaa acttccgcgg tgtttagaga
     4441 ttggaaccag tagagaaatg cacggtggct accactgtga agttggttcc taaaagacta
     4501 aggcacgtcc cagcgcagaa acccgggaag tttgaaatga attaaaacat tttccttcat
     4561 attttaatag tcatgaaaat gcaacaggaa aagagggttt gtgccaaatt ctaagaatgg
     4621 ccctttctga aagacaagca ggggagactc gtgtgtataa tctgctccca cataaaaaga
     4681 gtaaatgtaa cttaatagtt ttgtaaatgg gagagggggg atctataaac tataaatatg
     4741 ttattttatt ttttgtacat ttttaagaag aaaaaataaa tattcacaac atgaaaaaaa
     4801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4861 aaaaaaaaaa a
//
