LOCUS       NM_001105974            3719 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus gremlin 2, DAN family BMP antagonist (Grem2),
            mRNA.
ACCESSION   NM_001105974 XM_001058662 XM_222923
VERSION     NM_001105974.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3719)
  AUTHORS   Zhou X, Xu W, Wang Y, Zhang H, Zhang L, Li C, Yao S, Huang Z, Huang
            L and Luo D.
  TITLE     LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early
            chondrogenic differentiation of rat mesenchymal stem cells under
            hypoxic conditions
  JOURNAL   Cell Mol Biol Lett 26 (1), 22 (2021)
   PUBMED   34049478
  REMARK    GeneRIF: LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress
            early chondrogenic differentiation of rat mesenchymal stem cells
            under hypoxic conditions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3719)
  AUTHORS   Nilsson EE, Larsen G and Skinner MK.
  TITLE     Roles of Gremlin 1 and Gremlin 2 in regulating ovarian primordial
            to primary follicle transition
  JOURNAL   Reproduction 147 (6), 865-874 (2014)
   PUBMED   24614542
  REMARK    GeneRIF: Suggest that Grem2 is a part of the signaling network of
            growth factors that regulate the primordial to primary follicle
            transition.
REFERENCE   3  (bases 1 to 3719)
  AUTHORS   Nolan K, Kattamuri C, Luedeke DM, Deng X, Jagpal A, Zhang F,
            Linhardt RJ, Kenny AP, Zorn AM and Thompson TB.
  TITLE     Structure of protein related to Dan and Cerberus: insights into the
            mechanism of bone morphogenetic protein antagonism
  JOURNAL   Structure 21 (8), 1417-1429 (2013)
   PUBMED   23850456
REFERENCE   4  (bases 1 to 3719)
  AUTHORS   Kattamuri C, Luedeke DM, Nolan K, Rankin SA, Greis KD, Zorn AM and
            Thompson TB.
  TITLE     Members of the DAN family are BMP antagonists that form highly
            stable noncovalent dimers
  JOURNAL   J Mol Biol 424 (5), 313-327 (2012)
   PUBMED   23063586
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_222923.4, XM_001058662.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ130108.1, CB544309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3719
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..3719
                     /gene="Grem2"
                     /gene_synonym="RGD1560008"
                     /note="gremlin 2, DAN family BMP antagonist"
                     /db_xref="GeneID:289264"
                     /db_xref="RGD:1560008"
     exon            1..245
                     /gene="Grem2"
                     /gene_synonym="RGD1560008"
                     /inference="alignment:Splign:2.1.0"
     exon            246..3719
                     /gene="Grem2"
                     /gene_synonym="RGD1560008"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..753
                     /gene="Grem2"
                     /gene_synonym="RGD1560008"
                     /note="gremlin 2 homolog, cysteine knot superfamily;
                     gremlin-2"
                     /codon_start=1
                     /product="gremlin-2 precursor"
                     /protein_id="NP_001099444.1"
                     /db_xref="GeneID:289264"
                     /db_xref="RGD:1560008"
                     /translation="MFWKLSLTLLLVAVLVKVAETRKNRPAGAIPSPYKDGSTNNSER
                     WHHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCN
                     SFYIPRHVKKEEDSFQSCAFCKPQRVTSVIVELECPGLDPPFRIKKIQKVKHCRCMSV
                     NLSDSDKQ"
ORIGIN      
        1 gtgctgtctc cagctccctc cacatctgca ggcgcggcca ggacgcgctc cgccctctgc
       61 gctctcctag gctcccttcg ctctgcacaa cctcgctgtt tccccggcct cctgcagaac
      121 caagctgcag ctgcccggga agatccggcg cacaccccgc tgtggattgt gtcattcaca
      181 cagaggagag ggacagggag acacaccagg gaaccgagaa ggaggcttcc atctcgtcat
      241 tgcaggatgt tctggaagct ctcgctgacc ttgctcctgg tggctgtgct ggtaaaggta
      301 gccgaaacac ggaagaacag gcctgcgggc gccatcccct cgccttacaa ggatggtagc
      361 accaacaact cagagagatg gcatcaccag atcaaggagg tgctggcctc cagccaggag
      421 gccctggtgg tcaccgagcg caagtacctg aagagtgact ggtgcaagac gcagccactg
      481 cggcagacgg tgagcgagga gggttgccgc agccgcacca tcctcaaccg cttttgctat
      541 ggccagtgca actccttcta catcccacga cacgtgaaaa aggaggagga ctccttccaa
      601 tcctgcgctt tctgcaagcc ccagcgtgtc acctctgtca tcgtggagct cgaatgcccg
      661 ggtctcgatc cacctttccg aatcaagaag atccagaagg tgaagcattg ccggtgcatg
      721 tcggtgaacc tcagtgactc tgacaagcag tgaactcacc gcggcaggat gcaagctcag
      781 ccttgagcac ccttccccct gggttgcacc accgccactt ctgttgagct cactcacaat
      841 ctgtccggtg tccctgtcag cagcaaatgc atctcttagg gctaacagcg tccttgtcac
      901 aaatacggac cacaagtgaa gctttgtcga cgtgtccccg atccacccca ggctacactt
      961 gtgtctccaa atccatgttg cggatcggac acagaagatg ttggtaaact ccactcccag
     1021 aaactcgaca ggacttttca ggagatgcac tgccatccgg gattgacgtt tccaccatgt
     1081 ggaaaagcca gtctttccct ggccacatcc tacactccag cttgaccctt cccctggtga
     1141 aggatgcatg actcttctgt tgcaaacttt tgttggccac cagacctctg tggtgtggaa
     1201 attcgttctt ctgacctggg agctgcccag ctctgccgct gctgtaatgc ctatgcgggc
     1261 agcatctcta aaggagatgc tcacctgcaa ggggtccggg aataaacctg gtacccatga
     1321 ggacaagccg agctaagtgg atcaggaaat ggacttccct aggaactgta ctgagcaggc
     1381 aagactcccc acacctctgg acaccaccat gtcttttttc ctcctcatag actccatcta
     1441 aagctcaaga taaactctgg tgcgcatgct attcccgctg ccatggtatc actcacaagg
     1501 tttctgtatt aatgtcagtt ttataattga cctatcacgt taaaaaaaac agttaaaagt
     1561 attatcaaca tattcatata tcaagtcacg tgtttggact ctagctttgc tgcaccattc
     1621 tgaatagaga gtataagcat ggagtgatct gtggaaaaac tgccaggtca gcaattcact
     1681 gccccccccc ccactttttt ccagattaag cagggaggtg ggacacgtca tgattttact
     1741 tttaatacat cacagaagac actaaataaa gctttgtcgc atagtgtaga aatcggatta
     1801 ggacagatgg cacatacaga ggagtcacta ggaagctgta aatcttgaaa ggcacatgtg
     1861 agatgagacc tggtactgtt ttcactgcca ttacacaaag caaacaaata ttttctatta
     1921 aatgatatgg aagaatatac ggtatggaga ctttttttga cacaggcaga aatatagagc
     1981 aaatatagag ggtagtaacg taggtgaact gtccctcaga ggacagctgc ctttacaaag
     2041 agtagacccc taaaaatacc aagaaacatt tcagccatct tcagttttgc tgaggagttg
     2101 ttgaagtctc tgtagtgtgg tcttttgacg tgaggacttt aaattattta ttttccttca
     2161 aaattacact caagttctct ttgtgcaatt tttcccgggg aggcctccct gtgcatggca
     2221 tgtacggaat ctgacaaatg tgaatgagaa gccattggtg ggaatcagaa tatgctaaaa
     2281 cccttgggtt gatcatttct gagtccacgc tcttgccaag aacgggtttc ctagtatgtg
     2341 agagagatga tccataagct gatggagact caagcttctg ggtacttagc aatgatgttg
     2401 gctctccagt ctgccacttg gagaaagagg gttgtgatga gctggggagg gtgtgtcatg
     2461 gagccttttg cctgtattgc aatgcaggtt ttctagttta gttacgtctg ccacacagtg
     2521 accccaagta cagagtgtgt ggttttgaag gggattttag cttcagaaat gagagcgccc
     2581 agcctgggaa caggagagag aaaggagggg aagtggaaaa aaatcacaga gggctggaaa
     2641 ccccagggat gagggcaaaa agtgaagagg gggctagaag tcagagctac agttttacac
     2701 ttttagcaga aaaggtcaag ctagagccag agcagaacat gcagcagaaa agctgtgaag
     2761 gagattatga gtgtccttaa tggaggatga taacgtgtaa ccagaggctg aggagaagat
     2821 tctcacaccc agctgcaaag ccagcctatg ttattctatt aatgggaccc acacattaac
     2881 aagaaaagtt aagttaggaa cccacaaagt atatacatga gcactctttt ttgatcccaa
     2941 tcgtgggtgt acccatgaag gctatatgat atgctatggt ctgaggctat ttcttggctt
     3001 attgtatgta tacagtttac ctttgaatgg ctcaaattgt atttaaattt tgtcttgttt
     3061 ataaatgaag aaaagctata agtataatgt aattatttta taggtatact attaagttat
     3121 agaacaaata aagatactct aggattctat gtgatcctgg catcatgtgc cataaaaact
     3181 gaattctgca cttgtgtcct tgggtagcaa aggattgtgg tgcactcaga gtgcatttat
     3241 ccagcctctg cgagttcacc cttggctcct atcacaaacg ttccttgggg gcttgagatc
     3301 ttctaagaga atcagaaaca ggcatcaagc aagcagatct gatgaggatg gttctcacat
     3361 ccagtctcta ggaacttcaa gccttttttg agacacccac cagttgaatc cagaatgtac
     3421 tcacagtgtt cttggaagaa gagatattga atgagaaagc tttgcacgaa agatgcaaag
     3481 agaagtccac tgtcagtttc ctcttctctc ctgtagccag tgcaccacac tcatgtctta
     3541 cagaagccag aaattatgtt gttttgtttc attctatgtt gactttccac gggtttcgac
     3601 atttattaat ttaaacatat ctcagcctca cagtgttgtc attttcctgc aaactgagtt
     3661 atctgccatt taagacatgc aacaatcaat aaaagaaata aaaaccttga taaaattgc
//
