LOCUS       NM_019282               3809 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus gremlin 1, DAN family BMP antagonist (Grem1),
            mRNA.
ACCESSION   NM_019282
VERSION     NM_019282.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3809)
  AUTHORS   Guan,X., Shi,C., Wang,Y., He,Y., Li,Y., Yang,Y., Mu,W., Li,W. and
            Hou,T.
  TITLE     The possible role of Gremlin1 in inflammatory apical periodontitis
  JOURNAL   Arch Oral Biol 157, 105848 (2024)
   PUBMED   37977053
  REMARK    GeneRIF: The possible role of Gremlin1 in inflammatory apical
            periodontitis.
REFERENCE   2  (bases 1 to 3809)
  AUTHORS   Guan,X., He,Y., Li,Y., Shi,C., Wei,Z., Zhao,R., Han,Y., Pan,L.,
            Yang,J. and Hou,T.
  TITLE     Gremlin aggravates periodontitis via activation of the nuclear
            factor-kappa B signaling pathway
  JOURNAL   J Periodontol 93 (10), 1589-1602 (2022)
   PUBMED   34993960
  REMARK    GeneRIF: Gremlin aggravates periodontitis via activation of the
            nuclear factor-kappa B signaling pathway.
REFERENCE   3  (bases 1 to 3809)
  AUTHORS   Chen,S., Lei,L., Li,Z., Chen,F., Huang,Y., Jiang,G., Guo,X.,
            Zhao,Z., Liu,H., Wang,H., Liu,C., Zheng,Z. and Wang,J.
  TITLE     Grem1 accelerates nucleus pulposus cell apoptosis and
            intervertebral disc degeneration by inhibiting TGF-beta-mediated
            Smad2/3 phosphorylation
  JOURNAL   Exp Mol Med 54 (4), 518-530 (2022)
   PUBMED   35440754
  REMARK    GeneRIF: Grem1 accelerates nucleus pulposus cell apoptosis and
            intervertebral disc degeneration by inhibiting TGF-beta-mediated
            Smad2/3 phosphorylation.
REFERENCE   4  (bases 1 to 3809)
  AUTHORS   Meng,L., Teng,X., Liu,Y., Yang,C., Wang,S., Yuan,W., Meng,J.,
            Chi,H., Duan,L. and Liu,X.
  TITLE     Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced
            by Systemic-to-Pulmonary Shunts
  JOURNAL   J Am Heart Assoc 9 (15), e016586 (2020)
   PUBMED   32750294
  REMARK    GeneRIF: Vital Roles of Gremlin-1 in Pulmonary Arterial
            Hypertension Induced by Systemic-to-Pulmonary Shunts.
REFERENCE   5  (bases 1 to 3809)
  AUTHORS   Feng,Z., Zhang,X., Li,L., Wang,C., Feng,M., Zhao,K., Zhao,R.,
            Liu,J. and Fang,Y.
  TITLE     Tumor-associated macrophage-derived exosomal microRNA-155-5p
            stimulates intracranial aneurysm formation and macrophage
            infiltration
  JOURNAL   Clin Sci (Lond) 133 (22), 2265-2282 (2019)
   PUBMED   31657855
  REMARK    GeneRIF: Tumor-associated macrophage-derived exosomal miR-155-5p
            promotes intracranial aneurysm formation via GREM1.
REFERENCE   6  (bases 1 to 3809)
  AUTHORS   Chen,B., Athanasiou,M., Gu,Q. and Blair,D.G.
  TITLE     Drm/Gremlin transcriptionally activates p21(Cip1) via a novel
            mechanism and inhibits neoplastic transformation
  JOURNAL   Biochem Biophys Res Commun 295 (5), 1135-1141 (2002)
   PUBMED   12135612
REFERENCE   7  (bases 1 to 3809)
  AUTHORS   Topol,L.Z., Bardot,B., Zhang,Q., Resau,J., Huillard,E., Marx,M.,
            Calothy,G. and Blair,D.G.
  TITLE     Biosynthesis, post-translation modification, and functional
            characterization of Drm/Gremlin
  JOURNAL   J Biol Chem 275 (12), 8785-8793 (2000)
   PUBMED   10722723
REFERENCE   8  (bases 1 to 3809)
  AUTHORS   Merino,R., Rodriguez-Leon,J., Macias,D., Ganan,Y., Economides,A.N.
            and Hurle,J.M.
  TITLE     The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and
            programmed cell death in the developing limb
  JOURNAL   Development 126 (23), 5515-5522 (1999)
   PUBMED   10556075
REFERENCE   9  (bases 1 to 3809)
  AUTHORS   Hsu,D.R., Economides,A.N., Wang,X., Eimon,P.M. and Harland,R.M.
  TITLE     The Xenopus dorsalizing factor Gremlin identifies a novel family of
            secreted proteins that antagonize BMP activities
  JOURNAL   Mol Cell 1 (5), 673-683 (1998)
   PUBMED   9660951
REFERENCE   10 (bases 1 to 3809)
  AUTHORS   Topol,L.Z., Marx,M., Laugier,D., Bogdanova,N.N., Boubnov,N.V.,
            Clausen,P.A., Calothy,G. and Blair,D.G.
  TITLE     Identification of drm, a novel gene whose expression is suppressed
            in transformed cells and which can inhibit growth of normal but not
            transformed cells in culture
  JOURNAL   Mol Cell Biol 17 (8), 4801-4810 (1997)
   PUBMED   9234736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Y10019.1 and JAXUCZ010000003.1.
            
            On Jul 6, 2012 this sequence version replaced NM_019282.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.3342759.1,
                                           SRR26360172.744102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                Y10019.1           1-29
            30-2878             JAXUCZ010000003.1  120966639-120969487 c
            2879-3808           Y10019.1           30-959
            3809-6657           JAXUCZ010000003.1  120966639-120969487 c
FEATURES             Location/Qualifiers
     source          1..3809
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..3809
                     /gene="Grem1"
                     /gene_synonym="Cktsf1b1; drm"
                     /note="gremlin 1, DAN family BMP antagonist"
                     /db_xref="GeneID:50566"
                     /db_xref="RGD:2359"
     exon            1..138
                     /gene="Grem1"
                     /gene_synonym="Cktsf1b1; drm"
                     /inference="alignment:Splign:2.1.0"
     exon            139..3809
                     /gene="Grem1"
                     /gene_synonym="Cktsf1b1; drm"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..694
                     /gene="Grem1"
                     /gene_synonym="Cktsf1b1; drm"
                     /note="gremlin-1; down-regulated in Mos-transformed cells
                     protein; gremlin 1 homolog, cysteine knot superfamily;
                     cysteine knot superfamily 1, BMP antagonist 1"
                     /codon_start=1
                     /product="gremlin-1 precursor"
                     /protein_id="NP_062155.1"
                     /db_xref="GeneID:50566"
                     /db_xref="RGD:2359"
                     /translation="MNRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDS
                     EQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQT
                     IHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPE
                     LQPPTKKKRVTRVKQCRCISIDLD"
ORIGIN      
        1 acctggggag ccagagcacc gcagtagcgg cactttcctt cgtgttcttc ccgcgtcgag
       61 cccgagtggc tccggccgcg gtcgcacgca acgccacgcg tccacagcga aggacttgag
      121 gatccactga ggtgacagaa tgaatcgcac ggcatacacc gtaggagctt tgcttctcct
      181 cctgggaacc ctactgccag cagctgaagg gaaaaagaaa gggtcccaag gagccatccc
      241 acctcctgac aaggctcagc acaatgactc cgagcagacc cagtccccac cacaacctgg
      301 ctccaggacc cgggggcggg gccaggggcg gggcaccgcc atgcctggag aggaggtgct
      361 tgagtccagc caagaggccc tgcatgtgac agagcgcaaa tacctgaagc gagattggtg
      421 caaaactcag cccctgaagc agaccatcca tgaggagggc tgcaacagcc gcactatcat
      481 caatcgcttc tgttacggcc agtgcaactc cttctacatc cccaggcata tccgaaaaga
      541 ggaaggctcc tttcagtctt gctccttctg caagcccaag aaattcacca ccatgatggt
      601 cacactcaac tgtcctgagc tacagccacc caccaagaag aaaagagtca cacgcgtgaa
      661 gcagtgtcgt tgcatatcca tcgacttgga ttaagtcaaa gggggcacat tcagcctgtc
      721 atagccatgc cgagagccac acccaaacca cccgattcct acttggctta aacctagagg
      781 ccagaagaac cagcagttgc ttcctggctg gaggctgctt atgcatagag tatgcgcatg
      841 agtgtgcatg ggtacctgtg ggtgtttcca aacaccagcg gaaacagcct ctgcaggaag
      901 gcacttcctg ttactgtgct tcagatggtc ggaaatgctc acaccactgg acccaacacc
      961 cacaggggca gggctgtagt tgactttgac cttgtgttcc atgtgcctcc tgggcaccag
     1021 gatttcattt gagaatgaat actaacggag gaggtaactc tgagggccgc attagactcg
     1081 gaactgtttg ttcagtgctc tcccacaacc cattcctttc tttgctctcc ctgaccttag
     1141 tccatgttct taaattaatt cacttgatgt gagtgtaaat ttctttcgtc ttgtgaagaa
     1201 ccttcagagt gtggggagac aagtgataaa ggcaaacaga acaggggatt gacacaggag
     1261 cattgagact gaggactagt ctggccagtg aaattcagta gcaagatgtt cagagtttaa
     1321 agattgttcc ccccaaacaa tatgagtctt gttttagcaa aggggcttta ctgatattta
     1381 aaagaaccca gacagacaga ggagaaatat aatcagcaaa aaaaccaatt ctctgtgccg
     1441 gtatctgtga cctactgaca atatctgtaa tccaatgtta agggtgaaat attgaccact
     1501 tctgttttaa gaaccaagtg aaaggaaaaa aaaaatatgg ccttctactt actttgcctc
     1561 tcaggaggat gactgagagc gttgttcgct agggtaagaa agacaaaacc tcctaggctt
     1621 agttttgctg gattaacatt gctttcccat cattcctgaa aaaatgcttc agagatgcag
     1681 aaccttccaa taaaatcgtg cttttcttga gaccatttgc cagtaagggt cagtgttaga
     1741 tgagagagct gtctgctgca tgtgagttag acatgtctgg ggcttcttct gtttggcttt
     1801 tgttatagga gagaaccaga gatgagagag ctgatgagag aacagagaga gagagagagg
     1861 gggccaatcc cttagggaag cactagggta tattaacagg ccacctacac ccaatggatc
     1921 tatgtgacat tgtaatcatt atgcctacta tggatgctgt cctctgaata cacatggctg
     1981 cccaatgtct acttagcatc tatgtaaggg ccagagaaag gtgactgggc cttggtacat
     2041 tttggtttgg ctaagcaata ctctttaaga ctgacattct agctataaat gccccagata
     2101 ctttttttgc cttttcctct cagagcgact agtcaagtga tatgtcattt ggaaggcaga
     2161 cattcactgc ccatcaaaga taccacagtc aaagaaccat tgggagtaaa gaaacttttt
     2221 gttttggtct agcccacccg cccatgtaac atcgaaacag gaaccatatt acaaggcaaa
     2281 agctatcttg aattcccaaa acactgggtc taattttgaa agtttaaaag tcactggtga
     2341 tgactccaca gtaagtgaac ttgtgcgagc atagccgtga gtttcatttg tactgcgtgc
     2401 tccttcactg aatctttgag gcttccatat ccatagccac atagtcacag ggtggatttg
     2461 attaggccca cacatacaaa ggtgggtttg gagggtggtg aagagggaaa aataagagag
     2521 gatgaagatg aaaatataga cccacaccag agaggaaaaa tgacactcgg tgctgaaaaa
     2581 cactgtgtcc catcttaatt ctgccacaaa catgcagtct tgctaaaaat caacaacaac
     2641 aataataaaa acgtttggca gccacagtta cctttaggag cttgtaccac agtctctctt
     2701 gtaagctgga tttagatttg gttcttgagg attgcctcaa aattaacttc tttgaaacga
     2761 tcagcagcat aagtgcccta aaagcacatc accggccaac ggctgggacg tctgccttcc
     2821 ttgccgtgcc tagatcgaga ccatcagaaa tgtgtccgct gccgtttatt ggagatgccc
     2881 cgtctgtcgc tgattctgga cgcaccagcg atgcaaggat ggacactttc tccaacattg
     2941 tagtagaacc aatttttttt agcaagcttt gttgcagtct ccaccttacc tgttaaaata
     3001 atgccagaaa ccaaatatga atcttacggc attcaatttg tgcttggcac tgaaagagga
     3061 aagccacaca ccagataagt ctgagtgccc ctttgccatt gtactcttca aagtgagaaa
     3121 cctggaggaa ggatagtttc caccatgtgg aatgtgaata agcaaaagag ttatggttat
     3181 ttaatgtaat taggaattct aggtccttcg gttactgtga tttcgaatgt tttctttctc
     3241 tgttttatac gacagcctct gagttgggca aagaagaaac aggccgttgt atgttgctag
     3301 agactttcgt caggtcaggg ggacacacag tcttgtcaca tatgaagaga tgttaccaag
     3361 tcaacgacaa gccttatttt ttaacgttga atgttcctta aaggctgaca cttctgaagc
     3421 aatgttagga aagactttaa atgttatttt gagagacttc tgtgcgtata caagcagata
     3481 atgacggcta gttcagacaa gcagaacatt tctaaacgag aagtccgagc tgaacgactg
     3541 aaagagattc ctcgccatat tgaatatcat ctacattgtg tatttaatat actttaatca
     3601 ttttgaaaca acgaaggatt atgcaggcta tgacggaact actaccttgc tatggatgag
     3661 ggttgggcag gatttaatgg tctcatagaa gctaatttgg cttaaagttt tatgaatctg
     3721 taactagaat tttattttca ccctaataac attctatata acctttgcca aaaaagcaat
     3781 caataaatta aacctcttct ttctgtgca
//
