LOCUS       NM_001198725             759 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus gene rich cluster, C10 gene (Grcc10), mRNA.
ACCESSION   NM_001198725 XM_002726446 XM_002729427
VERSION     NM_001198725.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Platzer,K., Huning,I., Obieglo,C., Schwarzmayr,T., Gabriel,R.,
            Strom,T.M., Gillessen-Kaesbach,G. and Kaiser,F.J.
  TITLE     Exome sequencing identifies compound heterozygous mutations in
            C12orf57 in two siblings with severe intellectual disability,
            hypoplasia of the corpus callosum, chorioretinal coloboma, and
            intractable seizures
  JOURNAL   Am J Med Genet A 164A (8), 1976-1980 (2014)
   PUBMED   24798461
  REMARK    Review article
REFERENCE   2  (bases 1 to 759)
  AUTHORS   Salih,M.A., Tzschach,A., Oystreck,D.T., Hassan,H.H., AlDrees,A.,
            Elmalik,S.A., El Khashab,H.Y., Wienker,T.F., Abu-Amero,K.K. and
            Bosley,T.M.
  TITLE     A newly recognized autosomal recessive syndrome affecting
            neurologic function and vision
  JOURNAL   Am J Med Genet A 161A (6), 1207-1213 (2013)
   PUBMED   23633300
REFERENCE   3  (bases 1 to 759)
  AUTHORS   Akizu,N., Shembesh,N.M., Ben-Omran,T., Bastaki,L., Al-Tawari,A.,
            Zaki,M.S., Koul,R., Spencer,E., Rosti,R.O., Scott,E., Nickerson,E.,
            Gabriel,S., da Gente,G., Li,J., Deardorff,M.A., Conlin,L.K.,
            Horton,M.A., Zackai,E.H., Sherr,E.H. and Gleeson,J.G.
  TITLE     Whole-exome sequencing identifies mutated c12orf57 in recessive
            corpus callosum hypoplasia
  JOURNAL   Am J Hum Genet 92 (3), 392-400 (2013)
   PUBMED   23453666
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Zahrani,F., Aldahmesh,M.A., Alshammari,M.J., Al-Hazzaa,S.A. and
            Alkuraya,F.S.
  TITLE     Mutations in c12orf57 cause a syndromic form of colobomatous
            microphthalmia
  JOURNAL   Am J Hum Genet 92 (3), 387-391 (2013)
   PUBMED   23453665
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM049692.1, FM062242.1 and JAXUCZ010000004.1.
            
            On or before Nov 10, 2010 this sequence version replaced
            XM_002729427.1, XM_002726446.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN543740.1, BQ206797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               FM049692.1         1-467
            468-753             FM062242.1         247-532
            754-759             JAXUCZ010000004.1  159237562-159237567 c
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..759
                     /gene="Grcc10"
                     /note="gene rich cluster, C10 gene"
                     /db_xref="GeneID:100362005"
                     /db_xref="RGD:2318975"
     exon            1..351
                     /gene="Grcc10"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..680
                     /gene="Grcc10"
                     /note="C10 protein; protein C10-like"
                     /codon_start=1
                     /product="protein C10"
                     /protein_id="NP_001185654.1"
                     /db_xref="GeneID:100362005"
                     /db_xref="RGD:2318975"
                     /translation="MASASAQPAALSAEQAKVVLAEVIQAFSAPENAVRMDEARDNAC
                     NDMGKMLQFVLPVATQIQQEVIKAYGFSCDGEGVLKFARLVKSYEAQDPEIASLSGKL
                     KALFLPPMTLPPHGPASGSSVAAS"
     exon            352..528
                     /gene="Grcc10"
                     /inference="alignment:Splign:2.1.0"
     exon            529..759
                     /gene="Grcc10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttttaga atttgtctag taggttttct gacttcggtc ggaaaacccc tcccaacctg
       61 actggtttct aatatcagca agtagttact gtcctcgccg agctatgggg ctgggggctt
      121 tcggcccact ctagtttcct aggaagtacg cgtgtgctag attcacgctc gggaacttcc
      181 gcctcctgca atacagcttc ctttctgcct ccacaggtcc gcagccgtgg gggaggcggc
      241 tggctgcagg ctcctccgga tctcagtgtt cacactattc aagcaccgag tggcgtccta
      301 tggcgtccgc ctcggctcag cctgcggctc tgagcgcaga gcaggccaag gtggtcttgg
      361 cggaggtgat ccaagcgttc tcggccccag agaacgccgt gcgtatggac gaggctagag
      421 acaatgcgtg caacgatatg ggcaagatgc tgcaattcgt gctgcctgta gccacacaga
      481 tccagcagga ggttattaaa gcctatggct tcagctgcga cggggaaggt gtccttaagt
      541 ttgcccgcct ggtcaagtct tacgaagccc aggatcctga gattgccagc ctgtcaggca
      601 agctaaaggc cttgttcctg ccacccatga cactaccacc ccacgggcct gcttccggaa
      661 gcagtgtggc tgcctcctga gattgattct tttctgtgtg ccgctgctat gaaggaggcc
      721 cttgtgttcc agaggataat aaatgtgctt gtggctaaa
//
