LOCUS       NM_053403               2445 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus growth factor receptor bound protein 7 (Grb7),
            mRNA.
ACCESSION   NM_053403
VERSION     NM_053403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2445)
  AUTHORS   Gotovac,J.R., Liu,D.S., Yates,M.J., Milne,J.V., Macpherson,A.A.,
            Simpson,K.J., Eslick,G.D., Mitchell,C., Duong,C.P., Phillips,W.A.
            and Clemons,N.J.
  TITLE     GRB7 is an oncogenic driver and potential therapeutic target in
            oesophageal adenocarcinoma
  JOURNAL   J Pathol 252 (3), 317-329 (2020)
   PUBMED   32737994
REFERENCE   2  (bases 1 to 2445)
  AUTHORS   Stroes,C.I., Schokker,S., Creemers,A., Molenaar,R.J.,
            Hulshof,M.C.C.M., van der Woude,S.O., Bennink,R.J., Mathot,R.A.A.,
            Krishnadath,K.K., Punt,C.J.A., Verhoeven,R.H.A., van Oijen,M.G.H.,
            Creemers,G.J., Nieuwenhuijzen,G.A.P., van der Sangen,M.J.C.,
            Beerepoot,L.V., Heisterkamp,J., Los,M., Slingerland,M., Cats,A.,
            Hospers,G.A.P., Bijlsma,M.F., van Berge Henegouwen,M.I.,
            Meijer,S.L. and van Laarhoven,H.W.M.
  TITLE     Phase II Feasibility and Biomarker Study of Neoadjuvant Trastuzumab
            and Pertuzumab With Chemoradiotherapy for Resectable Human
            Epidermal Growth Factor Receptor 2-Positive Esophageal
            Adenocarcinoma: TRAP Study
  JOURNAL   J Clin Oncol 38 (5), 462-471 (2020)
   PUBMED   31809243
REFERENCE   3  (bases 1 to 2445)
  AUTHORS   Lundby,A., Franciosa,G., Emdal,K.B., Refsgaard,J.C., Gnosa,S.P.,
            Bekker-Jensen,D.B., Secher,A., Maurya,S.R., Paul,I., Mendez,B.L.,
            Kelstrup,C.D., Francavilla,C., Kveiborg,M., Montoya,G., Jensen,L.J.
            and Olsen,J.V.
  TITLE     Oncogenic Mutations Rewire Signaling Pathways by Switching Protein
            Recruitment to Phosphotyrosine Sites
  JOURNAL   Cell 179 (2), 543-560 (2019)
   PUBMED   31585087
REFERENCE   4  (bases 1 to 2445)
  AUTHORS   Tsai,N.P., Lin,Y.L., Tsui,Y.C. and Wei,L.N.
  TITLE     Dual action of epidermal growth factor: extracellular
            signal-stimulated nuclear-cytoplasmic export and coordinated
            translation of selected messenger RNA
  JOURNAL   J Cell Biol 188 (3), 325-333 (2010)
   PUBMED   20142421
  REMARK    GeneRIF: EGF also activates focal adhesion kinase in the cytoplasm
            to rephosphorylate Grb7, releasing KOR mRNA for active translation.
REFERENCE   5  (bases 1 to 2445)
  AUTHORS   Tsai,N.P., Ho,P.C. and Wei,L.N.
  TITLE     Regulation of stress granule dynamics by Grb7 and FAK signalling
            pathway
  JOURNAL   EMBO J 27 (5), 715-726 (2008)
   PUBMED   18273060
REFERENCE   6  (bases 1 to 2445)
  AUTHORS   Tanaka,S., Sugimachi,K., Kawaguchi,H., Saeki,H., Ohno,S. and
            Wands,J.R.
  TITLE     Grb7 signal transduction protein mediates metastatic progression of
            esophageal carcinoma
  JOURNAL   J Cell Physiol 183 (3), 411-415 (2000)
   PUBMED   10797316
REFERENCE   7  (bases 1 to 2445)
  AUTHORS   Kasus-Jacobi,A., Bereziat,V., Perdereau,D., Girard,J. and
            Burnol,A.F.
  TITLE     Evidence for an interaction between the insulin receptor and Grb7.
            A role for two of its binding domains, PIR and SH2
  JOURNAL   Oncogene 19 (16), 2052-2059 (2000)
   PUBMED   10803466
REFERENCE   8  (bases 1 to 2445)
  AUTHORS   Kasus-Jacobi,A., Perdereau,D., Auzan,C., Clauser,E., Van
            Obberghen,E., Mauvais-Jarvis,F., Girard,J. and Burnol,A.F.
  TITLE     Identification of the rat adapter Grb14 as an inhibitor of insulin
            actions
  JOURNAL   J Biol Chem 273 (40), 26026-26035 (1998)
   PUBMED   9748281
REFERENCE   9  (bases 1 to 2445)
  AUTHORS   Kishi,T., Sasaki,H., Akiyama,N., Ishizuka,T., Sakamoto,H.,
            Aizawa,S., Sugimura,T. and Terada,M.
  TITLE     Molecular cloning of human GRB-7 co-amplified with CAB1 and
            c-ERBB-2 in primary gastric cancer
  JOURNAL   Biochem Biophys Res Commun 232 (1), 5-9 (1997)
   PUBMED   9125150
REFERENCE   10 (bases 1 to 2445)
  AUTHORS   Tanaka,S., Mori,M., Akiyoshi,T., Tanaka,Y., Mafune,K., Wands,J.R.
            and Sugimachi,K.
  TITLE     Coexpression of Grb7 with epidermal growth factor receptor or
            Her2/erbB2 in human advanced esophageal carcinoma
  JOURNAL   Cancer Res 57 (1), 28-31 (1997)
   PUBMED   8988034
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081757.1.
            
            On Sep 16, 2004 this sequence version replaced NM_053403.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081757.1, AF190121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132268
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2445
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2445
                     /gene="Grb7"
                     /note="growth factor receptor bound protein 7"
                     /db_xref="GeneID:84427"
                     /db_xref="RGD:619759"
     exon            1..443
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            444..600
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     CDS             449..2056
                     /gene="Grb7"
                     /note="growth factor receptor binding protein GRB7; GRB7
                     adapter protein; epidermal growth factor receptor GRB-7"
                     /codon_start=1
                     /product="growth factor receptor-bound protein 7"
                     /protein_id="NP_445855.1"
                     /db_xref="GeneID:84427"
                     /db_xref="RGD:619759"
                     /translation="MELDLSPSHLSSSPEDVCPTPGTPPETPPPPDNPPPGDVKRSQP
                     LPIPSSRKLREEEFQATSLPSIPNPFPELCSPPSQKPILGGSSGARGLLPRDSSRLCV
                     VKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDENWGLVECHPYLALERGLEDH
                     ESVVEVQEAWPVGGDSRFIFRKNFAKYELFKSPPHTLFPEKMVSSCLDTPTGISHEDL
                     IQNFLNAGSFPEIQGFLQLRGSGRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQ
                     YVADINESNVYVVTQGRKLYGIPTDFGFCVKPNKLRNGHKGLHIFCSEDEQSRTCWLS
                     AFRLFKYGVQLYKNYQQAQSRHLRLSYLGSPPLRSVSDNTLVAMDFSGHAGRVIENPQ
                     EALSAATEEAQAWRKKTNHRLSLPTPCSGLSLSAAIHRTQPWFHGRISREESQRLIGQ
                     QGLVDGVFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEDEGCLYFSMDDGQTRFTDL
                     LQLVEFHQLNRGILPCLLRHCCARVAL"
     exon            601..751
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            752..908
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1030
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1108
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1258
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1369
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1468
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1549
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1666
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1727
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1815
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1909
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2420
                     /gene="Grb7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacagcctcc aaactcccct tcccatgtag tcaggattct agatttttct ctttccagcc
       61 tgttctcttt gactcttcct tgcctctgcc gggcacctgc tctctctcct agcacctgct
      121 gccctgtagg aagggcaaga gccaattcca ggcggtgcac agtgaggagt ctccacccct
      181 cctcctgcgc ttccttctcc agggcgcctc tcaggccccg ccctcacctg cccaagataa
      241 ttttagtttc cctgggcctg gaatctggat acgcagggct cgctccatat tctcccgcct
      301 caacatccaa aggcgggcta accctcctac cacctggaga gaagagagag agggttcgaa
      361 atcaaatcca agggtctggg acctctagac agagccagcc tttgggtccc ggtgtcccgc
      421 tccttctgct ggagttcctc caggtgccat ggaactggat ctgagcccgt ctcatctcag
      481 cagctcccca gaagatgtgt gcccaactcc tgggacccct cccgagactc ctccgccccc
      541 ggataaccct ccgcccggcg atgtgaagcg gtctcagcct ttgcccatcc caagtagcag
      601 gaaacttcga gaagaggagt ttcaggcaac ctctctaccc tccatcccca accccttccc
      661 cgagctctgc agcccacctt cacagaaacc cattcttggt ggttcctccg gtgctagggg
      721 gttgcttcct cgagactcca gccgcctctg tgtggtgaag gtgtacagtg aagatggagc
      781 ctgccggtct gtggaagtgg cggcaggtgc gacggctcgc catgtgtgtg agatgctggt
      841 gcagcgagct cacgccctga gcgatgagaa ctggggcctg gtggagtgcc acccctattt
      901 ggctctggag cggggtttgg aggaccatga gtctgtggta gaagtgcagg aggcctggcc
      961 tgtgggtgga gacagccgct tcatcttccg taaaaacttc gccaagtatg aactcttcaa
     1021 gagccctccg cacaccctgt tcccagaaaa gatggtttcc agctgtctgg atacaccaac
     1081 aggcatatcc catgaagacc tcatccagaa cttcctgaat gctggcagct tccctgagat
     1141 ccagggcttc ctgcagcttc ggggatcagg ccgggggtca ggtcgaaagc tttggaaacg
     1201 attcttctgc ttcctgcgtc ggtctggcct ctattactcg accaagggca cctctaagga
     1261 cccgagacac ctacagtacg tggcagatat aaatgagtcc aatgtgtatg tggtgaccca
     1321 gggccgcaag ctgtatggga tacccaccga cttcggcttt tgtgtcaagc ccaacaagct
     1381 tcgaaatggc cacaaggggc tccacatctt ctgcagcgag gatgagcaga gtcggacttg
     1441 ctggctgtcc gccttccggc tcttcaagta cggggtacag ctatataaga attatcagca
     1501 ggcccagtct cgtcacctgc gcttatcgta tttggggtct ccacccttga ggagtgtctc
     1561 agataatacc ctggtggcca tggacttctc tggccatgct gggcgtgtca ttgagaaccc
     1621 ccaggaagct ctgagtgctg ccacggagga agcccaggcc tggaggaaga agacaaacca
     1681 ccgtctcagc ctgcccaccc cgtgctccgg cctgagcctc agtgcagcta tccatcgcac
     1741 ccagccctgg tttcatggac gaatctcccg ggaggagagc cagcggctaa ttggacagca
     1801 gggcctggtg gatggtgtat tcctggtccg ggagagccag cggaacccac agggcttcgt
     1861 tctgtctctg tgccatctgc agaaagtcaa acattatctc atcttgccaa gcgaagatga
     1921 aggctgcctt tacttcagca tggatgacgg ccagacccgt ttcacagacc tgctgcagct
     1981 ggtggaattc caccagctga accgaggcat cctgccctgc ttgctgcgcc actgctgtgc
     2041 ccgtgtggcc ctctgaggcc acacaagctg ttacagccat ggggctgctt atcgcccttc
     2101 tgctccgttc agtggactcg gtgcagatgg gtgggatgat aaacagatga agagctcccc
     2161 ccacttttct cccacttttt tttttacctc cctcaggtaa tgaaacatcc cccagccctg
     2221 ttcatccctg actcctgtcc ccaaaggagg cattgtggtc ctctcccctt ggtagagctc
     2281 ctgaggcagt gaagggcatt atgagaggag taggggcagc ccgggtggtc tcatgcccca
     2341 cccacactct gtacagactg agaggccagt tgatctgctc tgttttatac cagtgataat
     2401 aaagattatt ttttgataca aaaaaaaaaa aaaaaaaaaa aaaaa
//
