LOCUS       NM_031623               1954 bp    mRNA    linear   ROD 16-FEB-2024
DEFINITION  Rattus norvegicus growth factor receptor bound protein 14 (Grb14),
            mRNA.
ACCESSION   NM_031623 XM_346655
VERSION     NM_031623.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1954)
  AUTHORS   Eze,I.C., Imboden,M., Kumar,A., von Eckardstein,A., Stolz,D.,
            Gerbase,M.W., Kunzli,N., Pons,M., Kronenberg,F., Schindler,C. and
            Probst-Hensch,N.
  TITLE     Air pollution and diabetes association: Modification by type 2
            diabetes genetic risk score
  JOURNAL   Environ Int 94, 263-271 (2016)
   PUBMED   27281273
REFERENCE   2  (bases 1 to 1954)
  AUTHORS   Perdereau,D., Cailliau,K., Browaeys-Poly,E., Lescuyer,A., Carre,N.,
            Benhamed,F., Goenaga,D. and Burnol,A.F.
  TITLE     Insulin-induced cell division is controlled by the adaptor Grb14 in
            a Chfr-dependent manner
  JOURNAL   Cell Signal 27 (4), 798-806 (2015)
   PUBMED   25578860
  REMARK    GeneRIF: These results show that Chfr and Grb14 collaborate in a
            negative feedback loop controlling insulin-stimulated cell
            division.
REFERENCE   3  (bases 1 to 1954)
  AUTHORS   Rajala,R.V., Basavarajappa,D.K., Dighe,R. and Rajala,A.
  TITLE     Spatial and temporal aspects and the interplay of Grb14 and protein
            tyrosine phosphatase-1B on the insulin receptor phosphorylation
  JOURNAL   Cell Commun Signal 11, 96 (2013)
   PUBMED   24350791
  REMARK    GeneRIF: The phosphorylation status of the BPS region of Grb14
            determines the positive or negative role it will play in insulin
            receptor signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1954)
  AUTHORS   Yang,H.C., Liang,Y.J., Chen,J.W., Chiang,K.M., Chung,C.M., Ho,H.Y.,
            Ting,C.T., Lin,T.H., Sheu,S.H., Tsai,W.C., Chen,J.H., Leu,H.B.,
            Yin,W.H., Chiu,T.Y., Chern,C.L., Lin,S.J., Tomlinson,B., Guo,Y.,
            Sham,P.C., Cherny,S.S., Lam,T.H., Thomas,G.N. and Pan,W.H.
  TITLE     Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension
            susceptibility genes in Han Chinese with a genome-wide gene-based
            association study
  JOURNAL   PLoS One 7 (3), e32907 (2012)
   PUBMED   22479346
REFERENCE   5  (bases 1 to 1954)
  AUTHORS   Browaeys-Poly,E., Blanquart,C., Perdereau,D., Antoine,A.F.,
            Goenaga,D., Luzy,J.P., Chen,H., Garbay,C., Issad,T., Cailliau,K.
            and Burnol,A.F.
  TITLE     Grb14 inhibits FGF receptor signaling through the regulation of
            PLCgamma recruitment and activation
  JOURNAL   FEBS Lett 584 (21), 4383-4388 (2010)
   PUBMED   20932831
REFERENCE   6  (bases 1 to 1954)
  AUTHORS   Moncoq,K., Broutin,I., Craescu,C.T., Vachette,P., Ducruix,A. and
            Durand,D.
  TITLE     SAXS study of the PIR domain from the Grb14 molecular adaptor: a
            natively unfolded protein with a transient structure primer?
  JOURNAL   Biophys J 87 (6), 4056-4064 (2004)
   PUBMED   15465854
REFERENCE   7  (bases 1 to 1954)
  AUTHORS   Moncoq,K., Broutin,I., Larue,V., Perdereau,D., Cailliau,K.,
            Browaeys-Poly,E., Burnol,A.F. and Ducruix,A.
  TITLE     The PIR domain of Grb14 is an intrinsically unstructured protein:
            implication in insulin signaling
  JOURNAL   FEBS Lett 554 (3), 240-246 (2003)
   PUBMED   14623073
REFERENCE   8  (bases 1 to 1954)
  AUTHORS   Lyons,R.J., Deane,R., Lynch,D.K., Ye,Z.S., Sanderson,G.M.,
            Eyre,H.J., Sutherland,G.R. and Daly,R.J.
  TITLE     Identification of a novel human tankyrase through its interaction
            with the adaptor protein Grb14
  JOURNAL   J Biol Chem 276 (20), 17172-17180 (2001)
   PUBMED   11278563
REFERENCE   9  (bases 1 to 1954)
  AUTHORS   Reilly,J.F., Mickey,G. and Maher,P.A.
  TITLE     Association of fibroblast growth factor receptor 1 with the adaptor
            protein Grb14. Characterization of a new receptor binding partner
  JOURNAL   J Biol Chem 275 (11), 7771-7778 (2000)
   PUBMED   10713090
REFERENCE   10 (bases 1 to 1954)
  AUTHORS   Kasus-Jacobi,A., Perdereau,D., Auzan,C., Clauser,E., Van
            Obberghen,E., Mauvais-Jarvis,F., Girard,J. and Burnol,A.F.
  TITLE     Identification of the rat adapter Grb14 as an inhibitor of insulin
            actions
  JOURNAL   J Biol Chem 273 (40), 26026-26035 (1998)
   PUBMED   9748281
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000115.1.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_031623.3.
            
            On Nov 27, 2020 this sequence version replaced NM_031623.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF076619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093047 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               JACYVU010000115.1  43140373-43140626   c
            255-387             JACYVU010000115.1  43139014-43139146   c
            388-544             JACYVU010000115.1  43065748-43065904   c
            545-666             JACYVU010000115.1  43050796-43050917   c
            667-741             JACYVU010000115.1  43048872-43048946   c
            742-879             JACYVU010000115.1  43045771-43045908   c
            880-990             JACYVU010000115.1  43042272-43042382   c
            991-1086            JACYVU010000115.1  43041987-43042082   c
            1087-1167           JACYVU010000115.1  43035885-43035965   c
            1168-1284           JACYVU010000115.1  43029146-43029262   c
            1285-1357           JACYVU010000115.1  43028984-43029056   c
            1358-1445           JACYVU010000115.1  43028781-43028868   c
            1446-1539           JACYVU010000115.1  43026668-43026761   c
            1540-1954           JACYVU010000115.1  43025033-43025447   c
FEATURES             Location/Qualifiers
     source          1..1954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..1954
                     /gene="Grb14"
                     /note="growth factor receptor bound protein 14"
                     /db_xref="GeneID:58844"
                     /db_xref="RGD:61869"
     exon            1..254
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1686
                     /gene="Grb14"
                     /note="GRB14 adapter protein"
                     /codon_start=1
                     /product="growth factor receptor-bound protein 14"
                     /protein_id="NP_113811.2"
                     /db_xref="GeneID:58844"
                     /db_xref="RGD:61869"
                     /translation="MTTSLQDGQSAAGRAGAQDSPLAVQVCRVAQGKGDAQDPAQVPG
                     LHALSPASDATRRGAMDRRKAKDLEVQETPSIPNPFPELCCSPLTSVLSAGLFPRSNS
                     RKKQVIKVYSEDESSRALEVPSDVTARDVCQLLILKNHYVDDNSWTLFEHLSHTGVER
                     TVEDHELLTEVLSHWVMEEDNKLYLRKNYAKYEFFKNPMYFFPEHMVSFATEMNGDRS
                     LTQIPQMFLSSNTYPEIHGFLHAKEQGKKSWKKAYFFLRRSGLYFSTKGTSKEPRHLQ
                     FFSEFSTSNVYMSLAGKKKHGAPTPYGFCFKPTKAGGPRDLKMLCAEEDQSRMCWVTA
                     IRLLKYGMQLYQNYMHPSQARSACSSQSVSPMRSVSENSLVAMDFSGQKTRVIDNPTE
                     ALSVAVEEGLAWRKKGCLRLGNHGSPTAPSQSSAVNMALHRSQPWFHHRISRDEAQQL
                     ITRQGPVDGVFLVRDSQSNPRTFVLSMSHGQKIKHFQIIPVEDDGEVFHTLDDGHTKF
                     TDLIQLVEFYQLNKGVLPCKLKHYCARMAV"
     exon            255..387
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            388..544
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            545..666
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            667..741
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            742..879
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            880..990
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1086
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1167
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1284
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1357
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1445
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1539
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1954
                     /gene="Grb14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctggacccc agcctttctt cgctttcgcc tcgcggtcga tgactcccta gaccccctgg
       61 cctacgatca tgaccacgtc cctgcaagat gggcagagcg ccgcgggccg ggcgggcgcc
      121 caggactcgc cgctggcagt gcaggtgtgc cgcgttgccc agggcaaggg agacgcccag
      181 gacccggctc aggtccccgg actgcacgcg ctgtccccgg cctcagatgc gacccgccgc
      241 ggtgccatgg acaggagaaa agcgaaagat ctggaagttc aggaaacgcc ttccattcct
      301 aaccccttcc ctgagctctg ctgttctcca cttacatcgg tgctgtcagc aggcctcttc
      361 cccagatcaa attcaaggaa gaaacaggtg attaaagttt acagcgagga tgagagcagc
      421 agagcgttag aggtgcccag tgacgtcaca gcccgtgatg tctgccagct gttgatcctg
      481 aagaaccact atgtcgacga caatagctgg accctttttg agcacctgtc tcacacaggc
      541 gtagaaagga cagtggagga ccatgagctg ctgactgaag tgctgtctca ttgggtgatg
      601 gaagaagata ataagctgta tcttagaaag aattatgcca aatatgaatt ttttaagaac
      661 ccaatgtatt tctttccaga gcacatggtg tcttttgcaa ctgaaatgaa cggtgacaga
      721 tcccttacac agatcccgca gatgttttta agctcaaaca catatcctga aatccatggc
      781 ttcctgcatg caaaggaaca ggggaagaag tcttggaaaa aagcttactt ttttctcaga
      841 agatctggtt tatatttttc tactaaaggc acatccaagg aaccacggca cttgcagttt
      901 ttcagtgaat tcagcactag taatgtttac atgtcactgg caggcaaaaa aaagcatgga
      961 gcgccgactc cctatggatt ctgctttaag cctaccaaag caggagggcc ccgggacctg
     1021 aaaatgctgt gtgcagaaga agaccaaagc aggatgtgct gggtgaccgc cattagattg
     1081 ctcaagtatg gcatgcagct gtaccagaat tatatgcatc catcccaagc tagaagcgcc
     1141 tgcagttctc agagcgtatc acccatgaga agcgtatcag agaattccct agtagcaatg
     1201 gacttctcag gtcagaagac cagagtcata gacaacccca ctgaagccct ttcggttgcc
     1261 gttgaggaag gactcgcttg gaggaaaaaa ggatgtttac gcctggggaa tcatgggagt
     1321 cccactgcgc cctctcagag ctctgctgtg aacatggctc tccaccggtc ccagccatgg
     1381 tttcaccaca gaatttctag agatgaagct cagcagttga ttacccggca ggggcctgtg
     1441 gatggagttt tcttggtacg ggatagtcag agtaacccca gaacttttgt actgtcaatg
     1501 agtcacggac aaaagataaa acactttcaa attatacccg tggaagatga tggtgaggtg
     1561 ttccacaccc tggatgatgg ccatacgaag ttcacagatc tcatccagct cgtggagttc
     1621 taccagctca acaagggggt ccttccttgc aagctgaagc attactgtgc taggatggct
     1681 gtttagccaa actatctgtg actcgttaaa ctatggaaga tggaggatgc aaagaagaat
     1741 gattagagag agagagagag agagagagag agagagagag agagagagag agagagagag
     1801 gagatcacaa ggctggaaac aaatcatggt gaaaagaaga ttcacctgtg ggttacaaaa
     1861 aaataggtca cgtattgcaa attagtgaag acttggattc gtattactct cgttacttta
     1921 aatttattag ttaaaattaa accttattaa aaaa
//
