LOCUS       NP_113811                538 aa            linear   ROD 28-MAR-2024
DEFINITION  growth factor receptor-bound protein 14 [Rattus norvegicus].
ACCESSION   NP_113811 XP_346656
VERSION     NP_113811.2
DBSOURCE    REFSEQ: accession NM_031623.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 538)
  AUTHORS   Eze,I.C., Imboden,M., Kumar,A., von Eckardstein,A., Stolz,D.,
            Gerbase,M.W., Kunzli,N., Pons,M., Kronenberg,F., Schindler,C. and
            Probst-Hensch,N.
  TITLE     Air pollution and diabetes association: Modification by type 2
            diabetes genetic risk score
  JOURNAL   Environ Int 94, 263-271 (2016)
   PUBMED   27281273
REFERENCE   2  (residues 1 to 538)
  AUTHORS   Perdereau,D., Cailliau,K., Browaeys-Poly,E., Lescuyer,A., Carre,N.,
            Benhamed,F., Goenaga,D. and Burnol,A.F.
  TITLE     Insulin-induced cell division is controlled by the adaptor Grb14 in
            a Chfr-dependent manner
  JOURNAL   Cell Signal 27 (4), 798-806 (2015)
   PUBMED   25578860
  REMARK    GeneRIF: These results show that Chfr and Grb14 collaborate in a
            negative feedback loop controlling insulin-stimulated cell
            division.
REFERENCE   3  (residues 1 to 538)
  AUTHORS   Rajala,R.V., Basavarajappa,D.K., Dighe,R. and Rajala,A.
  TITLE     Spatial and temporal aspects and the interplay of Grb14 and protein
            tyrosine phosphatase-1B on the insulin receptor phosphorylation
  JOURNAL   Cell Commun Signal 11, 96 (2013)
   PUBMED   24350791
  REMARK    GeneRIF: The phosphorylation status of the BPS region of Grb14
            determines the positive or negative role it will play in insulin
            receptor signaling.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 538)
  AUTHORS   Yang,H.C., Liang,Y.J., Chen,J.W., Chiang,K.M., Chung,C.M., Ho,H.Y.,
            Ting,C.T., Lin,T.H., Sheu,S.H., Tsai,W.C., Chen,J.H., Leu,H.B.,
            Yin,W.H., Chiu,T.Y., Chern,C.L., Lin,S.J., Tomlinson,B., Guo,Y.,
            Sham,P.C., Cherny,S.S., Lam,T.H., Thomas,G.N. and Pan,W.H.
  TITLE     Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension
            susceptibility genes in Han Chinese with a genome-wide gene-based
            association study
  JOURNAL   PLoS One 7 (3), e32907 (2012)
   PUBMED   22479346
REFERENCE   5  (residues 1 to 538)
  AUTHORS   Browaeys-Poly,E., Blanquart,C., Perdereau,D., Antoine,A.F.,
            Goenaga,D., Luzy,J.P., Chen,H., Garbay,C., Issad,T., Cailliau,K.
            and Burnol,A.F.
  TITLE     Grb14 inhibits FGF receptor signaling through the regulation of
            PLCgamma recruitment and activation
  JOURNAL   FEBS Lett 584 (21), 4383-4388 (2010)
   PUBMED   20932831
REFERENCE   6  (residues 1 to 538)
  AUTHORS   Moncoq,K., Broutin,I., Craescu,C.T., Vachette,P., Ducruix,A. and
            Durand,D.
  TITLE     SAXS study of the PIR domain from the Grb14 molecular adaptor: a
            natively unfolded protein with a transient structure primer?
  JOURNAL   Biophys J 87 (6), 4056-4064 (2004)
   PUBMED   15465854
REFERENCE   7  (residues 1 to 538)
  AUTHORS   Moncoq,K., Broutin,I., Larue,V., Perdereau,D., Cailliau,K.,
            Browaeys-Poly,E., Burnol,A.F. and Ducruix,A.
  TITLE     The PIR domain of Grb14 is an intrinsically unstructured protein:
            implication in insulin signaling
  JOURNAL   FEBS Lett 554 (3), 240-246 (2003)
   PUBMED   14623073
REFERENCE   8  (residues 1 to 538)
  AUTHORS   Lyons,R.J., Deane,R., Lynch,D.K., Ye,Z.S., Sanderson,G.M.,
            Eyre,H.J., Sutherland,G.R. and Daly,R.J.
  TITLE     Identification of a novel human tankyrase through its interaction
            with the adaptor protein Grb14
  JOURNAL   J Biol Chem 276 (20), 17172-17180 (2001)
   PUBMED   11278563
REFERENCE   9  (residues 1 to 538)
  AUTHORS   Reilly,J.F., Mickey,G. and Maher,P.A.
  TITLE     Association of fibroblast growth factor receptor 1 with the adaptor
            protein Grb14. Characterization of a new receptor binding partner
  JOURNAL   J Biol Chem 275 (11), 7771-7778 (2000)
   PUBMED   10713090
REFERENCE   10 (residues 1 to 538)
  AUTHORS   Kasus-Jacobi,A., Perdereau,D., Auzan,C., Clauser,E., Van
            Obberghen,E., Mauvais-Jarvis,F., Girard,J. and Burnol,A.F.
  TITLE     Identification of the rat adapter Grb14 as an inhibitor of insulin
            actions
  JOURNAL   J Biol Chem 273 (40), 26026-26035 (1998)
   PUBMED   9748281
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NP_113811.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF076619.1, SRR26643429.11741.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840105,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     Protein         1..538
                     /product="growth factor receptor-bound protein 14"
                     /note="GRB14 adapter protein"
                     /calculated_mol_wt=60480
     Region          1..73
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O88900.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylthreonine.
                     /evidence=ECO:0000250|UniProtKB:Q14449; propagated from
                     UniProtKB/Swiss-Prot (O88900.1)"
     Region          105..189
                     /region_name="Ubl1_cv_Nsp3_N-like"
                     /note="first ubiquitin-like (Ubl) domain located at the
                     N-terminus of coronavirus SARS-CoV non-structural protein
                     3 (Nsp3) and related proteins; cl28922"
                     /db_xref="CDD:475130"
     Region          228..349
                     /region_name="PH_APBB1IP"
                     /note="Amyloid beta (A4) Precursor protein-Binding, family
                     B, member 1 Interacting Protein pleckstrin homology (PH)
                     domain; cd01259"
                     /db_xref="CDD:269961"
     Region          367..412
                     /region_name="BPS"
                     /note="BPS (Between PH and SH2); pfam08947"
                     /db_xref="CDD:462644"
     Site            370
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O88900.1)"
     Site            373
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (O88900.1)"
     Region          431..538
                     /region_name="SH2_Grb14"
                     /note="Src homology 2 (SH2) domain found in the growth
                     factor receptor bound, subclass 14 (Grb14) proteins;
                     cd10414"
                     /db_xref="CDD:198277"
     Site            order(444,464..466,469,485)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:198277"
     Site            order(486,518)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:198277"
     CDS             1..538
                     /gene="Grb14"
                     /coded_by="NM_031623.3:141..1757"
                     /db_xref="GeneID:58844"
                     /db_xref="RGD:61869"
ORIGIN      
        1 mttslqdgqs aagragaqds plavqvcrva qgkgdaqdpa qvpglhalsp asdatrrgam
       61 drrkakdlev qetpsipnpf pelccsplts vlsaglfprs nsrkkqvikv ysedessral
      121 evpsdvtard vcqllilknh yvddnswtlf ehlshtgver tvedhellte vlshwvmeed
      181 nklylrknya kyeffknpmy ffpehmvsfa temngdrslt qipqmflssn typeihgflh
      241 akeqgkkswk kayfflrrsg lyfstkgtsk eprhlqffse fstsnvymsl agkkkhgapt
      301 pygfcfkptk aggprdlkml caeedqsrmc wvtairllky gmqlyqnymh psqarsacss
      361 qsvspmrsvs enslvamdfs gqktrvidnp tealsvavee glawrkkgcl rlgnhgspta
      421 psqssavnma lhrsqpwfhh risrdeaqql itrqgpvdgv flvrdsqsnp rtfvlsmshg
      481 qkikhfqiip veddgevfht lddghtkftd liqlvefyql nkgvlpcklk hycarmav
//
