LOCUS       NM_001401404            5227 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus growth factor receptor bound protein 10 (Grb10),
            transcript variant 2, mRNA.
ACCESSION   NM_001401404 XM_039092318
VERSION     NM_001401404.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5227)
  AUTHORS   Reddy,M.A., Das,S., Zhuo,C., Jin,W., Wang,M., Lanting,L. and
            Natarajan,R.
  TITLE     Regulation of Vascular Smooth Muscle Cell Dysfunction Under
            Diabetic Conditions by miR-504
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (5), 864-873 (2016)
   PUBMED   26941017
REFERENCE   2  (bases 1 to 5227)
  AUTHORS   Liu,M., Bai,J., He,S., Villarreal,R., Hu,D., Zhang,C., Yang,X.,
            Liang,H., Slaga,T.J., Yu,Y., Zhou,Z., Blenis,J., Scherer,P.E.,
            Dong,L.Q. and Liu,F.
  TITLE     Grb10 promotes lipolysis and thermogenesis by
            phosphorylation-dependent feedback inhibition of mTORC1
  JOURNAL   Cell Metab 19 (6), 967-980 (2014)
   PUBMED   24746805
REFERENCE   3  (bases 1 to 5227)
  AUTHORS   Xia,H.F., Cao,J.L., Jin,X.H. and Ma,X.
  TITLE     MiR199a is implicated in embryo implantation by regulating Grb10 in
            rat
  JOURNAL   Reproduction 147 (1), 91-99 (2013)
   PUBMED   24149516
  REMARK    GeneRIF: In rat uterus, enforced miR199a expression suppresses cell
            proliferation partially through targeting Grb10.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5227)
  AUTHORS   Ma,L., Wei,Q., Deng,H., Zhang,Q., Li,G., Tang,N., Xie,J. and
            Chen,Y.
  TITLE     Growth factor receptor-bound protein 10-mediated negative
            regulation of the insulin-like growth factor-1 receptor-activated
            signalling pathway results in cognitive disorder in diabetic rats
  JOURNAL   J Neuroendocrinol 25 (7), 626-634 (2013)
   PUBMED   23614367
  REMARK    GeneRIF: findings indicate that endogenous overexpression of Grb10
            functions as a suppressor of the IGF1-IR pathway, which may
            represent an important mechanism for regulating cognitive disorder
            in diabetes
REFERENCE   5  (bases 1 to 5227)
  AUTHORS   Ajiro,M., Nishidate,T., Katagiri,T. and Nakamura,Y.
  TITLE     Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary
            carcinogenesis
  JOURNAL   Int J Oncol 37 (5), 1085-1093 (2010)
   PUBMED   20878056
REFERENCE   6  (bases 1 to 5227)
  AUTHORS   Mori,K., Giovannone,B. and Smith,R.J.
  TITLE     Distinct Grb10 domain requirements for effects on glucose uptake
            and insulin signaling
  JOURNAL   Mol Cell Endocrinol 230 (1-2), 39-50 (2005)
   PUBMED   15664450
REFERENCE   7  (bases 1 to 5227)
  AUTHORS   Murdaca,J., Treins,C., Monthouel-Kartmann,M.N., Pontier-Bres,R.,
            Kumar,S., Van Obberghen,E. and Giorgetti-Peraldi,S.
  TITLE     Grb10 prevents Nedd4-mediated vascular endothelial growth factor
            receptor-2 degradation
  JOURNAL   J Biol Chem 279 (25), 26754-26761 (2004)
   PUBMED   15060076
REFERENCE   8  (bases 1 to 5227)
  AUTHORS   Giovannone,B., Lee,E., Laviola,L., Giorgino,F., Cleveland,K.A. and
            Smith,R.J.
  TITLE     Two novel proteins that are linked to insulin-like growth factor
            (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling
  JOURNAL   J Biol Chem 278 (34), 31564-31573 (2003)
   PUBMED   12771153
REFERENCE   9  (bases 1 to 5227)
  AUTHORS   Mounier,C., Lavoie,L., Dumas,V., Mohammad-Ali,K., Wu,J., Nantel,A.,
            Bergeron,J.J., Thomas,D.Y. and Posner,B.I.
  TITLE     Specific inhibition by hGRB10zeta of insulin-induced glycogen
            synthase activation: evidence for a novel signaling pathway
  JOURNAL   Mol Cell Endocrinol 173 (1-2), 15-27 (2001)
   PUBMED   11223174
REFERENCE   10 (bases 1 to 5227)
  AUTHORS   Laviola,L., Giorgino,F., Chow,J.C., Baquero,J.A., Hansen,H.,
            Ooi,J., Zhu,J., Riedel,H. and Smith,R.J.
  TITLE     The adapter protein Grb10 associates preferentially with the
            insulin receptor as compared with the IGF-I receptor in mouse
            fibroblasts
  JOURNAL   J Clin Invest 99 (5), 830-837 (1997)
   PUBMED   9062339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 11, 2022 this sequence version replaced XM_039092318.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.45129.1,
                                           SRR26643285.39339.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000014.1  90816182-90816387   c
            207-285             JAXUCZ010000014.1  90763754-90763832   c
            286-450             JAXUCZ010000014.1  90750479-90750643   c
            451-676             JAXUCZ010000014.1  90747355-90747580   c
            677-830             JAXUCZ010000014.1  90744032-90744185   c
            831-995             JAXUCZ010000014.1  90732473-90732637   c
            996-1152            JAXUCZ010000014.1  90729099-90729255   c
            1153-1268           JAXUCZ010000014.1  90724037-90724152   c
            1269-1337           JAXUCZ010000014.1  90723741-90723809   c
            1338-1475           JAXUCZ010000014.1  90723275-90723412   c
            1476-1586           JAXUCZ010000014.1  90722575-90722685   c
            1587-1685           JAXUCZ010000014.1  90721723-90721821   c
            1686-1763           JAXUCZ010000014.1  90716515-90716592   c
            1764-1880           JAXUCZ010000014.1  90715907-90716023   c
            1881-1947           JAXUCZ010000014.1  90715114-90715180   c
            1948-2035           JAXUCZ010000014.1  90714834-90714921   c
            2036-2129           JAXUCZ010000014.1  90712347-90712440   c
            2130-5227           JAXUCZ010000014.1  90708653-90711750   c
FEATURES             Location/Qualifiers
     source          1..5227
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..5227
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /note="growth factor receptor bound protein 10"
                     /db_xref="GeneID:498416"
                     /db_xref="RGD:1566234"
     exon            1..206
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            207..285
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            286..450
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..2276
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /note="isoform 2 is encoded by transcript variant 2; GRB10
                     adapter protein; Growth factor receptor-bound protein 10"
                     /codon_start=1
                     /product="growth factor receptor-bound protein 10 isoform
                     2"
                     /protein_id="NP_001388333.1"
                     /db_xref="GeneID:498416"
                     /db_xref="RGD:1566234"
                     /translation="MNANLPARTKPFRILRGWERCRTRNRIAKHALGLQVLMNNDINS
                     SVESLNSACNMQSDTDTVPLLENGQSASNQPSASSSRGQPQASPRQKMQRSQPVHIQP
                     LRRLQEEDQQLRTSSLPAIPNPFPELAGGAPGSPPSVAPSSLPPPPSQPPAKHFPPGF
                     QLAKLTRPGLWTKTTARFSKRQPKNQCQTDTANAVSRIPTSQMEKLRLRKDVKVFSED
                     GTSKVVEILTDMTARDLCQLLVYKSHCVDDNSWTLVEHHPQLGLERCLEDHEIVVQVE
                     STMPSESKFLFRKNYAKYEFFKNPVNFFPDQMVTWCQQSNGGQAQLLQNFLNSSSCPE
                     IQGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTSKEPRHLQLLADLEESSIFYLIAG
                     KKQYNAPNEHGMCIKPNKAKIEMKELRLLCAEDEQIRTCWMTAFRLLKYGMLLYQNYR
                     IPQQRKGLAPPFNAPMRSVSENSLVAMDFSGQIGRVIDNPAEAQSAALEEGHAWRKRS
                     TRMNILSSQSPLHPSTLNSVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQS
                     NPKAFVLTLCHQQKIRNFQILPCEDDGQTFFTLDDGNTKFSDLIQLVDFYQLNKGVLP
                     CKLKHHCIRVAL"
     exon            451..676
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            677..830
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            831..995
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1152
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1268
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1337
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1475
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1586
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1685
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1763
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1880
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1947
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2035
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2129
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..5227
                     /gene="Grb10"
                     /gene_synonym="RGD1566234"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcggcag gaagagaagg gcgctgcgac cagtggcggg cgggattcgc gttccgagac
       61 ccacgggagc acgaagtttc cgcgcaccgt ctcacgcacg gcgactggga ccgtccagtg
      121 tccgtctttg ccttcggctt tttcgcaggg actcgtgcaa cgtgtggcca gcggccacgc
      181 ggaggcgacg aggagctgca cgccaggaca aagtggggca gtcaacgtcc aaatccgaaa
      241 acctagctaa gtctgggttt tcgccacaac caagaagcca accagaaata gggcaggaga
      301 caccaaggac tgccaccagg ggtcggcaca gccaaagact acagcaagcg cagggaaaaa
      361 gagccatgaa tgctaatctg ccagcacgga ccaagccatt ccgtattctc agaggttggg
      421 agcgctgtcg gaccaggaac cgcattgcca agcatgctct tgggcttcaa gtcctaatga
      481 acaacgatat taactcatcc gtggaaagcc ttaactcagc ttgcaacatg cagtctgaca
      541 ctgacactgt gccacttctt gagaatggcc agagtgccag caaccagccg tcagcatcca
      601 gctcccgggg acagcctcag gcgtccccga ggcagaagat gcagcgctcg cagcctgtgc
      661 acattcaacc gctcaggcgc cttcaggagg aagaccagca gctccgaact tcatctcttc
      721 cggccatccc caatccgttt ccggagctcg ctgggggggc ccctgggagc cctccttcgg
      781 ttgctcctag ctccttacct cctcctccga gccagcctcc tgccaagcat ttccctccag
      841 gctttcagct ggcgaaactc acccgtccag gtctgtggac aaagaccact gcgagatttt
      901 caaagaggca acctaagaac cagtgtcaaa ccgacactgc gaatgcagtg tcacggattc
      961 ccacttcaca gatggagaag ctgaggctca gaaaggatgt caaagtcttt agtgaagatg
     1021 ggacaagcaa agtggtggag attctaaccg acatgactgc cagggacctg tgccagctgc
     1081 tggtttacaa aagtcactgt gtggatgaca acagctggac tctggtggag caccacccac
     1141 aactgggact agagaggtgc ctggaggacc atgagatcgt ggtccaagtg gagagcacca
     1201 tgccaagtga gagtaaattc ttattcagaa agaactatgc caagtacgag ttctttaaga
     1261 accctgtgaa cttctttccg gatcagatgg tcacctggtg ccagcagtcc aacggtggcc
     1321 aggcccagct tctgcagaat ttcctgaact ccagcagctg ccctgagatc caggggttct
     1381 tgcaggtgaa ggaggtggga cgcaagtctt ggaagaagct gtatgtgtgc ctgcgcagat
     1441 ctggccttta ttactccacc aaggggactt caaaggaacc cagacacctg cagctgctgg
     1501 ctgacctcga agaaagcagc atcttctacc tgattgccgg aaagaagcag tacaacgcac
     1561 ccaatgaaca cgggatgtgc atcaagccaa acaaagcgaa gatcgagatg aaggagctgc
     1621 gtctgctctg tgccgaagat gagcagatcc gtacttgctg gatgacagcc ttcagactgc
     1681 tcaagtatgg aatgctcctg taccaaaact atcgcatccc gcagcagaga aagggtttgg
     1741 ctcctccttt caacgcgcct atgcgcagtg tttctgagaa ttctcttgtg gccatggatt
     1801 tttctggaca aattggaaga gtgattgata acccggctga agcccagagt gctgccctgg
     1861 aagagggcca tgcctggcgg aagcgaagca caaggatgaa tatcctaagc agccaaagtc
     1921 cccttcatcc ttcgaccctg aattcggtga ttcacaggac tcagcattgg ttccatggac
     1981 gtatctctcg cgaggaatct cacaggatca tcaagcaaca aggtctcgtg gacgggctgt
     2041 tcctcctccg tgacagtcag agcaatccaa aggctttcgt gctgacgctg tgtcaccagc
     2101 agaagattag aaacttccag atcttaccct gcgaggatga tgggcaaacc ttcttcactc
     2161 tggatgatgg gaacaccaag ttctcggatc tgattcagct ggtcgacttc taccagctca
     2221 acaaaggcgt cctgccctgc aagctgaagc accactgcat ccgcgtggcc ttatgacctc
     2281 cttgcccact caggctggag gcagcaacac tggaacggag aagagaggcc tgcatgaggg
     2341 tgagaacaca cacccactcc cacccaagga ctcagaataa catggctttc tgatcggtac
     2401 caaccgacca acatcaatta gttattggac tttacaaaga tttgccgctg cggatcaaac
     2461 aggaccacct ccctctgcat cagccattta aattggggga gggaagagat ccagtgcaag
     2521 tgtgggaaga aactggaatg atgattttga ttaggccacg tagggtgaaa accgcagaga
     2581 aaagattgga aatgaactct tgccctggaa taaccttgac aattcaaacc gcgatgttta
     2641 ctttttgtat tgatcacttt tttgcactcc ttcttcgttg tcaatgttgt actcagccta
     2701 tggtaggaga ggatgtggct ttgcaaccca gatgagacaa agattttttg aattggcagg
     2761 cttcggccta caaatgggtc ccccaagttt tcttagatgg catcctgcgc tctgcaggtt
     2821 atgacagtgt ggatttggct cctacattat agacacccca gtccttccca ttatacttga
     2881 aaagcttttt tttttttttt aagaaataat aaaataaaaa gtgtcaaccg cagttgacac
     2941 caagcatgtt ttgtggacgc agtcaagctg ccacagtctg gtcatcgttg ttgttgtgct
     3001 gacgtctggt catttattat tagtgtgtct cgttctccag tgccggagac ctcattactt
     3061 tggaaaactc gctgttcccc agcgcagcac agccgcatga gctcagcttc agactgatgt
     3121 ccgccagcct tcttggaaca cattggtatt cattgtggat gccacacaat ccatccgggg
     3181 tgcctcgtgc ctcccatttt cacagccgcc cactgttgta gaatgatcgc tgcctttacc
     3241 ctctgcagta gcctccgcca tttcagttct cccacagggg tggggtgggg gtggggttaa
     3301 aggatcgaaa gagaaaaatg ccaacttgtt ggccttgtgc tcttgtcact ctgagcatgt
     3361 ttggtgatta aagagaagga aacactgcag aggcacaggc ataggctggc tttgagtctt
     3421 cgcttgatga cctctgcacc ctactgaaaa ccccctaagc cagccggagc agggtatgaa
     3481 gaggtcctgc ctctgctggc ttagggtgag aagtacctca cagtggttgt gaacattgga
     3541 tagtttttag gaggatgatg tttgcctcct ttgagaaagg agtcagaagg tggccggagt
     3601 gatcattggt cccctgagct ccatggagga ccctctgttg tccccttgat gattcatcag
     3661 gcatgagagt agcagacagg actcccttga ggaacacaga cagctgtggt gatcacattt
     3721 atttcccttt cttgacacca cacaggaagt ctgctacaca cctgagctag ccactagatt
     3781 gcctgtcccg actgcgcgaa gtgctcccca gggagccact tctgattgcg ctgcggttga
     3841 cggcccggtg gaagattaat gacagcgctt tgtaacgcag gccagcggca cgctggtcca
     3901 cggtgtagga acactgtagt tcacagacca cgcaaccgtg tttccacgag atgttattac
     3961 aacaaatgaa gaattttttt cctttttttc attttaatct tttttgactt ttttttagta
     4021 aaacattttc ttacgcataa acgctcaatt gcatttctct ttctttcgca gctagttaat
     4081 cattcagttg acaatgagag aattctcaag ttcatacttg gcagcaggct cccactgatc
     4141 ttccccttga gacaaatagt ggacatttca gttttaccat attcatttct ttccgctgac
     4201 ttcgaggtca gacctttaca aacagataac aaacagccct aggatttctt tctccagttt
     4261 acacagacca gtccccacag tgcataaccc tttactcttc tgcctctaca gtagacagct
     4321 aagatgtgta tctcatattt ataagtacgc attctattta agcggaagta taggcttgac
     4381 tctggttcac aattttgtac gtagctggtt tgacgtagta ttttgtactt cccttgctga
     4441 agtgaattgt tgaaggctgc aagccacccg ccttgagtgc agcagacttc agtgaccccg
     4501 agctcgctca ccagcctttg cacaggtagc tgggaattcc accagaaaca gctggtccct
     4561 aggttagcgg gcacccagcc gcccctaacc ggagactgaa ggacaattga cttttatttt
     4621 tgtatttaat tgacatgaat gtaaggggac agctcagggt tgtttggagc ctgtttgact
     4681 ttgcaatctc tgcctgtgat tttcttttct taagaacaac tccgtgtaac cacctggact
     4741 aagttgagaa ggaaaatgcc aaatgctttg ggtttttagc gttttaatac gtaggctctg
     4801 ttatattatt aggtgttaag agtttccaaa cgtgttttct tttttctttt tttgtttgct
     4861 taaactttga agaaatatgt gcctcagctt agatgttttg tcttctcctt tctgcactta
     4921 aatacctgac agcctgtccg atcactgtgc ctccgagggc gctactagct catcgtagat
     4981 ttgtgatatc atagtgtaaa ctgcagtgac cggaaaatga cctgacatgt aaacgttttc
     5041 agggaatgca gagggtgtta attgatagac aaaaccttta tcccgcgtgc tttgcttcac
     5101 tctgtgctat atagctcttt ggctcgtgaa cctaattgta aactttcagg tatttttgta
     5161 caaataaggg actgatgttc tgtttcttgt tattagaaat aaacattaat aaagtgttct
     5221 tcatttc
//
