LOCUS       NM_001025749            1560 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus GRB2-related adaptor protein (Grap), mRNA.
ACCESSION   NM_001025749 XM_343909
VERSION     NM_001025749.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1560)
  AUTHORS   Li,C., Bademci,G., Subasioglu,A., Diaz-Horta,O., Zhu,Y., Liu,J.,
            Mitchell,T.G., Abad,C., Seyhan,S., Duman,D., Cengiz,F.B.,
            Tokgoz-Yilmaz,S., Blanton,S.H., Farooq,A., Walz,K., Zhai,R.G. and
            Tekin,M.
  TITLE     Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is
            linked to sensorineural hearing loss
  JOURNAL   Proc Natl Acad Sci U S A 116 (4), 1347-1352 (2019)
   PUBMED   30610177
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098740.1.
            
            On Jul 22, 2005 this sequence version replaced XM_343909.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098740.1, EX491728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1560
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1560
                     /gene="Grap"
                     /note="GRB2-related adaptor protein"
                     /db_xref="GeneID:363616"
                     /db_xref="RGD:1306884"
     exon            1..142
                     /gene="Grap"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..718
                     /gene="Grap"
                     /codon_start=1
                     /product="GRB2-related adapter protein"
                     /protein_id="NP_001020920.1"
                     /db_xref="GeneID:363616"
                     /db_xref="RGD:1306884"
                     /translation="MESVALYNFQATESDELAFNKGDTLKILNMDDDQNWYKAELRGA
                     EGFVPKNYIRVKPHPWYSGRISRQLAEETLMKRNHLGAFLIRESESSPGEFSVSVNYG
                     DQVQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTIAKRRQIFLCDEQPLIKPPRA
                     CFAQAQFDFSAQDPSQLSLRRGDIVEIVECEDPHWWRGRAGGRLGFFPRSYVQPVHL"
     exon            143..240
                     /gene="Grap"
                     /inference="alignment:Splign:2.1.0"
     exon            241..363
                     /gene="Grap"
                     /inference="alignment:Splign:2.1.0"
     exon            364..532
                     /gene="Grap"
                     /inference="alignment:Splign:2.1.0"
     exon            533..1536
                     /gene="Grap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcaactgca ggaagcagga agctgtagct gctgggtcct cggctgaagc ccaggggcag
       61 tgggatggag tccgtggccc tctacaactt ccaggccacc gagagtgatg agctggcctt
      121 caacaagggg gacacgctta agatcctaaa catggacgat gatcagaatt ggtacaaggc
      181 cgagctccga ggagccgagg gttttgttcc caagaactac atccgtgtaa agccacaccc
      241 gtggtactca ggcaggattt cccgacagct ggctgaagag actctgatga aacgcaacca
      301 cctaggagcc ttcctgatcc gggaaagcga gagttcccct ggcgagttct cagtttctgt
      361 gaactatggc gaccaggtgc agcacttcaa agtgcttcga gaggcctcgg ggaagtactt
      421 cctgtgggag gagaagttca actccctcaa cgagctggtt gacttctacc gaaccaccac
      481 catcgctaag aggcggcaga tcttcctgtg tgatgagcag ccgctgatca agccgccccg
      541 ggcttgcttt gcccaggctc agtttgactt ctcggcacag gacccatctc agctcagcct
      601 ccgccgaggt gacattgtcg aaattgtgga gtgtgaggac ccacactggt ggcggggccg
      661 ggcaggcggg cgcctgggct tcttcccacg gagctatgtg caaccggtac acttgtgacc
      721 ccacaagacc agaggagcga tgctctgggc tcagattctt cacactaacc aggaccgatg
      781 ttggtcacca ccaggctggg agcagaggct tctggcctga ctgcttccca ttggtctctg
      841 ggtttgtgct atcacctgcc attgacaagg cccatcctct ccagacttga ggaccaactg
      901 ctaatggctt gggcccagct cagaaagtgc ttcccttgag cagccatctg ctgcccatct
      961 tccaaaggcc tttcaggttg tgcaagttac tgggaactgg cttagccctg agcaatgtca
     1021 acttccataa gagtacaaag ttcctcccac tccaacagct tggggcctcc tggccttgcc
     1081 caccagcatt ggaatgaggt tatatagagg tgaatcctgt tggaagaggc ctgataggca
     1141 tggaagcaat gcagtgggtc ccttcctgtt ggctacaggc agagcccagc ttggaggcct
     1201 tggctatgca ggttcaggag gaacagccag acagctggca tcaagtgaat gtacagtgca
     1261 agggggtggt gcctggccat ggaggaatcc tgagctgctg ctacccagag tcagagcacc
     1321 ttcagattgg gaatactgag tcagacttgg caaggcctgg tgggctttgg ggaagacaga
     1381 cagacagaca gacagacaga gaaagaaaga gagacagaga gagaacttct gtggtgagtc
     1441 cagggctgtt ctaagaccct ccaagctatg agcctggcat accctaagct cccaacctgt
     1501 acctgccata ttcaaaataa aacatttacc agtggaaaaa aaaaaaaaaa aaaaaaaaaa
//
