LOCUS       NM_001106411            1062 bp    mRNA    linear   ROD 14-NOV-2023
DEFINITION  Rattus norvegicus glutathione peroxidase 8 (Gpx8), mRNA.
ACCESSION   NM_001106411 XM_001067684 XM_215486
VERSION     NM_001106411.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1062)
  AUTHORS   Cueto-Urena C, Ramirez-Exposito MJ, Mayas MD, Carrera-Gonzalez MP,
            Godoy-Hurtado A and Martinez-Martos JM.
  TITLE     Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns
  JOURNAL   Genes (Basel) 14 (9), 1674 (2023)
   PUBMED   37761814
  REMARK    GeneRIF: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1062)
  AUTHORS   Mehmeti I, Lortz S, Avezov E, Jorns A and Lenzen S.
  TITLE     ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect
            insulin-secreting INS-1E beta-cells against lipotoxicity by
            improving the ER antioxidative capacity
  JOURNAL   Free Radic Biol Med 112, 121-130 (2017)
   PUBMED   28751022
  REMARK    GeneRIF: Endoplasmic reticulum (ER)-resident antioxidative GPx7 and
            GPx8 enzyme isoforms protect insulin-secreting beta-cells against
            lipotoxicity by improving the ER antioxidative capacity.
REFERENCE   3  (bases 1 to 1062)
  AUTHORS   Nguyen VD, Saaranen MJ, Karala AR, Lappi AK, Wang L, Raykhel IB,
            Alanen HI, Salo KE, Wang CC and Ruddock LW.
  TITLE     Two endoplasmic reticulum PDI peroxidases increase the efficiency
            of the use of peroxide during disulfide bond formation
  JOURNAL   J Mol Biol 406 (3), 503-515 (2011)
   PUBMED   21215271
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473955.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_215486.4, XM_001067684.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229597.1, FQ220265.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1062
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q14"
     gene            1..1062
                     /gene="Gpx8"
                     /gene_synonym="RGD1307506"
                     /note="glutathione peroxidase 8"
                     /db_xref="GeneID:294744"
                     /db_xref="RGD:1307506"
     exon            1..237
                     /gene="Gpx8"
                     /gene_synonym="RGD1307506"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..663
                     /gene="Gpx8"
                     /gene_synonym="RGD1307506"
                     /EC_number="1.11.1.9"
                     /codon_start=1
                     /product="probable glutathione peroxidase 8"
                     /protein_id="NP_001099881.1"
                     /db_xref="GeneID:294744"
                     /db_xref="RGD:1307506"
                     /translation="MEPLGAYPLKCSGPKAKIFAVLLSMVLCTVMLFLLQLKFLKPRI
                     NSFYSFEVKDAKGRMVSLEKFKGKASLVVNVASDCRFTDKSYETLRELHKEFGPYHFN
                     VLAFPCNQFGESEPKSSKEVESFARKNYGVTFPIFHKIKILGPEAEPAFRFLVDSSKK
                     EPRWNFWKYLVNPEGQVVKFWRPEEPLEAIRPHVSQMIGQIILKKKEDL"
     exon            238..499
                     /gene="Gpx8"
                     /gene_synonym="RGD1307506"
                     /inference="alignment:Splign:2.1.0"
     exon            500..1062
                     /gene="Gpx8"
                     /gene_synonym="RGD1307506"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccagcctgc tgagactccc agaatcatcc aaaatggagc ctctcggtgc ctacccacta
       61 aaatgttccg ggcccaaagc aaagatattt gcagttttgc tatctatggt tctgtgcacc
      121 gtgatgcttt ttctccttca gttaaaattc ctgaagccga gaatcaacag cttctactcc
      181 tttgaagtga aggatgccaa aggaaggatg gtgtctctgg aaaagttcaa aggcaaagct
      241 tccctagttg taaacgtggc tagtgactgc cggttcacag acaagagtta cgagaccctc
      301 agggagctgc acaaggagtt tgggccctat cacttcaacg tcctggcttt cccgtgcaat
      361 cagtttggag aatcggagcc caagtccagc aaggaggtag aatcttttgc aagaaaaaac
      421 tacggagtca cattccccat cttccacaag attaagattt tagggccgga agcagaacct
      481 gcgtttagat ttcttgttga ttcttccaag aaggaaccaa ggtggaactt ttggaagtat
      541 ctggtcaacc ctgagggaca agtcgtgaag ttctggaggc cagaagaacc ccttgaagcc
      601 atcagacctc atgtgtcaca aatgattggg caaatcattc ttaaaaagaa agaggatcta
      661 tgaaagcacc gtggagtcag gccagtacaa aaggacagag ggcctcctct tagattccaa
      721 aacatacagt gcgaaaagat gtttaaggcc atcttactac taagttgcag tggctgtccc
      781 caagatagga atgttacaaa ggagggaaga aggggttgag gtcttagcca aagaatcatg
      841 atgaagtata ttacttctac tgaccagaag ggaaatccag gatgctctgt caccaatacc
      901 ctttactgtt acagtccaac ttaattttct ctagggttaa ccttgtggga aatccaatgc
      961 ccaaggtcac catgtgggcc aacgaacact gtgagggtgg caattttgga gtgaccaact
     1021 ctagatgtaa taaaatatac aatgaatgtt gcaaaatata aa
//
