LOCUS       NM_001106673            1035 bp    mRNA    linear   ROD 14-NOV-2023
DEFINITION  Rattus norvegicus glutathione peroxidase 7 (Gpx7), mRNA.
ACCESSION   NM_001106673 XM_001060175 XM_216473
VERSION     NM_001106673.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1035)
  AUTHORS   Cueto-Urena C, Ramirez-Exposito MJ, Mayas MD, Carrera-Gonzalez MP,
            Godoy-Hurtado A and Martinez-Martos JM.
  TITLE     Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns
  JOURNAL   Genes (Basel) 14 (9), 1674 (2023)
   PUBMED   37761814
  REMARK    GeneRIF: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1035)
  AUTHORS   Mehmeti I, Lortz S, Avezov E, Jorns A and Lenzen S.
  TITLE     ER-resident antioxidative GPx7 and GPx8 enzyme isoforms protect
            insulin-secreting INS-1E beta-cells against lipotoxicity by
            improving the ER antioxidative capacity
  JOURNAL   Free Radic Biol Med 112, 121-130 (2017)
   PUBMED   28751022
  REMARK    GeneRIF: Endoplasmic reticulum (ER)-resident antioxidative GPx7 and
            GPx8 enzyme isoforms protect insulin-secreting beta-cells against
            lipotoxicity by improving the ER antioxidative capacity.
REFERENCE   3  (bases 1 to 1035)
  AUTHORS   Peng D, Belkhiri A, Hu T, Chaturvedi R, Asim M, Wilson KT, Zaika A
            and El-Rifai W.
  TITLE     Glutathione peroxidase 7 protects against oxidative DNA damage in
            oesophageal cells
  JOURNAL   Gut 61 (9), 1250-1260 (2012)
   PUBMED   22157330
REFERENCE   4  (bases 1 to 1035)
  AUTHORS   Nguyen VD, Saaranen MJ, Karala AR, Lappi AK, Wang L, Raykhel IB,
            Alanen HI, Salo KE, Wang CC and Ruddock LW.
  TITLE     Two endoplasmic reticulum PDI peroxidases increase the efficiency
            of the use of peroxide during disulfide bond formation
  JOURNAL   J Mol Biol 406 (3), 503-515 (2011)
   PUBMED   21215271
REFERENCE   5  (bases 1 to 1035)
  AUTHORS   Peng DF, Razvi M, Chen H, Washington K, Roessner A, Schneider-Stock
            R and El-Rifai W.
  TITLE     DNA hypermethylation regulates the expression of members of the
            Mu-class glutathione S-transferases and glutathione peroxidases in
            Barrett's adenocarcinoma
  JOURNAL   Gut 58 (1), 5-15 (2009)
   PUBMED   18664505
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474008.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001060175.1, XM_216473.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ229888.1, AW142311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093045, SAMN16093046
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1035
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q34"
     gene            1..1035
                     /gene="Gpx7"
                     /note="glutathione peroxidase 7"
                     /db_xref="GeneID:298376"
                     /db_xref="RGD:1306999"
     exon            1..193
                     /gene="Gpx7"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..619
                     /gene="Gpx7"
                     /EC_number="1.11.1.9"
                     /codon_start=1
                     /product="glutathione peroxidase 7 precursor"
                     /protein_id="NP_001100143.1"
                     /db_xref="GeneID:298376"
                     /db_xref="RGD:1306999"
                     /translation="MVAAVATAWLLLWAAACTQSEQDFYDFKAVNIRGKLVSLEKYRG
                     SVSLVVNVASECGFTDQNYRALQQLQRDLGPYHFNVLAFPCNQFGQQEPDSNREIENF
                     ARRTYSVSFPMFSKIAVTGTGAHPAFKYLTQTSGKEPTWNFWKYLVAPDGKVVGAWDP
                     TVPVEEIKPRITEQVMKLILQKREDL"
     exon            194..455
                     /gene="Gpx7"
                     /inference="alignment:Splign:2.1.0"
     exon            456..1035
                     /gene="Gpx7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggggtccc gtctgccttg tctttgccct cgccaagtcg ccacctcgga agtgagccat
       61 ggttgcggct gtggcgacgg cgtggctgct cctgtgggcc gcggcctgca cgcaatccga
      121 gcaagacttc tacgacttca aggcggtgaa catccggggc aagctggtgt cgctggagaa
      181 gtaccgcggc tcggtttccc tggtggtgaa tgtagctagc gaatgtggct tcacagacca
      241 gaactaccga gccttgcagc agctgcagcg ggacctgggc ccctaccatt ttaacgtgct
      301 tgctttccct tgcaaccagt ttggccaaca ggaaccagac agcaacaggg agattgagaa
      361 ctttgcccgc cgcacctaca gtgtctcttt ccccatgttt agcaagatcg cagtcactgg
      421 cactggtgcc caccctgcct tcaaatacct aacccaaact tctgggaagg agcccacctg
      481 gaacttctgg aagtacctag tggccccaga cggaaaggtg gtgggggcat gggatcccac
      541 tgtgccggtg gaggagatca agccccgtat tacagagcag gtgatgaagc tcatccttca
      601 gaaacgagaa gacttgtgac tgggtccccc tgaaaccccc attcctcagc aaactcaagt
      661 ggtgcttcaa gggcagagag ccaatgcttc tcttcccttc gctccctcag aggacgagcc
      721 taagacttgg atgatttgaa tccaagggca acgaacaggc actgctggcc aatgagagtt
      781 cttaacagca catcacccgc cagcaggcct ctagccaaag gaaatatggc atggctctga
      841 ggcagtcatc tacctagcca gccaagtctt acctcacagg gaggctgtga ggattagcgt
      901 ctaataccca tgaacatgcc tgggggcagt gctagccaag gggaagcact ccgcacagtt
      961 ttccacatgt aaacaaacat tatctgtgat aataaaactt gagttcgaca taaatgtcta
     1021 gcccacggaa tccta
//
