LOCUS       NM_147165               1150 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus glutathione peroxidase 6 (Gpx6), mRNA.
ACCESSION   NM_147165
VERSION     NM_147165.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1150)
  AUTHORS   Cueto-Urena,C., Ramirez-Exposito,M.J., Mayas,M.D.,
            Carrera-Gonzalez,M.P., Godoy-Hurtado,A. and Martinez-Martos,J.M.
  TITLE     Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns
  JOURNAL   Genes (Basel) 14 (9), 1674 (2023)
   PUBMED   37761814
  REMARK    GeneRIF: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1150)
  AUTHORS   Sorolla,M.A., Reverter-Branchat,G., Tamarit,J., Ferrer,I., Ros,J.
            and Cabiscol,E.
  TITLE     Proteomic and oxidative stress analysis in human brain samples of
            Huntington disease
  JOURNAL   Free Radic Biol Med 45 (5), 667-678 (2008)
   PUBMED   18588971
REFERENCE   3  (bases 1 to 1150)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
REFERENCE   4  (bases 1 to 1150)
  AUTHORS   Dear,T.N., Campbell,K. and Rabbitts,T.H.
  TITLE     Molecular cloning of putative odorant-binding and
            odorant-metabolizing proteins
  JOURNAL   Biochemistry 30 (43), 10376-10382 (1991)
   PUBMED   1931961
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M76733.1 and JAXUCZ010000017.1.
            
            On Jul 19, 2017 this sequence version replaced NM_147165.1.
            
            Summary: This gene encodes a member of the glutathione peroxidase
            family. Glutathione peroxidases catalyze the reduction of a variety
            of hydroperoxides using glutathione as a specific electron donor
            substrate, and thereby protect cells against oxidative damage.
            Expression of this gene is restricted to embryos and adult
            olfactory epithelium. The mouse and rat orthologs contain a
            cysteine (Cys) residue at the active site, unlike the human
            counterpart, which is a selenoprotein, containing selenocysteine
            (Sec) instead. [provided by RefSeq, Jul 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: M76733.1, SRR22582424.2047321.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               M76733.1           1-236
            237-93516040        JAXUCZ010000017.1  1-93515804
            93516041-93516668   M76733.1           238-865
            93516669-93516953   M76733.1           867-1151
FEATURES             Location/Qualifiers
     source          1..1150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="F344"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q11"
     gene            1..1150
                     /gene="Gpx6"
                     /gene_synonym="OBPII; Ry2d1"
                     /note="glutathione peroxidase 6"
                     /db_xref="GeneID:259233"
                     /db_xref="RGD:628789"
     exon            1..132
                     /gene="Gpx6"
                     /gene_synonym="OBPII; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..711
                     /gene="Gpx6"
                     /gene_synonym="OBPII; Ry2d1"
                     /EC_number="1.11.1.9"
                     /note="GPx-6; GSHPx-6; odorant-metabolizing protein RY2D1"
                     /codon_start=1
                     /product="glutathione peroxidase 6 precursor"
                     /protein_id="NP_671694.1"
                     /db_xref="GeneID:259233"
                     /db_xref="RGD:628789"
                     /translation="MTQQFWGPCLFSLFMAVLAQETLDPQKSKVDCNKGVAGTVYEYG
                     ANTLDGGEYVQFQQYAGKHILFVNVASFCGLTATYPELNTLQEELRPFNVSVLGFPCN
                     QFGKQEPGKNSEILLGLKYVRPGGGFVPNFQLFEKGDVNGDNEQKVFSFLKSSCPPTS
                     ELLGSPEHLFWDPMKVHDIRWNFEKFLVGPDGAPVMRWFHQTPVRVVQSDIMEYLNQT
                     RTQ"
     exon            133..286
                     /gene="Gpx6"
                     /gene_synonym="OBPII; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
     exon            287..404
                     /gene="Gpx6"
                     /gene_synonym="OBPII; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..504
                     /gene="Gpx6"
                     /gene_synonym="OBPII; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..1150
                     /gene="Gpx6"
                     /gene_synonym="OBPII; Ry2d1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagttcctg aggtctgaga ctcatccagt cttctttgta caaccatgac ccagcagttc
       61 tggggtccct gtcttttctc attgtttatg gctgtattgg ctcaggagac actggatcct
      121 caaaaatcaa aggtggattg caacaaaggg gtggctggca ccgtctatga gtacggagcc
      181 aacaccttag atggtgggga gtatgtccag ttccagcagt atgcaggaaa gcacatcctc
      241 tttgtcaacg tggcgtcctt ctgtggcctg acagctacgt accctgaact gaacacattg
      301 caggaggagc tgagaccatt caatgtcagt gttttgggct ttccatgcaa ccagtttgga
      361 aaacaagaac ctggaaagaa ctcagagatc ctccttggac tcaaatatgt tcgcccaggc
      421 ggtggctttg ttcccaattt ccagctcttt gagaaggggg atgtgaacgg agacaatgaa
      481 caaaaggttt tttctttcct aaagagctcc tgccctccca cctctgaact tcttggctct
      541 ccagaacatc tcttctggga tcccatgaag gtccatgaca ttcgctggaa ctttgagaag
      601 ttcctggtgg gaccggatgg agcccctgtc atgcgctggt tccaccagac tcctgtcaga
      661 gttgtccagt cagacatcat ggagtaccta aaccaaaccc gtacccagta ggatgtttta
      721 caaatagtgc ctttgctcca ccccttcacc agcctccata tgatcaaagc ctgcaacact
      781 acttgtgtcc ttactaatgt gtgtacaaac agaagtttat ttgtggtagg catatgcatg
      841 cattggaaat taagttaaaa aaaaacaatt atccacccag atatctgact ctcatatatc
      901 tagtttccct aatctagtcc aaaagaaagt catattttgg caatgatgat ccagacaatt
      961 ccatatatct aaaaagtgat ctaccaagac cctaatctat cattcacagc actggtgggt
     1021 taaaagaagt gggaacgggt ggccagatcc tctgggtccc agtatcttct cctcccaagc
     1081 tgggcatgct ttgtcaagct ctccttctgt ttagctcctt agtacaacac tgacccatag
     1141 ttatcttagg
//
