LOCUS       NM_001105738            1641 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus glutathione peroxidase 5 (Gpx5), mRNA.
ACCESSION   NM_001105738 XM_001059839 XM_574039
VERSION     NM_001105738.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1641)
  AUTHORS   Cueto-Urena,C., Ramirez-Exposito,M.J., Mayas,M.D.,
            Carrera-Gonzalez,M.P., Godoy-Hurtado,A. and Martinez-Martos,J.M.
  TITLE     Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns
  JOURNAL   Genes (Basel) 14 (9), 1674 (2023)
   PUBMED   37761814
  REMARK    GeneRIF: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1641)
  AUTHORS   Maremanda,K.P., Khan,S. and Jena,G.B.
  TITLE     Role of Zinc Supplementation in Testicular and Epididymal Damages
            in Diabetic Rat: Involvement of Nrf2, SOD1, and GPX5
  JOURNAL   Biol Trace Elem Res 173 (2), 452-464 (2016)
   PUBMED   27025721
  REMARK    GeneRIF: Diabetic testes showed decreased Nrf2, HO-1, SOD1, PCNA,
            and Bcl-2 expressions whereas increased COX-2, NF-kappaB, MT, IL-6,
            and p-ERK levels. SOD1 and GPX5 were decreased in the epididymis of
            diabetic rat, whereas Zn supplementation attenuated these changes.
REFERENCE   3  (bases 1 to 1641)
  AUTHORS   Taylor,A., Robson,A., Houghton,B.C., Jepson,C.A., Ford,W.C. and
            Frayne,J.
  TITLE     Epididymal specific, selenium-independent GPX5 protects cells from
            oxidative stress-induced lipid peroxidation and DNA mutation
  JOURNAL   Hum Reprod 28 (9), 2332-2342 (2013)
   PUBMED   23696541
  REMARK    GeneRIF: Data (from studies with recombinant GPX5) suggest that
            GPX5 is secreted by epididymis via exocytosis/epididymosomes; then
            GPX5 is able to associate with (or transfer to) plasma membrane of
            sperm where it may protect sperm against oxidative damage.
REFERENCE   4  (bases 1 to 1641)
  AUTHORS   Chabory,E., Damon,C., Lenoir,A., Kauselmann,G., Kern,H., Zevnik,B.,
            Garrel,C., Saez,F., Cadet,R., Henry-Berger,J., Schoor,M.,
            Gottwald,U., Habenicht,U., Drevet,J.R. and Vernet,P.
  TITLE     Epididymis seleno-independent glutathione peroxidase 5 maintains
            sperm DNA integrity in mice
  JOURNAL   J Clin Invest 119 (7), 2074-2085 (2009)
   PUBMED   19546506
REFERENCE   5  (bases 1 to 1641)
  AUTHORS   Rejraji,H., Vernet,P. and Drevet,J.R.
  TITLE     GPX5 is present in the mouse caput and cauda epididymidis lumen at
            three different locations
  JOURNAL   Mol Reprod Dev 63 (1), 96-103 (2002)
   PUBMED   12211066
REFERENCE   6  (bases 1 to 1641)
  AUTHORS   Vernet,P., Faure,J., Dufaure,J.P. and Drevet,J.R.
  TITLE     Tissue and developmental distribution, dependence upon testicular
            factors and attachment to spermatozoa of GPX5, a murine
            epididymis-specific glutathione peroxidase
  JOURNAL   Mol Reprod Dev 47 (1), 87-98 (1997)
   PUBMED   9110319
REFERENCE   7  (bases 1 to 1641)
  AUTHORS   Perry,A.C., Jones,R., Niang,L.S., Jackson,R.M. and Hall,L.
  TITLE     Genetic evidence for an androgen-regulated epididymal secretory
            glutathione peroxidase whose transcript does not contain a
            selenocysteine codon
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 863-870 (1992)
   PUBMED   1386734
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001105738.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.948265.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN12840114
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000017.1  48131853-48131965
            114-267             JAXUCZ010000017.1  48133628-48133781
            268-385             JAXUCZ010000017.1  48135862-48135979
            386-485             JAXUCZ010000017.1  48136439-48136538
            486-1641            JAXUCZ010000017.1  48137646-48138801
FEATURES             Location/Qualifiers
     source          1..1641
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q11"
     gene            1..1641
                     /gene="Gpx5"
                     /note="glutathione peroxidase 5"
                     /db_xref="GeneID:113919"
                     /db_xref="RGD:69227"
     exon            1..113
                     /gene="Gpx5"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..692
                     /gene="Gpx5"
                     /EC_number="1.11.1.9"
                     /note="epididymal secretory glutathione peroxidase; EGLP;
                     epididymis-specific glutathione peroxidase-like protein;
                     GPx-5; GSHPx-5"
                     /codon_start=1
                     /product="epididymal secretory glutathione peroxidase
                     precursor"
                     /protein_id="NP_001099208.1"
                     /db_xref="GeneID:113919"
                     /db_xref="RGD:69227"
                     /translation="MAIQLRVFYLVPLLLASYVQTTPRLEKMKMDCYKDVKGTIYNYE
                     ALSLNGKERIPFKQYAGKHVLFVNVATYCGLTIQYPELNALQDDLKQFGLVILGFPCN
                     QFGKQEPGDNTEILPGLKYVRPGKGFLPNFQLFAKGDVNGEKEQEIFTFLKRSCPHPS
                     ETVVTSKHTFWEPIKVHDIRWNFEKFLVGPNGVPVMRWFHQAPVSTVKSDILAYLNQF
                     KTI"
     exon            114..267
                     /gene="Gpx5"
                     /inference="alignment:Splign:2.1.0"
     exon            268..385
                     /gene="Gpx5"
                     /inference="alignment:Splign:2.1.0"
     exon            386..485
                     /gene="Gpx5"
                     /inference="alignment:Splign:2.1.0"
     exon            486..1641
                     /gene="Gpx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacccgaa gtcggcagta ttagtcatgg ctatacagct aagagtcttc tatctcgttc
       61 cacttcttct agccagctat gtgcagacaa cccccaggct ggaaaagatg aagatggact
      121 gctacaaaga tgtgaaaggc accatctaca actacgaggc tctgtctctt aatgggaagg
      181 aacgcattcc attcaagcag tatgcaggaa agcacgtcct ctttgtcaat gtggctacct
      241 attgtggtct gacaattcag tatcctgaac tgaatgcact ccaggatgat ctgaagcaat
      301 ttggcttggt tatattgggc tttccctgca accaatttgg aaagcaagaa ccaggagaca
      361 atacagagat tcttcctggg ctcaagtatg ttcgtccggg aaaaggattt ttacctaatt
      421 tccagctttt tgcgaaaggg gatgtaaatg gtgaaaaaga gcaggaaatc tttaccttct
      481 tgaagcgctc ctgtcctcac ccctcagaga ctgtggtcac aagcaaacat acattctggg
      541 agccaataaa agtccatgac atccgctgga actttgagaa gtttctggtg ggacccaacg
      601 gtgtccctgt catgcgctgg ttccaccagg ctcctgtcag cactgtcaag tctgacatcc
      661 tggcgtacct gaatcaattc aaaaccatat aggaaggcaa gcttctgatc tcttcctcct
      721 ctttctccct gaaagctgct ctgaaaaaag actccacctt ctcagcatgc tctttactga
      781 aatggactct acctgcccaa gtcaccccta aattacctaa gttcttcccc tgcacaagca
      841 gatttgtgtc tggaaagctg aagatgtttt tccttgttag atttatgagt taaagaaaga
      901 aaagagaaga aaggaaaaga aaagaaaaga aaagaaaaga aaagaaaaga aaagctaaat
      961 ccagaggcct cagttacagg tttggctggg tgtgttagta ttcacctaca atgtgaacac
     1021 tcagcagaca ttacagacat ttcagacaga cagagacaag aggaacatga attctaggcc
     1081 agcctgggct acaagaaatc ttgtgtcaaa acaaaaaaat ccatcaacaa caacgtaacc
     1141 tgtttgaacc actcaaattc accaaaggac attaggctag cttggttgga cattgtatct
     1201 ggaggaagag tccccttggc cattctgagt ctttctcttc ccagcctgaa ggtggagaaa
     1261 gagcaatgga ggatggtcag acaacctagg ttgttcctcc taaaatgtgt gtctcccgag
     1321 acaaatgcct tgtcagttcc tgagttcttt tagttcggtc ttcatccctg tcccatcctg
     1381 tctgcccttc tcctgtggcc agtccaaggg agagtaggag aagattgact cacacaggaa
     1441 gagggcatct ccctgctgtc aggatccggg acttgtccct gatgctgcaa aagtgcacct
     1501 tctggtttga tcttcactgg ttcagctagt gcttttgagc agggatgtca tttgaagaat
     1561 aggaccccga ccctacccca acctgggatt cctcaacttc agaactagac atattatttc
     1621 caataaaatg ttttctgaag c
//
