LOCUS       NM_022525               1568 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutathione peroxidase 3 (Gpx3), mRNA.
ACCESSION   NM_022525 XM_346395
VERSION     NM_022525.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1568)
  AUTHORS   Li,Y., Zhou,Y., Liu,D., Wang,Z., Qiu,J., Zhang,J., Chen,P.,
            Zeng,G., Guo,Y., Wang,X., DiSanto,M.E. and Zhang,X.
  TITLE     Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis
            via AMPK /ERK1/2 pathway and resisted autophagy-related ferroptosis
            via AMPK/mTOR pathway in hyperplastic prostate
  JOURNAL   J Transl Med 21 (1), 575 (2023)
   PUBMED   37633909
  REMARK    GeneRIF: Glutathione Peroxidase 3 induced mitochondria-mediated
            apoptosis via AMPK /ERK1/2 pathway and resisted autophagy-related
            ferroptosis via AMPK/mTOR pathway in hyperplastic prostate.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1568)
  AUTHORS   Cueto-Urena,C., Ramirez-Exposito,M.J., Mayas,M.D.,
            Carrera-Gonzalez,M.P., Godoy-Hurtado,A. and Martinez-Martos,J.M.
  TITLE     Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns
  JOURNAL   Genes (Basel) 14 (9), 1674 (2023)
   PUBMED   37761814
  REMARK    GeneRIF: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1568)
  AUTHORS   Saleh,S., Ghanaatpisheh,A., Haghshenas,H., Parvin,N.,
            Mikaeiliagah,E., Kargar Jahromi,H. and Ebrahimi,B.
  TITLE     The effect of leaf hydroalcoholic extract of Ephedra pachyclada
            infertility in male rats treated with cyclophosphamide: An
            experimental study
  JOURNAL   Int J Reprod Biomed 21 (4), 285-294 (2023)
   PUBMED   37260555
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1568)
  AUTHORS   Pei,J., Tian,X., Yu,C., Luo,J., Zhang,J., Hua,Y. and Wei,G.
  TITLE     GPX3 and GSTT1 as biomarkers related to oxidative stress during
            renal ischemia reperfusion injuries and their relationship with
            immune infiltration
  JOURNAL   Front Immunol 14, 1136146 (2023)
   PUBMED   37033969
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1568)
  AUTHORS   Wu,X., Tang,S., Dai,Q., Yi,B., Yang,S., Sun,J., Zhong,Y., Lin,W.,
            Liu,J., Liu,Y., Wang,J., Liu,J., Liao,Q., Zhang,W. and Zhang,H.
  TITLE     Vitamin D-vitamin D receptor alleviates oxidative stress in
            ischemic acute kidney injury via upregulating glutathione
            peroxidase 3
  JOURNAL   FASEB J 37 (2), e22738 (2023)
   PUBMED   36583727
REFERENCE   6  (bases 1 to 1568)
  AUTHORS   Yoshimura,S., Watanabe,K., Suemizu,H., Onozawa,T., Mizoguchi,J.,
            Tsuda,K., Hatta,H. and Moriuchi,T.
  TITLE     Tissue specific expression of the plasma glutathione peroxidase
            gene in rat kidney
  JOURNAL   J Biochem 109 (6), 918-923 (1991)
   PUBMED   1939013
REFERENCE   7  (bases 1 to 1568)
  AUTHORS   Esworthy,R.S., Chu,F.F., Paxton,R.J., Akman,S. and Doroshow,J.H.
  TITLE     Characterization and partial amino acid sequence of human plasma
            glutathione peroxidase
  JOURNAL   Arch Biochem Biophys 286 (2), 330-336 (1991)
   PUBMED   1897960
REFERENCE   8  (bases 1 to 1568)
  AUTHORS   Avissar,N., Whitin,J.C., Allen,P.Z., Palmer,I.S. and Cohen,H.J.
  TITLE     Antihuman plasma glutathione peroxidase antibodies: immunologic
            investigations to determine plasma glutathione peroxidase protein
            and selenium content in plasma
  JOURNAL   Blood 73 (1), 318-323 (1989)
   PUBMED   2491950
REFERENCE   9  (bases 1 to 1568)
  AUTHORS   Maddipati,K.R. and Marnett,L.J.
  TITLE     Characterization of the major hydroperoxide-reducing activity of
            human plasma. Purification and properties of a selenium-dependent
            glutathione peroxidase
  JOURNAL   J Biol Chem 262 (36), 17398-17403 (1987)
   PUBMED   3693360
REFERENCE   10 (bases 1 to 1568)
  AUTHORS   Takahashi,K., Avissar,N., Whitin,J. and Cohen,H.
  TITLE     Purification and characterization of human plasma glutathione
            peroxidase: a selenoglycoprotein distinct from the known cellular
            enzyme
  JOURNAL   Arch Biochem Biophys 256 (2), 677-686 (1987)
   PUBMED   3619451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000010.1, FM059908.1,
            FM066296.1, FM067533.1, FM066354.1 and CK477403.1.
            
            On Aug 3, 2016 this sequence version replaced NM_022525.3.
            
            Summary: The protein encoded by this gene belongs to the
            glutathione peroxidase family, members of which catalyze the
            reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by
            glutathione, and thereby protect cells against oxidative damage.
            Several isozymes of this gene family exist in vertebrates, which
            vary in cellular location and substrate specificity. This isozyme
            is secreted and is predominantly expressed in rat kidney, which
            appears to be the major source of the enzyme in plasma.
            Dysregulation of this isozyme has been associated with
            obesity-related metabolic complications. This isozyme is also a
            selenoprotein, containing the rare amino acid selenocysteine (Sec)
            at its active site. Sec is encoded by the UGA codon, which normally
            signals translation termination. The 3' UTRs of selenoprotein mRNAs
            contain a conserved stem-loop structure, designated the Sec
            insertion sequence (SECIS) element, that is necessary for the
            recognition of UGA as a Sec codon, rather than as a stop signal.
            [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228545.1, FQ228965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            protein contains selenocysteine  :: PMID: 1939013
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000010.1  39529335-39529380
            47-540              FM059908.1         1-494
            541-637             FM066296.1         483-579
            638-791             FM067533.1         516-669
            792-1402            FM066354.1         42-652
            1403-1568           CK477403.1         45-210
FEATURES             Location/Qualifiers
     source          1..1568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..1568
                     /gene="Gpx3"
                     /gene_synonym="GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P"
                     /note="glutathione peroxidase 3"
                     /db_xref="GeneID:64317"
                     /db_xref="RGD:69224"
     exon            1..238
                     /gene="Gpx3"
                     /gene_synonym="GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..832
                     /gene="Gpx3"
                     /gene_synonym="GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P"
                     /EC_number="1.11.1.9"
                     /note="UGA stop codon recoded as selenocysteine; plasma
                     glutathione peroxidase"
                     /codon_start=1
                     /transl_except=(pos:368..370,aa:Sec)
                     /product="glutathione peroxidase 3 precursor"
                     /protein_id="NP_071970.2"
                     /db_xref="GeneID:64317"
                     /db_xref="RGD:69224"
                     /translation="MARILRASCLLSLLLAGFVPPGRGQEKSKTDCHGGMSGTIYEYG
                     ALTIDGEEYIPFKQYAGKYILFVNVASYUGLTDQYLELNALQEELGPFGLVILGFPCN
                     QFGKQEPGENSEILPSLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTA
                     ELLGSPGRLFWEPMKIHDIRWNFEKFLVGPDGIPIMRWYHRTTVSNVKMDILSYMRRQ
                     AALGARGK"
     exon            239..392
                     /gene="Gpx3"
                     /gene_synonym="GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     exon            393..510
                     /gene="Gpx3"
                     /gene_synonym="GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     exon            511..610
                     /gene="Gpx3"
                     /gene_synonym="GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     exon            611..1555
                     /gene="Gpx3"
                     /gene_synonym="GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1352..1425
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Gpx3"
                     /gene_synonym="GPx-3; GPx-P; Gpxp; GSHPx-3; GSHPx-P"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
ORIGIN      
        1 tcttgccctt taaatcctaa ccgcgttgct attggctagg aagcctccgg cctggctgcg
       61 gattggccac agtggagggc ttgaaatgtg gctgggcgct tcggacacct cagacggacg
      121 gtggccaccc caagacgcgc cccagcccgc catggcccgg atccttcggg catcctgcct
      181 cctgtccctg ctcctggccg ggtttgttcc gccgggccgg ggacaagaga agtccaagac
      241 agactgccat ggcggtatga gcggtaccat ctacgagtat ggagccctta ccatcgatgg
      301 ggaggaatac attcctttta agcagtatgc tggcaaatac atcctctttg tcaacgtagc
      361 cagctactga ggtctgacag accaatacct tgaactgaat gcactacaag aagaacttgg
      421 cccattcggc ctggtcattc tgggcttccc ttgcaaccaa tttggcaaac aggagccagg
      481 cgagaactcg gagatcctgc ctagtctcaa gtacgttcga ccgggtgggg gctttgtgcc
      541 taatttccag ctctttgaga aaggagacgt gaacggggag aaagagcaga agttctacac
      601 tttcctgaag aactcctgcc ctcccactgc ggaactcctg ggctcacctg gccgcctctt
      661 ttgggaaccc atgaagatcc atgacatccg ctggaacttt gagaagttcc tggtggggcc
      721 agatggcata ccaattatgc gctggtacca ccggaccaca gtcagcaacg tcaagatgga
      781 catcctgtcc tatatgaggc ggcaggcagc cctgggggcc agagggaagt aactgatgcc
      841 ctaccccacc ccaccccatc ccctgcccat catgcaaggg ctggggaggg gctcttcagg
      901 aaggaagcaa aaaacggaat cattctacac atacatccca gattcccttc cttattacat
      961 aaaagacaag cttggcacaa ctgtgtgcct gtaccactgt gcacacgtgg caactgtccc
     1021 actgtgtgcc atgcactgcc tgcctggaac ccagggacag accatctgtg ctcacggttt
     1081 ggtacaacac cttcacactt tctccagctt cccgttccaa atgagcccaa agcaaacaca
     1141 agttctaagt ccaatggtcc tgctcaaacc tgaacatcat tcttggggcc agcatctccc
     1201 atatgcccac atgacacatc cgggctcact atgccaccag cctccttcat ccctcctgaa
     1261 ggaccctcct aagtctccaa ccccatccca cagtgctcct gagaagagcc gagacaatgg
     1321 tgagcacgat ggccatgtgc tccaagtcag gggtggtgtc tccatgaagg aggggcccga
     1381 agcccttgtg ggcgggcctc ccctgagccc gtctgtggtg ccagccctta gtgcattcag
     1441 gcttaggctc ccaggcaggg acaccatccc cctctctgga ggacatgcct tcttctcact
     1501 ctgtccactg gcatctctcg caccccatct gcccaataaa cgtctttctg cagcaaaaaa
     1561 aaaaaaaa
//
