LOCUS       NP_899653                190 aa            linear   ROD 03-APR-2024
DEFINITION  glutathione peroxidase 2 [Rattus norvegicus].
ACCESSION   NP_899653 XP_238459
VERSION     NP_899653.2
DBSOURCE    REFSEQ: accession NM_183403.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 190)
  AUTHORS   Cueto-Urena,C., Ramirez-Exposito,M.J., Mayas,M.D.,
            Carrera-Gonzalez,M.P., Godoy-Hurtado,A. and Martinez-Martos,J.M.
  TITLE     Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns
  JOURNAL   Genes (Basel) 14 (9), 1674 (2023)
   PUBMED   37761814
  REMARK    GeneRIF: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 190)
  AUTHORS   Goodla,L., Manubolu,M., Pathakoti,K., Jayakumar,T., Sheu,J.R.,
            Fraker,M., Tchounwou,P.B. and Poondamalli,P.R.
  TITLE     Protective Effects of Ammannia baccifera Against CCl4-Induced
            Oxidative Stress in Rats
  JOURNAL   Int J Environ Res Public Health 16 (8), 1440 (2019)
   PUBMED   31018559
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 190)
  AUTHORS   Hughes,D.J., Kunicka,T., Schomburg,L., Liska,V., Swan,N. and
            Soucek,P.
  TITLE     Expression of Selenoprotein Genes and Association with Selenium
            Status in Colorectal Adenoma and Colorectal Cancer
  JOURNAL   Nutrients 10 (11), 1812 (2018)
   PUBMED   30469315
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 190)
  AUTHORS   Saxena,A., Fayad,R., Kaur,K., Truman,S., Greer,J., Carson,J.A. and
            Chanda,A.
  TITLE     Dietary selenium protects adiponectin knockout mice against chronic
            inflammation induced colon cancer
  JOURNAL   Cancer Biol Ther 18 (4), 257-267 (2017)
   PUBMED   28045589
REFERENCE   5  (residues 1 to 190)
  AUTHORS   Herlan,L., Schulz,A., Schulte,L., Schulz,H., Hubner,N. and
            Kreutz,R.
  TITLE     Novel candidate genes for impaired nephron development in a rat
            model with inherited nephron deficit and albuminuria
  JOURNAL   Clin Exp Pharmacol Physiol 42 (10), 1051-1058 (2015)
   PUBMED   26192016
REFERENCE   6  (residues 1 to 190)
  AUTHORS   Drew,J.E., Farquharson,A.J., Arthur,J.R., Morrice,P.C. and
            Duthie,G.G.
  TITLE     Novel sites of cytosolic glutathione peroxidase expression in colon
  JOURNAL   FEBS Lett 579 (27), 6135-6139 (2005)
   PUBMED   16229841
  REMARK    GeneRIF: Novel sites of Gpx2 expression were observed in colon
            lymphatic tissue.
REFERENCE   7  (residues 1 to 190)
  AUTHORS   Drew,J.E., Arthur,J.R., Farquharson,A.J., Russell,W.R.,
            Morrice,P.C. and Duthie,G.G.
  TITLE     Salicylic acid modulates oxidative stress and glutathione
            peroxidase activity in the rat colon
  JOURNAL   Biochem Pharmacol 70 (6), 888-893 (2005)
   PUBMED   16038882
REFERENCE   8  (residues 1 to 190)
  AUTHORS   Esworthy,R.S., Binder,S.W., Doroshow,J.H. and Chu,F.F.
  TITLE     Microflora trigger colitis in mice deficient in selenium-dependent
            glutathione peroxidase and induce Gpx2 gene expression
  JOURNAL   Biol Chem 384 (4), 597-607 (2003)
   PUBMED   12751789
REFERENCE   9  (residues 1 to 190)
  AUTHORS   Esworthy,R.S., Aranda,R., Martin,M.G., Doroshow,J.H., Binder,S.W.
            and Chu,F.F.
  TITLE     Mice with combined disruption of Gpx1 and Gpx2 genes have colitis
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 281 (3), G848-G855 (2001)
   PUBMED   11518697
REFERENCE   10 (residues 1 to 190)
  AUTHORS   Esworthy,R.S., Swiderek,K.M., Ho,Y.S. and Chu,F.F.
  TITLE     Selenium-dependent glutathione peroxidase-GI is a major glutathione
            peroxidase activity in the mucosal epithelium of rodent intestine
  JOURNAL   Biochim Biophys Acta 1381 (2), 213-226 (1998)
   PUBMED   9685647
  REMARK    GeneRIF: The Swiss-Prot/TrEMBL Accession Number for glutathione
            peroxidase 2 is P83645.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG664050.1, CX570255.1 and
            BQ196565.1.
            
            On Apr 13, 2007 this sequence version replaced NP_899653.1.
            
            Summary: The protein encoded by this gene belongs to the
            glutathione peroxidase family, members of which catalyze the
            reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by
            glutathione, and thereby protect cells against oxidative damage.
            Several isozymes of this gene family exist in vertebrates, which
            vary in cellular location and substrate specificity. This isozyme
            is predominantly expressed in the gastrointestinal tract in
            rodents, is localized in the cytoplasm, and whose preferred
            substrate is hydrogen peroxide. Knockout studies in mice lacking
            this gene suggest a role for this isozyme in intestinal
            inflammation and colon cancer development. This isozyme is also a
            selenoprotein, containing the rare amino acid selenocysteine (Sec)
            at its active site. Sec is encoded by the UGA codon, which normally
            signals translation termination. The 3' UTRs of selenoprotein mRNAs
            contain a conserved stem-loop structure, designated the Sec
            insertion sequence (SECIS) element, that is necessary for the
            recognition of UGA as a Sec codon, rather than as a stop signal.
            Pseudogenes of this locus have been identified on chromosomes 2 and
            X. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220474.1, CX570255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: inferred from conservation
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..190
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     Protein         1..190
                     /product="glutathione peroxidase 2"
                     /EC_number="1.11.1.9"
                     /EC_number="1.11.1.12"
                     /note="glutathione peroxidase-gastrointestinal; GPx-2;
                     phospholipid hydroperoxide glutathione peroxidase GPX2"
                     /calculated_mol_wt=21843
     Region          7..182
                     /region_name="GSH_Peroxidase"
                     /note="Glutathione (GSH) peroxidase family; tetrameric
                     selenoenzymes that catalyze the reduction of a variety of
                     hydroperoxides including lipid peroxidases, using GSH as a
                     specific electron donor substrate. GSH peroxidase contains
                     one selenocysteine residue per...; cd00340"
                     /db_xref="CDD:238207"
     Site            order(40,74,152)
                     /site_type="active"
                     /note="catalytic residues [active]"
                     /db_xref="CDD:238207"
     Site            40
                     /site_type="other"
                     /note="Selenocysteine"
     Site            order(73,76,78,81,84,88)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238207"
     CDS             1..190
                     /gene="Gpx2"
                     /gene_synonym="GPX-GI; GSHPx-2; GSHPx-GI"
                     /coded_by="NM_183403.2:122..694"
                     /note="UGA stop codon recoded as selenocysteine"
                     /db_xref="GeneID:29326"
                     /db_xref="RGD:727780"
ORIGIN      
        1 mayiaksfyd lsaigldgek idfntfrgra vlienvaslu gtttrdytql nelqcrfprr
       61 lvvlgfpcnq fghqencqne eilnslkyvr pgggfqptfs ltqkcdvngq nqhpvfaylk
      121 dklpypyddp fslmtdpkli iwspvrrsdv swnfekflig pegepfrrys rtfqtiniep
      181 dikrllkvai
//
