LOCUS       NM_030826                930 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus glutathione peroxidase 1 (Gpx1), mRNA.
ACCESSION   NM_030826
VERSION     NM_030826.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Cueto-Urena,C., Ramirez-Exposito,M.J., Mayas,M.D.,
            Carrera-Gonzalez,M.P., Godoy-Hurtado,A. and Martinez-Martos,J.M.
  TITLE     Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns
  JOURNAL   Genes (Basel) 14 (9), 1674 (2023)
   PUBMED   37761814
  REMARK    GeneRIF: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in
            Experimental Brain Tumors Reveals Gender-Dependent Patterns.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 930)
  AUTHORS   Lei,L., Zhang,F., Huang,J., Yang,X., Zhou,X., Yan,H., Chen,C.,
            Zheng,S., Si,L., Jose,P.A., Zeng,C. and Yang,J.
  TITLE     Selenium deficiency causes hypertension by increasing renal AT1
            receptor expression via GPx1/H2O2/NF-kappaB pathway
  JOURNAL   Free Radic Biol Med 200, 59-72 (2023)
   PUBMED   36868433
  REMARK    GeneRIF: Selenium deficiency causes hypertension by increasing
            renal AT1 receptor expression via GPx1/H2O2/NF-kappaB pathway.
REFERENCE   3  (bases 1 to 930)
  AUTHORS   Lu,B., Li,J., Gui,M., Yao,L., Fan,M., Zhou,X. and Fu,D.
  TITLE     Salvianolic acid B inhibits myocardial I/R-induced ROS generation
            and cell apoptosis by regulating the TRIM8/GPX1 pathway
  JOURNAL   Pharm Biol 60 (1), 1458-1468 (2022)
   PUBMED   35968584
  REMARK    GeneRIF: Salvianolic acid B inhibits myocardial I/R-induced ROS
            generation and cell apoptosis by regulating the TRIM8/GPX1 pathway.
REFERENCE   4  (bases 1 to 930)
  AUTHORS   Laribi,A., Aouf,S., Gabbouj,S., Bouaouinaa,N., Zakhama,A. and
            Harizi,H.
  TITLE     Human glutathione peroxidase codon 198 variant increases
            nasopharyngeal carcinoma risk and progression
  JOURNAL   Eur Arch Otorhinolaryngol 278 (10), 4027-4034 (2021)
   PUBMED   33616746
REFERENCE   5  (bases 1 to 930)
  AUTHORS   Christensen,M.J. and Burgener,K.W.
  TITLE     Dietary selenium stabilizes glutathione peroxidase mRNA in rat
            liver
  JOURNAL   J Nutr 122 (8), 1620-1626 (1992)
   PUBMED   1640255
REFERENCE   6  (bases 1 to 930)
  AUTHORS   Ho,Y.S. and Howard,A.J.
  TITLE     Cloning and characterization of the rat glutathione peroxidase gene
  JOURNAL   FEBS Lett 301 (1), 5-9 (1992)
   PUBMED   1451786
REFERENCE   7  (bases 1 to 930)
  AUTHORS   Yoshimura,S., Takekoshi,S., Watanabe,K. and Fujii-Kuriyama,Y.
  TITLE     Determination of nucleotide sequence of cDNA coding rat glutathione
            peroxidase and diminished expression of the mRNA in selenium
            deficient rat liver
  JOURNAL   Biochem Biophys Res Commun 154 (3), 1024-1028 (1988)
   PUBMED   3408482
REFERENCE   8  (bases 1 to 930)
  AUTHORS   Reddy,A.P., Hsu,B.L., Reddy,P.S., Li,N.Q., Thyagaraju,K.,
            Reddy,C.C., Tam,M.F. and Tu,C.P.
  TITLE     Expression of glutathione peroxidase I gene in selenium-deficient
            rats
  JOURNAL   Nucleic Acids Res 16 (12), 5557-5568 (1988)
   PUBMED   2838821
REFERENCE   9  (bases 1 to 930)
  AUTHORS   Ho,Y.S., Howard,A.J. and Crapo,J.D.
  TITLE     Nucleotide sequence of a rat glutathione peroxidase cDNA
  JOURNAL   Nucleic Acids Res 16 (11), 5207 (1988)
   PUBMED   3387231
REFERENCE   10 (bases 1 to 930)
  AUTHORS   Lawrence,R.A. and Burk,R.F.
  TITLE     Glutathione peroxidase activity in selenium-deficient rat liver
  JOURNAL   Biochem Biophys Res Commun 71 (4), 952-958 (1976)
   PUBMED   971321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FQ139913.1 and FQ231953.1.
            
            On Jul 15, 2016 this sequence version replaced NM_030826.3.
            
            Summary: The protein encoded by this gene belongs to the
            glutathione peroxidase family, members of which catalyze the
            reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by
            glutathione, and thereby protect cells against oxidative damage.
            Other studies indicate that H2O2 is also essential for
            growth-factor mediated signal transduction, mitochondrial function,
            and maintenance of thiol redox-balance; therefore, by limiting H2O2
            accumulation, glutathione peroxidases are also involved in
            modulating these processes. Several isozymes of this gene family
            exist in vertebrates, which vary in cellular location and substrate
            specificity. This isozyme is the most abundant, is ubiquitously
            expressed and localized in the cytoplasm, and whose preferred
            substrate is hydrogen peroxide. It is also a selenoprotein,
            containing the rare amino acid selenocysteine (Sec) at its active
            site. Sec is encoded by the UGA codon, which normally signals
            translation termination. The 3' UTRs of selenoprotein mRNAs contain
            a conserved stem-loop structure, designated the Sec insertion
            sequence (SECIS) element, that is necessary for the recognition of
            UGA as a Sec codon, rather than as a stop signal. [provided by
            RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227523.1, FQ211052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: PMID: 3408482
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-501               FQ139913.1         1-501
            502-930             FQ231953.1         505-933
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..930
                     /gene="Gpx1"
                     /gene_synonym="GSHPx; GSHPx-1"
                     /note="glutathione peroxidase 1"
                     /db_xref="GeneID:24404"
                     /db_xref="RGD:2729"
     exon            1..339
                     /gene="Gpx1"
                     /gene_synonym="GSHPx; GSHPx-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..699
                     /gene="Gpx1"
                     /gene_synonym="GSHPx; GSHPx-1"
                     /EC_number="1.11.1.9"
                     /EC_number="1.11.1.12"
                     /note="UGA stop codon recoded as selenocysteine; cellular
                     glutathione peroxidase; GPx-1; phospholipid-hydroperoxide
                     glutathione peroxidase GPX1"
                     /codon_start=1
                     /transl_except=(pos:232..234,aa:Sec)
                     /product="glutathione peroxidase 1"
                     /protein_id="NP_110453.3"
                     /db_xref="GeneID:24404"
                     /db_xref="RGD:2729"
                     /translation="MSAARLSAVAQSTVYAFSARPLAGGEPVSLGSLRGKVLLIENVA
                     SLUGTTTRDYTEMNDLQKRLGPRGLVVLGFPCNQFGHQENGKNEEILNSLKYVRPGGG
                     FEPNFTLFEKCEVNGEKAHPLFTFLRNALPAPSDDPTALMTDPKYIIWSPVCRNDISW
                     NFEKFLVGPDGVPVRRYSRRFRTIDIEPDIEALLSKQPSNP"
     exon            340..910
                     /gene="Gpx1"
                     /gene_synonym="GSHPx; GSHPx-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      743..818
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Gpx1"
                     /gene_synonym="GSHPx; GSHPx-1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      886..891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gpx1"
                     /gene_synonym="GSHPx; GSHPx-1"
     polyA_site      910
                     /gene="Gpx1"
                     /gene_synonym="GSHPx; GSHPx-1"
ORIGIN      
        1 gaagccacgt gatctcagcc ccatccagtt aaaaggaggt gctgggctct gactgcgcta
       61 cagcggattt ttgagtccaa tatcttctac agtatgtctg ctgctcggct ctccgcggtg
      121 gcacagtcca ccgtgtatgc cttctccgcg cgcccgctgg cgggcgggga gcccgtgagc
      181 ctgggctccc tgcggggcaa ggtgctgctc attgagaatg tcgcgtccct ctgaggcacc
      241 acgacccggg actacaccga aatgaatgat ctgcagaagc gtctggggcc tcgtggcctg
      301 gtggtgctcg gtttcccgtg caatcagttc ggacatcagg agaatggcaa gaatgaagag
      361 attctgaatt ccctcaagta tgtccgaccc ggtggtgggt tcgagcccaa ctttacattg
      421 tttgagaagt gcgaggtgaa tggtgagaag gctcacccgc tctttacctt cctgcggaat
      481 gccttgccag cacccagtga cgatcccact gcgctcatga ccgaccccaa gtacatcatt
      541 tggtccccgg tgtgccgcaa cgacatttcc tggaactttg agaagttcct ggtaggtcca
      601 gacggtgttc cagtgcgcag atacagcagg cgctttcgca ccatcgacat cgaacccgat
      661 atagaagccc tgctgtccaa gcagcctagc aacccctaag gcattcctgg tatctgggct
      721 tggtgatggc tggctgccct ccggggggag gtttttccat gacggtgttt cctctaaatt
      781 tacatggaga aacacctgat ttccagaaaa atcccctcag atgggcgctg gtctcgtcca
      841 ttcccgatgc ctttacgcct aaagaaaggc ggtttcacca ctaagaataa agtgctgaat
      901 gtcaaagaac aaaaaaaaaa aaaaaaaaaa
//
