LOCUS       NM_001012057            3645 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus glutamic--pyruvic transaminase 2 (Gpt2), mRNA.
ACCESSION   NM_001012057 XM_226351
VERSION     NM_001012057.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3645)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3645)
  AUTHORS   Qian,K., Zhong,S., Xie,K., Yu,D., Yang,R. and Gong,D.W.
  TITLE     Hepatic ALT isoenzymes are elevated in gluconeogenic conditions
            including diabetes and suppressed by insulin at the protein level
  JOURNAL   Diabetes Metab Res Rev 31 (6), 562-571 (2015)
   PUBMED   25865565
  REMARK    GeneRIF: Data suggest that both Alt1 and Alt2 are induced in liver
            during gluconeogenesis and in diabetes (Goto-Kakizaki rats); in
            hepatocytes, both Alt1 and Alt2 are induced by glucocorticoid
            dexamethasone and are suppressed by insulin.
REFERENCE   3  (bases 1 to 3645)
  AUTHORS   Rafter,I., Graberg,T., Kotronen,A., Strommer,L., Mattson,C.M.,
            Kim,R.W., Ehrenborg,E., Andersson,H.B., Yki-Jarvinen,H.,
            Schuppe-Koistinen,I., Ekblom,B., Cotgreave,I. and Glinghammar,B.
  TITLE     Isoform-specific alanine aminotransferase measurement can
            distinguish hepatic from extrahepatic injury in humans
  JOURNAL   Int J Mol Med 30 (5), 1241-1249 (2012)
   PUBMED   22922605
REFERENCE   4  (bases 1 to 3645)
  AUTHORS   Coss,C.C., Bauler,M., Narayanan,R., Miller,D.D. and Dalton,J.T.
  TITLE     Alanine aminotransferase regulation by androgens in non-hepatic
            tissues
  JOURNAL   Pharm Res 29 (4), 1046-1056 (2012)
   PUBMED   22167351
REFERENCE   5  (bases 1 to 3645)
  AUTHORS   Liu,R., Pan,X. and Whitington,P.F.
  TITLE     Increased hepatic expression is a major determinant of serum
            alanine aminotransferase elevation in mice with nonalcoholic
            steatohepatitis
  JOURNAL   Liver Int 29 (3), 337-343 (2009)
   PUBMED   18710424
REFERENCE   6  (bases 1 to 3645)
  AUTHORS   Yang,R.Z., Park,S., Reagan,W.J., Goldstein,R., Zhong,S., Lawton,M.,
            Rajamohan,F., Qian,K., Liu,L. and Gong,D.W.
  TITLE     Alanine aminotransferase isoenzymes: molecular cloning and
            quantitative analysis of tissue expression in rats and serum
            elevation in liver toxicity
  JOURNAL   Hepatology 49 (2), 598-607 (2009)
   PUBMED   19085960
REFERENCE   7  (bases 1 to 3645)
  AUTHORS   Jadhao,S.B., Yang,R.Z., Lin,Q., Hu,H., Anania,F.A., Shuldiner,A.R.
            and Gong,D.W.
  TITLE     Murine alanine aminotransferase: cDNA cloning, functional
            expression, and differential gene regulation in mouse fatty liver
  JOURNAL   Hepatology 39 (5), 1297-1302 (2004)
   PUBMED   15122758
  REMARK    Erratum:[Hepatology. 2004 Jul;40(1):269. Jadaho Sanjay B [corrected
            to Jadhao Sanjay B]]
REFERENCE   8  (bases 1 to 3645)
  AUTHORS   Yang,R.Z., Blaileanu,G., Hansen,B.C., Shuldiner,A.R. and Gong,D.W.
  TITLE     cDNA cloning, genomic structure, chromosomal mapping, and
            functional expression of a novel human alanine aminotransferase
  JOURNAL   Genomics 79 (3), 445-450 (2002)
   PUBMED   11863375
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On Sep 19, 2016 this sequence version replaced NM_001012057.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.52464.1,
                                           SRR26643298.75629.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               JAXUCZ010000019.1  37732495-37732759   c
            266-355             JAXUCZ010000019.1  37722306-37722395   c
            356-464             JAXUCZ010000019.1  37720148-37720256   c
            465-595             JAXUCZ010000019.1  37717770-37717900   c
            596-839             JAXUCZ010000019.1  37715076-37715319   c
            840-919             JAXUCZ010000019.1  37711043-37711122   c
            920-1056            JAXUCZ010000019.1  37708798-37708934   c
            1057-1231           JAXUCZ010000019.1  37707554-37707728   c
            1232-1387           JAXUCZ010000019.1  37705793-37705948   c
            1388-1500           JAXUCZ010000019.1  37704051-37704163   c
            1501-3645           JAXUCZ010000019.1  37700023-37702167   c
FEATURES             Location/Qualifiers
     source          1..3645
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..3645
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /note="glutamic--pyruvic transaminase 2"
                     /db_xref="GeneID:307759"
                     /db_xref="RGD:1305462"
     exon            1..265
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1591
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /EC_number="2.6.1.2"
                     /note="glutamic pyruvate transaminase (alanine
                     aminotransferase) 2"
                     /codon_start=1
                     /product="alanine aminotransferase 2"
                     /protein_id="NP_001012057.1"
                     /db_xref="GeneID:307759"
                     /db_xref="RGD:1305462"
                     /translation="MQRAAVLVRRGSCPRASGPWGRSHSSAAAEASAALKVRPERSPR
                     DRILTLESMNPQVKAVEYAVRGPIVLKAGEIEMELQRGIKKPFTEVIRANIGDAHAMG
                     QQPITFLRQVMALCTYPNLLNSPSFPEDAKKRARRILQACGGNSLGSYSASQGVNCIR
                     EDVAAFITRRDGVPADPDNIYLTTGASDGISTILKLLVSGGGKSRTGVMIPIPQYPLY
                     SAVISELDAIQVNYYLDEDNCWALNVDELRRALRQAKDHCDPKVLCIINPGNPTGQVQ
                     SRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMGPEYSSNVELAS
                     FHSTSKGYMGECGYRGGYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPV
                     PGEESFEQFTREKESVLGNLAKKAKLTEDLFNQVPGIQCNPLQGAMYAFPRILIPAKA
                     VEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVEKLKTVLH
                     KVKDFHLKFLEKYS"
     exon            266..355
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     exon            356..464
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     exon            465..595
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     exon            596..839
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     exon            840..919
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1056
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1231
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1387
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1500
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..3645
                     /gene="Gpt2"
                     /gene_synonym="ALT2; Cc2-5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttaacctc ggaagattcg cgatgcagcg ggcagcggtg ctggtgcggc ggggctcctg
       61 cccccgcgcc tcgggcccct ggggccgtag tcacagcagc gctgcagccg aagcctcggc
      121 ggcgctcaag gtgcgaccag agcgtagccc tcgagaccgc atcctcaccc tggagtccat
      181 gaacccgcag gtgaaggccg tggagtacgc tgtgcgggga cccatcgtgc tcaaggccgg
      241 cgagatcgag atggagctgc agcggggtat caaaaaacca ttcactgagg taatccgagc
      301 caacattggg gatgcccatg ctatgggcca gcagccaatc accttccttc gtcaggtgat
      361 ggctctctgc acctacccga acctgctaaa cagccccagc ttcccggaag atgctaagaa
      421 gcgagcgcgg cggatcctgc aggcttgcgg tggaaacagc ctggggtctt acagtgcgag
      481 ccagggcgtt aactgtatcc gagaggacgt ggcagccttt atcaccagga gagatggtgt
      541 acctgcagac ccagacaaca tttacctgac tactggagcg agcgacggta tttctacgat
      601 cctgaagctc ctggtctccg gcggtggcaa gtcacggacc ggggtgatga tccccatccc
      661 acagtacccc ttgtactccg cggtcatctc cgagctcgac gccatccagg tgaactacta
      721 tctggatgag gacaactgct gggctttgaa cgtggacgag ctccggcggg cactgcggca
      781 agctaaagac cactgtgacc ctaaagttct ctgcatcatc aaccccggaa accccacagg
      841 ccaggtacaa agcagaaagt gcatagaaga tgtgattcac tttgcctggg aagagaagct
      901 ttttctcctg gctgacgagg tataccagga caacgtgtac tctccggact gcagattcca
      961 ctcctttaag aaagtgcttt accagatggg gcctgagtac tcgagtaatg tggagcttgc
     1021 ctccttccac tccacctcca agggctacat gggcgaatgc ggctacagag gaggctacat
     1081 ggaggtgatc aatttgcacc ccgagatcaa aggccagctg gttaagctcc tctcggtccg
     1141 cctctgtccg ccagtgtctg gacaggccgc gatggacatt gttgtgaatc caccggtgcc
     1201 aggagaggag tcctttgagc aattcaccag ggaaaaagaa tccgtccttg gtaatctggc
     1261 caaaaaagca aagctgacag aagatctgtt taaccaagtc ccggggatcc agtgcaaccc
     1321 cttgcaagga gccatgtatg cattccctcg gattctcatc cctgccaagg ccgtggaggc
     1381 agctcagtcc cataaaatgg ctccagatat gttttactgc atgaaactcc tggaagaaac
     1441 tggcatctgt gtcgtgcctg gcagtggctt tggacagcga gaaggcacct accacttcag
     1501 aatgacaatt ctccctccag tggagaaact gaagacagta ctccacaagg tgaaagattt
     1561 tcacctgaag ttcctggaga agtactcatg aggatgcctc tgcaccagag agagacccca
     1621 ataccaccca ggccttcctc atggactctg cctcagacct catgcaggtc accaaccctg
     1681 ttcatcatca ttttccaagg agacttcttt ctttgtgcct tgatgttcga gagttcttct
     1741 gagcaaacag tgattttgca atgtctcccg ggccctgttt tttttttttt ttttttaaat
     1801 gccaccaaag tagtcaacct gcttggcaga tgtaattgag attctctgac ttgctgttct
     1861 gtttggaaag tacttttggg ttttaagcag ccaggctaca ttgaaatgag atatttcaga
     1921 tctggagaaa caagcaggtg ttgggaaata cgtgacttaa catgataagg gctgggttcc
     1981 agaaaccaac agtgagatct gtgaaataaa acccttacca gtgtggcagc gcagcgtttt
     2041 ggacagtaaa cctgcaagtc tagtgaggac tcagagaaag ctgtagcaca gcacagacaa
     2101 catggaagtc agtagtagga cagggctcat cagagaccag gttagattac actggcttac
     2161 cctacagcag ttttctccag gtttggctga gcctttatgc acaccattgc cctctgctgg
     2221 tggcagccga gataagcaag gactgaaaat ggatcctttc acaaggccct gaaggttttt
     2281 taactgtttc aaactgactc tggttcgtcc gtaactaacg gatcatggtg cctggttaca
     2341 ctggctgcca agaaggagca catgcaatct gattccgtgt tctcgtcaca tcagtttcct
     2401 gcctccctcc ctgatcagag gacagcagct tatatcatcg gccatccctg tgggtcacaa
     2461 ggtagcagcc accaatcaag tgtattcctt gaattagcac acctgggtgg gccgtgtgca
     2521 cacccaggac attggtgcta cagggaaagc caggccaggt tttcctctcc atctcttaac
     2581 cgtccctgtc cttcagtgag agtgcgggac tccagctcag gagtctgggt acccagggga
     2641 gcttaaggag ccagagagag aaggaagtag cacaagaatg gaaacagcct cctgccctag
     2701 aatcccacac tgcagggggc gcaactgaga aaaagaactt caagttgtta acactcacgg
     2761 gcaagcgaga ggcaccttac tgtggaggaa acagccacat ccacaacagg atgcaatgct
     2821 ctataacttt tcctttaaag ccgaaaagct agcatgtatg cttgctgggc atttgatcca
     2881 gatgtgctcc ggagttctga gattcttcca tgaaaggtta actagaggct agtatatttt
     2941 ttatattttt gtaacaattg gcttttttca tggggggtgg gggggtggag gtggaagagt
     3001 ttagtattta taggcctaac gagtccaata atttttataa gtgtcttcag actatggaca
     3061 atcctccaaa ttttgcaaat gtttacatgt ttttttttaa gatgataaat acgcttgatt
     3121 tgctttttaa ataaaagttt tagctgttct aagagattaa cttcaagtag gaatgaatgc
     3181 tggttatggt agttgggatt ttctacaggt tctgttccca tgccttttct acgccggcct
     3241 cactcaagag ccctcatgtg ggtgtggctg tgaagcctga acaggctgga cctggacagc
     3301 cccacctcag agacattgtt tccacttgga tgtgagcagg cacaggcctg cctgcccttt
     3361 gctactcatc attatcagtt cttccagcct ccttggcgtg ggtcctggtc atagccctgc
     3421 tgggaggctc tgaacaataa aacatgatca gcttggtcaa taaaatctaa aagttgcgtg
     3481 gggctgagta tggtggcaca ctttaatccc agcaccgggg aggcagaggc agcctggtgt
     3541 ctgtgagttt gagtcctgtc tgatttacat agtaagaccc tgtcacaaca aaattgaaaa
     3601 caactacaga agcaataaat agttgagtgg atgtcactaa ttaaa
//
