LOCUS       NM_031039               1741 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus glutamic--pyruvic transaminase (Gpt), mRNA.
ACCESSION   NM_031039
VERSION     NM_031039.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Zhao,G., Zhao,L., Li,Y., Wang,L. and Hu,Z.
  TITLE     Influences of Edaravone on Necroptosis-Related Proteins and
            Oxidative Stress in Rats with Lower Extremity Ischemia/Reperfusion
            Injury
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 68 (7), 95-100 (2022)
   PUBMED   36495512
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Kim,H.J., Kim,S.Y., Shin,S.P., Yang,Y.J., Bang,C.S., Baik,G.H.,
            Kim,D.J., Ham,Y.L., Choi,E.Y. and Suk,K.T.
  TITLE     Immunological measurement of aspartate/alanine aminotransferase in
            predicting liver fibrosis and inflammation
  JOURNAL   Korean J Intern Med 35 (2), 320-330 (2020)
   PUBMED   30665287
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Govindasami,S., Uddandrao,V.V.S., Raveendran,N. and Sasikumar,V.
  TITLE     Therapeutic Potential of Biochanin-A Against Isoproterenol-Induced
            Myocardial Infarction in Rats
  JOURNAL   Cardiovasc Hematol Agents Med Chem 18 (1), 31-36 (2020)
   PUBMED   32026788
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Reshma,P.L., Binu,P., Anupama,N., Vineetha,R.C., Abhilash,S.,
            Nair,R.H. and Raghu,K.G.
  TITLE     Pretreatment of Tribulus terrestris L. causes anti-ischemic
            cardioprotection through MAPK mediated anti-apoptotic pathway in
            rat
  JOURNAL   Biomed Pharmacother 111, 1342-1352 (2019)
   PUBMED   30841448
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Mahale,A.R., Prabhu,S.D., Nachiappan,M., Fernandes,M. and Ullal,S.
  TITLE     Clinical relevance of reporting fatty liver on ultrasound in
            asymptomatic patients during routine health checkups
  JOURNAL   J Int Med Res 46 (11), 4447-4454 (2018)
   PUBMED   30185098
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   Yang,R.Z., Blaileanu,G., Hansen,B.C., Shuldiner,A.R. and Gong,D.W.
  TITLE     cDNA cloning, genomic structure, chromosomal mapping, and
            functional expression of a novel human alanine aminotransferase
  JOURNAL   Genomics 79 (3), 445-450 (2002)
   PUBMED   11863375
REFERENCE   7  (bases 1 to 1741)
  AUTHORS   Hirazawa,K., Oka,M., Ogura,Y., Miyahara,M., Hazama,S. and Suzuki,T.
  TITLE     New technique for inducing reversible obstructive jaundice in the
            rat
  JOURNAL   Eur Surg Res 29 (3), 195-201 (1997)
   PUBMED   9161836
REFERENCE   8  (bases 1 to 1741)
  AUTHORS   Ishiguro,M., Takio,K., Suzuki,M., Oyama,R., Matsuzawa,T. and
            Titani,K.
  TITLE     Complete amino acid sequence of human liver cytosolic alanine
            aminotransferase (GPT) determined by a combination of conventional
            and mass spectral methods
  JOURNAL   Biochemistry 30 (43), 10451-10457 (1991)
   PUBMED   1931970
REFERENCE   9  (bases 1 to 1741)
  AUTHORS   Ishiguro,M., Suzuki,M., Takio,K., Matsuzawa,T. and Titani,K.
  TITLE     Complete amino acid sequence of rat liver cytosolic alanine
            aminotransferase
  JOURNAL   Biochemistry 30 (24), 6048-6053 (1991)
   PUBMED   2043642
REFERENCE   10 (bases 1 to 1741)
  AUTHORS   Griffeth,L.K., Rosen,G.M., Tschanz,C. and Rauckman,E.J.
  TITLE     Effects of model traumatic injury on hepatic drug metabolism in the
            rat. I. In vivo antipyrine metabolism
  JOURNAL   Drug Metab Dispos 11 (6), 517-525 (1983)
   PUBMED   6140133
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031039.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D10354.1, BC097937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               JAXUCZ010000007.1  110297285-110297559
            276-365             JAXUCZ010000007.1  110297692-110297781
            366-474             JAXUCZ010000007.1  110297853-110297961
            475-608             JAXUCZ010000007.1  110298072-110298205
            609-852             JAXUCZ010000007.1  110298377-110298620
            853-932             JAXUCZ010000007.1  110298826-110298905
            933-1069            JAXUCZ010000007.1  110298975-110299111
            1070-1244           JAXUCZ010000007.1  110299196-110299370
            1245-1400           JAXUCZ010000007.1  110299477-110299632
            1401-1513           JAXUCZ010000007.1  110299722-110299834
            1514-1741           JAXUCZ010000007.1  110299907-110300134
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1741
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /note="glutamic--pyruvic transaminase"
                     /db_xref="GeneID:81670"
                     /db_xref="RGD:621720"
     exon            1..275
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1604
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /EC_number="2.6.1.2"
                     /note="glutamic pyruvate transaminase; ALT1; GPT 1;
                     glutamic--alanine transaminase 1; glutamic--pyruvic
                     transaminase 1; glutamate pyruvate transaminase 1;
                     glutamic pyruvic transaminase (alanine aminotrasferase);
                     glutamic pyruvic transaminase 1, soluble;
                     glutamic-pyruvate transaminase (alanine aminotransferase)"
                     /codon_start=1
                     /product="alanine aminotransferase 1"
                     /protein_id="NP_112301.1"
                     /db_xref="GeneID:81670"
                     /db_xref="RGD:621720"
                     /translation="MASRVNDQSQASRNGLKGKVLTLDTMNPCVRRVEYAVRGPIVQR
                     ALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPITFFRQVLALCVYPNLLSSPDFPE
                     DAKRRAERILQACGGHSLGAYSISSGIQPIREDVAQYIERRDGGIPADPNNIFLSTGA
                     SDAIVTMLKLLVSGEGRARTGVLIPIPQYPLYSAALAELDAVQVDYYLDEERAWALDI
                     AELRRALCQARDRCCPRVLCVINPGNPTGQVQTRECIEAVIRFAFKEGLFLMADEVYQ
                     DNVYAEGSQFHSFKKVLMEMGPPYSTQQELASFHSVSKGYMGECGFRGGYVEVVNMDA
                     EVQKQMGKLMSVRLCPPVPGQALMDMVVSPPTPSEPSFKQFQAERQEVLAELAAKAKL
                     TEQVFNEAPGIRCNPVQGAMYSFPQVQLPLKAVQRAQELGLAPDMFFCLCLLEETGIC
                     VVPGSGFGQQEGTYHFRMTILPPMEKLRLLLEKLSHFHAKFTHEYS"
     exon            276..365
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..474
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..608
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..852
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..932
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1069
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1244
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1400
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1513
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1741
                     /gene="Gpt"
                     /gene_synonym="ALAT; Gpt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcagtgtg aagggtgttg tcttacctct cgcagatttt cccattccca gccctgattt
       61 ccccactgga cccttctcct tctgaaccag catcctgcct ggtttgagca gtcatggcct
      121 cacgggtgaa tgatcaaagc caggcttcaa ggaatgggct gaagggaaag gtgctaactc
      181 tggacactat gaacccatgt gtgcggaggg tggagtatgc agttcgagga cccattgtgc
      241 agcgtgcctt ggagctggag caggagctgc gtcagggtgt gaagaagccg tttactgagg
      301 tcatccgtgc caacattggg gatgcacaag ccatggggca gagacccatc accttcttcc
      361 gccaggtcct ggccctctgt gtctacccca atcttctgag cagtcctgac ttcccagagg
      421 atgccaagag aagggcagaa cgcatcttgc aggcctgcgg gggccacagc ctgggtgcct
      481 atagcattag ctctggaatc cagccgatcc gggaggatgt ggcgcaatac attgagagaa
      541 gagacggagg catccccgca gacccgaaca acatatttct atccacaggg gccagcgatg
      601 ccatcgtgac aatgctcaag ctgctggtat ctggcgaggg ccgtgcacga acaggtgtac
      661 tcattcccat tcctcagtac ccactgtact cagccgcgct ggctgaactg gacgccgtgc
      721 aagtggacta ctacctggac gaagagcgcg cctgggctct ggacatcgca gagctgcggc
      781 gcgctctgtg ccaggcacgt gaccgttgct gccctcgagt actgtgcgtc atcaaccccg
      841 gcaaccccac tgggcaggtg cagacccgtg agtgcatcga ggccgtaatc cgctttgctt
      901 tcaaagaagg actcttcttg atggctgatg aggtatacca ggacaacgtg tatgccgagg
      961 gctctcagtt ccattcattc aagaaggtgc tcatggagat ggggccaccg tattccacgc
     1021 agcaggagct tgcttctttc cactcagtct ctaagggcta catgggcgag tgcgggtttc
     1081 gtggtggcta tgtggaggtg gtaaacatgg atgctgaggt gcagaaacag atggggaagc
     1141 tgatgagtgt gcggctgtgt ccaccagtgc caggccaggc cttgatggac atggtggtca
     1201 gtccgccaac accctccgag ccgtccttca agcagtttca agcagagaga caggaggtgc
     1261 tggctgaact agcagccaag gctaagctca cggagcaggt cttcaatgag gctcccggga
     1321 tccgctgcaa cccagtgcag ggcgccatgt attccttccc tcaagtgcag ctgcccttga
     1381 aagcggtgca gcgtgctcag gaactgggcc tggcccctga catgttcttc tgcctgtgcc
     1441 tcctggaaga gactggcatc tgcgttgtgc ccgggagtgg ctttgggcag caggagggca
     1501 cctatcattt ccggatgacc attctgcccc ccatggagaa actgcggctg ctgctggaaa
     1561 aactcagtca cttccatgcc aagttcaccc atgagtactc ctgaagccac tgctagggcc
     1621 acactggaca gtctctgacg caacaaaccg agggtcctta ggaaccctca gtatttctga
     1681 ttttgtctag ggtctcggta actgtccctg cgggtcccta ataaatctga tgtcagcctg
     1741 a
//
