LOCUS       NM_001191962            2516 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus G-protein signaling modulator 2 (Gpsm2), mRNA.
ACCESSION   NM_001191962 XM_575015
VERSION     NM_001191962.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2516)
  AUTHORS   Chiu,C.W.N., Monat,C., Robitaille,M., Lacomme,M., Daulat,A.M.,
            Macleod,G., McNeill,H., Cayouette,M. and Angers,S.
  TITLE     SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by
            Negatively Regulating the Galphai-LGN-NuMA Ternary Complex
  JOURNAL   Dev Cell 36 (1), 50-62 (2016)
   PUBMED   26766442
REFERENCE   2  (bases 1 to 2516)
  AUTHORS   Bird,S.L., Heald,R. and Weis,K.
  TITLE     RanGTP and CLASP1 cooperate to position the mitotic spindle
  JOURNAL   Mol Biol Cell 24 (16), 2506-2514 (2013)
   PUBMED   23783028
REFERENCE   3  (bases 1 to 2516)
  AUTHORS   Kiyomitsu,T. and Cheeseman,I.M.
  TITLE     Cortical dynein and asymmetric membrane elongation coordinately
            position the spindle in anaphase
  JOURNAL   Cell 154 (2), 391-402 (2013)
   PUBMED   23870127
  REMARK    Erratum:[Cell. 2013 Sep 12;154(6):1401]
REFERENCE   4  (bases 1 to 2516)
  AUTHORS   Jia,M., Li,J., Zhu,J., Wen,W., Zhang,M. and Wang,W.
  TITLE     Crystal structures of the scaffolding protein LGN reveal the
            general mechanism by which GoLoco binding motifs inhibit the
            release of GDP from Galphai
  JOURNAL   J Biol Chem 287 (44), 36766-36776 (2012)
   PUBMED   22952234
REFERENCE   5  (bases 1 to 2516)
  AUTHORS   Kotak,S., Busso,C. and Gonczy,P.
  TITLE     Cortical dynein is critical for proper spindle positioning in human
            cells
  JOURNAL   J Cell Biol 199 (1), 97-110 (2012)
   PUBMED   23027904
REFERENCE   6  (bases 1 to 2516)
  AUTHORS   Walsh,T., Shahin,H., Elkan-Miller,T., Lee,M.K., Thornton,A.M.,
            Roeb,W., Abu Rayyan,A., Loulus,S., Avraham,K.B., King,M.C. and
            Kanaan,M.
  TITLE     Whole exome sequencing and homozygosity mapping identify mutation
            in the cell polarity protein GPSM2 as the cause of nonsyndromic
            hearing loss DFNB82
  JOURNAL   Am J Hum Genet 87 (1), 90-94 (2010)
   PUBMED   20602914
REFERENCE   7  (bases 1 to 2516)
  AUTHORS   Izaki,T., Kamakura,S., Kohjima,M. and Sumimoto,H.
  TITLE     Two forms of human Inscuteable-related protein that links Par3 to
            the Pins homologues LGN and AGS3
  JOURNAL   Biochem Biophys Res Commun 341 (4), 1001-1006 (2006)
   PUBMED   16458856
REFERENCE   8  (bases 1 to 2516)
  AUTHORS   Sans,N., Wang,P.Y., Du,Q., Petralia,R.S., Wang,Y.X., Nakka,S.,
            Blumer,J.B., Macara,I.G. and Wenthold,R.J.
  TITLE     mPins modulates PSD-95 and SAP102 trafficking and influences NMDA
            receptor surface expression
  JOURNAL   Nat Cell Biol 7 (12), 1179-1190 (2005)
   PUBMED   16299499
  REMARK    Erratum:[Nat Cell Biol. 2006 Jan;8(1):100]
REFERENCE   9  (bases 1 to 2516)
  AUTHORS   Du,Q. and Macara,I.G.
  TITLE     Mammalian Pins is a conformational switch that links NuMA to
            heterotrimeric G proteins
  JOURNAL   Cell 119 (4), 503-516 (2004)
   PUBMED   15537540
REFERENCE   10 (bases 1 to 2516)
  AUTHORS   Du,Q., Stukenberg,P.T. and Macara,I.G.
  TITLE     A mammalian Partner of inscuteable binds NuMA and regulates mitotic
            spindle organization
  JOURNAL   Nat Cell Biol 3 (12), 1069-1075 (2001)
   PUBMED   11781568
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XM_575015.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.11331.1,
                                           SRR26643291.7541.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000002.1  199054750-199054805 c
            57-278              JAXUCZ010000002.1  199048483-199048704 c
            279-414             JAXUCZ010000002.1  199047928-199048063 c
            415-557             JAXUCZ010000002.1  199045721-199045863 c
            558-681             JAXUCZ010000002.1  199044981-199045104 c
            682-797             JAXUCZ010000002.1  199044764-199044879 c
            798-953             JAXUCZ010000002.1  199041298-199041453 c
            954-1062            JAXUCZ010000002.1  199039550-199039658 c
            1063-1192           JAXUCZ010000002.1  199038984-199039113 c
            1193-1263           JAXUCZ010000002.1  199030888-199030958 c
            1264-1443           JAXUCZ010000002.1  199027992-199028171 c
            1444-1594           JAXUCZ010000002.1  199018243-199018393 c
            1595-1812           JAXUCZ010000002.1  199017248-199017465 c
            1813-2516           JAXUCZ010000002.1  199015250-199015953 c
FEATURES             Location/Qualifiers
     source          1..2516
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2516
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="G-protein signaling modulator 2"
                     /db_xref="GeneID:362021"
                     /db_xref="RGD:1560967"
     CDS             1..2037
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /note="G-protein signalling modulator 2 (AGS3-like, C.
                     elegans); G-protein signaling modulator 2 (AGS3-like, C.
                     elegans)"
                     /codon_start=1
                     /product="G-protein-signaling modulator 2"
                     /protein_id="NP_001178891.1"
                     /db_xref="GeneID:362021"
                     /db_xref="RGD:1560967"
                     /translation="MEGNLMSMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGV
                     SFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEA
                     KASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFG
                     CPGPQDVGEFPEEVRLALQAAVELYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNF
                     RDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYRKTLLLARQLK
                     DRAVEAQSCYSLGNTYTLLQDYEKAIEYHLKHLAIAQELKDRIGEGRACWSLGNAYTA
                     LGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSMMSENIEI
                     DGSLHGAGTKLGRRHSMENMELMKLTPEKVPNWNSEILAKQKPCIAKSSAKLLFVNRL
                     KGKKSKSGSASTKALHHASNPIDHRAPHAQKKVGSDAVGDEGFFDLLRRLQSSRMEDQ
                     RCHLQENRTASVAASSATPKMVKAPSASVVSPNTDEFLDLLASSQSRRLDDQRASFSN
                     LPGLRLTEGNNQSVLERLMTNDKKEPDEDFFDILVKCQGSRLDDQRCAPPPAATKGPT
                     VPDEDFFSLILRSQAKRMDEQRVLLQRDPNRDSEFGLKELLQNNALLEFKHSGK"
     exon            1..56
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            57..278
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            279..414
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            415..557
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            558..681
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            682..797
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            798..953
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1062
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1192
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1263
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1443
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1594
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1812
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2516
                     /gene="Gpsm2"
                     /gene_synonym="RGD1560967"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagggaa atttgatgag catgagggaa gaccattcct ttcatgtccg ctacagaatg
       61 gaagcttctt gcctcgagct ggccttggaa ggagaacgtc tgtgtaaatc aggggactgc
      121 cgcgctggcg tttcgttttt tgaagccgcg gttcaagttg gaactgaaga cctgaaaacg
      181 ctcagtgcta tttacagcca gctgggcaac gcttacttct acttacacga ctacgccaag
      241 gcgctagagt accaccacca tgacttaacc ctggcgagga ctattggaga ccagctcggg
      301 gaagcgaaag ccagcggcaa tcttggaaac accttgaagg tgcttgggaa cttcgatgaa
      361 gcgatagtgt gttgccagcg acacctggat atctccagag aacttaatga caaggtggga
      421 gaagcaagag ctctctataa tcttggaaat gtgtatcacg ccaaagggaa aagtttcggc
      481 tgcccaggtc cacaagatgt aggagagttt ccagaagaag tgaggctcgc cctacaggca
      541 gctgtggagc tctatgagga aaacctgtcg ttagtaactg ctctaggtga ccgagcagcc
      601 cagggacgag cctttgggaa cctcggcaac acacactacc tcctcggcaa cttcagggat
      661 gccgttatag ctcatgagca gcgtctcctg attgcaaaag agttcggaga taaggcggcc
      721 gaaagaagag cgtacagcaa cctcggaaat gcgtacatat tccttggtga attcgaaact
      781 gcttccgaat actacaggaa gacactgctg ctggctcggc agctgaaaga cagagccgtg
      841 gaagctcagt cctgctacag tcttgggaat acatacactc tgcttcagga ctacgagaag
      901 gccatcgagt accacctcaa gcacttagcg attgcccagg agctcaagga tcgaattggt
      961 gaagggagag cgtgttggag tttaggaaat gcatacacgg ctctaggaaa tcatgaccaa
     1021 gcaatgcatt ttgctgaaaa gcacttggaa atttcaagag aggttgggga caaaagcggc
     1081 gagctgactg cacggctgaa cctctcagac ctgcagatgg ttcttggtct gagctatagc
     1141 acaaataatt ccatgatgtc tgagaacatc gaaatcgatg gcagcttaca tggtgcaggc
     1201 accaaactgg gacgaagaca tagtatggag aacatggaac ttatgaagtt aacaccagaa
     1261 aaggtcccga attggaacag tgaaattctc gctaaacaga aaccttgcat tgccaaatcg
     1321 tctgcaaagc tcctatttgt caacagactg aaggggaaaa agtccaaaag cggcagcgcc
     1381 tccactaagg ctctccacca cgccagcaac cccatcgacc accgcgctcc acatgcccag
     1441 aagaaagtcg gctcggacgc ggtcggagat gagggattct ttgacttact gaggcgactt
     1501 cagagcagca ggatggagga ccagaggtgc cacttacagg agaaccggac agcgtccgtg
     1561 gccgcttcct ctgctacccc caagatggtg aaagcaccgt cggcttctgt ggtatccccc
     1621 aacaccgatg agtttttaga tctccttgct agctcgcaga gccgccgtct ggatgaccag
     1681 agggccagct tcagtaattt gccagggctc cgtctgacag aaggcaacaa tcagtccgta
     1741 cttgagcgcc tgatgacaaa tgacaagaaa gagcctgatg aggacttctt tgacatcctt
     1801 gtaaagtgtc aggggtccag gttagatgat cagagatgtg ctccaccacc tgctgccaca
     1861 aaggggccga ctgtccccga cgaagacttt tttagcctca ttttacgctc tcaagctaaa
     1921 aggatggatg aacaaagagt tctgctacag agagatccaa acagggacag tgagtttgga
     1981 ctaaaggaac ttttgcaaaa taatgctctg ttggaattta agcattcagg gaaataacta
     2041 gcaaaccaca agatggtgtg gtatttccta ctaaagaaaa ggaggttccc tcgggacact
     2101 gcagggaaac tcatcttaca cagcaccgta gtagtcacca agttttccgg gtgtaaatgt
     2161 tgaagtacta agggactgaa aggtgcttct tcaacctacc cgaccttgag actctgcttg
     2221 ggtgacttaa gattccttgg ctagggtttg tgtactagga atttaaacga atcctacact
     2281 agaattcagt cctttcttac tgaggtcatt ttttaaggat ctagttaaca atgacttttt
     2341 tatatacccg cccaagaata tagtggattg cattgtttac tgaaaataat gtaaatttcc
     2401 tatgtaaaaa aggtgaaaat agtcataaaa ttctagctta agaaaactat attcaatata
     2461 tttttaggca aagccagtga aggagatgag aaataaacta cttttagcat gccttg
//
