LOCUS       NM_144745               3425 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus G-protein signaling modulator 1 (Gpsm1),
            transcript variant 1, mRNA.
ACCESSION   NM_144745
VERSION     NM_144745.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3425)
  AUTHORS   Conley,J.M. and Watts,V.J.
  TITLE     Differential effects of AGS3 expression on D(2L) dopamine
            receptor-mediated adenylyl cyclase signaling
  JOURNAL   Cell Mol Neurobiol 33 (4), 551-558 (2013)
   PUBMED   23504261
  REMARK    GeneRIF: AGS3 reduced D(2L)DR-mediated sensitization of AC1 and
            AC2.
REFERENCE   2  (bases 1 to 3425)
  AUTHORS   Wang,W., Li,Q., Zou,F., Yu,Z., Wang,Y., Lu,T., Hu,T. and Cui,G.
  TITLE     Increased expression of AGS3 in rat brain cortex after traumatic
            brain injury
  JOURNAL   J Neurosci Res 91 (5), 726-736 (2013)
   PUBMED   23404409
  REMARK    GeneRIF: This study demonistrated that the ags3 expression
            increassing in rat brain cortex after traumatic brain injury.
REFERENCE   3  (bases 1 to 3425)
  AUTHORS   Yuzawa,S., Kamakura,S., Iwakiri,Y., Hayase,J. and Sumimoto,H.
  TITLE     Structural basis for interaction between the conserved cell
            polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched
            protein (LGN)
  JOURNAL   Proc Natl Acad Sci U S A 108 (48), 19210-19215 (2011)
   PUBMED   22074847
REFERENCE   4  (bases 1 to 3425)
  AUTHORS   Regner,K.R., Nozu,K., Lanier,S.M., Blumer,J.B., Avner,E.D.,
            Sweeney,W.E. Jr. and Park,F.
  TITLE     Loss of activator of G-protein signaling 3 impairs renal tubular
            regeneration following acute kidney injury in rodents
  JOURNAL   FASEB J 25 (6), 1844-1855 (2011)
   PUBMED   21343176
  REMARK    GeneRIF: These data suggest that Gpsm1 acts through a novel
            receptor-independent mechanism to facilitate renal tubular
            epithelial cell proliferation and renal tubular regeneration.
REFERENCE   5  (bases 1 to 3425)
  AUTHORS   Xu,Z., Xia,B., Gong,Q., Bailey,J., Groves,B., Radeke,M., Wood,S.A.,
            Szumlinski,K.K. and Ma,D.
  TITLE     Identification of a deubiquitinating enzyme as a novel
            AGS3-interacting protein
  JOURNAL   PLoS One 5 (3), e9725 (2010)
   PUBMED   20305814
  REMARK    GeneRIF: levels of AGS3 and USP9x are co-regulated in the
            prefrontal cortex of rats withdrawn from repeated cocaine treatment
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3425)
  AUTHORS   Bernard,M.L., Peterson,Y.K., Chung,P., Jourdan,J. and Lanier,S.M.
  TITLE     Selective interaction of AGS3 with G-proteins and the influence of
            AGS3 on the activation state of G-proteins
  JOURNAL   J Biol Chem 276 (2), 1585-1593 (2001)
   PUBMED   11042168
REFERENCE   7  (bases 1 to 3425)
  AUTHORS   Natochin,M., Lester,B., Peterson,Y.K., Bernard,M.L., Lanier,S.M.
            and Artemyev,N.O.
  TITLE     AGS3 inhibits GDP dissociation from galpha subunits of the Gi
            family and rhodopsin-dependent activation of transducin
  JOURNAL   J Biol Chem 275 (52), 40981-40985 (2000)
   PUBMED   11024022
REFERENCE   8  (bases 1 to 3425)
  AUTHORS   De Vries,L., Fischer,T., Tronchere,H., Brothers,G.M.,
            Strockbine,B., Siderovski,D.P. and Farquhar,M.G.
  TITLE     Activator of G protein signaling 3 is a guanine dissociation
            inhibitor for Galpha i subunits
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14364-14369 (2000)
   PUBMED   11121039
REFERENCE   9  (bases 1 to 3425)
  AUTHORS   Peterson,Y.K., Bernard,M.L., Ma,H., Hazard,S. 3rd, Graber,S.G. and
            Lanier,S.M.
  TITLE     Stabilization of the GDP-bound conformation of Gialpha by a peptide
            derived from the G-protein regulatory motif of AGS3
  JOURNAL   J Biol Chem 275 (43), 33193-33196 (2000)
   PUBMED   10969064
  REMARK    GeneRIF: The GPR motif in this protein and other proteins is
            actually associated with activity as a GDI - guanine nucleotide
            dissociation inhibitor and not GTPase activator as initially
            suggested.
REFERENCE   10 (bases 1 to 3425)
  AUTHORS   Takesono,A., Cismowski,M.J., Ribas,C., Bernard,M., Chung,P.,
            Hazard,S. 3rd, Duzic,E. and Lanier,S.M.
  TITLE     Receptor-independent activators of heterotrimeric G-protein
            signaling pathways
  JOURNAL   J Biol Chem 274 (47), 33202-33205 (1999)
   PUBMED   10559191
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB743977.1, AF107723.1, CB615566.1, BC105302.1 and BF408282.1.
            
            On Feb 28, 2009 this sequence version replaced NM_144745.1.
            
            Transcript Variant: This variant (1, also known as AGS3-LONG)
            represents the longer transcript and encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               CB743977.1         49-446
            399-952             AF107723.1         523-1076
            953-1015            CB615566.1         509-571
            1016-2572           AF107723.1         1140-2696
            2573-3406           BC105302.1         2974-3807
            3407-3425           BF408282.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3425
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..3425
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /note="G-protein signaling modulator 1"
                     /db_xref="GeneID:246254"
                     /db_xref="RGD:628682"
     exon            1..186
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..2140
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /note="isoform a is encoded by transcript variant 1;
                     activator of G-protein signaling 3; G-protein signalling
                     modulator 1 (AGS3-like, C. elegans); G-protein signaling
                     modulator 1 (AGS3-like, C. elegans)"
                     /codon_start=1
                     /product="G-protein-signaling modulator 1 isoform a"
                     /protein_id="NP_653346.2"
                     /db_xref="GeneID:246254"
                     /db_xref="RGD:628682"
                     /translation="MASPAPPAAEELPGPAARRLYSRMEASCLELALEGERLCKAGDF
                     KAGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEYARALQFHKHDLLLARTIGDR
                     MGEAKASGNLGNTLKVLGRFDEAIVCCQRHLDIAQEQGDKVGEARALYNIGNVYHAKG
                     KQLSWNAAQDPGHLPPDVRETLHRASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYL
                     LGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHIFLGRFDVAAEHYKKTLQLS
                     RQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLVIAQELADRVGEGRACWSLGN
                     AYVSMGSPAQALTFAKKHLQISQEIGDRNGELTARMNIAHLQLALGRLTSPAAAEKPD
                     LAGYEAQGARPKRTQRLSAETWDLLRLPLDREQNGETHHTGDWRGPSRDSLPLPMRSR
                     KYQEGPDAIERRPREGSHSPLDSADVRVQVPRTGIPRAPSSDEECFFDLLSKFQSSRM
                     DDQRCPLEEGQAGAAEATAAPTLEERAAQPSVTASPQTEEFFDLIASSQSRRLDDQRA
                     SVGSLPGLRITLNNVGHLRGDGDPQEPGDEFFNMLIKYQSSRIDDQRCPPPDVLPRGP
                     TMPDEDFFSLIQRVQAKRMDEQRVDLAGSPDQEASGLPDPRQQCPPGAS"
     exon            187..408
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            409..544
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            545..687
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            688..811
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            812..927
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1083
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1192
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1316
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1387
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1567
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1724
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1933
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..3408
                     /gene="Gpsm1"
                     /gene_synonym="Ags3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcctcggcgt ctcgcgcgga cgcgcggaca ggcggacgga cgcgcggaca ggcgggcaga
       61 tcggcagtcg gacggccgca gcgcggggcg gtgctcctgc tcggcgcgtc cccgactcat
      121 ggcgagcccg gccccgcccg cggccgagga gctcccgggc ccagccgcca ggcgcctcta
      181 ctccaggatg gaggcctcct gtctggagct ggcactggaa ggtgagcggc tgtgcaaggc
      241 gggggacttc aaggcaggtg tggccttctt tgaggctgcc gtgcaggtgg gcactgagga
      301 cctgaagaca ctgagtgcta tctacagcca gctgggcaat gcctacttct acctgaagga
      361 gtatgccagg gccctgcagt tccacaaaca tgacttgctg ctggcacgga ccattggcga
      421 ccgcatgggg gaagccaagg ccagtgggaa cctgggcaac acactcaagg tcctgggccg
      481 attcgatgag gcaattgtct gttgccagcg acacttggac attgcccagg agcaggggga
      541 caaggttggg gaagcgagag cactctacaa cattggaaat gtgtaccatg ccaagggcaa
      601 acagctatcc tggaacgctg cacaggaccc tgggcacctg ccacctgatg tccgtgagac
      661 actgcacagg gcctctgagt tctatgagag gaacctgtcc ttggtgaagg agctaggcga
      721 tcgggcagcc cagggcagag cctatggcaa cctgggtaac acccactacc tgctggggaa
      781 cttcacagaa gctacaacct tccacaaaga gcgcctggcc attgctaagg agtttggaga
      841 caaggcagct gagaggagag cctacagcaa cttgggcaat gctcacatct tcctggggcg
      901 ctttgatgtg gctgctgaac attacaagaa gacgctgcag ctgtctcggc agctccggga
      961 ccaggccgtg gaagcacagg cttgctacag tctggggaac acctacacac tgctgcagga
     1021 ctacgagcgg gctgctgagt accacctgcg gcaccttgtc attgcccagg agctggctga
     1081 tagggtggga gagggccgag cttgctggag cctggggaac gcctacgtgt ccatggggag
     1141 ccccgcacag gccttgacct ttgccaaaaa acatctgcag atctcccagg agattggaga
     1201 ccgaaatgga gagctcacgg cccgcatgaa tattgctcac ctgcagctgg cactgggccg
     1261 gctgactagc cctgcggcgg cagagaagcc agatctggct ggctatgagg cacaaggagc
     1321 aagacccaaa aggacacaga ggctgagtgc ggagacctgg gacctgctgc ggctccccct
     1381 ggaccgggag caaaatggag agacccacca cacaggggac tggaggggtc caagcaggga
     1441 ctcgcttcct ctccccatga ggagcaggaa gtaccaggaa ggtccagatg ccattgagag
     1501 gagaccccgg gagggtagcc actctccact ggacagtgct gatgtaaggg tacaggtgcc
     1561 tcgcacgggt atccccaggg ccccgtcctc tgacgaggag tgtttcttcg atctgctgag
     1621 taagttccag agcagtcgta tggatgacca acgctgtccc ctggaggaag gccaggctgg
     1681 ggctgctgag gctacagctg ccccaaccct ggaggagaga gcggctcagc cctctgtaac
     1741 agcttcacca cagactgaag agttctttga cctcattgcc agctcccaga gccgccggct
     1801 ggatgaccag agggctagcg taggcagcct gcctgggctt cgcatcaccc tcaacaacgt
     1861 ggggcacctc cgaggcgacg gggaccccca ggagccaggg gatgagtttt tcaacatgct
     1921 tatcaaatac cagtcctcca ggattgatga ccagcgctgt ccaccccctg atgtgctgcc
     1981 ccgaggcccc accatgcctg atgaggattt cttcagcctt atccagaggg tgcaggctaa
     2041 gcggatggat gagcagcgtg tggacctggc tgggagtcca gaccaagagg ccagtgggct
     2101 gcctgatccc cggcagcaat gtccgccagg tgccagctaa ggcctcaccc ctacagccag
     2161 ccatgcccta ctctggactc tgtaggctca cagttgtcca cagtggccat gaccccccag
     2221 taagccaaat cctcccaagg ccatgatgga gagccagctc agccccaacc ccttcctccc
     2281 actgagccag atggtgggca cacacccctc aagaaccccc caccctaggt ggtgggctca
     2341 ggctagagct gctgtatggg ggagggcatg cttctgtccc catatgatcc acagcttaac
     2401 tgcaggccct gccctgccct gtcctgcccc aggccgggcc ttcagcatgt tggccccaag
     2461 ccccggtgct gtccagagtc ttctccctca agccctgccc tgccaaatgt gaaattctgc
     2521 caactctccc aagctcccca gaggggtttc aaagacttct ggtgggggct acagtggcaa
     2581 ggcatcttct gtcccccagc tggtcctggg acggctatga aggaggtaca ctgctctgcc
     2641 tcacctcccc agggcaggcc tatcctggtt gtggcaggcc tggctgtgcc caaccctgct
     2701 gtgggagatt ggcggctgtg aagtccagat accctgacct gatagtctcc agacttgtac
     2761 ttggcctttg agaaaagctg gaccccgcct ctggcagcgg gaagaggcaa gcctccaagc
     2821 caagagcata gggtcttgtc ctaggagtgc ttggctggca gtggacattc atgaggaatc
     2881 tgctctacta gatcctccag gcctcttggt gaacatctac cttggattac tagggagatg
     2941 gtatcttggc tttctcccca aggaggggtc cagctgcaat atctgagttg gacatagggc
     3001 actatagctg gggtggagag actcaggcag aactgagaac tacatccatg agatagaccc
     3061 ttggggaccg tggtcctatt tcttgcctgc aggcactata ggcagccctc ctggagggct
     3121 ctgtacaacc ttctaaccca gagcctctta ccctgtagcc taggagggag ccagggcaag
     3181 ggcaactggg gacccaactt ctgagagaga gagacaccat cactctgagg gcagaagcgg
     3241 aaaccagagc acagggtctc gggcgggaca cggtggccgc ccgcatactt gaatgtacat
     3301 gcatatttat tgcttacacg tgtttgccat gttgttcacg ggtcctttcc aacccgagag
     3361 gtacgtttgt tttgttttac ccaaaaataa aaaaatctgc caagtggaaa aaaaaaaaaa
     3421 aaaaa
//
