LOCUS       NM_001017477            1388 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein pathway suppressor 2 (Gps2), mRNA.
ACCESSION   NM_001017477 XM_573129
VERSION     NM_001017477.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1388)
  AUTHORS   Cardamone,M.D., Tanasa,B., Cederquist,C.T., Huang,J.,
            Mahdaviani,K., Li,W., Rosenfeld,M.G., Liesa,M. and Perissi,V.
  TITLE     Mitochondrial Retrograde Signaling in Mammals Is Mediated by the
            Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus
            Translocation
  JOURNAL   Mol Cell 69 (5), 757-772 (2018)
   PUBMED   29499132
REFERENCE   2  (bases 1 to 1388)
  AUTHORS   Lentucci,C., Belkina,A.C., Cederquist,C.T., Chan,M., Johnson,H.E.,
            Prasad,S., Lopacinski,A., Nikolajczyk,B.S., Monti,S.,
            Snyder-Cappione,J., Tanasa,B., Cardamone,M.D. and Perissi,V.
  TITLE     Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates
            Multiple Stages of B Cell Development
  JOURNAL   J Biol Chem 292 (7), 2754-2772 (2017)
   PUBMED   28039360
REFERENCE   3  (bases 1 to 1388)
  AUTHORS   Huang,J., Cardamone,M.D., Johnson,H.E., Neault,M., Chan,M.,
            Floyd,Z.E., Mallette,F.A. and Perissi,V.
  TITLE     Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate
            in Protecting G Protein Pathway Suppressor 2 (GPS2) from
            Proteasomal Degradation
  JOURNAL   J Biol Chem 290 (31), 19044-19054 (2015)
   PUBMED   26070566
REFERENCE   4  (bases 1 to 1388)
  AUTHORS   Guo,C., Li,Y., Gow,C.H., Wong,M., Zha,J., Yan,C., Liu,H., Wang,Y.,
            Burris,T.P. and Zhang,J.
  TITLE     The optimal corepressor function of nuclear receptor corepressor
            (NCoR) for peroxisome proliferator-activated receptor gamma
            requires G protein pathway suppressor 2
  JOURNAL   J Biol Chem 290 (6), 3666-3679 (2015)
   PUBMED   25519902
REFERENCE   5  (bases 1 to 1388)
  AUTHORS   Cardamone,M.D., Tanasa,B., Chan,M., Cederquist,C.T.,
            Andricovich,J., Rosenfeld,M.G. and Perissi,V.
  TITLE     GPS2/KDM4A pioneering activity regulates promoter-specific
            recruitment of PPARgamma
  JOURNAL   Cell Rep 8 (1), 163-176 (2014)
   PUBMED   24953653
REFERENCE   6  (bases 1 to 1388)
  AUTHORS   Jakobsson,T., Venteclef,N., Toresson,G., Damdimopoulos,A.E.,
            Ehrlund,A., Lou,X., Sanyal,S., Steffensen,K.R., Gustafsson,J.A. and
            Treuter,E.
  TITLE     GPS2 is required for cholesterol efflux by triggering histone
            demethylation, LXR recruitment, and coregulator assembly at the
            ABCG1 locus
  JOURNAL   Mol Cell 34 (4), 510-518 (2009)
   PUBMED   19481530
REFERENCE   7  (bases 1 to 1388)
  AUTHORS   Zhang,D., Harry,G.J., Blackshear,P.J. and Zeldin,D.C.
  TITLE     G-protein pathway suppressor 2 (GPS2) interacts with the regulatory
            factor X4 variant 3 (RFX4_v3) and functions as a transcriptional
            co-activator
  JOURNAL   J Biol Chem 283 (13), 8580-8590 (2008)
   PUBMED   18218630
REFERENCE   8  (bases 1 to 1388)
  AUTHORS   Diederichs,S., Baumer,N., Ji,P., Metzelder,S.K., Idos,G.E.,
            Cauvet,T., Wang,W., Moller,M., Pierschalski,S., Gromoll,J.,
            Schrader,M.G., Koeffler,H.P., Berdel,W.E., Serve,H. and
            Muller-Tidow,C.
  TITLE     Identification of interaction partners and substrates of the cyclin
            A1-CDK2 complex
  JOURNAL   J Biol Chem 279 (32), 33727-33741 (2004)
   PUBMED   15159402
REFERENCE   9  (bases 1 to 1388)
  AUTHORS   Yoon,H.G., Chan,D.W., Huang,Z.Q., Li,J., Fondell,J.D., Qin,J. and
            Wong,J.
  TITLE     Purification and functional characterization of the human N-CoR
            complex: the roles of HDAC3, TBL1 and TBLR1
  JOURNAL   EMBO J 22 (6), 1336-1346 (2003)
   PUBMED   12628926
REFERENCE   10 (bases 1 to 1388)
  AUTHORS   Zhang,J., Kalkum,M., Chait,B.T. and Roeder,R.G.
  TITLE     The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the
            JNK pathway through the integral subunit GPS2
  JOURNAL   Mol Cell 9 (3), 611-623 (2002)
   PUBMED   11931768
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083699.1.
            
            On Apr 29, 2005 this sequence version replaced XM_573129.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083699.1, SRR8487227.283012.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1388
                     /gene="Gps2"
                     /note="G protein pathway suppressor 2"
                     /db_xref="GeneID:497941"
                     /db_xref="RGD:1562746"
     exon            1..378
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..1268
                     /gene="Gps2"
                     /codon_start=1
                     /product="G protein pathway suppressor 2"
                     /protein_id="NP_001017477.1"
                     /db_xref="GeneID:497941"
                     /db_xref="RGD:1562746"
                     /translation="MPALLERPKLSNAMARALHRHIMMERERKRQEEEEVDKMMEQKM
                     KEEQERRKKKEMEERMSLEETKEQILKLQQKLSALQEEKHQLFLQLKKVLHEEEKRRR
                     KEQSDLTTLTSAAYQQSLTVHTGTHLLSMQGSPGGHNRPGTLMAADRAKQMFGPQVLT
                     TRHYVGSAAAFAGTPEHGQFQGSPGGAYGTAQPPPHYGPTQPAYSPSQQLRAPSAFPA
                     VQYLSQPQPQPYAVHGHFQPTQTGFLQPGSALSLQKQMEHANQQTSFSDSSSLRPMHP
                     QALHPAPGLLASPQLPVQIQAAGKSGFATTSQPGPRLPFIQHSQNPRFYHK"
     exon            379..488
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..601
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..681
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
     exon            682..764
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
     exon            765..918
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1008
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1088
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1184
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1356
                     /gene="Gps2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaagcgccga gaaggcgggt aggggggttg gcgccagggc tacgagggag gggcgggggc
       61 gcggagtcta agacccccgc acgcgcgccg gcgctgaggc tgagacccgg gagggacgct
      121 ggtgcccggg acacgtgatc gaagtggcga gcgggcggcc gacgggcttc cgccttggcg
      181 ggtcgcagta cctctgagct cccacttccc tgcaggcccc gcctgaggtc tggcaatcag
      241 tgacagagtc gggtgcccac tgcccaagcg tcaccaacag catcatgccc gcacttctgg
      301 agcgccccaa gctttccaac gccatggcca gggctctgca ccggcacatc atgatggagc
      361 gggagcgcaa acggcaggag gaggaagagg tggacaagat gatggaacag aagatgaaag
      421 aagaacagga gagaagaaag aaaaaggaaa tggaagagag aatgtcacta gaagagacca
      481 aggaacaaat tctgaaactg cagcagaagc tttcagctct acaggaagag aaacaccagc
      541 ttttcttgca gctcaagaaa gttttgcatg aggaagaaaa acggaggcga aaggaacaga
      601 gtgacttaac cactctgaca tcagctgcat accagcagag cctgacggtt catacaggaa
      661 ctcacctcct cagcatgcag gggagtcctg gaggacacaa ccgcccaggt actctgatgg
      721 cagctgacag agccaagcag atgtttggac cacaagtgct tacgacccgg cactacgtgg
      781 gatcagcagc tgcttttgca ggaaccccag aacatggaca attccaaggc agtccagggg
      841 gcgcttatgg gactgcccag cccccacctc attatgggcc aacacaacca gcctatagtc
      901 ctagccagca gctgagagct ccgtcagcat ttcctgcggt gcagtaccta tctcagccac
      961 agccacaacc ctatgcagtg catggccact ttcagcccac tcagacaggg ttcctccagc
     1021 ccggtagtgc cctctctttg caaaaacaga tggagcatgc caaccagcag actagcttct
     1081 ctgactcatc ttctctgcgg cccatgcatc cccaagctct gcatccagcc cctggactcc
     1141 tggcttcccc tcagctccct gtacagatac aagcagccgg gaagtcaggc tttgccacca
     1201 ccagccaacc gggccctcga ctccctttca tccaacacag ccagaaccca cgattctatc
     1261 acaagtaacc accagataac tccaacccac cctccatccc tcagggtggg ttcttatgtg
     1321 tcccaaacga ataaaatgta caaaatctac ctaccaaaaa aaaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaa
//
