LOCUS       NM_053969               2037 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein pathway suppressor 1 (Gps1), transcript
            variant 1, mRNA.
ACCESSION   NM_053969
VERSION     NM_053969.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2037)
  AUTHORS   Chen,Y., Chen,X., Yu,J., Xu,X., Wei,X., Gu,X., Liu,C., Zhang,D. and
            Xu,Z.
  TITLE     JAB1 is Involved in Neuropathic Pain by Regulating JNK and
            NF-kappaB Activation After Chronic Constriction Injury
  JOURNAL   Neurochem Res 41 (5), 1119-1129 (2016)
   PUBMED   26700435
  REMARK    GeneRIF: JAB1 promotes neuropathic pain via positively regulating
            JNK and NF-kappaB activation
REFERENCE   2  (bases 1 to 2037)
  AUTHORS   Cayli,S., Ocakli,S., Senel,U., Eyerci,N. and Delibasi,T.
  TITLE     Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in
            testicular ischaemia-reperfusion injury
  JOURNAL   J Mol Histol 47 (1), 91-100 (2016)
   PUBMED   26754107
  REMARK    GeneRIF: VCP and Jab1 provide a novel signaling pathway for
            testicular ischemia and may play an important role in
            ischemia-reperfusion injury induced cell death in rat testis.
REFERENCE   3  (bases 1 to 2037)
  AUTHORS   Cheng,X., Zhou,Z., Xu,G., Zhao,J., Wu,H., Long,L., Wen,H., Gu,X.
            and Wang,Y.
  TITLE     Dynamic changes of Jab1 and p27kip1 expression in injured rat
            sciatic nerve
  JOURNAL   J Mol Neurosci 51 (1), 148-158 (2013)
   PUBMED   23370976
  REMARK    GeneRIF: Sciatic nerve crush resulted in a significant upregulation
            of Jab1.
REFERENCE   4  (bases 1 to 2037)
  AUTHORS   Lu,H., Liang,X., Issaenko,O.A. and Hallstrom,T.C.
  TITLE     Jab1/CSN5 mediates E2F dependent expression of mitotic and
            apoptotic but not DNA replication targets
  JOURNAL   Cell Cycle 10 (19), 3317-3326 (2011)
   PUBMED   21937878
  REMARK    GeneRIF: Jab1/CSN5, when elevated in certain tumors, may evade
            triggering E2F1 aopotosis through the frequent, simultaneous
            co-activation of PI3K activity.
REFERENCE   5  (bases 1 to 2037)
  AUTHORS   Sharon,M., Mao,H., Boeri Erba,E., Stephens,E., Zheng,N. and
            Robinson,C.V.
  TITLE     Symmetrical modularity of the COP9 signalosome complex suggests its
            multifunctionality
  JOURNAL   Structure 17 (1), 31-40 (2009)
   PUBMED   19141280
REFERENCE   6  (bases 1 to 2037)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   7  (bases 1 to 2037)
  AUTHORS   Kang,S.W., Shin,Y.J., Shim,Y.J., Jeong,S.Y., Park,I.S. and Min,B.H.
  TITLE     Clusterin interacts with SCLIP (SCG10-like protein) and promotes
            neurite outgrowth of PC12 cells
  JOURNAL   Exp Cell Res 309 (2), 305-315 (2005)
   PUBMED   16038898
REFERENCE   8  (bases 1 to 2037)
  AUTHORS   Nitz,B., Ivell,R., Hartung,S., Middendorff,R. and Olcese,J.
  TITLE     A fusca gene homologue in mammalian tissues: Developmental
            regulation in the rat testes
  JOURNAL   Mol Cell Endocrinol 144 (1-2), 131-138 (1998)
   PUBMED   9863633
REFERENCE   9  (bases 1 to 2037)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 2037)
  AUTHORS   Spain,B.H., Bowdish,K.S., Pacal,A.R., Staub,S.F., Koo,D.,
            Chang,C.Y., Xie,W. and Colicelli,J.
  TITLE     Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11),
            suppress G-protein- and mitogen-activated protein kinase-mediated
            signal transduction in yeast and mammalian cells
  JOURNAL   Mol Cell Biol 16 (12), 6698-6706 (1996)
   PUBMED   8943324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB771566.1 and BC061746.1.
            
            On Aug 10, 2012 this sequence version replaced NM_053969.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061746.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CB771566.1         1-51
            52-2037             BC061746.1         1-1986
FEATURES             Location/Qualifiers
     source          1..2037
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..2037
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /note="G protein pathway suppressor 1"
                     /db_xref="GeneID:117039"
                     /db_xref="RGD:621532"
     exon            1..232
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1663
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /note="isoform 1 is encoded by transcript variant 1; COP9
                     signalosome complex subunit 1; SGN1; signalosome subunit
                     1; JAB1-containing signalosome subunit 1; GPS-1"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 1 isoform 1"
                     /protein_id="NP_446421.3"
                     /db_xref="GeneID:117039"
                     /db_xref="RGD:621532"
                     /translation="MRGSPAPSSASSSASDLSRSPAHSRSDLRPGTSGDYSLSASLSA
                     CTLLSEGAVEPMQIDVDPQEDPQNAPDVNYVVENPTLDLEQYAASYSGLMRIERLQFI
                     ADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPP
                     LDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALK
                     CYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQ
                     TQAILTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDFPELLSPSNVAVYGGLCALA
                     TFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMY
                     LAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTTVAALEDELTQLILEGLINA
                     RIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMILRAAVLRNQIHVKSPPREG
                     SQGELTPANSQSRMSTNM"
     exon            233..325
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            326..507
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            508..672
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            673..808
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            809..886
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            887..947
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1033
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1128
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1234
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1315
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1453
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1588
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2012
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggcccccg ccccgccccc gcctcgcgcg ccaacgcttt tcgtgcgggt gctggcctct
       61 cagagaggtg cgtcaggcca agatgcgggg cagcccggcg cccagctctg cctcgtcgtc
      121 ggcctccgac ttgagccgca gccctgcgca cagcaggtca gacttgcggc ccggcacgtc
      181 gggcgactac agcctgagcg ccagcctgtc ggcctgcacg ctactttccg agggggccgt
      241 ggaacccatg cagattgatg tagatccgca ggaagatccc cagaacgcac ctgatgtcaa
      301 ctacgtggtg gagaacccca ccctggatct ggagcagtat gcagccagct acagtggtct
      361 gatgcgtatt gagcggctac agtttattgc tgaccgctgc cctccgttgc gagtggaggc
      421 cttgaaaatg gctctgtcct tcgtgcagag gaccttcaat gtggacatgt atgaagagat
      481 acaccggaag ctctctgagg ctaccaggga gctgcagaat gcacctgatg ccatccctga
      541 gagtggagtg gagcccccac ccctggacac agcctgggtg gaggccactc ggaagaaggc
      601 cctgttgaaa ctggagaagt tagacacgga cttgaagaac tacaagggca attctatcaa
      661 ggagagcatc aggcgcggcc atgatgacct gggtgaccac tacctggact gtggggacct
      721 cagcaatgcc ctcaagtgtt attcgcgagc ccgagactac tgcaccagtg ctaagcatgt
      781 catcaacatg tgcctcaatg tcatcaaggt cagtgtctac ttgcagaatt ggtctcatgt
      841 gttaagctat gtcagcaagg ctgagtctac tccagagatt gctgagcagc ggggagagcg
      901 ggacagccag actcaagcca tcctcaccaa gctcaagtgt gctgcaggct tggctgagct
      961 ggctgcacga aagtataagc aagctgccaa gtgcttcctt ctggcttcct ttgatcactg
     1021 tgatttccca gagctgctgt cccccagcaa tgtggctgtc tatggtggcc tatgtgcctt
     1081 agccaccttt gaccggcagg agctgcaacg caatgtcatc tccagcagct ccttcaagtt
     1141 gttcctggag ctggagccac aggtcagaga catcatcttc aaattttatg agtccaagta
     1201 tgcctcatgc ttgaagatgt tggacgagat gaaggacaac ctgctcctgg acatgtacct
     1261 ggcccctcac gtcaggacac tgtataccca gatccgtaac cgggctctca tccaatactt
     1321 cagcccctat gtgtcagctg atatgcacaa gatggctgct gccttcaaca caacagttgc
     1381 agctctggag gatgagctca cacagctcat cctggagggc cttattaatg cccgcatcga
     1441 ctcacacagc aagatactgt atgctcgaga cgtggatcag cgtagcacca cctttgagaa
     1501 gtccctgctg atgggcaagg agttccaacg acgggccaaa gccatgattc tgagagcagc
     1561 tgtgctacgc aaccagatcc atgtcaagtc tcctcctaga gaagggagcc aaggggagct
     1621 gactccagca aacagccagt cacggatgag caccaacatg tgaaaggcat tcccgtgacc
     1681 ttcagactag tctgcacagc tcctctgcca gtggaagcag cacctgggcc tcctgcctgc
     1741 tttcctcaag atgagacccc agactgtgtg gttcattaga gcagtccagc ccctgggatg
     1801 ccagttcatt ggccttccgc tcggaggccc cctctgctgt ggtaggcagg ctgcccagta
     1861 tggccattcg ggcctgactc taggtttctg tcccaatgaa acagaccatg tgcaattccc
     1921 aggtaagggt tcctcaaccc ttcctgtcca tgtagttctg actgcagcag tgtcactaac
     1981 caagtagtcc attaaagtac agattgatca ttaaaaaaaa aaaaaaaaaa aaaaaaa
//
