LOCUS       NM_001270939            1863 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein pathway suppressor 1 (Gps1), transcript
            variant 2, mRNA.
ACCESSION   NM_001270939
VERSION     NM_001270939.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1863)
  AUTHORS   Chen,Y., Chen,X., Yu,J., Xu,X., Wei,X., Gu,X., Liu,C., Zhang,D. and
            Xu,Z.
  TITLE     JAB1 is Involved in Neuropathic Pain by Regulating JNK and
            NF-kappaB Activation After Chronic Constriction Injury
  JOURNAL   Neurochem Res 41 (5), 1119-1129 (2016)
   PUBMED   26700435
  REMARK    GeneRIF: JAB1 promotes neuropathic pain via positively regulating
            JNK and NF-kappaB activation
REFERENCE   2  (bases 1 to 1863)
  AUTHORS   Cayli,S., Ocakli,S., Senel,U., Eyerci,N. and Delibasi,T.
  TITLE     Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in
            testicular ischaemia-reperfusion injury
  JOURNAL   J Mol Histol 47 (1), 91-100 (2016)
   PUBMED   26754107
  REMARK    GeneRIF: VCP and Jab1 provide a novel signaling pathway for
            testicular ischemia and may play an important role in
            ischemia-reperfusion injury induced cell death in rat testis.
REFERENCE   3  (bases 1 to 1863)
  AUTHORS   Cheng,X., Zhou,Z., Xu,G., Zhao,J., Wu,H., Long,L., Wen,H., Gu,X.
            and Wang,Y.
  TITLE     Dynamic changes of Jab1 and p27kip1 expression in injured rat
            sciatic nerve
  JOURNAL   J Mol Neurosci 51 (1), 148-158 (2013)
   PUBMED   23370976
  REMARK    GeneRIF: Sciatic nerve crush resulted in a significant upregulation
            of Jab1.
REFERENCE   4  (bases 1 to 1863)
  AUTHORS   Lu,H., Liang,X., Issaenko,O.A. and Hallstrom,T.C.
  TITLE     Jab1/CSN5 mediates E2F dependent expression of mitotic and
            apoptotic but not DNA replication targets
  JOURNAL   Cell Cycle 10 (19), 3317-3326 (2011)
   PUBMED   21937878
  REMARK    GeneRIF: Jab1/CSN5, when elevated in certain tumors, may evade
            triggering E2F1 aopotosis through the frequent, simultaneous
            co-activation of PI3K activity.
REFERENCE   5  (bases 1 to 1863)
  AUTHORS   Sharon,M., Mao,H., Boeri Erba,E., Stephens,E., Zheng,N. and
            Robinson,C.V.
  TITLE     Symmetrical modularity of the COP9 signalosome complex suggests its
            multifunctionality
  JOURNAL   Structure 17 (1), 31-40 (2009)
   PUBMED   19141280
REFERENCE   6  (bases 1 to 1863)
  AUTHORS   Fang,L., Wang,X., Yamoah,K., Chen,P.L., Pan,Z.Q. and Huang,L.
  TITLE     Characterization of the human COP9 signalosome complex using
            affinity purification and mass spectrometry
  JOURNAL   J Proteome Res 7 (11), 4914-4925 (2008)
   PUBMED   18850735
REFERENCE   7  (bases 1 to 1863)
  AUTHORS   Kang,S.W., Shin,Y.J., Shim,Y.J., Jeong,S.Y., Park,I.S. and Min,B.H.
  TITLE     Clusterin interacts with SCLIP (SCG10-like protein) and promotes
            neurite outgrowth of PC12 cells
  JOURNAL   Exp Cell Res 309 (2), 305-315 (2005)
   PUBMED   16038898
REFERENCE   8  (bases 1 to 1863)
  AUTHORS   Nitz,B., Ivell,R., Hartung,S., Middendorff,R. and Olcese,J.
  TITLE     A fusca gene homologue in mammalian tissues: Developmental
            regulation in the rat testes
  JOURNAL   Mol Cell Endocrinol 144 (1-2), 131-138 (1998)
   PUBMED   9863633
REFERENCE   9  (bases 1 to 1863)
  AUTHORS   Wei,N., Tsuge,T., Serino,G., Dohmae,N., Takio,K., Matsui,M. and
            Deng,X.W.
  TITLE     The COP9 complex is conserved between plants and mammals and is
            related to the 26S proteasome regulatory complex
  JOURNAL   Curr Biol 8 (16), 919-922 (1998)
   PUBMED   9707402
REFERENCE   10 (bases 1 to 1863)
  AUTHORS   Spain,B.H., Bowdish,K.S., Pacal,A.R., Staub,S.F., Koo,D.,
            Chang,C.Y., Xie,W. and Colicelli,J.
  TITLE     Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11),
            suppress G-protein- and mitogen-activated protein kinase-mediated
            signal transduction in yeast and mammalian cells
  JOURNAL   Mol Cell Biol 16 (12), 6698-6706 (1996)
   PUBMED   8943324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB792560.1, X87885.1 and BC061746.1.
            
            Transcript Variant: This variant (2) has an alternate 5' exon, com
            pared to variant 1. The resulting isoform (2) is shorter and has a
            distinct N-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X87885.1, SRR8487231.86468.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                CB792560.1         51-95
            46-1231             X87885.1           1-1186
            1232-1863           BC061746.1         1355-1986
FEATURES             Location/Qualifiers
     source          1..1863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..1863
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /note="G protein pathway suppressor 1"
                     /db_xref="GeneID:117039"
                     /db_xref="RGD:621532"
     exon            1..58
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1489
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /note="isoform 2 is encoded by transcript variant 2; COP9
                     signalosome complex subunit 1; SGN1; signalosome subunit
                     1; JAB1-containing signalosome subunit 1; GPS-1"
                     /codon_start=1
                     /product="COP9 signalosome complex subunit 1 isoform 2"
                     /protein_id="NP_001257868.1"
                     /db_xref="GeneID:117039"
                     /db_xref="RGD:621532"
                     /translation="MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPTLDL
                     EQYAASYSGLMRIERLQFIADRCPPLRVEALKMALSFVQRTFNVDMYEEIHRKLSEAT
                     RELQNAPDAIPESGVEPPPLDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRG
                     HDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYV
                     SKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCFLLASFDHCDF
                     PELLSPSNVAVYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKY
                     ASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHKMAAAFNTT
                     VAALEDELTQLILEGLINARIDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMI
                     LRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM"
     exon            59..151
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            152..333
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            334..498
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            499..634
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            635..712
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            713..773
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            774..859
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            860..954
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1060
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1141
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1279
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1414
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1838
                     /gene="Gps1"
                     /gene_synonym="MFH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcgctgcgg caccgggggt ggaagatgcc gctgccggtt caggtgttta acttgcaggg
       61 ggccgtggaa cccatgcaga ttgatgtaga tccgcaggaa gatccccaga acgcacctga
      121 tgtcaactac gtggtggaga accccaccct ggatctggag cagtatgcag ccagctacag
      181 tggtctgatg cgtattgagc ggctacagtt tattgctgac cgctgccctc cgttgcgagt
      241 ggaggccttg aaaatggctc tgtccttcgt gcagaggacc ttcaatgtgg acatgtatga
      301 agagatacac cggaagctct ctgaggctac cagggagctg cagaatgcac ctgatgccat
      361 ccctgagagt ggagtggagc ccccacccct ggacacagcc tgggtggagg ccactcggaa
      421 gaaggccctg ttgaaactgg agaagttaga cacggacttg aagaactaca agggcaattc
      481 tatcaaggag agcatcaggc gcggccatga tgacctgggt gaccactacc tggactgtgg
      541 ggacctcagc aatgccctca agtgttattc gcgagcccga gactactgca ccagtgctaa
      601 gcatgtcatc aacatgtgcc tcaatgtcat caaggtcagt gtctacttgc agaattggtc
      661 tcatgtgtta agctatgtca gcaaggctga gtctactcca gagattgctg agcagcgggg
      721 agagcgggac agccagactc aagccatcct caccaagctc aagtgtgctg caggcttggc
      781 tgagctggct gcacgaaagt ataagcaagc tgccaagtgc ttccttctgg cttcctttga
      841 tcactgtgat ttcccagagc tgctgtcccc cagcaatgtg gctgtctatg gtggcctatg
      901 tgccttagcc acctttgacc ggcaggagct gcaacgcaat gtcatctcca gcagctcctt
      961 caagttgttc ctggagctgg agccacaggt cagagacatc atcttcaaat tttatgagtc
     1021 caagtatgcc tcatgcttga agatgttgga cgagatgaag gacaacctgc tcctggacat
     1081 gtacctggcc cctcacgtca ggacactgta tacccagatc cgtaaccggg ctctcatcca
     1141 atacttcagc ccctatgtgt cagctgatat gcacaagatg gctgctgcct tcaacacaac
     1201 agttgcagct ctggaggatg agctcacaca gctcatcctg gagggcctta ttaatgcccg
     1261 catcgactca cacagcaaga tactgtatgc tcgagacgtg gatcagcgta gcaccacctt
     1321 tgagaagtcc ctgctgatgg gcaaggagtt ccaacgacgg gccaaagcca tgattctgag
     1381 agcagctgtg ctacgcaacc agatccatgt caagtctcct cctagagaag ggagccaagg
     1441 ggagctgact ccagcaaaca gccagtcacg gatgagcacc aacatgtgaa aggcattccc
     1501 gtgaccttca gactagtctg cacagctcct ctgccagtgg aagcagcacc tgggcctcct
     1561 gcctgctttc ctcaagatga gaccccagac tgtgtggttc attagagcag tccagcccct
     1621 gggatgccag ttcattggcc ttccgctcgg aggccccctc tgctgtggta ggcaggctgc
     1681 ccagtatggc cattcgggcc tgactctagg tttctgtccc aatgaaacag accatgtgca
     1741 attcccaggt aagggttcct caacccttcc tgtccatgta gttctgactg cagcagtgtc
     1801 actaaccaag tagtccatta aagtacagat tgatcattaa aaaaaaaaaa aaaaaaaaaa
     1861 aaa
//
