LOCUS       NM_001398762            4518 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor, class C, group 5,
            member B (Gprc5b), mRNA.
ACCESSION   NM_001398762 XM_006230110
VERSION     NM_001398762.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4518)
  AUTHORS   Kurabayashi,N., Nguyen,M.D. and Sanada,K.
  TITLE     The G protein-coupled receptor GPRC5B contributes to neurogenesis
            in the developing mouse neocortex
  JOURNAL   Development 140 (21), 4335-4346 (2013)
   PUBMED   24089469
REFERENCE   2  (bases 1 to 4518)
  AUTHORS   Kim,Y.J., Sano,T., Nabetani,T., Asano,Y. and Hirabayashi,Y.
  TITLE     GPRC5B activates obesity-associated inflammatory signaling in
            adipocytes
  JOURNAL   Sci Signal 5 (251), ra85 (2012)
   PUBMED   23169819
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4518)
  AUTHORS   Sano,T., Kim,Y.J., Oshima,E., Shimizu,C., Kiyonari,H., Abe,T.,
            Higashi,H., Yamada,K. and Hirabayashi,Y.
  TITLE     Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice;
            behavioral abnormalities in GPRC5B-deficient mice
  JOURNAL   Biochem Biophys Res Commun 412 (3), 460-465 (2011)
   PUBMED   21840300
REFERENCE   4  (bases 1 to 4518)
  AUTHORS   Li,Y., Zhang,Y., Qiu,F. and Qiu,Z.
  TITLE     Proteomic identification of exosomal LRG1: a potential urinary
            biomarker for detecting NSCLC
  JOURNAL   Electrophoresis 32 (15), 1976-1983 (2011)
   PUBMED   21557262
REFERENCE   5  (bases 1 to 4518)
  AUTHORS   Cool,B.H., Chan,G.C., Lee,L., Oshima,J., Martin,G.M. and Hu,Q.
  TITLE     A flanking gene problem leads to the discovery of a Gprc5b splice
            variant predominantly expressed in C57Bl/6J mouse brain and in
            maturing neurons
  JOURNAL   PLoS One 5 (4), e10351 (2010)
   PUBMED   20436672
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4518)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 4518)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 22, 2021 this sequence version replaced XM_006230110.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2057757.1,
                                           SRR26360176.1206326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840107, SAMN12840110
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000001.1  182772133-182772276 c
            145-1175            JAXUCZ010000001.1  182760342-182761372 c
            1176-1333           JAXUCZ010000001.1  182752697-182752854 c
            1334-4518           JAXUCZ010000001.1  182748247-182751431 c
FEATURES             Location/Qualifiers
     source          1..4518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q35"
     gene            1..4518
                     /gene="Gprc5b"
                     /note="G protein-coupled receptor, class C, group 5,
                     member B"
                     /db_xref="GeneID:293546"
                     /db_xref="RGD:1309510"
     exon            1..144
                     /gene="Gprc5b"
                     /inference="alignment:Splign:2.1.0"
     exon            145..1175
                     /gene="Gprc5b"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1378
                     /gene="Gprc5b"
                     /note="G protein-coupled receptor, family C, group 5,
                     member B"
                     /codon_start=1
                     /product="G-protein coupled receptor family C group 5
                     member B precursor"
                     /protein_id="NP_001385691.1"
                     /db_xref="GeneID:293546"
                     /db_xref="RGD:1309510"
                     /translation="MRTHQVLPLPLLLVIASVASENASTSRGCGLDLLPQYVSLCDLD
                     AIWGIVVEAVAGAGALITLLLMLILLVRLPFIKDKERRRPVCLHFLFLLGTLGLFGLT
                     FAFIIRMDETICSIRRFLWGVLFALCFSCLLSQAWRVRRLVRQGTSPASWQLVSLALC
                     LMLVQVIIATEWLVLTVLRDTKPACAYEPMDFVMALIYDMVLLAITLAQSLFTLCGKF
                     KRWKVNGAFILITTFLSVLIWVIWMTMYLFGNSLIKRADAWSDPTLAITLVASGWVFV
                     IFHAIPEIHYTLLPPLQENPPNYFDTSQPRMRETAFEEEMHLPRAYMENKAFSMDEHN
                     AALRSAVGFSNGSLEQRSSSLGKKPSSLGNRPSAPFRSNVYQPTEMAVVLNGGTIPTA
                     PPSHAGRHHW"
     exon            1176..1333
                     /gene="Gprc5b"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..4518
                     /gene="Gprc5b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcagc tcggaagggc gatgcagtga ggcgggctcg gctggcgggc gtgcgcgcag
       61 agcgggggcc gcgggcgcgt tgcagagatg tgacttgggc ccagggccag cagaagcgtc
      121 ggcgctgcgg ggacgcgagg gtcgagtgtt cctggtgtca gagagaaaga tgagaaccca
      181 ccaagtgctt cccttgcccc tgctcctggt gattgcctct gtggcttcgg agaacgccag
      241 cacgtcccgg ggctgtgggc tggaccttct tcctcagtac gtgtccctgt gcgacctgga
      301 cgccatttgg ggaatcgtgg tggaggcagt ggccggggca ggggccctga tcacactgct
      361 tctgatgctt attctcctgg tgagactgcc cttcatcaag gacaaggaaa ggaggcggcc
      421 tgtgtgcctc cacttcctct tcctgctggg gaccctgggc ctctttggcc tgacgtttgc
      481 tttcatcatc cggatggacg agacaatctg ctccatccga cgcttcctct ggggtgtcct
      541 cttcgcactc tgcttttcct gcctgctgag ccaggcgtgg cgggtacgga ggctggtgcg
      601 ccagggcacg agcccggcca gctggcagct ggtgagcctg gcactgtgcc tgatgctggt
      661 gcaggtcatc atcgccactg agtggctggt gctgactgtg ctacgtgaca cgaagccggc
      721 ctgcgcctac gagcccatgg attttgtgat ggcgctcatc tacgacatgg tgctgctggc
      781 tatcacccta gcgcagtccc tcttcacact gtgtggcaag ttcaagcggt ggaaggtgaa
      841 cggagccttc atcctcatca ctaccttcct ctctgtgctc atctgggtga tctggatgac
      901 catgtacctc ttcggcaact cgttaattaa gcgggcagat gcctggagcg accctacctt
      961 ggccatcacg ctggtagcca gcggatgggt cttcgtcatc ttccacgcca ttccagagat
     1021 ccactacacc cttctcccac ccctgcagga gaacccaccc aactacttcg atacttcaca
     1081 gccccggatg cgggagacgg cctttgagga ggaaatgcac ctgcctcggg cctacatgga
     1141 aaacaaggcc ttctccatgg atgaacataa cgcagctctt cgatcagcag taggcttttc
     1201 caatggaagc ttggagcaaa gatccagcag cctggggaag aagcccagca gcttgggaaa
     1261 ccggcccagt gcgcccttca gaagcaatgt gtaccagccg acagagatgg ccgtcgtgct
     1321 caatggtggg actatcccaa ctgctccgcc atctcacgcg ggaagacacc actggtgaaa
     1381 ggccttaagt tccagagaat aagaatctct cttaccgatt ttattccctg gctgtgtctt
     1441 tcttgagggt gaaatcaata accatggcag agacaggcca cctggaagcc aggaaatctg
     1501 agaattccca ccaaggggat ttcgtgtaaa tgtgacatat ggatgaactg gaaagctaac
     1561 agtgaccgcc ctcccctccc ctgccacaca cgcaaacacg gaatcatcct gcaaactaaa
     1621 tcagagctaa ctgccaatag tcttagactc actcagaagc gtggctggga aactgagtca
     1681 tccagcaggg gcaggacaga aaagaagtca tagctggtgt gccagactgt gttggcttat
     1741 tacacgaggg gttggagccg gcctgccacc cctaccctcc tcaccaaatg cgggtcccca
     1801 gggagatctt ttggagataa ctgtgacctt gaggttaact catggatcag tctccctggc
     1861 ctttgcttgc ctggtgggtg gcccacgcag ttcaggagac tttaagaggt tgtggctatg
     1921 attctaaagg cccaacaggg agctgtgtag ctaataggag tgaaagaacc atagaacgtg
     1981 ccaaagagga gaaggtactc ggaccttgaa gtgaccatca catgtagaca gaggtgacca
     2041 accgttgttc cttctgtggg cctcttgctc taccaagcac cccacccacc ccaacctccc
     2101 ctacagagtg acagaagtat ccctcctcct tcttcccctc tccctttccc tcctcttgca
     2161 ggtgctcctc catgcctccc cccaccccca cccccatcct gagttcattc ccatgctcat
     2221 ttcagaagct caaacagggc caccagcttg aagcttcagg ggaggcaggc tgaaaggcag
     2281 gcagcagagc aaccttttcg taatgatgtc ctatggctgg gctccccagg ggtgacctct
     2341 aggatggaga gaggacatat ggttgcctag ctgctggtga cttctggggt attttccctt
     2401 cgcgtgggta gaagtccagg atataatgag ctccgtggag gtttccttct gcttttggag
     2461 ggtatggaga atgttttatt tttggtttcc gatggttcta tgaaagtggc ccccttccca
     2521 gttgtcattt gtcatggctt ccatctgtcc tgagcaagtc attcctttgt cgctaggcat
     2581 ctccagcatc cctgccatta aagccctgtg ttctctgcac tgtttggcca gcatagtctc
     2641 tagcaacctt tccctgctaa gggtttgaac ctgaccatat ggactgtgta aacaagggtt
     2701 gcagcctctg cacacactct aatcgctatg ttgctttctc tataaaaaac tacccataag
     2761 cctttaacct ttaatgaaag caaattttta aaaggttagt gtttgggggt gggggtgggg
     2821 actgacctcc ttttaagcca gtacatctga gctaagtgtt ttaataaatc tgatttttct
     2881 caaggcccca gtctctgctg tgtcccctcc ctgccctagc ctatccttgc agatccttag
     2941 ggaggtgagg caaatctggc cagcgcttgg ctcccctgca agttttcctt acagctagtg
     3001 catcaccgtg catgggaacc agaaagcatg gcacccaaag gccccccttc ccaacctcct
     3061 gagatgcctc acccccatcc agagcatgtg cttgcttcca gagaatttga atcagtcctt
     3121 tgtccttaag gaccatcaag tggtgggcta agaacttaaa ggcctgagga ggtggggaag
     3181 gaaagaaagc tagagctgcg tggggctggg gctgttgcat gcactaccca gccttctgca
     3241 aagaaatctc caagcacctc gggccagtcc ggtgacaaac gtcagcgctc cgcgttcttg
     3301 tgccaggaag tggctgtcca cccccgctct ctggagtcct ttggagcttt ctgatgtcac
     3361 cagtaactcg gtctgcaaaa tccccccttg cagaagggag aagctgacat gattgatggt
     3421 tttctctcta agctctttgt tgtccacgta tgaggtgagc accgcaccgt acaaatggct
     3481 gtgcagagag cagcatctct gcactgtaaa acagaaccac gttgagccac aagaaacctc
     3541 cttgcttagt gaggcatttc agttttgctt tttgttcttt ccgatcctga taggttattg
     3601 cgcttctggg ctttgtttta tctcggcttt aagattcggg gtgggttgaa tgtttttaca
     3661 tggagggcgg aagtgggagc aaaggaatta ggtcaacgtc tactattatt ttgagttcaa
     3721 attcacctga agaggaccga ggaccacgag gcaactccac ccagagactg tggcagccag
     3781 cttctgacag agcaaggctg aaatgcagaa tcccatggca cctgtttaag tgttgataga
     3841 cccaagactt ggttggggaa aatggtctag aaagtcatct gtgaataacc ccaaactgca
     3901 agcacaactt ggcatgcccg ggtactaata ccatattggg actataacca ccgctctgtc
     3961 ccctcctgag tgaagactcc atagaggtct ggagtcagtt gccaaggtag caggacaatg
     4021 gcagagggga ggggctccaa tgtgtcagct gtttctaaag ttaagatctg gttgttgtct
     4081 gccccacccc cacacagagg aggtcaaggc cagggaacaa gtgcagggtg ggggaagagt
     4141 tgtcttttga atttgccaaa tggcaaagta gaagggggca ctggcattta cacatccaag
     4201 gatgtagcaa ctgtgagctg atgagagccc ttggcaggtg ctttattcat taagagctat
     4261 ggctcgtttt tgatagataa tatatattta ttaaatgtat taatgtgtat tttataatgt
     4321 accctcactc ttcccctcat cctggctgac ttgcatactt ataaacaaaa actgtttaag
     4381 aaatttccag acaatcagta tgtacagggc tgtatataaa atatcacaga ctttaaaggt
     4441 tgttaagcat gggcagatag gttttatttt caaaatgctg ttcttaacaa gaaaataaag
     4501 gctttactat ttacctaa
//
