LOCUS       NM_031696               4155 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus G-protein coupled receptor 88 (Gpr88), mRNA.
ACCESSION   NM_031696
VERSION     NM_031696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4155)
  AUTHORS   Galet,B., Ingallinesi,M., Pegon,J., Do Thi,A., Ravassard,P., Faucon
            Biguet,N. and Meloni,R.
  TITLE     G-protein coupled receptor 88 knockdown in the associative striatum
            reduces psychiatric symptoms in a translational male rat model of
            Parkinson disease
  JOURNAL   J Psychiatry Neurosci 46 (1), E44-E55 (2021)
   PUBMED   32667145
  REMARK    GeneRIF: G-protein coupled receptor 88 knockdown in the associative
            striatum reduces psychiatric symptoms in a translational male rat
            model of Parkinson disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4155)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   3  (bases 1 to 4155)
  AUTHORS   Calderon-Zamora,L., Ruiz-Hernandez,A., Romero-Nava,R.,
            Leon-Sicairos,N., Canizalez-Roman,A., Hong,E., Huang,F. and
            Villafana,S.
  TITLE     Possible involvement of orphan receptors GPR88 and GPR124 in the
            development of hypertension in spontaneously hypertensive rat
  JOURNAL   Clin Exp Hypertens 39 (6), 513-519 (2017)
   PUBMED   28678544
  REMARK    GeneRIF: Therefore, we conclude that GPR88 and GPR124 receptors may
            be involved in the development or maintenance of high blood
            pressure.
REFERENCE   4  (bases 1 to 4155)
  AUTHORS   Massart,R., Mignon,V., Stanic,J., Munoz-Tello,P., Becker,J.A.,
            Kieffer,B.L., Darmon,M., Sokoloff,P. and Diaz,J.
  TITLE     Developmental and adult expression patterns of the
            G-protein-coupled receptor GPR88 in the rat: Establishment of a
            dual nuclear-cytoplasmic localization
  JOURNAL   J Comp Neurol 524 (14), 2776-2802 (2016)
   PUBMED   26918661
  REMARK    GeneRIF: In the developing cortex, GPR88 shifts on the day of birth
            to the nuclei of neurons in layers V to II.
REFERENCE   5  (bases 1 to 4155)
  AUTHORS   Meirsman,A.C., Le Merrer,J., Pellissier,L.P., Diaz,J., Clesse,D.,
            Kieffer,B.L. and Becker,J.A.
  TITLE     Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning,
            and Low Anxiety Reversed by Delta Opioid Antagonist
  JOURNAL   Biol Psychiatry 79 (11), 917-927 (2016)
   PUBMED   26188600
REFERENCE   6  (bases 1 to 4155)
  AUTHORS   Ingallinesi,M., Le Bouil,L., Biguet,N.F., Thi,A.D., Mannoury la
            Cour,C., Millan,M.J., Ravassard,P., Mallet,J. and Meloni,R.
  TITLE     Local inactivation of Gpr88 in the nucleus accumbens attenuates
            behavioral deficits elicited by the neonatal administration of
            phencyclidine in rats
  JOURNAL   Mol Psychiatry 20 (8), 951-958 (2015)
   PUBMED   25155879
  REMARK    GeneRIF: Results suggest a role for Gpr88 in the regulation of
            cognitive and motor functions, and support its relevance to the
            pathophysiology and treatment of schizophrenia and other disorders
            involving dysfunction of the accumbens-striatal complex
REFERENCE   7  (bases 1 to 4155)
  AUTHORS   Quintana,A., Sanz,E., Wang,W., Storey,G.P., Guler,A.D., Wanat,M.J.,
            Roller,B.A., La Torre,A., Amieux,P.S., McKnight,G.S., Bamford,N.S.
            and Palmiter,R.D.
  TITLE     Lack of GPR88 enhances medium spiny neuron activity and alters
            motor- and cue-dependent behaviors
  JOURNAL   Nat Neurosci 15 (11), 1547-1555 (2012)
   PUBMED   23064379
REFERENCE   8  (bases 1 to 4155)
  AUTHORS   Massart,R., Guilloux,J.P., Mignon,V., Sokoloff,P. and Diaz,J.
  TITLE     Striatal GPR88 expression is confined to the whole projection
            neuron population and is regulated by dopaminergic and
            glutamatergic afferents
  JOURNAL   Eur J Neurosci 30 (3), 397-414 (2009)
   PUBMED   19656174
  REMARK    GeneRIF: GPR88 is confined to striatal medium spiny neurons and
            indicate that L-DOPA-mediated behavioural effects in
            hemiparkinsonian rats may involve normalization of striatal GPR88
            levels
REFERENCE   9  (bases 1 to 4155)
  AUTHORS   Mizushima,K., Miyamoto,Y., Tsukahara,F., Hirai,M., Sakaki,Y. and
            Ito,T.
  TITLE     A novel G-protein-coupled receptor gene expressed in striatum
  JOURNAL   Genomics 69 (3), 314-321 (2000)
   PUBMED   11056049
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031696.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB042407.1, SRR26643290.9777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               JAXUCZ010000002.1  206880553-206880929 c
            378-4155            JAXUCZ010000002.1  206876373-206880150 c
FEATURES             Location/Qualifiers
     source          1..4155
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..4155
                     /gene="Gpr88"
                     /note="G-protein coupled receptor 88"
                     /db_xref="GeneID:64443"
                     /db_xref="RGD:61921"
     exon            1..377
                     /gene="Gpr88"
                     /inference="alignment:Splign:2.1.0"
     exon            378..4155
                     /gene="Gpr88"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..1604
                     /gene="Gpr88"
                     /note="probable G-protein coupled receptor 88;
                     striatum-specific G-protein coupled receptor"
                     /codon_start=1
                     /product="G protein-coupled receptor 88"
                     /protein_id="NP_113884.1"
                     /db_xref="GeneID:64443"
                     /db_xref="RGD:61921"
                     /translation="MTNSSSTSTSTTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIG
                     GTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPAGSAEPP
                     GDWDSGGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQVLYQRRHTAG
                     MLALSWALALGLVLLLPPWAPKPGAEPPQVHYPALLAAGALLAQTALLLHCYLGIVRR
                     VRVSVKRVSVLNFHLLHQLPGCAAAAAAFPAAPHAPGAGGAAHPAQPQPLPAALQPRR
                     AQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPL
                     LYTWRNEEFRRSVRSVLPGVGDAAAAAAAATAVPAMSQAQLGTRAAGQHW"
ORIGIN      
        1 atagggtgcg ctcctctcca gctcagcttc tgctcttgca gccagacatc ctcgctgctg
       61 ctgctgctgc tgccgcctgc ctgcctgcct gcctgcctgc ctgcctgcct gcctgcccac
      121 cctcctggac ttgcagccta ccgcttgact ttttctccaa ttctactgcc agctgaggag
      181 actccccaca gctgctggct cctgcctggg accatgtgtg cgaatgctgc acgggaaaag
      241 caaggcgttt gctcctggca tggatcccag cgcagtttct cctgttgact tctggaccgc
      301 agatgcagct gctgaggagg tatttcctgg catctctccc tctgctatca ccagctaagg
      361 actggcccca aatcaagcag gcaagtgtcg ggatgggcca cgctacacca agccaacgct
      421 agggcgcgag gtgtgaagag ttggccagaa tgaccaactc ctcctccact tcgacctcca
      481 ccaccaccgg aggatccctg ctgctgctct gcgaggaaga agaatcgtgg gcgggccggc
      541 ggatcccggt gtctctcctg tactcggggc tggccatcgg gggcacgctg gccaacggta
      601 tggtcatcta tcttgtgtcg tccttccgaa agctgcagac caccagcaac gccttcattg
      661 tgaatggctg cgccgcggat ctcagcgtct gcgccctctg gatgccacag gaggcggtac
      721 tggggctcct gcccgccggc tccgcggagc ccccggggga ctgggacagt ggcggaggca
      781 gctacagact gctccggggc gggttgttgg gcctcgggct cactgtgtcc cttctgtccc
      841 attgcctcgt ggctctgaac cgctacttgc tcatcaccag ggcgcctgcc acctaccagg
      901 tgctgtacca gcggcgccac acggcgggca tgctggcact gtcctgggcg ctcgccttgg
      961 gtctggtgtt gttgctcccg ccttgggctc ccaagccggg agcggagccc ccgcaagtcc
     1021 actaccccgc gctcctggcg gcgggagcgt tgctggcaca gacggcgctg ctgctgcact
     1081 gctacctggg catcgtgcgc cgcgtgcgcg tcagcgtcaa gcgggtcagc gtgctcaact
     1141 tccacctgct gcaccagcta ccgggctgcg ccgccgccgc cgccgccttc cccgccgccc
     1201 cgcacgctcc gggtgccgga ggcgccgctc atcccgcgca gcctcaaccc ctgccggccg
     1261 ccctgcagcc tcgtcgggcg cagcggcgtc tcagcggttt gtctgtgctg ctgctctgct
     1321 gcgtcttcct gctggccacg cagccgctgg tgtgggtgag cctggccagc ggcttctccc
     1381 tcccggtgcc ctggggcgtg caggcggcca gctggctcct gtgctgcgcc ctgtcggcgc
     1441 tcaacccgct gctctatact tggaggaacg aggagttccg cagatcagtg cgttcagttc
     1501 tgcccggcgt cggggacgca gctgcggccg ctgcagccgc caccgcggtg ccagccatgt
     1561 cccaggcgca actgggtacc cgggcggctg gccagcattg gtaacacacc tttcttggag
     1621 gggcttccta agctacttgc cgcaccgcac cacctccttc ttttgtaagc tatccccgtc
     1681 ccctgggaag atcccggtgg aggagatttt cgtcttcttt cctagtgcaa tacctgaacc
     1741 aaggtcttcc cctaaatgga gcccaattgt gtgcggccat tcgactttta cctttttgtt
     1801 gctgtgttct aaagacaccc ttaggtccat tcagacaccc agatcgcaag gacttgtaaa
     1861 ctggcatttt aaaagaaccg gttaatttat ttcaagcttg cttttgaaaa agaactttca
     1921 tagcaaacaa cccttccgac ctccaccgtc ttacattcga agcgccttga gtgtgtgggt
     1981 gtgcatgagc caaaggtaac accgtggagg aatacattgt gtgtgtgtgt gtgtagacag
     2041 tattctaacc atgcttcctt ctgttgtagt ttagtctttg tatattgacc tcgaagagtg
     2101 aaaccacagg tgtgtacacg ggcgtgagtt gccattgagc ccccaagccc tttattctta
     2161 aaagggtttg ttttttttct tttcttttta aattgagtca tttttgaaat gagatcgact
     2221 ctcaagccag tgaggaaaca aaccaaatgt attattttac tctcctcttt attcccttct
     2281 aaggtggaaa gttaccgtcg agtattaaag tggaaaaaaa tgtcaagttt tggatggtcc
     2341 gaaactagaa atggaatttt gaaagcaaaa aaaagggggg ggaggggcta tctattttag
     2401 gtcgcagttt cacattttct aaggcatgca cacttcttgc taccctcatt tgtaaccgac
     2461 ttatttgcct ctgagtgtga tcgcaacttt gaacattctg tactataatg gttgctaggg
     2521 aggatgactc ctgtattctc tttaagatat ctcaatgcac atgacataat taaacactga
     2581 taccataatt gcatagctaa tgttagctgc tattgcatgc tcctagatgc tagaacttat
     2641 cgggcatgtg gcatacaaag caatacccat tagacaagga cattttactt cttccagaag
     2701 aaaaggcctt tcagtcattt gaaaagagac ttagacgaac ctgtggctac ctagagttct
     2761 tgtcttgaac tggtttgtga gaaaactccc atttggggac tttatctccc cagtgaaacc
     2821 aatggtcagg atgataccct aatacagtct ggatccacaa aggtattgtg tactttaggg
     2881 gttacacaag ccacacgtta ggaaatagca ctgtcttatg ttgttcatat aatatatata
     2941 tatatatata ttacagaaac atttactatt atatcatgtc tgttgaagag ggaatcatgc
     3001 aggcagttat gcaggaggag aatggtccaa acgggactct gttctccagt gtatcagttg
     3061 aggtccgaca tcttcatctt tgacttccta aatgtggtta gatgcattta taatgtacaa
     3121 taacatgcga catcattttg taaaattaac aggggagaaa gtaacaagag gtgtagatca
     3181 gtctgttagt cacatcaaat ctgaggccaa atagcctcga ttaacctggt agttcaggag
     3241 cgcagacagc ttgctttgct gcactcttgg accaagaatg gtaaggacgc ttgtatattt
     3301 gaaaacgtat gggaggcacg aggaaacgga cattttgtag taagacaaaa taaaataaat
     3361 atgtttgtca ctaacagtac atcagcagtc atgtcattaa ccaaactgtg tgcatgtatc
     3421 atttttctct tatggagatt ttctttttct gtttccagtt tcctggattc agatgttgaa
     3481 ttaaagttta gataatgctt ctcttggctc tagctcttct ttcttgggta tcttctctct
     3541 gtctgtcttg aggatactgt accagaagac actgttccaa aacacgactg atacagagtg
     3601 acttcttttg ttggctgtaa gtttattttc agtttctaaa atgccttttt actttatata
     3661 attacataag ctccttacat tggtctgaga aaagaaatag ccatgttttc tttctgtaaa
     3721 cactgaggaa tgggttataa agagaacaga gaggtggtga ttttctaaag ctctgtcaac
     3781 cagccactct agataagcgt tgttcttgtt tctcaaagat gatgcaaacc agtttcctct
     3841 ctgtccttac aatgtgcaac atatataaag agctttgtga atgggaatct gataccttgc
     3901 catgtttctg gctagcgctc ccgggctggc actgcgccac gtgggagact tttgattaat
     3961 ttactagtaa ttaactccac aggactgact ccttttagtt ttaaagtagc gctgacgtat
     4021 ctaaaaacgc ctaggcgctg cctgcgagtg ttggagttac tgctttgaca aattaaagta
     4081 atggagattg tgttcttatt taaatgaaac cacatattat ccactcagga ataaaaaaaa
     4141 aaaatcctaa ctgct
//
