LOCUS       NP_113884                384 aa            linear   ROD 30-MAR-2024
DEFINITION  G protein-coupled receptor 88 [Rattus norvegicus].
ACCESSION   NP_113884
VERSION     NP_113884.1
DBSOURCE    REFSEQ: accession NM_031696.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 384)
  AUTHORS   Galet,B., Ingallinesi,M., Pegon,J., Do Thi,A., Ravassard,P., Faucon
            Biguet,N. and Meloni,R.
  TITLE     G-protein coupled receptor 88 knockdown in the associative striatum
            reduces psychiatric symptoms in a translational male rat model of
            Parkinson disease
  JOURNAL   J Psychiatry Neurosci 46 (1), E44-E55 (2021)
   PUBMED   32667145
  REMARK    GeneRIF: G-protein coupled receptor 88 knockdown in the associative
            striatum reduces psychiatric symptoms in a translational male rat
            model of Parkinson disease.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 384)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   3  (residues 1 to 384)
  AUTHORS   Calderon-Zamora,L., Ruiz-Hernandez,A., Romero-Nava,R.,
            Leon-Sicairos,N., Canizalez-Roman,A., Hong,E., Huang,F. and
            Villafana,S.
  TITLE     Possible involvement of orphan receptors GPR88 and GPR124 in the
            development of hypertension in spontaneously hypertensive rat
  JOURNAL   Clin Exp Hypertens 39 (6), 513-519 (2017)
   PUBMED   28678544
  REMARK    GeneRIF: Therefore, we conclude that GPR88 and GPR124 receptors may
            be involved in the development or maintenance of high blood
            pressure.
REFERENCE   4  (residues 1 to 384)
  AUTHORS   Massart,R., Mignon,V., Stanic,J., Munoz-Tello,P., Becker,J.A.,
            Kieffer,B.L., Darmon,M., Sokoloff,P. and Diaz,J.
  TITLE     Developmental and adult expression patterns of the
            G-protein-coupled receptor GPR88 in the rat: Establishment of a
            dual nuclear-cytoplasmic localization
  JOURNAL   J Comp Neurol 524 (14), 2776-2802 (2016)
   PUBMED   26918661
  REMARK    GeneRIF: In the developing cortex, GPR88 shifts on the day of birth
            to the nuclei of neurons in layers V to II.
REFERENCE   5  (residues 1 to 384)
  AUTHORS   Meirsman,A.C., Le Merrer,J., Pellissier,L.P., Diaz,J., Clesse,D.,
            Kieffer,B.L. and Becker,J.A.
  TITLE     Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning,
            and Low Anxiety Reversed by Delta Opioid Antagonist
  JOURNAL   Biol Psychiatry 79 (11), 917-927 (2016)
   PUBMED   26188600
REFERENCE   6  (residues 1 to 384)
  AUTHORS   Ingallinesi,M., Le Bouil,L., Biguet,N.F., Thi,A.D., Mannoury la
            Cour,C., Millan,M.J., Ravassard,P., Mallet,J. and Meloni,R.
  TITLE     Local inactivation of Gpr88 in the nucleus accumbens attenuates
            behavioral deficits elicited by the neonatal administration of
            phencyclidine in rats
  JOURNAL   Mol Psychiatry 20 (8), 951-958 (2015)
   PUBMED   25155879
  REMARK    GeneRIF: Results suggest a role for Gpr88 in the regulation of
            cognitive and motor functions, and support its relevance to the
            pathophysiology and treatment of schizophrenia and other disorders
            involving dysfunction of the accumbens-striatal complex
REFERENCE   7  (residues 1 to 384)
  AUTHORS   Quintana,A., Sanz,E., Wang,W., Storey,G.P., Guler,A.D., Wanat,M.J.,
            Roller,B.A., La Torre,A., Amieux,P.S., McKnight,G.S., Bamford,N.S.
            and Palmiter,R.D.
  TITLE     Lack of GPR88 enhances medium spiny neuron activity and alters
            motor- and cue-dependent behaviors
  JOURNAL   Nat Neurosci 15 (11), 1547-1555 (2012)
   PUBMED   23064379
REFERENCE   8  (residues 1 to 384)
  AUTHORS   Massart,R., Guilloux,J.P., Mignon,V., Sokoloff,P. and Diaz,J.
  TITLE     Striatal GPR88 expression is confined to the whole projection
            neuron population and is regulated by dopaminergic and
            glutamatergic afferents
  JOURNAL   Eur J Neurosci 30 (3), 397-414 (2009)
   PUBMED   19656174
  REMARK    GeneRIF: GPR88 is confined to striatal medium spiny neurons and
            indicate that L-DOPA-mediated behavioural effects in
            hemiparkinsonian rats may involve normalization of striatal GPR88
            levels
REFERENCE   9  (residues 1 to 384)
  AUTHORS   Mizushima,K., Miyamoto,Y., Tsukahara,F., Hirai,M., Sakaki,Y. and
            Ito,T.
  TITLE     A novel G-protein-coupled receptor gene expressed in striatum
  JOURNAL   Genomics 69 (3), 314-321 (2000)
   PUBMED   11056049
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB042407.1, SRR26643290.9777.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..384
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     Protein         1..384
                     /product="G protein-coupled receptor 88"
                     /note="probable G-protein coupled receptor 88;
                     striatum-specific G-protein coupled receptor"
                     /calculated_mol_wt=40069
     Site            3
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9ESP4.1)"
     Region          33..347
                     /region_name="7tm_GPCRs"
                     /note="seven-transmembrane G protein-coupled receptor
                     superfamily; cl28897"
                     /db_xref="CDD:475119"
     Region          34..58
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320339"
     Site            36..56
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESP4.1)"
     Region          67..89
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320339"
     Site            74..94
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESP4.1)"
     Region          114..136
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320339"
     Site            117..136
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESP4.1)"
     Site            159..179
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESP4.1)"
     Region          160..176
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320339"
     Region          190..213
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320339"
     Site            196..216
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESP4.1)"
     Region          283..305
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320339"
     Site            286..306
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESP4.1)"
     Site            311..331
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ESP4.1)"
     Region          315..340
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320339"
     CDS             1..384
                     /gene="Gpr88"
                     /coded_by="NM_031696.2:450..1604"
                     /db_xref="GeneID:64443"
                     /db_xref="RGD:61921"
ORIGIN      
        1 mtnssststs tttggsllll ceeeeswagr ripvsllysg laiggtlang mviylvssfr
       61 klqttsnafi vngcaadlsv calwmpqeav lgllpagsae ppgdwdsggg syrllrggll
      121 glgltvslls hclvalnryl litrapatyq vlyqrrhtag mlalswalal glvlllppwa
      181 pkpgaeppqv hypallaaga llaqtalllh cylgivrrvr vsvkrvsvln fhllhqlpgc
      241 aaaaaafpaa phapgaggaa hpaqpqplpa alqprraqrr lsglsvlllc cvfllatqpl
      301 vwvslasgfs lpvpwgvqaa swllccalsa lnpllytwrn eefrrsvrsv lpgvgdaaaa
      361 aaaatavpam sqaqlgtraa gqhw
//
