LOCUS       NM_022254               3351 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 85 (Gpr85), mRNA.
ACCESSION   NM_022254
VERSION     NM_022254.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3351)
  AUTHORS   Fujita-Jimbo,E., Tanabe,Y., Yu,Z., Kojima,K., Mori,M., Li,H.,
            Iwamoto,S., Yamagata,T., Momoi,M.Y. and Momoi,T.
  TITLE     The association of GPR85 with PSD-95-neuroligin complex and autism
            spectrum disorder: a molecular analysis
  JOURNAL   Mol Autism 6, 17 (2015)
   PUBMED   25780553
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3351)
  AUTHORS   Matsumoto,M., Beltaifa,S., Weickert,C.S., Herman,M.M., Hyde,T.M.,
            Saunders,R.C., Lipska,B.K., Weinberger,D.R. and Kleinman,J.E.
  TITLE     A conserved mRNA expression profile of SREB2 (GPR85) in adult
            human, monkey, and rat forebrain
  JOURNAL   Brain Res Mol Brain Res 138 (1), 58-69 (2005)
   PUBMED   15893849
  REMARK    GeneRIF: The areas expressing high levels of SREB2 mRNA overlap
            with brain structures known to possess high levels of plasticity,
            namely, the hippocampal formation, olfactory system, and supraoptic
            and paraventricular nuclei.
REFERENCE   3  (bases 1 to 3351)
  AUTHORS   Matsumoto,M., Saito,T., Takasaki,J., Kamohara,M., Sugimoto,T.,
            Kobayashi,M., Tadokoro,M., Matsumoto,S., Ohishi,T. and Furuichi,K.
  TITLE     An evolutionarily conserved G-protein coupled receptor family,
            SREB, expressed in the central nervous system
  JOURNAL   Biochem Biophys Res Commun 272 (2), 576-582 (2000)
   PUBMED   10833454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 26, 2021 this sequence version replaced NM_022254.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2522750.1,
                                           SRR26360176.887944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840129 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-601               JAXUCZ010000004.1  43074306-43074906   c
            602-725             JAXUCZ010000004.1  43073771-43073894   c
            726-3351            JAXUCZ010000004.1  43070194-43072819   c
FEATURES             Location/Qualifiers
     source          1..3351
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..3351
                     /gene="Gpr85"
                     /gene_synonym="PKrCx1; SREB2; Srep2"
                     /note="G protein-coupled receptor 85"
                     /db_xref="GeneID:64020"
                     /db_xref="RGD:71011"
     exon            1..601
                     /gene="Gpr85"
                     /gene_synonym="PKrCx1; SREB2; Srep2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..725
                     /gene="Gpr85"
                     /gene_synonym="PKrCx1; SREB2; Srep2"
                     /inference="alignment:Splign:2.1.0"
     exon            726..3351
                     /gene="Gpr85"
                     /gene_synonym="PKrCx1; SREB2; Srep2"
                     /inference="alignment:Splign:2.1.0"
     CDS             896..2008
                     /gene="Gpr85"
                     /gene_synonym="PKrCx1; SREB2; Srep2"
                     /note="Super Conserved Receptor Expressed in Brain 2"
                     /codon_start=1
                     /product="probable G-protein coupled receptor 85"
                     /protein_id="NP_071590.1"
                     /db_xref="GeneID:64020"
                     /db_xref="RGD:71011"
                     /translation="MANYSHAADNILQNLSPLTAFLKLTSLGFIIGVSVVGNLLISIL
                     LVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFNSVKNGSTWTYGTLTCKVIAFLGV
                     LSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDV
                     GTYSFIREEDQCTFQHRSFRANDSLGFMLLLALILLATQLVYLKLIFFVHDRRKMKPV
                     QFVAAVSQNWTFHGPGASGQAAANWLAGFGRGPTPPTLLGIRQNANTTGRRRLLVLDE
                     FKMEKRISRMFYIMTFLFLTLWGPYLVACYWRVFARGPVVPGGFLTAAVWMSFAQAGI
                     NPFVCIFSNRELRRCFSTTLLYCRKSRLPREPYCVI"
ORIGIN      
        1 caaagatcag cagggaaaaa tcatttgaga agaaatctac aaggcgcatc caatgcttag
       61 caggaccacc ctgacagaga aaggaagacg atgtttcggg aaggcaaggg ttcggggcag
      121 ctggggtgga ggcggcggtc cgcggcacgg tggcttcgtg cgctgcccta ggggaagagg
      181 atgggcctga ggtccgggaa gagccttccc gagcccacca ctgccaatgc ggggagggaa
      241 aagttccgaa gctgcctcga gggaacaaaa gcctgatttg gggccggctg aactggactg
      301 gacattgaag caagccagcc tgctccggag acaggcaggg ggctcctgct ggctcggcgg
      361 aggccggagc aaccctcgcc gccgccctcg ccaccgcgcc gccgccgccg cggcccctgc
      421 gttactgggg gagacggtgc cgctgcgaca ggggaggacg cggctggagc tgaaggaggc
      481 tccaacgcgc aggcgccgcc gagccctgcc tggatgctca gtcaaggcac tcaggaaaaa
      541 aaaaatcagc aatttataga aagaagaagc tatagtctgt cgggatatcc aacaccaaca
      601 ggggtggtgg atttcaggtt tcgtaatgtt gcatgatgcg atcggtattt acccggggat
      661 gtaccggttg ggaaattaac atcatcggat gcagttctgc ctgggcttcc atcagcatat
      721 tccagatatt ctgatggcaa atcaaatgga aggcaagagg aagcatgacc acagattgga
      781 tctgaactct ttgtggatta cattttcagt aaaatgtatg gatctatctt ttccttgttc
      841 ttatatctag atcatgagac ttgactgagg ctgtttcctt atcctccatc catctatggc
      901 gaactatagc catgcagctg acaacatttt gcaaaatctc tcgcctctaa cagcctttct
      961 gaaactgact tccttgggtt tcataatagg agtcagtgtg gtgggcaacc ttctgatctc
     1021 cattttgcta gtgaaagata agaccttgca tagagctcct tactacttcc tgctggatct
     1081 gtgctgctca gacatcctca gatctgcaat ttgttttcca tttgtattca actctgtcaa
     1141 aaatggctct acctggactt acgggactct gacttgcaaa gtgattgcct ttctgggggt
     1201 tttgtcctgt ttccacactg ccttcatgct cttctgcatc agcgtcacca gatacttagc
     1261 catcgcccat caccgcttct atacaaagag gctgaccttt tggacgtgtt tggctgtgat
     1321 ctgcatggtg tggactctgt ctgtggccat ggcatttccc ccagttttag atgtaggcac
     1381 ctactcattc attagggagg aggatcagtg taccttccaa caccgctcct tcagggctaa
     1441 cgattcccta ggatttatgc tgctccttgc tctcatcctc ctagccacac agcttgtcta
     1501 cctcaagctg atattttttg tccacgatcg aaggaaaatg aagccagtcc agtttgtagc
     1561 agcagtgagt cagaactgga cctttcatgg ccctggagct agtggccagg cagctgccaa
     1621 ttggctagca ggatttggaa ggggtcccac accacccacc ttgctgggca tcaggcaaaa
     1681 tgcgaatacc acaggcagaa gacggctctt ggttttggat gagttcaaaa tggagaaaag
     1741 aatcagcaga atgttctata taatgacttt cctcttccta accttgtggg gtccctacct
     1801 ggtggcctgc tattggagag tttttgcaag agggcctgta gtaccagggg gatttctaac
     1861 agccgctgtc tggatgagtt tcgcccaagc aggaatcaat ccctttgtct gcattttctc
     1921 caacagggag ctgaggcgct gtttcagcac aacccttctt tactgcagaa aatccaggtt
     1981 accaagggaa ccttactgtg ttatatgagg gagcatctgt aaatctttag ccttgtgaga
     2041 tactaaccct ctctgctaag caattgtggc ctgtagccat gtcttgagaa gaaaaaaaaa
     2101 agaaaacaag gatggaatca gcagttgtaa ggatttggtc aacgttctgc agtctttgca
     2161 atagttcacc tataatcctg ttttaaatct cagagtgatc ctgctgactg ctggcgaagg
     2221 tttgtaatta agaaaggaca gaaccactgc cctaagtttc tttctgtggg tgaacactag
     2281 ataatgaacg tagcaggtgc taagtatcag tgctaaatgc tgtgtatatc atcacatatg
     2341 aaaaaaaact taaaaaaaca attagcattg gacattttaa taaattaagt tgacatgagg
     2401 taaatgtgtt gataaaagct aattttagaa gtttgaagac tttaaaacat ttcatactat
     2461 ttttgttttg caaagactac actactgggg gacttaacag tactgtaatt cttaaaaaga
     2521 tgtgccatga attattgggg tacaacactt taaacacgcc ttgtgagttt gggggaagca
     2581 ttccaaagca gtatattggt tccaattaga gtttaccttt tttgtattaa tatattgcta
     2641 tttctaaatc ccactttcct tccctaccag tgaaattgct agcattgaac tgtattatgt
     2701 gttttttgtt aattcagtaa aaaaaaaaaa aagtttccag tttgtttcta ttttacaaat
     2761 gctagatatc tgtccgggag gcaacatgaa tggaatcaac tgaccacaga tgagcagttc
     2821 taaaaatgca gaataaacac gtgttgcctt aaagggttat ctagtatcct tcatcttctt
     2881 tagcaatgga gcaagtagtc aagaggcatt gaaccagtaa ctggccatgg ctgttcattg
     2941 ggaattcatg gaagagcatt caatgctttc ccctcttccc tcacgtgctt tgaaagttca
     3001 agtacacacc attaagataa tgagattttc ttctgaggtg tgctacccat tctagtgtgt
     3061 tctaagaagc agacagttga tatgtgttta tattgtaagt cagctgtcag gggagcccac
     3121 agccttagtg tgacatctgg cacaatttgt gaagcattta ttgtatggaa ggcacagtct
     3181 tctttatact ttctgcacat tcagtgtatt ggtcctttcg attatttcag ttctaacttg
     3241 tgaaagctta taatatgatt tctggtattt tagaaataca ttagattctg tgagtctcat
     3301 tctttaagat acagatgtgt gaacttcaat ataaagttgc atttgccaaa a
//
