LOCUS       NM_001108049            3115 bp    mRNA    linear   ROD 17-OCT-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 68 (Gpr68), transcript
            variant 1, mRNA.
ACCESSION   NM_001108049 XM_001065526 XM_234483
VERSION     NM_001108049.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3115)
  AUTHORS   Zhao,D., Zhang,M., Yang,L. and Zeng,M.
  TITLE     GPR68 Improves Nerve Damage and Myelination in an Immature Rat
            Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to
            Mediate BDNF
  JOURNAL   ACS Chem Neurosci 13 (3), 423-431 (2022)
   PUBMED   35025202
  REMARK    GeneRIF: GPR68 Improves Nerve Damage and Myelination in an Immature
            Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB
            to Mediate BDNF.
REFERENCE   2  (bases 1 to 3115)
  AUTHORS   Horiguchi,K., Higuchi,M., Yoshida,S., Nakakura,T., Tateno,K.,
            Hasegawa,R., Takigami,S., Ohsako,S., Kato,T. and Kato,Y.
  TITLE     Proton receptor GPR68 expression in dendritic-cell-like
            S100beta-positive cells of rat anterior pituitary gland: GPR68
            induces interleukin-6 gene expression in extracellular
            acidification
  JOURNAL   Cell Tissue Res 358 (2), 515-525 (2014)
   PUBMED   25129106
  REMARK    GeneRIF: S100beta-positive dendritic-like cells can sense an
            increase in extracellular protons via GPR68 and respond by the
            production of IL-6 in order to suppress the up-regulation of Pomc
            expression.
REFERENCE   3  (bases 1 to 3115)
  AUTHORS   Nakakura,T., Mogi,C., Tobo,M., Tomura,H., Sato,K., Kobayashi,M.,
            Ohnishi,H., Tanaka,S., Wayama,M., Sugiyama,T., Kitamura,T.,
            Harada,A. and Okajima,F.
  TITLE     Deficiency of proton-sensing ovarian cancer G protein-coupled
            receptor 1 attenuates glucose-stimulated insulin secretion
  JOURNAL   Endocrinology 153 (9), 4171-4180 (2012)
   PUBMED   22733973
REFERENCE   4  (bases 1 to 3115)
  AUTHORS   Li,H., Wang,D., Singh,L.S., Berk,M., Tan,H., Zhao,Z., Steinmetz,R.,
            Kirmani,K., Wei,G. and Xu,Y.
  TITLE     Abnormalities in osteoclastogenesis and decreased tumorigenesis in
            mice deficient for ovarian cancer G protein-coupled receptor 1
  JOURNAL   PLoS One 4 (5), e5705 (2009)
   PUBMED   19479052
  REMARK    Erratum:[PLoS One. 2015 Apr 13;10(4):e0125463. doi:
            10.1371/journal.pone.0125463. PMID: 25875929]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3115)
  AUTHORS   Yang,M., Mailhot,G., Birnbaum,M.J., MacKay,C.A., Mason-Savas,A. and
            Odgren,P.R.
  TITLE     Expression of and role for ovarian cancer G-protein-coupled
            receptor 1 (OGR1) during osteoclastogenesis
  JOURNAL   J Biol Chem 281 (33), 23598-23605 (2006)
   PUBMED   16787916
  REMARK    GeneRIF: OGR1 is expressed early during osteoclastogenesis both in
            vivo and in vitro and plays a role in osteoclast differentiation.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001065526.1, XM_234483.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760396, SAMEA5760433
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3115
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..3115
                     /gene="Gpr68"
                     /note="G protein-coupled receptor 68"
                     /db_xref="GeneID:314386"
                     /db_xref="RGD:1309559"
     exon            1..81
                     /gene="Gpr68"
                     /inference="alignment:Splign:2.1.0"
     exon            82..159
                     /gene="Gpr68"
                     /inference="alignment:Splign:2.1.0"
     exon            160..557
                     /gene="Gpr68"
                     /inference="alignment:Splign:2.1.0"
     exon            558..3115
                     /gene="Gpr68"
                     /inference="alignment:Splign:2.1.0"
     CDS             656..1783
                     /gene="Gpr68"
                     /codon_start=1
                     /product="ovarian cancer G-protein coupled receptor 1"
                     /protein_id="NP_001101519.1"
                     /db_xref="GeneID:314386"
                     /db_xref="RGD:1309559"
                     /translation="MRSKAPSGPKMGNITTENSSLPCPIDHTIHQTLAPVVYVTVLVV
                     GFPANCLSLYFGYLQIKARNELGVYLCNLTIADLFYICSLPFWLQYVLQHDNWSHGDL
                     SCQVCGILLYENIYISVGFLCCISIDRYLAVAHPFRFHQFRTLKAAVGVSVLIWAKEL
                     LTSIYFLKHKEVIEDEDRHRVCFEHYPIQAWQRGINYYRFLVGFLFPICLLLASYQGI
                     LRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSLWESSCDFAKSIFN
                     IYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTSRAREAYPLGA
                     PEASGKSGAQGEEPELLTKLHSAFQTPNSLGLGGPPTVGLA"
ORIGIN      
        1 aggtggatgc caagcctcca tcatacctgt gccacgccct cgccttgcga gctgcgtgcc
       61 ttccgtgtcc accagagaga ggagtcccca gcctctcctg gccgctcacg caccgcaccg
      121 gaggacatta ggccgtcgtc ccagactgtc gcggcgcagg aattgagaga gggagagctt
      181 gtctgtgtgc agggtcgtcc aggcactgtc aagttgagct gtaggagtcc agggctggag
      241 gtttgagggt agagcctggc tggatgggtt gaaccggagt cgactctttc taggttctcc
      301 cacagagaac tctcagggct gctgagggtg gacctcactg ctggttcccc atttcctcct
      361 caactggctg tggactcctc gctgccttcc tttgccttcc caggaggctc tagaagaagc
      421 caatcggtgt aggtatgggg ctggatagtt tccaaactga cccacttgcg ggacagaaat
      481 caatttaata gcttaagacc tgttttcaaa agaaatgaga tagaagagac aatgccagca
      541 tgaaaaacaa gcagcagggg tccacctacc accgatgatg tctagatcct gatacatttg
      601 caccaccttc tataaacaag atggcaagag agagattggc ttcatctcca agcccatgag
      661 gagtaaggcc ccttctggcc caaagatggg gaacatcact acagaaaact cctcactacc
      721 ttgccccatt gaccacacca tccaccagac actggcccca gtggtctatg tgaccgtgct
      781 ggtggtgggc ttcccggcca actgcctatc cctctacttt gggtacttgc agatcaaggc
      841 ccgaaatgag ctgggagtgt acctgtgtaa cctgaccatt gcagacctat tctatatctg
      901 ttcgctcccc ttctggctgc agtacgtact ccagcatgac aactggtccc acggtgacct
      961 atcctgccag gtgtgtggca tcctcctcta tgagaacatt tacatcagcg tgggcttcct
     1021 ctgctgtatc tccatcgacc gctacctggc tgtggcccac cccttccgct tccaccagtt
     1081 ccgcaccctg aaggcagccg tgggtgtcag tgtgctcatc tgggccaagg agctgctgac
     1141 cagcatctac ttcctcaagc acaaggaggt catcgaagac gaggaccggc accgagtctg
     1201 ctttgagcat taccctatcc aggcgtggca gcgtggcatc aactactacc gtttcctggt
     1261 gggctttctc tttcccatct gcctgctgct ggcctcctac cagggcatcc tgcgggctgt
     1321 gcgccgcagc catggcaccc agaagagccg caaggaccag attcagcggc tggtgctcag
     1381 caccgtggtc atcttcctgg cttgcttcct gccctaccac gtgctgctgc tggtgcgcag
     1441 cctctgggag agcagctgtg actttgccaa gagcatcttc aacatctatc acttctccct
     1501 cctcctcacc agcttcaact gtgtagctga cccggtgctg tactgctttg tcagtgagac
     1561 cactcacagg gacctagccc gcctccgagg agcctgccta gccttcctta cctgctctag
     1621 gacaagcagg gccagggagg cctaccctct gggtgcccct gaggcctctg ggaaaagtgg
     1681 ggcccagggc gaggagcctg aattgttaac caagctccac tcagccttcc agacccctaa
     1741 ctcactggga ttgggagggc cccccacagt tggcttggcc tagcttgagt catatgtgtg
     1801 tgagcttcca ccgacaggcc ttgtggtctg gagcttgcat ggtggctgtc tcccattttg
     1861 tcatgaatag gtgcctcgct cttcaggaag gaaccatggt cttgggcccc agccaggtca
     1921 ctctggccca ctggaagttt gctctgtgtg ctgaacctgg gcactgctga ctgcatgagt
     1981 gagccctgtc tccctccatg ttctctgcag ctgcctgggc tacagatggg tgggagtcag
     2041 aattgtcact tccaggaggt ttgcaaagag cagcgggcct gggggtgtgg agaggagtgt
     2101 agggacctgg gtgctcgttc acctgcaagc tttccctgtt gtcacagatg ataccagccc
     2161 aaatatgctg tggtcttgtg tgacatagga agctgtgttg tgaccatcag tactgagctc
     2221 gcctctaaac tagtgtggac cagaagactg gttaaggtga agactagggc ggggttgggg
     2281 caccgatatt ggtgacccag ggataagagc agagaggcag tcagggaaga agccccagcg
     2341 ccagacacat ctcactttac agggcttatg gaacagattc cccaacccct aagggctgat
     2401 gggaaaaaat ccccagggct cctcggagag atgccagggg ccctttaaga tgccatacta
     2461 aagcttaata aaaaggctta ggcctgaagc tgtgtcccta gccaaattcc tagcacaggc
     2521 ttttcctaat tagctttttt tgtgtgtcca tctggccaaa gtgcgggacc cgagagcctg
     2581 agggaaaaga gagagggaga atatgaaaat gacagagtgt ccaggacaac tgtgtgctaa
     2641 gacactgatg ccagggtcat gtgactgctg ccagtaaccc ctacccttct ccacatgcac
     2701 cttcaagagg agtaaacagt ttcccagaat tcctagttcc aataaactaa caacacacat
     2761 acacatgact gcgtctcttg actgcaggtt tggctcaagc tccattttgg tgtaggagag
     2821 ttggcaggaa taactgcatg ccagagagac ctacacctac cccagcctag atccgtgtgg
     2881 ggcaatggta atagctaagt gttctgtacc tctttgtccc acagtatttc cccgtttgac
     2941 ctgaaattct ggattcgcac tggcttggag tggatcaagc taagcccagc tccccttacc
     3001 aaggagagct gtatttttgt gttgtcttct ctcttacgcc aagtatccct gtgttgcact
     3061 gtgagatggg tttatgtagt gacttcaatc tgccaataaa acaaagtaac caatc
//
