LOCUS       NM_001106751            2012 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus G-protein coupled receptor 65 (Gpr65), mRNA.
ACCESSION   NM_001106751 XM_001063813 XM_234367
VERSION     NM_001106751.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Ma,X.D., Hang,L.H., Shao,D.H., Shu,W.W., Hu,X.L. and Luo,H.
  TITLE     TDAG8 activation attenuates cerebral ischaemia-reperfusion injury
            via Akt signalling in rats
  JOURNAL   Exp Neurol 293, 115-123 (2017)
   PUBMED   28365474
  REMARK    GeneRIF: This study showed that TDAG8 plays an important
            neuroprotective role through inhibition of neuronal apoptosis and
            alleviation of neurological deficits by activating the Akt
            signalling pathway in rats.
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   McGuire,J., Herman,J.P., Ghosal,S., Eaton,K., Sallee,F.R. and
            Sah,R.
  TITLE     Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor
            cloned from rat brain
  JOURNAL   Biochem Biophys Res Commun 386 (3), 420-425 (2009)
   PUBMED   19501050
  REMARK    GeneRIF: These results open up new areas of investigation into the
            relevance of TDAG8 in pH homeostasis and pathological states
            associated with acid-base dys-regulation in the brain such as
            ischemia and panic disorder.
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Ishii,S., Kihara,Y. and Shimizu,T.
  TITLE     Identification of T cell death-associated gene 8 (TDAG8) as a novel
            acid sensing G-protein-coupled receptor
  JOURNAL   J Biol Chem 280 (10), 9083-9087 (2005)
   PUBMED   15618224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 29, 2022 this sequence version replaced NM_001106751.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.26902.1,
                                           SRR26643284.9185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000006.1  123254754-123254800
            48-2012             JAXUCZ010000006.1  123260794-123262758
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2012
                     /gene="Gpr65"
                     /gene_synonym="Tdag8"
                     /note="G-protein coupled receptor 65"
                     /db_xref="GeneID:299242"
                     /db_xref="RGD:1311832"
     exon            1..47
                     /gene="Gpr65"
                     /gene_synonym="Tdag8"
                     /inference="alignment:Splign:2.1.0"
     exon            48..2012
                     /gene="Gpr65"
                     /gene_synonym="Tdag8"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..1453
                     /gene="Gpr65"
                     /gene_synonym="Tdag8"
                     /note="T cell death associated protein 8"
                     /codon_start=1
                     /product="psychosine receptor"
                     /protein_id="NP_001100221.1"
                     /db_xref="GeneID:299242"
                     /db_xref="RGD:1311832"
                     /translation="MTMNSTCVEEQHDLDHYLFPVVYIFVFIVSVPANIGSLCVSFLQ
                     AKKENELGVYLFSLSLSDLLYALTLPLWINYTWNKDNWTLSPTLCKGSVFFTYLNFYS
                     STAFLTCIALDRYLAVVYPLRFSFLRTRRFAFITSLSIWILESVFNSILLWEDETSVE
                     YCDAEKSNFTLCYDKYPLEKWQINLNLFRTFLGYAIPLVTIMICNHKVYRAVKHNQAT
                     ENNERRRIIKLLASITLTFILCFTPFHVMVLIRCILERNVNFNNKTGKQTFTVYRITV
                     ALTSLNCVADPILYCFVTETGRSDMWNILKVCARKRNRSRGQKRDILSVSTRDTIELE
                     IIE"
ORIGIN      
        1 agagttgcca ccctcctcag acaagagaag catcactcca gaaacggaat caggacactt
       61 ttaaaagaac gcccggtggt atgaaaataa aaccagggtg ttcacagctt caccaatctc
      121 caatctcctg taagattcaa aagaacagat gagaggctaa aatcccatga ttctaaacat
      181 gaagacttct gatggttaaa tctaattaac tgctttaaat caccgccagg agcttggatc
      241 ctgacttctg gcagtaatag tctgtgtaaa acttcgatct ataatcactc tctcaatgcc
      301 tggatgcact aatcagaaac ataagacact gagagaaaac cctgagagaa agagacttta
      361 acattgacaa tttacaaggc gagagtcctt tccccattta cagcctaaga agtaatgtaa
      421 tagccactgt aaagaaaaaa tgacgatgaa cagcacatgt gttgaagaac agcatgacct
      481 ggaccactat ttgttcccag tggtctacat atttgtgttt atagtcagcg tcccagccaa
      541 catcggctct ttatgtgtat cttttctgca agcgaagaag gaaaatgaac taggagttta
      601 cctcttcagt ctgtcactgt cagatctgct gtatgcgttg acgctgcctc tctggataaa
      661 ctacacttgg aataaagaca actggacgct ctctcccacc ttgtgcaaag gaagcgtttt
      721 cttcacctac ctgaactttt acagcagcac ggccttcctc acttgcattg ccttggaccg
      781 ctatttagca gtcgtctacc ctctaaggtt ttcttttcta agaacaagaa gatttgcatt
      841 tatcaccagc ctgtctatct ggatattgga atccgtcttt aactccatcc ttctgtggga
      901 agacgaaaca agtgtcgaat actgtgatgc agagaaatct aatttcactc tctgctatga
      961 caaataccct ctggagaagt ggcagataaa ccttaacctg ttcaggactt tcctgggcta
     1021 cgcaataccc ttggtcacca tcatgatctg caaccataaa gtctaccgcg ccgtgaagca
     1081 caaccaagct acggaaaaca acgaaaggag acggatcata aagctgcttg ccagcatcac
     1141 gctgactttc atcttatgct ttaccccttt ccacgtgatg gtgctcatcc gctgcatttt
     1201 agagcgcaac gtgaacttca ataacaagac tggaaagcag acatttacgg tgtacagaat
     1261 cacagtggcc ctgacgagtc taaactgtgt cgccgatcca attctctact gtttcgtgac
     1321 ggaaaccggg agatccgata tgtggaacat attaaaagtg tgtgctagga agcgcaatag
     1381 atcccgagga caaaaaagag acatactttc tgtgtccaca agagatacca tagaactgga
     1441 gattatagaa taaaaagtag aggccggtta agttacatga tattatctaa taaaaattat
     1501 actttggaaa agaaatccgg catagggcaa tcaagtgcga atactttagt ctacccccgt
     1561 ggagatattt tgaaggtgca ttgtacgact cctgtcctga ctttattaag taaggtacaa
     1621 aaatgtattc ttttgtatgt attctaatga tcagacatca tcatttcagt accaggtctc
     1681 tttgtctctg tgctataacc tccaagaagc atgtaggatg gtacatcggg ggccattcta
     1741 tctgatggtt aggattcctt tcgttgttgc tgtcttcgga ttttcagttt tatcatctgt
     1801 ataaacctgt cttcaacaag gtaactgcta aagactccta accacattca ttaacaaata
     1861 tttgaagcca ttccatgaac tgggattttc cattgagtac ttacttgggt tataaaagaa
     1921 atgttctcat gaactttgat gtttacatac atttggagat ctagtcacca catcacataa
     1981 agtaaaagta aatggctttt ttattttggt ct
//
