LOCUS       NP_001100110             425 aa            linear   ROD 18-MAR-2025
DEFINITION  probable G-protein coupled receptor 63 [Rattus norvegicus].
ACCESSION   NP_001100110 XP_001060842 XP_232847
VERSION     NP_001100110.1
DBSOURCE    REFSEQ: accession NM_001106640.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 425)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_232847.1, XP_001060842.1.
FEATURES             Location/Qualifiers
     source          1..425
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     Protein         1..425
                     /product="probable G-protein coupled receptor 63"
                     /calculated_mol_wt=47887
     Region          88..388
                     /region_name="7tmA_GPR63"
                     /note="G protein-coupled receptor 63, member of the class
                     A family of seven-transmembrane G protein-coupled
                     receptors; cd15404"
                     /db_xref="CDD:320526"
     Region          89..115
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320526"
     Region          122..147
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320526"
     Site            order(144,147..148,160..165,167..168,171,213,215..219,245,
                     248..250,252..254,256..257,333,336..337,339..340,343,
                     355..356,358..360,363,366..367)
                     /site_type="other"
                     /note="putative ligand binding pocket [chemical binding]"
                     /db_xref="CDD:320526"
     Region          160..190
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320526"
     Region          199..221
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320526"
     Region          245..274
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320526"
     Region          313..343
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320526"
     Region          356..381
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320526"
     CDS             1..425
                     /gene="Gpr63"
                     /coded_by="NM_001106640.3:418..1695"
                     /db_xref="GeneID:297952"
                     /db_xref="RGD:1306460"
ORIGIN      
        1 mvvsgvltap avlttphtgt snmtfvvyen spmnitaplp fqhpspgpll rysletmtst
       61 gfsslavnst vvtpapavfk slnlalqiil saimifilfv sflgnlvvcl mvyqkaamrs
      121 ainillasma fadmllavln mpfalvtilt trwifgkffc rlsamffwlf viegvailli
      181 isidrfliiv qrqdklnpyr akvliavswa tafsvafpla vgnpdlqips rapqcvfgyt
      241 tnsgyqayvi lislisffip flvilysfmg ilntlrhnal rihsypegic lsqvsklglm
      301 slqrpfqmsi dmsfktraft tililfavfi vcwapfttys lvatfskhfy yqhnffeist
      361 wllwlcylks alnpliyywr ikkfhdacld mmpksfkflp rlpghtrrri rpsavyvcge
      421 hrtvl
//
