LOCUS       NM_031806               2237 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 6 (Gpr6), mRNA.
ACCESSION   NM_031806
VERSION     NM_031806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2237)
  AUTHORS   Breivogel,C.S., McPartland,J.M. and Parekh,B.
  TITLE     Investigation of non-CB1, non-CB2 WIN55212-2-sensitive
            G-protein-coupled receptors in the brains of mammals, birds, and
            amphibians
  JOURNAL   J Recept Signal Transduct Res 38 (4), 316-326 (2018)
   PUBMED   30376752
  REMARK    GeneRIF: Pharmacological evidence of this receptor was found in the
            brains of mammals and pigeon, but not frog or newt. Bioinfomatics
            results implicate GPR6 as a possible candidate for the additional
            WIN55212-2-sensitive receptor.
REFERENCE   2  (bases 1 to 2237)
  AUTHORS   Benoit,M.E., Hernandez,M.X., Dinh,M.L., Benavente,F., Vasquez,O.
            and Tenner,A.J.
  TITLE     C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer
            disease mouse models, are essential for the C1q-mediated protection
            against amyloid-beta neurotoxicity
  JOURNAL   J Biol Chem 288 (1), 654-665 (2013)
   PUBMED   23150673
  REMARK    GeneRIF: C1q-induced LRP1B and GPR6 proteins expressed early in
            Alzheimer disease mouse models, are essential for the C1q-mediated
            protection against amyloid-beta neurotoxicity
REFERENCE   3  (bases 1 to 2237)
  AUTHORS   Padmanabhan,S., Myers,A.G. and Prasad,B.M.
  TITLE     Constitutively active GPR6 is located in the intracellular
            compartments
  JOURNAL   FEBS Lett 583 (1), 107-112 (2009)
   PUBMED   19059244
  REMARK    GeneRIF: The localization of GPR6 in HEK293 cells and striatal
            neurons was assessed.
REFERENCE   4  (bases 1 to 2237)
  AUTHORS   Ignatov,A., Lintzel,J., Kreienkamp,H.J. and Schaller,H.C.
  TITLE     Sphingosine-1-phosphate is a high-affinity ligand for the G
            protein-coupled receptor GPR6 from mouse and induces intracellular
            Ca2+ release by activating the sphingosine-kinase pathway
  JOURNAL   Biochem Biophys Res Commun 311 (2), 329-336 (2003)
   PUBMED   14592418
REFERENCE   5  (bases 1 to 2237)
  AUTHORS   Chenn,A., Levin,M.E. and McConnell,S.K.
  TITLE     Temporally and spatially regulated expression of a candidate
            G-protein-coupled receptor during cerebral cortical development
  JOURNAL   J Neurobiol 46 (3), 167-177 (2001)
   PUBMED   11169503
  REMARK    Erratum:[J Neurobiol 2001 Jun 5;47(3):244]
REFERENCE   6  (bases 1 to 2237)
  AUTHORS   Song,Z.H., Young,W.S. 3rd, Brownstein,M.J. and Bonner,T.I.
  TITLE     Molecular cloning of a novel candidate G protein-coupled receptor
            from rat brain
  JOURNAL   FEBS Lett 351 (3), 375-379 (1994)
   PUBMED   8082799
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031806.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF064706.1, U12006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000020.1  46075122-46075251   c
            131-2237            JAXUCZ010000020.1  46072480-46074586   c
FEATURES             Location/Qualifiers
     source          1..2237
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q12"
     gene            1..2237
                     /gene="Gpr6"
                     /note="G protein-coupled receptor 6"
                     /db_xref="GeneID:83683"
                     /db_xref="RGD:70939"
     exon            1..130
                     /gene="Gpr6"
                     /inference="alignment:Splign:2.1.0"
     exon            131..2237
                     /gene="Gpr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..1241
                     /gene="Gpr6"
                     /note="sphingosine 1-phosphate receptor GPR6; putative G
                     protein-coupled receptor (CNL3)"
                     /codon_start=1
                     /product="G-protein coupled receptor 6"
                     /protein_id="NP_113994.1"
                     /db_xref="GeneID:83683"
                     /db_xref="RGD:70939"
                     /translation="MNASAAALNESQVVAVAAEGAAAAATAAGTPDTSEWGPPAASAA
                     LGGGGGPNGSLELSSQLPAGPSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTP
                     ALRTPMFVLVGSLATADLLAGCGLILHFVFQYVVPSETVSLLMVGFLVASFAASVSSL
                     LAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLADRASCS
                     VVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATR
                     KGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPATYNSMINPIIYAFRN
                     QEIQRALWLLFCGCFQSKVPFRSRSPSEV"
ORIGIN      
        1 ctcagggaca ggagaccagt actttcctct tcgacgcggg gcagcctcct gcaggcagct
       61 gctcggaccg cgtagggcac acagccgcgg agcgcatgac cagagactcc cgggagccct
      121 gactcctcag ggagcagcat ctggcggcga tgaacgctag cgccgccgcg ctcaacgagt
      181 cccaggtggt ggcagtagcg gccgagggag cggcagctgc ggctacagca gcagggacac
      241 cggacaccag cgaatgggga cctccggcag catccgcggc gctgggaggc ggcggaggac
      301 ctaacgggtc actggagctg tcttcgcagc tgcccgcagg accctcagga cttctgcttt
      361 cggcagtgaa tccctgggat gtgctgctgt gcgtgtcggg gactgtgatc gcaggcgaaa
      421 atgcgctggt ggtggcgctc atcgcatcca ctcccgcgct gcgcacgccc atgtttgtgc
      481 tcgtgggtag tctggccact gctgacctgc tggcgggctg tggcctcatc ctacacttcg
      541 tgttccagta cgtggtgccc tcggagactg tgagcctgct catggtgggc ttcctggtgg
      601 cgtccttcgc cgcctcagtc agcagcctgc tcgctatcac agtggaccgt tacctgtccc
      661 tttacaacgc gctcacctac tactcgcgcc ggaccctgtt gggcgtgcac ctcttgctag
      721 cagccacctg gacagtgtcc ctcgggttgg ggttgctgcc cgttctaggc tggaactgct
      781 tggctgaccg cgcgtcctgc agcgtggtgc gccccctgac acgcagccat gtggcgttgc
      841 tctccacttc cttctttgtg gtctttggca tcatgctaca cttgtacgtg cgcatctgcc
      901 aggtggtctg gcgccacgcc caccagatcg ctttgcaaca gcactgccta gcaccaccac
      961 acttagcagc caccagaaag ggtgtgggaa ctttggccgt ggtgctaggc acttttgggg
     1021 ccagctggct gcccttcgcc atctattgtg tggtgggtag ccaagaggac ccggccatct
     1081 acacctatgc caccctgctg cctgccacct ataactccat gatcaatccc atcatctatg
     1141 ccttccgcaa ccaggagatc cagcgtgcct tgtggctcct gttctgtggc tgtttccaat
     1201 ccaaagtgcc cttccgctcc aggtccccca gtgaggtctg aagggctcct ccgtgtctcc
     1261 tcacccacat cacaaatcca acatgccggc ctttggtgag cttctaggtg cctgctgatg
     1321 aactcttgag gactcagtgg ttcggcgcga gtctgactgc cccgcaaagg gactggatgt
     1381 gaacgcaaca aactgactca gacaaagagg cttgttggca ttttacatat acagtgtata
     1441 cacgtgtaca tatatataca aatatttgta tcttctggag gtgttcaggg cctggagctt
     1501 cccgttctgt gaaaaaaact aacaaaatgt ggttgtatac tcaatcgtac atcacatttg
     1561 tcaagtgaag acattccaat actgcttaat aatagcactt tatttttagc tgctgaaatg
     1621 ccaagacagt gttgccatcc ccaagagcag gagaaaggga gtcagagatg tatttttgtt
     1681 gtatgtgata gaatattttg ctgcacatgc atcagtaaac tacaacatat tttgtacaca
     1741 aataaacaca ttataaaagt atgatcttgg gtatgtgata aattgtggca ttgtttggaa
     1801 tctgaattgt gagtgtgttt attttaaaag tctactgcac atctatctat catcttgtcc
     1861 cagggagagc cacatgaaat accagatcta aaccatggga tgaggcagta acattcatga
     1921 gtcatggagg aagtaacatt cacacgtggc atccccagaa cacgagaagg aaggctgtta
     1981 ctggtgcaag ttaatgtgct ctcttggtgg ccgggttggg aagacatgtt tcagaggtca
     2041 aaacaattca agtcacatag gcacaggtgt aaactctgaa gccacaactt accagcataa
     2101 ctttacaaac atgccaagat ttctcaacat ggcttattca gactgttgct acccaggtct
     2161 ggtagccagg tgcagagccc aataaaacca ataaaattct cctaaagcag gattcccaga
     2221 tcttcatggg gtaactg
//
