LOCUS       NM_001191915            2012 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 50 (Gpr50), mRNA.
ACCESSION   NM_001191915 XM_346374
VERSION     NM_001191915.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Batailler,M., Mullier,A., Sidibe,A., Delagrange,P., Prevot,V.,
            Jockers,R. and Migaud,M.
  TITLE     Neuroanatomical distribution of the orphan GPR50 receptor in adult
            sheep and rodent brains
  JOURNAL   J Neuroendocrinol 24 (5), 798-808 (2012)
   PUBMED   22512326
  REMARK    GeneRIF: An enlarged distribution of GPR50 protein in the brain.
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Izzo,G., Francesco,A., Ferrara,D., Campitiello,M.R., Serino,I.,
            Minucci,S. and d'Istria,M.
  TITLE     Expression of melatonin (MT1, MT2) and melatonin-related receptors
            in the adult rat testes and during development
  JOURNAL   Zygote 18 (3), 257-264 (2010)
   PUBMED   20109269
  REMARK    GeneRIF: the H9 melatonin-related receptor, are expressed in the
            adult rat testes and during development
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Sidibe,A., Mullier,A., Chen,P., Baroncini,M., Boutin,J.A.,
            Delagrange,P., Prevot,V. and Jockers,R.
  TITLE     Expression of the orphan GPR50 protein in rodent and human
            dorsomedial hypothalamus, tanycytes and median eminence
  JOURNAL   J Pineal Res 48 (3), 263-269 (2010)
   PUBMED   20210849
  REMARK    GeneRIF: Antibodies were used to study the expression of GPR50 in
            mouse, rat and human hypothalamus.GPR50 immunoreactivity (ir) was
            observed in dorsomedial hypothalamic (DMH) cells and in cells of
            the ependymal layer of the third ventricle of the hypothalamus.
REFERENCE   4  (bases 1 to 2012)
  AUTHORS   Levoye,A., Dam,J., Ayoub,M.A., Guillaume,J.L., Couturier,C.,
            Delagrange,P. and Jockers,R.
  TITLE     The orphan GPR50 receptor specifically inhibits MT1 melatonin
            receptor function through heterodimerization
  JOURNAL   EMBO J 25 (13), 3012-3023 (2006)
   PUBMED   16778767
REFERENCE   5  (bases 1 to 2012)
  AUTHORS   Reppert,S.M., Weaver,D.R., Ebisawa,T., Mahle,C.D. and
            Kolakowski,L.F. Jr.
  TITLE     Cloning of a melatonin-related receptor from human pituitary
  JOURNAL   FEBS Lett 386 (2-3), 219-224 (1996)
   PUBMED   8647286
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Jul 17, 2010 this sequence version replaced XM_346374.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1544091.1,
                                           SRR26360176.1399122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345330, SAMN09345331
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-236               JAXUCZ010000021.1  154413689-154413924
            237-2012            JAXUCZ010000021.1  154416500-154418275
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq37"
     gene            1..2012
                     /gene="Gpr50"
                     /gene_synonym="H9"
                     /note="G protein-coupled receptor 50"
                     /db_xref="GeneID:117097"
                     /db_xref="RGD:619863"
     exon            1..236
                     /gene="Gpr50"
                     /gene_synonym="H9"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1810
                     /gene="Gpr50"
                     /gene_synonym="H9"
                     /codon_start=1
                     /product="melatonin-related receptor"
                     /protein_id="NP_001178844.1"
                     /db_xref="GeneID:117097"
                     /db_xref="RGD:619863"
                     /translation="MATVPKSNMGPTKAIPTPFGCISCKLPKPDYPPALIIFVFCAMV
                     ITVVVDLIGNSMVILAVTKNKKLRNSGNIFVASLSVADMLVAIYPYPLMLYTMSVGGW
                     DLSQLQCQMVGLVTGLSVVGSIFNITAIAINRYCYICHSLQYKRIFSLRNTCIYLVVT
                     WVMTVLAVLPNVYIGTIEYDPRTYTCIFNYVNNPAFTVTIVCIHFVLPLIIVGYCYTK
                     IWIKVLAARDPAGQNPDNQFAEVRNFLTMFVIFLLFAVCWCPVNVLTVLVAVIPKEMA
                     GKIPNWLYLAAYCIAYFNSCLNAIIYGILNESFRREYWTIFHAMRHPILFISHLISAI
                     REAWETRVLTRARVRARDQVREQDRARACVAVAGTPRNVRNVLLPGDAAASPSDRASV
                     RPKSQTRSTSVYRKPASIHHKSISGHPKSASVYPRPASSVHCKPASVHFKPTSVHFKG
                     DSVYFKGDTVHFRAASKLVTSHRISAGPSTSHPTSMAGYIKSGTSHRATTTVDYLEPA
                     TTSHSVLTAVDLPEVSASHCLEMTTFGHLKPDIPASILPTVPPELAVTSATPPDATVI
                     PIPTGDYRKVVLIDDDSDDSDCSDEMAV"
     exon            237..2012
                     /gene="Gpr50"
                     /gene_synonym="H9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagatcttga gcttgcctgg gaggaatggc cacggtcccc aagagcaaca tgggacctac
       61 gaaggcaatt cccaccccat tcggctgcat tagctgtaag ctgccaaagc ccgactaccc
      121 accagcgcta atcatcttcg tgttctgcgc aatggtcatc actgtcgtcg tagacctgat
      181 tggaaactcc atggtcattt tggctgtgac caagaacaag aagctccgaa attctggcaa
      241 catctttgtg gccagcctct ctgtggcaga catgctcgtg gccatctacc cgtacccttt
      301 gatgctgtat accatgtcag ttgggggctg ggatctgagt cagctccagt gccagatggt
      361 cgggttggtc acaggactga gtgtagtcgg ttctatcttc aacattactg ccattgccat
      421 caaccggtac tgctacatct gccacagcct ccagtacaag cggatcttca gcctgcgcaa
      481 cacttgcatc tatctggttg ttacctgggt catgactgtt ctggctgtcc tgcctaatgt
      541 gtacattggc accattgagt atgaccctcg cacctacacc tgcatcttca actatgtgaa
      601 caaccctgcc tttactgtga ccattgtctg catccacttc gtcctccctc tcatcatagt
      661 cggttattgc tacacaaaaa tctggatcaa agtgctggca gcccgggacc cagctggaca
      721 gaatcctgac aaccagtttg ctgaggttcg aaattttcta accatgtttg tgatcttcct
      781 cctttttgca gtgtgctggt gccctgtcaa tgtgctcact gtgctggtgg ctgtcattcc
      841 aaaggaaatg gcaggcaaga tccccaactg gctttatctt gcagcctact gcatagccta
      901 cttcaacagc tgcctcaacg ccatcatcta cggtatcctc aatgagagtt tccgaagaga
      961 atactggacc atcttccatg ctatgcggca ccctatcctg ttcatctctc acctcatcag
     1021 cgctattcgg gaggcttggg agacccgagt tctcactcgt gcccgcgtcc gtgcccgtga
     1081 tcaagtccga gaacaagatc gtgctcgtgc ctgtgtcgct gtggcgggaa ccccgaggaa
     1141 cgtccggaat gttctactgc ctggtgatgc agcagcatcc ccttctgatc gtgcctctgt
     1201 ccgtcccaag tcccaaacca ggtctacttc tgtctaccgc aaacctgcct ctatccacca
     1261 taagtctatt tctggtcacc ccaagtctgc ctctgtctac cctaggccag cttcctctgt
     1321 ccattgcaaa cctgcctctg tccatttcaa acccacatct gttcatttca agggcgactc
     1381 tgtctatttc aagggagaca ctgtccattt cagggctgct tccaaacttg tcaccagtca
     1441 ccgtatctct gctggccctt ccaccagtca ccctacatcc atggctggct acattaaatc
     1501 tggtaccagc caccgtgcga ccaccactgt tgactatctc gaacctgcca ccaccagcca
     1561 ctctgtgctc actgctgtcg acctccctga ggtctcagcc tcccattgcc ttgagatgac
     1621 cacctttggc cacctcaaac ccgacattcc tgcctccatc cttcccactg taccccctga
     1681 gcttgctgtc acctctgcca cccctcctga tgccactgta atccccattc ccactggtga
     1741 ttaccgcaag gtcgtgctta ttgatgatga ttccgatgat tctgattgtt ctgatgagat
     1801 ggcggtgtga aaagtgttca tttcaggttt ccctgcttat gtactccaga gcgagatacg
     1861 tccattgtac acactgactg acacagacga cacggacccc cagacacagt ggaagttcca
     1921 tctacctttc gggcatactc ctctttggca ccctgtactt tgaaagtgtg tatatattct
     1981 tgctatctta gagattaaat ttccaagtgt ga
//
