LOCUS       NM_001025680            1513 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 4 (Gpr4), mRNA.
ACCESSION   NM_001025680 XM_218415
VERSION     NM_001025680.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1513)
  AUTHORS   He,H., Su,H., Chen,X., Chen,X. and Yang,S.
  TITLE     Interference with GPR4 inactivates NLRP3 inflammasome signaling by
            inhibiting LPAR1 expression to ameliorate oxygen-glucose
            deprivation/reoxygenation-induced inflammation and apoptosis of
            cardiomyocytes
  JOURNAL   Prostaglandins Other Lipid Mediat 174, 106863 (2024)
   PUBMED   38936540
  REMARK    GeneRIF: Interference with GPR4 inactivates NLRP3 inflammasome
            signaling by inhibiting LPAR1 expression to ameliorate
            oxygen-glucose deprivation/reoxygenation-induced inflammation and
            apoptosis of cardiomyocytes.
REFERENCE   2  (bases 1 to 1513)
  AUTHORS   Li,H., Liu,H., Zhang,N. and Zhu,Z.
  TITLE     Involvement of the G-Protein-Coupled Receptor 4 in the Increased
            Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus
            Pulposus Cells under the Degenerated Intervertebral Disc-Like
            Acidic Microenvironment
  JOURNAL   Biomed Res Int 2020, 1328436 (2020)
   PUBMED   32566653
  REMARK    GeneRIF: Involvement of the G-Protein-Coupled Receptor 4 in the
            Increased Expression of RANK/RANKL/OPG System and Neurotrophins by
            Nucleus Pulposus Cells under the Degenerated Intervertebral
            Disc-Like Acidic Microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1513)
  AUTHORS   Musha,S., Yoshida,S., Murakami,S., Kojima,R., Deai,M., Saso,N.,
            Mogi,C., Sato,K., Okajima,F. and Tomura,H.
  TITLE     Involvement of GPR4 in increased growth hormone and prolactin
            expressions by extracellular acidification in MtT/S cells
  JOURNAL   J Reprod Dev 66 (2), 175-180 (2020)
   PUBMED   31956173
  REMARK    GeneRIF: Involvement of GPR4 in increased growth hormone and
            prolactin expressions by extracellular acidification in MtT/S
            cells.
REFERENCE   4  (bases 1 to 1513)
  AUTHORS   Hosford,P.S., Mosienko,V., Kishi,K., Jurisic,G., Seuwen,K.,
            Kinzel,B., Ludwig,M.G., Wells,J.A., Christie,I.N., Koolen,L.,
            Abdala,A.P., Liu,B.H., Gourine,A.V., Teschemacher,A.G. and
            Kasparov,S.
  TITLE     CNS distribution, signalling properties and central effects of
            G-protein coupled receptor 4
  JOURNAL   Neuropharmacology 138, 381-392 (2018)
   PUBMED   29894771
  REMARK    GeneRIF: Results indicate that GPR4 is expressed by multiple
            neuronal populations and endothelium and that its pH sensitivity is
            affected by level of expression and l-lactic acid (LL). GPR4
            antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this
            effect is absent under anaesthesia, possibly due to the inhibitory
            effect of LL on GPR4.
REFERENCE   5  (bases 1 to 1513)
  AUTHORS   Chen,A., Dong,L., Leffler,N.R., Asch,A.S., Witte,O.N. and Yang,L.V.
  TITLE     Activation of GPR4 by acidosis increases endothelial cell adhesion
            through the cAMP/Epac pathway
  JOURNAL   PLoS One 6 (11), e27586 (2011)
   PUBMED   22110680
REFERENCE   6  (bases 1 to 1513)
  AUTHORS   Liu,J.P., Nakakura,T., Tomura,H., Tobo,M., Mogi,C., Wang,J.Q.,
            He,X.D., Takano,M., Damirin,A., Komachi,M., Sato,K. and Okajima,F.
  TITLE     Each one of certain histidine residues in G-protein-coupled
            receptor GPR4 is critical for extracellular proton-induced
            stimulation of multiple G-protein-signaling pathways
  JOURNAL   Pharmacol Res 61 (6), 499-505 (2010)
   PUBMED   20211729
REFERENCE   7  (bases 1 to 1513)
  AUTHORS   Tobo,M., Tomura,H., Mogi,C., Wang,J.Q., Liu,J.P., Komachi,M.,
            Damirin,A., Kimura,T., Murata,N., Kurose,H., Sato,K. and Okajima,F.
  TITLE     Previously postulated 'ligand-independent' signaling of GPR4 is
            mediated through proton-sensing mechanisms
  JOURNAL   Cell Signal 19 (8), 1745-1753 (2007)
   PUBMED   17462861
REFERENCE   8  (bases 1 to 1513)
  AUTHORS   Yang,L.V., Radu,C.G., Roy,M., Lee,S., McLaughlin,J., Teitell,M.A.,
            Iruela-Arispe,M.L. and Witte,O.N.
  TITLE     Vascular abnormalities in mice deficient for the G protein-coupled
            receptor GPR4 that functions as a pH sensor
  JOURNAL   Mol Cell Biol 27 (4), 1334-1347 (2007)
   PUBMED   17145776
REFERENCE   9  (bases 1 to 1513)
  AUTHORS   Ludwig,M.G., Vanek,M., Guerini,D., Gasser,J.A., Jones,C.E.,
            Junker,U., Hofstetter,H., Wolf,R.M. and Seuwen,K.
  TITLE     Proton-sensing G-protein-coupled receptors
  JOURNAL   Nature 425 (6953), 93-98 (2003)
   PUBMED   12955148
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099196.1.
            
            On Jul 22, 2005 this sequence version replaced XM_218415.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC099196.1 [ECO:0000345]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1513
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1513
                     /gene="Gpr4"
                     /note="G protein-coupled receptor 4"
                     /db_xref="GeneID:308408"
                     /db_xref="RGD:1311604"
     exon            1..1489
                     /gene="Gpr4"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1391
                     /gene="Gpr4"
                     /codon_start=1
                     /product="G-protein coupled receptor 4"
                     /protein_id="NP_001020851.1"
                     /db_xref="GeneID:308408"
                     /db_xref="RGD:1311604"
                     /translation="MDNSTGTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAA
                     YRQVRQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYSN
                     IYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSAPLFHDEL
                     FRDRYNHTFCFEKFPMERWVAWMNLYRVFVGFLFPWALMLLCYRGILRAVQSSVSTER
                     QEKVKIKRLALSLIAIVLVCFAPYHALLLSRSAVYLGRPWDCGFEERVFSAYHSSLAF
                     TSLNCVADPILYCLVNEGARSDVAKALHNLLRFLASNKPQEMANASLTLETPLTSKRS
                     TTGKTSGAVWAVPPTAQGDQVPLKVLLPPAQ"
ORIGIN      
        1 tatttttctg gtgcccccat ctttgcgctc tggttgttgt gcagaaaccc ccactgacat
       61 tagtcccacc tcttatccta tctccatcac tccttgacgt tcttcctctc aagttctcct
      121 tttgcttagc ctaccacaaa gcaactcgga tctcactcct tgtgaactgt ctcctgtgat
      181 gcttccctga gcctccaaag agggggctca gggggcctga tggcctcccg ccccccgtgg
      241 ccctgtagcc ccagtgggcc aggggaagcg cctgggaagt cccatcgccc aggatggaca
      301 acagcacggg cacgtgggag ggctgccatg tggactctcg agtggaccac ctcttcccac
      361 catccctcta catcttcgtc atcggggtgg ggctgcccac caactgcctg gccctgtggg
      421 cagcctaccg ccaggtgcgc cagcgcaatg agctgggcgt ctacctgatg aacttgagca
      481 tcgcagacct gctgtacatc tgtacgctgc cgctgtgggt cgactacttc ctccaccatg
      541 acaactggat ccacggcccc ggctcctgca agctctttgg cttcatcttc tacagcaaca
      601 tctacatcag catcgccttc ctgtgctgca tctccgtgga ccgctacctg gctgtggccc
      661 atccgctgcg ctttgcgcgc ctgcgccggg tcaagacagc agtagctgtg agctccgtgg
      721 tctgggccac cgagctaggc gccaactcgg caccgctctt tcatgacgag ctctttcgtg
      781 atcgctacaa ccacaccttc tgcttcgaga agttccccat ggagcgctgg gtggcctgga
      841 tgaacctgta ccgcgtcttt gtggggttcc tcttcccctg ggcactcatg ttgctgtgct
      901 accgcggcat cctgcgggcc gtacagagca gtgtgtccac cgagcgccag gagaaagtca
      961 agatcaaacg cctggccctg agcctcatcg ccatcgtgct ggtgtgcttt gcaccctacc
     1021 atgctctctt gctgtctcgc agcgctgtct atctgggccg gccctgggac tgtggcttcg
     1081 aggagcgagt cttctctgcc taccacagct ccctagcctt caccagcctc aattgcgtgg
     1141 ctgaccccat cctctactgc ctggtcaacg agggtgcccg tagtgacgtg gccaaagccc
     1201 tgcacaacct cctccgcttc ctggccagca acaagcccca ggagatggcc aatgcttccc
     1261 tcaccctgga gacaccattg acctccaaga ggagcaccac cggcaaaacg tctggggctg
     1321 tctgggcagt gcctcccact gcccaggggg accaggtgcc actgaaggtg ctgctgcccc
     1381 cggcacagtg agccccatgc ccaactgtca tcctgcaccc tccccattgt atgcaaatgt
     1441 atgtaaatat ggccatgtgg atattcatac gaatacaaga gaaaaatgaa aaaaaaaaaa
     1501 aaaaaaaaaa aaa
//
