LOCUS       NM_145784               2302 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus G protein-coupled receptor 37-like 1 (Gpr37l1),
            mRNA.
ACCESSION   NM_145784 XM_001062802 XM_573457
VERSION     NM_145784.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Kunihiro,J., Nabeka,H., Wakisaka,H., Unuma,K., Khan,M.S.I.,
            Shimokawa,T., Islam,F., Doihara,T., Yamamiya,K., Saito,S.,
            Hamada,F. and Matsuda,S.
  TITLE     Prosaposin and its receptors GRP37 and GPR37L1 show increased
            immunoreactivity in the facial nucleus following facial nerve
            transection
  JOURNAL   PLoS One 15 (12), e0241315 (2020)
   PUBMED   33259479
  REMARK    GeneRIF: Prosaposin and its receptors GRP37 and GPR37L1 show
            increased immunoreactivity in the facial nucleus following facial
            nerve transection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Islam,F., Khan,M.S.I., Nabeka,H., Shimokawa,T., Yamamiya,K. and
            Matsuda,S.
  TITLE     Age- and sex-associated changes in prosaposin and its receptors in
            the lacrimal glands of rats
  JOURNAL   Histol Histopathol 35 (1), 69-81 (2020)
   PUBMED   31215019
  REMARK    GeneRIF: Age- and sex-associated changes in prosaposin and its
            receptors in the lacrimal glands of rats.
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Islam,F., Khan,M.S.I., Nabeka,H., Saito,S., Li,X., Shimokawa,T.,
            Yamamiya,K., Kobayashi,N. and Matsuda,S.
  TITLE     Prosaposin and its receptors are differentially expressed in the
            salivary glands of male and female rats
  JOURNAL   Cell Tissue Res 373 (2), 439-457 (2018)
   PUBMED   29656342
  REMARK    GeneRIF: The present findings indicate that PSAP and its receptors,
            GPR37 and GPR37L1, are expressed in the major salivary glands of
            rats and their immunoreactivities differ considerably with age and
            sex.
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Coleman,J.L.J., Mouat,M.A., Wu,J., Jancovski,N., Bassi,J.K.,
            Chan,A.Y., Humphreys,D.T., Mrad,N., Yu,Z.Y., Ngo,T., Iismaa,S., Dos
            Remedios,C.G., Feneley,M.P., Allen,A.M., Graham,R.M. and Smith,N.J.
  TITLE     Orphan receptor GPR37L1 contributes to the sexual dimorphism of
            central cardiovascular control
  JOURNAL   Biol Sex Differ 9 (1), 14 (2018)
   PUBMED   29625592
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Giddens,M.M., Wong,J.C., Schroeder,J.P., Farrow,E.G., Smith,B.M.,
            Owino,S., Soden,S.E., Meyer,R.C., Saunders,C., LePichon,J.B.,
            Weinshenker,D., Escayg,A. and Hall,R.A.
  TITLE     GPR37L1 modulates seizure susceptibility: Evidence from mouse
            studies and analyses of a human GPR37L1 variant
  JOURNAL   Neurobiol Dis 106, 181-190 (2017)
   PUBMED   28688853
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Marazziti,D., Di Pietro,C., Golini,E., Mandillo,S., La Sala,G.,
            Matteoni,R. and Tocchini-Valentini,G.P.
  TITLE     Precocious cerebellum development and improved motor functions in
            mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 110 (41), 16486-16491 (2013)
   PUBMED   24062445
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Meyer,R.C., Giddens,M.M., Schaefer,S.A. and Hall,R.A.
  TITLE     GPR37 and GPR37L1 are receptors for the neuroprotective and
            glioprotective factors prosaptide and prosaposin
  JOURNAL   Proc Natl Acad Sci U S A 110 (23), 9529-9534 (2013)
   PUBMED   23690594
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Flister,M.J., Hoffman,M.J., Reddy,P., Jacob,H.J. and Moreno,C.
  TITLE     Congenic mapping and sequence analysis of the Renin locus
  JOURNAL   Hypertension 61 (4), 850-856 (2013)
   PUBMED   23460292
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Leng,N., Gu,G., Simerly,R.B. and Spindel,E.R.
  TITLE     Molecular cloning and characterization of two putative G
            protein-coupled receptors which are highly expressed in the central
            nervous system
  JOURNAL   Brain Res Mol Brain Res 69 (1), 73-83 (1999)
   PUBMED   10350639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC168215.1.
            
            On or before Oct 23, 2008 this sequence version replaced
            XM_573457.2, XM_001062802.1, NM_145784.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168215.1, AF087947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..2302
                     /gene="Gpr37l1"
                     /note="G protein-coupled receptor 37-like 1"
                     /db_xref="GeneID:252939"
                     /db_xref="RGD:628835"
     exon            1..673
                     /gene="Gpr37l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1489
                     /gene="Gpr37l1"
                     /note="endothelin B receptor-like protein 2; ETBR-LP-2;
                     G-protein coupled receptor CNS2; prosaposin receptor
                     GPR37L1"
                     /codon_start=1
                     /product="G-protein coupled receptor 37-like 1 precursor"
                     /protein_id="NP_665727.2"
                     /db_xref="GeneID:252939"
                     /db_xref="RGD:628835"
                     /translation="MRWLWPLAVSLAVVLAVGPSEVSGAATLSLGGHRAKVQEQQSRP
                     RRGTKDEGPKEVQHYVPEEWAEYPKPIHPAGLQPTKPLVATSPNPDKDGATSESGQEL
                     RTNLTGTPSQRLQIQNPLYPVTESSYSAYAVMLLALVVFAVGIVGNLSVMCIVWHSYY
                     LKSAWNSILASLALWDFLVLFFCLPIVIFNEITKQRLLGDVSCRAVPFMEVSSLGVTT
                     FSLCALGIDRFHVATSTLPKVRPIERCQSILAKLAVIWVGSMMLAVPELLLWQLAQEP
                     TPTMGTVDSCIMKPSADLPESLYSLVMTYQNARMWWYFGCYFCLPILFTVTCQLVTWR
                     VRGPPGRKPECRAGRHEQCESQLNSTVVGLTVVYAFCTLPENVCNIVVAYLSTELTRQ
                     TLDLLGLINQFSTFFKGAITPVLLLCICRPLGQAFLDCCCCCCCEECGGASDSSATVS
                     ADSKLKAEVSSSIYFHKPRESPPLLPLGTPC"
     exon            674..2280
                     /gene="Gpr37l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccctcacc tctctgaggc agctgtgccc tgctttcctg gccatgcggt ggctgtggcc
       61 cctggctgtc tctcttgctg tcgtgttggc tgtggggccg agtgaggtct ctggggctgc
      121 caccttatct ttgggtggtc atagagccaa ggtccaggag cagcagagtc gaccccgaag
      181 aggtaccaag gacgaggggc ccaaggaggt acagcactat gtacctgagg agtgggctga
      241 gtaccccaag cccatccacc ctgctggcct gcagcccacc aagcctttgg tggccactag
      301 ccccaaccca gacaaggatg gggccacctc agagagtgga caagagctga ggaccaacct
      361 gaccgggaca ccaagtcaga ggctgcagat tcagaacccc ctgtatccgg tgaccgagag
      421 ctcctatagt gcctatgccg tcatgctcct ggctctggtg gtatttgctg tgggtatcgt
      481 gggcaatctg tctgtcatgt gcattgtgtg gcacagctac tacttgaaga gtgcctggaa
      541 ctctatcctt gccagcctgg ctctctggga tttcctggtc ctcttcttct gcctaccaat
      601 tgtcatcttc aatgagatca ccaagcagag gctacttggg gatgtttctt gccgagcagt
      661 gcccttcatg gaggtctcct ccctgggagt cacaaccttc agtctctgtg ccctgggcat
      721 agaccgattc catgtggcca ccagcaccct gccaaaggtg agacccattg agagatgcca
      781 atcaatcctg gctaaactgg ctgtcatctg ggtgggctcc atgatgctgg ctgtgcctga
      841 actcctgctg tggcagctgg cacaagagcc cactcccacc atgggaactg tggactcatg
      901 tatcatgaaa ccttcagctg acctgcccga atccctctat tcgctggtga tgacctacca
      961 gaatgcccgc atgtggtggt attttggttg ctacttctgt ctgcccatcc tcttcaccgt
     1021 cacctgtcag ctggtgacat ggcgggtgcg gggcccaccg ggcaggaagc ctgagtgtag
     1081 agcgggcaga catgagcagt gtgagagtca gcttaacagc accgtggtgg gcctgactgt
     1141 ggtctatgcc ttctgtacgc tccctgaaaa cgtctgcaac atcgtggtgg cttacctctc
     1201 cactgagctc acgaggcaga ccctggacct cctgggcctc atcaaccagt tctccacgtt
     1261 cttcaagggc gccatcactc ccgtgctcct cctgtgcatc tgcaggccgc taggccaggc
     1321 cttcctggat tgctgctgct gttgctgctg tgaagaatgt ggtggggcat cagactcctc
     1381 agccactgtc agcgcggaca gcaagcttaa ggccgaagtg tcctcctcca tctacttcca
     1441 caagcccagg gagtcacccc cactcctgcc cctgggcacc ccttgctgag cccatggggg
     1501 aacaggagca ggcacagagc aggcagggga ggggggccat gccgatccat ggcggtctgc
     1561 tgattctttc acatggtctc actttggcct ctctctcatc ctgctgttta gagatggact
     1621 tggcttattt tgtcaacgac tgggcttttc aaagctccat ctacaaacaa tgctgttctt
     1681 accctcagag ggacctgcca gccttgtcct tcccacttgt agatggagat ctgtctagcc
     1741 attagagttg cccagcatct ccatctggcc accctcgagc ccgggcatgg ccttttgcct
     1801 gttctccctt tggtcttagg atctgactat tggctgagcc cctccatcat catgatggat
     1861 cctgtgttga tgagctccaa ctattgttgg accactatga tgtcgatgat catttctcta
     1921 cttctaccta gctccctatc ctggaccagg cacttctagg ggggctcacc taaccaagcc
     1981 caggattcca tttttttttt ttttttttgg ttcttttttt cggagctggg gaccgaaccc
     2041 agggccttgc gcttcctagg taagcgctct accactgagc taaatcccca gccccaggat
     2101 tccattttct aaagtgggtc tgtcttagcc ctgaatgtcc cttccctttt cccagaggag
     2161 tctctcactt ctgtcttccg ttcttagagg tactgcggtt gcattgcctg acccctgcct
     2221 cccgttaggt gctttcctgt agaaggccat tctggaaaaa caataaagta ggtaccacaa
     2281 aaaaaaaaaa aaaaaaaaaa aa
//
